Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste

info:eu-repo/semantics/publishedVersio

Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste

Extracellular vesicles; Biomedicine; NanobiotechnlogyVesículas extracelulares; Biomedicina; NanobiotecnologíaVesícules extracel·lulars; Biomedicina; Nanobiotecnologi

Demand Impact for Prices Ending with “9” and “0” in Online and Offline Consumer Goods Retail Trade Channels

Studies on demand impact for 9-ending and rounded prices have so far offered controversial results, with hardly any research focusing on their effect on online commerce or in a multichannel sales context. Our study aims to fill this gap by analyzing the conditions that influence the strategy behind setting such type of pricing in the multichannel retail business of fast-moving consumer goods (FMCG). To test the formulated hypotheses, scanner data from FMCG retailers are used. In addition to “demand” and “price”, “promotion communication”, “retailer type” and “price level” are included as moderators between 9-ending, rounded prices and demand. The results aim to provide, both in the academic and business fields, systematic findings of pricing relationships between online and offline channels which contribute to a better management strategy for “9-ending” and “rounded” prices. Keywords: Prices; 9-ending Prices; Rounded Prices; E-Commerce. JEL Classifications: M31, L81, C32 DOI: https://doi.org/10.32479/irmm.1068

Modelos territoriales de localización en Municipios de Menor nivel de actividad industrial al norte de la zona poniente del estado de México

En este trabajo se reflexiona sobre los patrones espaciales de localización industrial en lugares periféricos, considerando su contexto bajo la importancia actual del estudio de los modelos territoriales que distinguen a las empresas, las aglomeraciones y sus activos y que sirva de base posterior para valorar su potencial. En particular se enfoca a los que se ubican en lugares de menor nivel de industrialización en zonas periféricas urbanas y rurales (LIUR) al norte del Estado de México. Se asume que el origen del asentamiento de las empresas es natural y no planificado, con frecuencia encontrándose de manera aisladas, pero también, se trata la tipología y análisis de concentraciones que se han distinguido por un comportamiento especializado de unidades productivas, formando algún sistema localizado de producción. Para ambos se indica su identificación, patrones de distribución geográfica e importancia para el desarrollo regional, presentando resultados en dos niveles: agregado y local. En este último, mediante un caso de estudio ubicado en uno de sus municipios

Peripheral T-cell lymphoma with a T follicular-helper phenotype: a different entity? Results of the Spanish Real-T study

Peripheral T-cell lymphomaLimfoma perifèric de cèl·lules TLinfoma periférico de células TNodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7–73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.This work was supported by Takeda Farmacéutica España, S.A. The authors received no compensation for writing the manuscript

Impacto de la modalidad de carga de fluidos en el diagnóstico de la capacidad de respuesta a volumen

The purpose of this study was to describe the ‘charge of volume’ and evaluate the difference in proper proportion for ‘responders’ (PR) according the type of liquid, volume, the timing of infusion and the moment of evaluation. Methods: Medline and Embase searches were made for studies using charge of volumen as a cardiac precharge test among a technique description, fluid  response capacities reported definition and PR. Primary results were average PR, according liquid volumen, liquid type, infusion ratio and time for evaluation. Results: A total of 85 studies (3,601 patients) for the analysis. PR were 54.4% (IC 95% 46.9-62.7) where &lt;500 ml was administrated 57.2% (IC 95% 52.9-61.0) where 500 ml was administrated and 60.5% (IC 95% 35.9-79.2) where &gt;500 ml was administrated (p=0.71). PR was not influenced by the type of fluid. RP was similar among patients given a charge of volumen during &lt;15 minutes  (59.2%, IC 95% 54.2-64.1) and during 15-30 minutes (57.7%, IC 95% 52.4-62.4, p = 1). In time of infusion ≥30 minutes, a lesser 49.9% (IC 95% 45.6-54, p = 0.04) PR happened. Response was evaluated at the end of fluid exposure between 1 and 10 minutes, and &lt;10 minutes after fluid exposure. Responder´s proportion was 53.9%, 57.7% y 52.3% (p=0.47). Findings: PR decreases in a long infusion time.  Standardise charge of volumen is desirable.El objetivo de este estudio fue describir la “carga de volumen” y evaluar la diferencia en la proporción de "respondedores" (PR) según el tipo de fluido, el volumen, la duración de la infusión y el momento de la evaluación. Métodos: Se realizaron búsquedas en MEDLINE y Embase para estudios que utilizan la carga de volumen como una prueba de precarga cardíaca con una descripción de la técnica, una definición reportada de capacidad de respuesta de fluidos y PR. El resultado primario fue la PR media, según el volumen de líquido, el tipo de líquidos, la tasa de infusión y el tiempo de evaluación. Resultados: se incluyeron un total de 85 estudios (3601 pacientes) en el análisis. Las PR fueron 54.4% (IC 95% 46.9-62.7) donde se administró &lt;500 ml, 57.2% (IC 95% 52.9-61.0) donde se administraron 500 ml y 60.5% (IC 95% 35.9-79.2) donde&gt; 500 ml fue administrado (p = 0.71). El PR no se vio afectado por el tipo de fluido. La RP fue similar entre los pacientes a los que se administró una carga de volumen durante &lt;15 minutos (59.2%, IC 95% 54.2-64.1) y durante 15-30 minutos (57.7%, IC 95% 52.4-62.4, p = 1). Cuando el tiempo de infusión fue ≥30 minutos, hubo una PR menor de 49.9% (IC 95% 45.6-54, p = 0.04). La respuesta se evaluó al final de la exposición a los fluidos, entre 1 y 10 minutos, y &gt; 10 minutos después de la exposición a los fluidos. Las proporciones de respondedores fueron 53.9%, 57.7% y 52.3%, respectivamente (p = 0.47). Conclusiones: el PR disminuye con un tiempo de infusión largo. Es deseable estandarizar la carga de volumen

