Improving The Skill Of Analysis In Fifth And Sixth Grade Academic Excellence Students

The writer initiated and implemented a program designed to increase the higher cognitive skill of analysis in fifth and sixth grade Academic Excellence students. This was to be achieved by an eclectic approach involving language arts, mathematics, and social studies. The program employed daily and weekly lessons, as well as a three week research project. The primary objective was improvement of scores on the “Ross Test of Higher Cognitive Skills” as evidence by percentile upgrades on spring testing as compared to fall testing. Assessment was done on a weekly basis through oral and written evaluation in the form of anecdotal records, checklists and numerical evaluation forms. Spring test results and the correlation of checklist and evaluation forms indicated subminimal gains by students falling in the deficiency category (below the 30th percentile) during fail testing. These students all tested non-deficient in the spring. Average gains were evidenced by students in the 31st to 50th percentiles and 51st to 75th percentiles. All students, both in and out of the target group, showed substantial gains in analytical problem-solving. (Appendices include demographics of the school population, tabulations of both Fall and Spring test percentages, target group statistics and percentiles, a personal activity checklist, a lesson evaluation form, and target group lesson scores)

Staatliche Fachstellen für öffentliche Bibliotheken im Spiegel ihrer Publikationen

Am Anfang dieser Arbeit wird eine kurze Einführung in die Aufgaben der staatlichen Fachstellen für das öffentliche Bibliothekswesen gegeben. Allgemeine Ziele ihrer Publikationstätigkeit werden erläutert. Der erste Teil beschreibt die Fachstellen in Baden-Württemberg, Nordrhein-Westfalen und Rheinland-Pfalz. Der Schwerpunkt liegt auf den gedruckten Publikationen und jeweiligen Internetpräsentationen der Fachstellen. Der zweite Teil analysiert die Publikationen anhand ausgewählter Themen

The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor

Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear matrix-targeting signal that directs the AML1 protein to appropriate gene regulatory sites within the nucleus. Here we report that substitution of the chromosome 8-derived ETO protein for the multifunctional C terminus of AML1 precludes targeting of the factor to AML1 subnuclear domains. Instead, the AML1/ETO fusion protein is redirected by the ETO component to alternate nuclear matrix-associated foci. Our results link the ETO chromosomal translocation in AML with modifications in the intranuclear trafficking of the key hematopoietic regulatory factor, AML1. We conclude that misrouting of gene regulatory factors as a consequence of chromosomal translocations is an important characteristic of acute leukemias

Risk factors for development of proteinuria by type II (non-insulin dependent) diabetic patients

I. Renal involvement in non-insulin dependent diabetes mellitus patients is the single most important cause of renal failure. The aim of this study was to evaluate the clinical features and to assess the risk factors for the development of proteinuria by non-insulin dependent diabetic patients. 2. Risk factors (expressed as an odds ratio) were calculated by multiple logistic regression analysis taking into account age, sex, body mass index, known duration of diabetes, presence of arterial hypertension, fasting plasma glucose, cholesterol and triglycerides as independent variables and proteinuria as the dependent variable. Sixty-four normoalbuminuric (24-h albumin excretion rate 0.5 g, 31 females, mean age 59.3 years) were studied. 3. Protein uric patients were older, with a longer mean known duration of diabetes (12.4 vs 5.6 years), higher mean fasting plasma glucose (214 vs 168 mg/dl) and plasma creatinine (1.5 vs 1.1 mg/dl) and more frequently presented diabetic retinopathy (94% vs 23% ), peripheral neuropathy (94% vs 23%) and arterial hypertension (73% vs 16%) than normoalbuminuric patients. Age >50 years, body mass index >28.6 kgfm2, known duration of diabetes> 10 years, presence of arterial hypertension, and fasting plasma glucose> 160 mg/dl were significantly and independently associated with development of proteinuria

Effects of a 16-week multimodal exercise program on gait performance in individuals with dementia: a multicenter randomized controlled trial

