5,398 research outputs found
Reimagining Theories of Nationalism: A Critical Examiniation of Prevailing Nationalist Theories
Traditional theories of nationalism tend to fall in one of two categories: 1) top-down, or official nationalism, which holds that nationalist sentiments are created by state actors, or 2) bottom-up, or popular, nationalism, which holds that nationalist sentiments originate with the people. However, there are major flaws in both of those theories, as well as a decent amount of overlap between them. This paper dismantles the supposed binary between these two theories, and looks for a way to view the theories in combination with one another. Looking at the places of overlap, as well as the elements of each theory that should be discarded altogether, a different theory of nationalism - a hybrid theory - emerges. This paper applies the hybrid theory to a case study, Italy from the mid-1800s to mid-1900s, to see how the theory plays out in reality
Embracing the Vision: Our Work with Teachers Implementing GPS
Abstract: In 2005, three Kennesaw State University mathematics education faculty members began a series of workshops titled “Implementing the Georgia Performance Standards [GPS]: Embracing the Vision.” This workshop series has been underwritten by Georgia’s Teacher Quality Higher Education Program. The first series of workshops began with 6th grade teachers the first year the GPS was implemented and the project has been funded each subsequent year since its inception. Currently, we are working with Math III teachers as they implement the course for the first time. The initial focus for the project was on conceptual understanding versus procedural understanding, writing tasks that facilitate students’ conceptual understanding, assessment, and resources. While we have maintained these foci, we have found it necessary to emphasize mathematical content development and the process standards due to the needs of the participants. In this paper, we discuss the structure of our workshop series, focusing on process standards and mathematical content. We provide a specific example of a task we used with participants in our first Math III workshop to illuminate the features of our work
Paper 5: Embracing the Vision: Our Work with Teachers Implementing GPS
In 2005, three Kennesaw State University mathematics education faculty members began a series of workshops titled “Implementing the Georgia Performance Standards [GPS]: Embracing the Vision.” This workshop series has been underwritten by Georgia’s Teacher Quality Higher Education Program. The first series of workshops began with 6th grade teachers the first year the GPS was implemented and the project has been funded each subsequent year since its inception. Currently, we are working with Math III teachers as they implement the course for the first time. The initial focus for the project was on conceptual understanding versus procedural understanding, writing tasks that facilitate students’ conceptual understanding, assessment, and resources. While we have maintained these foci, we have found it necessary to emphasize mathematical content development and the process standards due to the needs of the participants. In this paper, we discuss the structure of our workshop series, focusing on process standards and mathematical content. We provide a specific example of a task we used with participants in our first Math III workshop to illuminate the features of our work
Atypical presentation of neuronal ceroid lipofuscinosis type 8 in a sibling pair and review of the eye findings and neurological features.
Purpose:To report atypical presentation of neuronal ceroid lipofuscinoses type 8 (CLN8) to the eye clinic and review clinical features of CLN8. Observations:Detailed eye exam by slit lamp exam, indirect ophthalmoscopy, fundus photography, optical coherence tomography, visual fields and electroretinogram (ERG). Molecular genetic testing using Next Generation Sequencing panel (NGS) and array Comparative Genomic Hybridization (aCGH).The siblings in this study presented to the eye clinic with retinitis pigmentosa and cystoid macular edema, and a history of seizures but no severe neurocognitive deficits or regression. Genetic testing identified a c.200CÂ >Â T (p.A67V) variant in the CLN8 gene and a deletion encompassing the entire gene. Electron microscopy of lymphocytes revealed fingerprint inclusions in both siblings. Conclusions:and Importance: Pathogenic variants in CLN8 account for the retinitis pigmentosa and seizures in our patients however, currently, they do not have regression or neurocognitive decline. The presentation of NCL can be very diverse and it is important for ophthalmologists to consider this in the differential diagnosis of retinal disorders with seizures or other neurological features. Molecular genetic testing of multiple genes causing isolated and syndromic eye disorders using NGS panels and aCGH along with additional complementary testing may often be required to arrive at a definitive diagnosis
Undergraduate Kinesiology Student Involvement in the Department and Sense of Belonging by Employment Status
Many undergraduate college students find the need to work either on or off campus in order to pay for their tuition and expenses. It is unknown whether or not employment impacts a students ability to be involved in the department or feel like they belong and not typically reported for Kinesiology programs. PURPOSE: To assess the impact employment had on college students in relation to their sense of belonging and involvement with their home department and to investigate belonging and involvement in Kinesiology students. METHODS: Undergraduate college/university students (18+ years) at a public institution in Southern California were recruited via flyers, social media, announcements and word of mouth to participate in an IRB approved online research study. The cross-sectional Qualtrics survey consisted of a few demographic questions (age, gender, major, employment status, etc.), 9 questions specific to involvement in the department (6-point Likert scale: 1=strongly disagree to 6=strongly agree) and 11 questions for belonging divided into two domains; social acceptance and valued competence (same Likert scale as involvement). For the involvement and belonging questions an average and sum score were determined for each individual, which was used in the statistical analysis. For employment, participants were asked if they were employed (yes/no) during the Spring 2023 semester, which was then coded to form the groups. Statistical analysis software (IBM SPSS v.28) was used to assess the differences between those that indicated they were employed and not employed and a p-value of 0.05 was implemented for significance. RESULTS: College undergraduate participants (N=149, age; 24.3 ĺśź 5.7 years, gender identification; n=1 other, n=111 female, and n=37 male, and Kinesiology n=83, or other majors n=59) indicated they were employed (n=86) or unemployed (n=26) and Kinesiology students reported similar employment statistics (employed n=51 and unemployed n=11). An Independent T-Test found no significant differences (P\u3e0.05) in involvement or belonging for employment status in all students and for those who declared Kinesiology as their major during Spring 2023. CONCLUSION: Employment status had no significant impact on an undergraduate student\u27s involvement in their major department or their sense of belonging