Impacto de la modalidad de carga de fluidos en el diagnóstico de la capacidad de respuesta a volumen

El objetivo de este estudio fue describir la “carga de volumen” y evaluar la diferencia en la proporción de "respondedores" (PR) según el tipo de fluido, el volumen, la duración de la infusión y el momento de la evaluación. Métodos: Se realizaron búsquedas en MEDLINE y Embase para estudios que utilizan la carga de volumen como una prueba de precarga cardíaca con una descripción de la técnica, una definición reportada de capacidad de respuesta de fluidos y PR. El resultado primario fue la PR media, según el volumen de líquido, el tipo de líquidos, la tasa de infusión y el tiempo de evaluación. Resultados: se incluyeron un total de 85 estudios (3601 pacientes) en el análisis. Las PR fueron 54.4% (IC 95% 46.9-62.7) donde se administró 500 ml fue administrado (p = 0.71). El PR no se vio afectado por el tipo de fluido. La RP fue similar entre los pacientes a los que se administró una carga de volumen durante 10 minutos después de la exposición a los fluidos. Las proporciones de respondedores fueron 53.9%, 57.7% y 52.3%, respectivamente (p = 0.47). Conclusiones: el PR disminuye con un tiempo de infusión largo. Es deseable estandarizar la carga de volumen. Abstract The purpose of this study was to describe the ‘charge of volume’ and evaluate the difference in proper proportion for ‘responders’ (PR) according the type of liquid, volume, the timing of infusion and the moment of evaluation. Methods: Medline and Embase searches were made for studies using charge of volumen as a cardiac precharge test among a technique description, fluid  response capacities reported definition and PR. Primary results were average PR, according liquid volumen, liquid type, infusion ratio and time for evaluation. Results: A total of 85 studies (3,601 patients) for the analysis. PR were 54.4% (IC 95% 46.9-62.7) where 500 ml was administrated (p=0.71). PR was not influenced by the type of fluid. RP was similar among patients given a charge of volumen during <15 minutes  (59.2%, IC 95% 54.2-64.1) and during 15-30 minutes (57.7%, IC 95% 52.4-62.4, p = 1). In time of infusion ≥30 minutes, a lesser 49.9% (IC 95% 45.6-54, p = 0.04) PR happened. Response was evaluated at the end of fluid exposure between 1 and 10 minutes, and <10 minutes after fluid exposure. Responder´s proportion was 53.9%, 57.7% y 52.3% (p=0.47). Findings: PR decreases in a long infusion time.  Standardise charge of volumen is desirable

Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide

Cancer stem cells; Combination therapy; NiclosamideCélulas madre cancerosas; Terapia combinada; NiclosamidaCèl·lules mare cancerígenes; Teràpia combinada; NiclosamidaCancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast cancer subtype with the highest number of CSCs and the poorest prognosis. Here, we aimed to identify potential drugs targeting CSCs to be further employed in combination with standard chemotherapy in TNBC treatment. The anti-CSC efficacy of up to 17 small drugs was tested in TNBC cell lines using cell viability assays on differentiated cancer cells and CSCs. Then, the effect of 2 selected drugs (8-quinolinol -8Q- and niclosamide -NCS-) in the cancer stemness features were evaluated using mammosphere growth, cell invasion, migration and anchorage-independent growth assays. Changes in the expression of stemness genes after 8Q or NCS treatment were also evaluated. Moreover, the potential synergism of 8Q and NCS with PTX on CSC proliferation and stemness-related signaling pathways was evaluated using TNBC cell lines, CSC-reporter sublines, and CSC-enriched mammospheres. Finally, the efficacy of NCS in combination with PTX was analyzed in vivo using an orthotopic mouse model of MDA-MB-231 cells. Among all tested drug candidates, 8Q and NCS showed remarkable specific anti-CSC activity in terms of CSC viability, migration, invasion and anchorage independent growth reduction in vitro. Moreover, specific 8Q/PTX and NCS/PTX ratios at which both drugs displayed a synergistic effect in different TNBC cell lines were identified. The sole use of PTX increased the relative presence of CSCs in TNBC cells, whereas the combination of 8Q and NCS counteracted this pro-CSC activity of PTX while significantly reducing cell viability. In vivo, the combination of NCS with PTX reduced tumor growth and limited the dissemination of the disease by reducing circulating tumor cells and the incidence of lung metastasis. The combination of 8Q and NCS with PTX at established ratios inhibits both the proliferation of differentiated cancer cells and the viability of CSCs, paving the way for more efficacious TNBC treatments.This work was supported by the Instituto de Salud Carlos III (ISCiii), through Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), an initiative that also counts with the assistance from the European Regional Development Fund (ERDF), specifically in the PENTRI-2 Project and by the “Fundació Marató TV3” (337/C/2013) to I.A., M.R. and E.V. Our laboratories were also supported by the Fondo de Investigaciones Sanitarias (FIS, grants PI20/1474 to S.S.J. and PI18/00871 and PI21/00936), co-financed by the ERDF and the 2017-SGR-638 of the Catalan Government to S.S.J. and EvoNano Project (GA800983), funded by European Union’s Horizon 2020 FET Open Programme. N.G.-A. was supported by grants from Pla Estratègic de Recerca i Innovació en Salut (PERIS) of Catalonia (SLT006/17/00270 270)

Lower Success Rate of Debridement and Implant Retention in Late Acute versus Early Acute Periprosthetic Joint Infection Caused by Staphylococcus spp. Results from a Matched Cohort Study

Background Surgical debridement, antibiotics and implant retention (DAIR) is currently recommended by international guidelines for both early acute (postsurgical) and late acute (hematogenous) periprosthetic joint infections (PJIs). However, due to a different pathogenesis of infection, a different treatment strategy may be needed. Questions/purposes (1) Compared with early acute PJIs, are late acute PJIs associated with a higher risk of DAIR failure? (2) When stratified by microorganism, is the higher risk of failure in late acute PJI associated with Staphylocococcus aureus infection? (3) When analyzing patients with S. aureus infection, what factors are independently associated with DAIR failure? Methods In this multicenter observational study, early acute and late acute PJIs treated with DAIR were retrospectively evaluated and matched according to treating center, year of diagnosis, and infection-causing microorganism. If multiple matches were available, the early acute PJI diagnosed closest to the late acute PJI was selected. A total of 132 pairs were included. Treatment success was defined as a retained implant during follow-up without the need for antibiotic suppressive therapy. Results Late acute PJIs had a lower treatment success (46% [60 of 132]) compared with early acute PJIs (76% [100 of 132]), OR 3.9 [95% CI 2.3 to 6.6]; p <0.001), but the lower treatment success of late acute PJIs was only observed when caused by Staphylococcus spp (S. aureus: 34% versus 75%; p <0.001; coagulase-negative staphylococci: 46% versus 88%; p = 0.013, respectively). On multivariable analysis, late acute PJI was the only independent factor associated with an unsuccessful DAIR when caused by S. aureus (OR 4.52 [95% CI 1.79 to 11.41]; p <0.001). Conclusions Although DAIR seems to be a successful therapeutic strategy in the management of early acute PJI, its use in late acute PJI should be reconsidered when caused by Staphylococcus spp. Our results advocate the importance of isolating the causative microorganism before surgery

Genetic signatures of demographic changes in an avian top predator during the last century : Bottlenecks and expansions of the Eurasian eagle owl in the Iberian Peninsula

Peer reviewe