Background There is a high prevalence of gait impairments in individuals with dementia (IWD). Gait impairments are associated with increased risk of falls, disability, and economic burden for health care systems. Only few studies have investigated the effectiveness of physical activity on gait performance in IWD, reporting promising but inconsistent results. Thus, this study aimed to investigate the effectiveness of a multimodal exercise program (MEP) on gait performance in IWD. Methods In this parallel-group randomized controlled trial, we enrolled 319 IWD of mild to moderate severity, living in care facilities, aged ≥ 65 years, and being able to walk at least 10 m. The control group (n = 118) received conventional treatment, whereas the intervention group (n = 201) additionally participated in a 16-week MEP specifically tailored to IWD. We examined the effects of the MEP on spatiotemporal gait parameters and dual task costs by using the gait analysis system GAITRite. Additionally, we compared characteristics between positive, non-, and negative responders, and investigated the impact of changes in underlying motor and cognitive performance in the intervention group by conducting multiple regression analyses. Results Two-factor analyses of variance with repeated measurements did not reveal any statistically significant time*group effects on either spatiotemporal gait parameters or dual task costs. Differences in baseline gait performance, mobility, lower limb strength, and severity of cognitive impairments were observed between positive, non-, and negative responders. Positive responders were characterized by lower motor performance compared to negative and non-responders, while non-responders showed better cognitive performance than negative responders. Changes in lower limb strength and function, mobility, executive function, attention, and working memory explained up to 39.4% of the variance of changes in gait performance. Conclusions The effectiveness of a standardized MEP on gait performance in IWD was limited, probably due to insufficient intensity and amount of specific walking tasks as well as the large heterogeneity of the sample. However, additional analyses revealed prerequisites of individual characteristics and impacts of changes in underlying motor and cognitive performance. Considering such factors may improve the effectiveness of a physical activity intervention among IWD

Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne.

BACKGROUND: Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied. OBJECTIVES: Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate facial and truncal acne. METHODS: Two phase III double-blind, randomized, vehicle-controlled, 12-week studies of once-daily trifarotene cream versus vehicle in subjects aged 9 years or older. The primary end points were rate of success on the face, as determined by the Investigator\u27s Global Assessment (clear or almost clear and ≥2-grade improvement), and absolute change from baseline in inflammatory and noninflammatory counts from baseline to week 12. The secondary end points were rate of success on the trunk (clear or almost clear and ≥2-grade improvement) and absolute change in truncal inflammatory and noninflammatory counts from baseline to week 12. Safety was assessed through adverse events, local tolerability, vital signs, and routine laboratory testing results. RESULTS: In both studies, at week 12 the facial success rates according to the Investigator\u27s Global Assessment and truncal Physician\u27s Global Assessment and change in inflammatory and noninflammatory lesion counts (both absolute and percentage) were all highly significant (P \u3c .001) in favor of trifarotene when compared with the vehicle. LIMITATIONS: Adjunctive topical or systemic treatments were not studied. CONCLUSION: These studies demonstrate that trifarotene appears to be safe, effective, and well tolerated in treatment of both facial and truncal acne

European Freshwater Ecosystem Assessment: Cross-walk between the Water Framework Directive and Habitats Directive types, status and pressures

The EU policies on the freshwater environment and nature and biodiversity are closely linked. The aims of the Water Framework Directive (WFD) and the Habitat Directive (HD) are to achieve good status for water bodies (WFD) and for habitats and species (HD) respectively. The types of rivers and lakes and their ecological status and pressures under the WFD are not directly comparable to the conservation status and threats for freshwater habitats and species under the HD (EC 2011a). The objective of this study has been to explore the possibilities of linking WFD and HD information on types of water bodies and habitats, and their status, pressures and measures, using WISE WFD information on types, ecological status, pressures and measures (EEA 2012, ETC-ICM 2012) and HD information on habitat types, conservation status and threats (EC 2007). The results may be used as input to the EEA Freshwater Ecosystem Assessment in 2015, and also for future European assessments of specific objectives, status and trends for various types of rivers and lakes after the reporting of the WFD 2nd RBMPs and the next HD article 17 reporting. The outcome may also be used as a basis for discussions of the potential and limitations for WFD and HD synergies in terms of monitoring programmes, assessment systems and measures to improve status. The general methodology used in this report is to analyse data and information reported by Member States on WFD types, ecological status and pressures in river and lake water bodies and on Habitats Directive freshwater habitats and their conservation status and threats. The major data sources used are the WISE-WFD database and the HD Article 17 databaseJRC.H.1-Water Resource

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