A Simple Model of Tetracycline Antibiotic Resistance in the Aquatic Environment (with Application to the Poudre River)
Antibiotic resistance is a major concern, yet it is unclear what causes the relatively high densities of resistant bacteria in the anthropogenically impacted environment. There are various possible scenarios (hypotheses): (A) Input of resistant bacteria from wastewater and agricultural sources is significant, but they do not grow in the environment; (B) Input of resistant bacteria is negligible, but the resistant bacteria (exogenous or endogenous) grow due to the selection pressure of the antibiotic; (C) Exogenous bacteria transfer the resistance to the endogenous bacteria and those grow. This paper presents a simple mechanistic model of tetracycline resistance in the aquatic environment. It includes state variables for tetracyclines, susceptible and resistant bacteria, and particulate and dissolved organic matter in the water column and sediment bed. The antibiotic partitions between freely dissolved, dissolved organic matter (DOM)-bound and solids-bound phases, and decays. Bacteria growth is limited by DOM, inhibited by the antibiotic (susceptible bacteria only) and lower due to the metabolic cost of carrying the resistance (resistant bacteria only). Resistant bacteria can transfer resistance to the susceptible bacteria (conjugation) and lose the resistance (segregation). The model is applied to the Poudre River and can reproduce the major observed (literature data) patterns of antibiotic concentration and resistance. The model suggests observed densities of resistant bacteria in the sediment bed cannot be explained by input (scenario A), but require growth (scenarios B or C)
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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of repeat transcripts and dipeptide repeat proteins trigger multiple mechanisms of neurotoxicity. How repeat transcripts get exported from the nucleus is unknown. Here, we show that depletion of the nuclear export adaptor SRSF1 prevents neurodegeneration and locomotor deficits in a
Drosophila model of C9ORF72-related disease. This intervention suppresses cell death of
patient-derived motor neuron and astrocytic-mediated neurotoxicity in co-culture assays. We
further demonstrate that either depleting SRSF1 or preventing its interaction with NXF1
specifically inhibits the nuclear export of pathological C9ORF72 transcripts, the production of
dipeptide-repeat proteins and alleviates neurotoxicity in Drosophila, patient-derived neurons
and neuronal cell models. Taken together, we show that repeat RNA-sequestration of SRSF1
triggers the NXF1-dependent nuclear export of C9ORF72 transcripts retaining expanded
hexanucleotide repeats and reveal a novel promising therapeutic target for neuroprotection
Archeological Survey of the Chalupa Wind Project - Arroyo Colorado Transmission Line Crossing Cameron County, Texas
Between December 3 and 8, 2018, Blanton & Associates, Inc. (B&A), on behalf of La Chalupa, LLC, conducted an archeological survey within the proposed Chalupa Wind Project - Arroyo Colorado Transmission Line Crossing (the Project), in Cameron County, Texas. The proposed overhead transmission line would be approximately 10.4 miles in length, 1.7 miles of which would be located on property owned by the Port of Harlingen Authority, a political subdivision of State, triggering compliance with the Antiquities Code of Texas and associated regulations outlined in 13 TAC 26. The project would also require a federal permit to be issued under the auspices of Section 10 of the Rivers and Harbors Act of 1899, which will require compliance with Section 106 of the National Historic Preservation Act and associated regulations outlined in 36 CFR 800. The project area consists of approximately 20.45 total acres. Twelve trenches were excavated in connection with this investigation. No archeological sites were identified. Based on these findings, B&A recommends that the proposed project proceed to completion without further archeological work. Curation of records generated in connection with this survey occurred at the University of Texas San Antonio’s Center for Archaeological Research
Fact and fiction : representations of the Asturian Revolution (1934-1938)
The purpose of this thesis is to study the literary response to the Asturian Revolution of October 1934. It will be shown that a distinct type of literature emerged reflecting the increasing political and social polarisation of Spanish society during the first decades of the twentieth century. Through a careful analysis of the texts published within four years of the Revolution, I will demonstrate how a set of writers, whether authors by profession, politicians, intellectuals, or workers, responded to the most important episode of working- class revolutionary action in Asturias before the Civil War. I will show that their aim was to not only record their experiences and thoughts on the events but also to guide and persuade their readers to adopt a particular political stand, often advocating revolutionary or counter-revolutionary action. These texts are examples of a trend set by intellectuals influenced by national and international political developments who sympathised with (and often openly militated in favour of) a political party line. This politically committed social literature displays a set of common features largely determined by the fact that the time span between the October Revolution and the writing of the works is short. The written responses are spontaneous as they were composed in the heat of the moment against a dramatic backdrop of revolutionary defeat and governmental repression. The texts in question are essentially documentary prose works in which the causes, course and outcome of the Revolution are narrated. By analysing the prose narrative works I will demonstrate that there is a gradual development in the literary characteristics of the texts, and that one group in particular deserves to be classified as 'non-fictional novels'. This term highlights the contrasting documentary and fictional nature of these novels, conditioned by a change in the concept of literature and its purpose, which was in turn prompted by the political and social situation facing Spanish society at the time
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