22,931 research outputs found
Two semi-automated computational approaches for spectroscopic analysis of stellar photospheres: detailed characterization at high resolution and abundance determination at medium resolution
We report on two distinct computational approaches to self-consistently
measure photospheric properties of large samples of stars. Both procedures
consist of a set of several semi-integrated tasks based on shell and Python
scripts, which efficiently run either our own codes or open source software
commonly adopted by the astronomical community. One approach aims to derive the
main stellar photospheric parameters and abundances of a few elements by
analysing high-resolution spectra from a given public library homogeneously
constructed. The other one is applied to recover the abundance of a single
element in stars with known photospheric parameters by using mid-resolution
spectra from another open homogeneous database and calibrating derived
abundances. Both semi-automated computational approaches provide homogeneity
and objectivity to every step of the process and represent a fast way to reach
partial and final results as well as to estimate measurement errors, making
possible to systematically evaluate and improve the distinct steps.Comment: 7 pages, 4 figures, conference paper (I Workshop of Computacao
Cientifica em Astronomia, Brazil, 2011) to appear in the Journal of
Computational Interdisciplinary Sciences - JCI
Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy
Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal transplantation (RTx) model of chronic allograft nephropathy (CAN). Materials and Methods. Left renal grafts from male Fisher and Lewis were transplanted into Lewis rats, generating allografts and isografts, respectively. Blood pressure, renal function, and proteinuria were monitored for up to 52 weeks. At termination, CAN was assessed in the renal tissue by light and electron microscopy, TG2 and ε(γ-glutamyl)-lysine by immunofluorescence, and the urinary ε(γ-glutamyl)-lysine by high performance liquid chromatography.
Results. Compared to the isograft, the allografts were hypertensive, proteinuric, and uraemic and developed CAN. Extracellular TG2 (glomerulus: 64.55 + 17.61 versus 2.11 + 0.17, P<0.001; interstitium: 13.72 + 1.62 versus 3.19 + 0.44, P<0.001), ε(γ-glutamyl)-lysine (glomerulus: 21.74 + 2.71 versus 1.98 + 0.37, P<0.01; interstitium: 37.96 + 17.06 versus 0.42 + 0.11, P<0.05), TG2 enzyme activity (1.09 + 0.13 versus 0.41 + 0.03 nmol/h/mg protein, P<0.05), TG2 mRNA (20-fold rise), and urinary ε(γ-glutamyl)-lysine (534.2 + 198.4 nmol/24 h versus 57.2 + 4.1 nmol/24 h,P<0.05) levels were significantly elevated in the allografts and showed a positive linear correlation with tubulointerstitial fibrosis. Conclusion. CAN was associated with upregulation of renal TG2 pathway, which has a potential for pharmacological intervention. The elevated urinary ε(γ-glutamyl)-lysine, measured for the first time in RTx, is a potential biomarker of CA
Strain-Tunable GaAs Quantum dot: A Nearly Dephasing-Free Source of Entangled Photon Pairs on Demand
Entangled photon generation from semiconductor quantum dots via the
biexciton-exciton cascade underlies various decoherence mechanisms related to
the solid-state nature of the quantum emitters. So far, this has prevented the
demonstration of nearly-maximally entangled photons without the aid of
inefficient and complex post-selection techniques that are hardly suitable for
quantum communication technologies. Here, we tackle this challenge using
strain-tunable GaAs quantum dots driven under two-photon resonant excitation
and with strictly-degenerate exciton states. We demonstrate experimentally that
our on-demand source generates polarization-entangled photons with fidelity of
0.978(5) and concurrence of 0.97(1) without resorting to post-selection
techniques. Moreover, we show that the remaining decoherence mechanisms can be
overcome using a modest Purcell enhancement so as to achieve a degree of
entanglement >0.99. Our results highlight that GaAs quantum dots can be readily
used in advanced communication protocols relying on the non-local properties of
quantum entanglement
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range. In parallel, the mode of action of these compounds was clarified and a quantitative model that links the dynamic ligand-protein cross-talk to observed cellular and in vitro activities was developed. The results support the potential of using dynamics-based approaches to develop original mechanism-based cancer therapeutics
Designed binary mixtures for subcritical organic Rankine cycles based on multiobjective optimization
The use of binary zeotropic mixtures as working fluids applied to Organic Rankine Cycles (ORCs) is investigated in this paper. In total, six (6) hydrocarbons and (2) hydrofluorocarbons are considered, leading to twenty-eight (28) possible binary combinations. The mixtures were tested with a basic Rankine cycle while using the heat source temperature as independent variable, which assumed six different values, ranging from 80 °C to 180 °C, in steps of 20 °C. The simulations aimed to identify the ideal mixtures that maximized the net power and exergetic efficiency, and minimized the heat exchanger’s global conductance for a given temperature of the heat source. The optimization process relied on a genetic algorithm and the selection of the best mixtures, on a non-dominated sorting method (NDS), which returned Pareto fronts gathering the best solutions. While no one specific ideal mixture was identified, the results showed that the range of the so-called ideal mixtures narrows as the heat source temperature increases, with mixtures including fluids like R245fa and pentane being good options, whereas at low temperature, a larger number of fluid mixtures perform well. Finally, a scale analysis is proposed and shows that the maximal net power varies linearly with a Number of Transfer Units (NTU) factor while its slope depends on the heat source temperature. The latter analysis is compared with the results obtained with the Pareto front and NDS, showing that both sets of results agree well while correlated by a single constant for the entire temperature range covered in the present study
Curso de Direitos Humanos na América Latina
Neste presente trabalho podemos observar os objetivos, metas, motivações e o
desenvolvimento do projeto de extensão “Curso de Direitos Humanos na América
Latina”, além de seu impacto na comunidade interna e externa. Destaca-se a
parceria dos representantes de movimentos sociais e professores doutores da
Universidade Federal da Integração Latino-Americana (UNILA) e da Universidade
Estadual do Oeste do Paraná (UNIOESTE). Desta forma, com as aulas expositivas e
os recursos audiovisuais oferecidos quinzenalmente nas salas de aula da UNILA –
campus Jardim Universitário, observou-se a importância do debate, da luta e da
militância por direitos humanos fundamentais na América Latina
Ultraviolet-A Light and Riboflavin Therapy for Acanthamoeba Keratitis: A Case Report
Purpose: To report ultraviolet-A (UV-A) light treatment in a patient with Acanthamoeba keratitis (AK). Methods: Interventional case report. A standard protocol for ultraviolet corneal therapy, with a power emission of 3 mW/cm2 and a wavelength of 370 nm, was used. The protocol included an 8-nm bandwidth at a 54-mm distance measured with a collimation system of diodes as well as a protective shield of riboflavin in a case of documented AK. Results: A 54-year-old female patient with AK, showing no therapeutic response to a wide variety of topical antimicrobial agents and with a visual acuity of 20/400, was treated with UV-A therapy. The patient displayed a favourable response in the first 24 h after treatment, with improvement of symptoms, visual acuity (to 20/200) and biomicroscopy cornea with haze degree I. By the third week post-treatment, the patient was symptom-free. Her visual acuity was 20/30, and the affected cornea was clear. Five months after treatment, there had been no recurrence, and her vision was 20/20. Conclusions: Treatment with UV-A light was an effective therapy in this case of AK
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