Edge strength of core drilled and waterjet cut holes in architectural glass

In structural glass design, an often-applied connection is a bolted connection subjected to in-plane tensile loads. Traditionally, the hole in the glass pane is manufactured by core drilling and conical edge finishing. An alternative method is by waterjet cutting the holes, resulting in cylindrically shaped holes. This research compares the edge strength of core drilled and waterjet cut holes. It focuses on in-plane tensile tests and consists of an experimental part in combination with a numerical part. In the in-plane tensile tests, peak stresses occur perpendicular to the load direction. These stresses are found to be higher for waterjet cut holes (+ 13%) compared to core drilled holes. As a result, the characteristic ultimate load is lower for waterjet cut holes (− 16%). Furthermore, the influence of thermally toughening the glass is found to be more favourable for the characteristic ultimate load of specimens containing core drilled holes than it is for waterjet cut holes. Next to that, it was found that the ultimate load linearly increases with the panel thickness. Eccentric loading, caused by insufficient bushing material or rotation of the bolt, only slightly decreases the ultimate load, provided that no hard contact between bolt and glass occurs. In addition, coaxial double ring tests were performed in the hole area, showing that waterjet cut holes result in larger stresses near the hole edge than core drilled holes. Furthermore, waterjet cut holes are found not to be perfectly round, while drilled holes are. This un-roundness negatively influences the ultimate load and the stresses in the glass; the larger the extent of un-roundness, the higher the stresses and the lower the ultimate load. Also, the orientation of the un-round hole is of influence on the stresses and ultimate load for the tensile test. It is concluded that waterjet cut holes result in lower characteristic ultimate loads and higher stresses. Due to the different edge finishing, the ultimate load still is lower compared to core drilled holes, even if the waterjet cut holes are perfectly round

Eye-Transcriptome and Genome-Wide Sequencing for Scolecophidia: Implications for Inferring the Visual System of the Ancestral Snake

Molecular genetic data have recently been incorporated in attempts to reconstruct the ecology of the ancestral snake, though this has been limited by a paucity of data for one of the two main extant snake taxa, the highly fossorial Scolecophidia. Here we present and analyze vision genes from the first eye-transcriptomic and genome-wide data for Scolecophidia, for Anilios bicolor, and A. bituberculatus, respectively. We also present immunohistochemistry data for retinal anatomy and visual opsin-gene expression in Anilios. Analyzed in the context of 19 lepidosaurian genomes and 12 eye transcriptomes, the new genome-wide and transcriptomic data provide evidence for a much more reduced visual system in Anilios than in non-scolecophidian (=alethinophidian) snakes and in lizards. In Anilios, there is no evidence of the presence of 7 of the 12 genes associated with alethinophidian photopic (cone) phototransduction. This indicates extensive gene loss and many of these candidate gene losses occur also in highly fossorial mammals with reduced vision. Although recent phylogenetic studies have found evidence for scolecophidian paraphyly, the loss in Anilios of visual genes that are present in alethinophidians implies that the ancestral snake had a better-developed visual system than is known for any extant scolecophidian

Microchannel cooling for the LHCb VELO Upgrade I

The LHCb VELO Upgrade I, currently being installed for the 2022 start of LHC Run 3, uses silicon microchannel coolers with internally circulating bi-phase \cotwo for thermal control of hybrid pixel modules operating in vacuum. This is the largest scale application of this technology to date. Production of the microchannel coolers was completed in July 2019 and the assembly into cooling structures was completed in September 2021. This paper describes the R\&D path supporting the microchannel production and assembly and the motivation for the design choices. The microchannel coolers have excellent thermal peformance, low and uniform mass, no thermal expansion mismatch with the ASICs and are radiation hard. The fluidic and thermal performance is presented.Comment: 31 pages, 27 figure

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Probe for LUminosity MEasurement in LHCb

A new detector capable of measuring the luminosity and beam conditions of the Large Hadron Collider (LHC) is proposed at the interaction point of the LHCb experiment. It will enable real time monitoring of beam parameters, which is of paramount importance in order to safely operate the LHC and its experiments in the beam conditions foreseen for Run 3, starting in 2021, and beyond, towards the High-Luminosity (HL) phase. The detector will provide both online and offline measurements with a feedback at the scale of a fraction of a second, to ensure a luminosity-leveling procedure and a real-time alarm to the LHC

Microchannel cooling for the LHCb VELO upgrade I

The LHCb VELO Upgrade I, currently being installed for the 2022 start of LHC Run 3, uses silicon microchannel coolers with internally circulating bi-phase for thermal control of hybrid pixel modules operating in vacuum. This is the largest scale application of this technology to date. Production of the microchannel coolers was completed in July 2019 and the assembly into cooling structures was completed in September 2021. This article describes the R&D path supporting the microchannel production and assembly and the motivation for the design choices, together with the achieved fluidic and thermal performance. The Thermal Figure of Merit of the microchannel coolers is measured on the final modules to be between 1.5 and 3.5 K cm W, depending on glue thickness. The microchannel coolers constitute 18% of the total radiation length of the VELO and less than 2% of the material seen before the second measured point on the tracks. Microchannel cooling is well suited to the VELO implementation due to the uniform mass distribution, close thermal expansion match with the module components and resistance to radiation