526 research outputs found

    A Closed-Form Solution of the Multi-Period Portfolio Choice Problem for a Quadratic Utility Function

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    In the present paper, we derive a closed-form solution of the multi-period portfolio choice problem for a quadratic utility function with and without a riskless asset. All results are derived under weak conditions on the asset returns. No assumption on the correlation structure between different time points is needed and no assumption on the distribution is imposed. All expressions are presented in terms of the conditional mean vectors and the conditional covariance matrices. If the multivariate process of the asset returns is independent it is shown that in the case without a riskless asset the solution is presented as a sequence of optimal portfolio weights obtained by solving the single-period Markowitz optimization problem. The process dynamics are included only in the shape parameter of the utility function. If a riskless asset is present then the multi-period optimal portfolio weights are proportional to the single-period solutions multiplied by time-varying constants which are depending on the process dynamics. Remarkably, in the case of a portfolio selection with the tangency portfolio the multi-period solution coincides with the sequence of the simple-period solutions. Finally, we compare the suggested strategies with existing multi-period portfolio allocation methods for real data.Comment: 38 pages, 9 figures, 3 tables, changes: VAR(1)-CCC-GARCH(1,1) process dynamics and the analysis of increasing horizon are included in the simulation study, under revision in Annals of Operations Researc

    VHE γ\gamma-ray observations of Markarian 501

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    Markarian 501, a nearby (z=0.033) X-ray selected BL Lacertae object, is a well established source of Very High Energy (VHE, E>=300 GeV) gamma rays. Dramatic variability in its gamma-ray emission on time-scales from years to as short as two hours has been detected. Multiwavelength observations have also revealed evidence that the VHE gamma-ray and hard X-ray fluxes may be correlated. Here we present results of observations made with the Whipple Collaboration's 10 m Atmospheric Cerenkov Imaging Telescope during 1999 and discuss them in the context of observations made on Markarian 501 during the period from 1996-1998

    Attentional learning helps language acquisition take shape for atypically developing children, not just children with Autism Spectrum Disorders

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    The shape bias-generalising labels to same shaped objects-has been linked to attentional learning or referential intent. We explore these origins in children with typical development (TD), autism spectrum disorders (ASD) and other developmental disorders (DD). In two conditions, a novel object was presented and either named or described. Children selected another from a shape, colour or texture match. TD children choose the shape match in both conditions, children with DD and 'high-verbal mental age' (VMA) children with ASD (language age > 4.6) did so in the name condition and 'low-VMA' children with ASD never showed the heuristic. Thus, the shape bias arises from attentional learning in atypically developing children and is delayed in ASD

    Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

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    Many genetic and physiological treatments that extend lifespan also confer resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, however, whether the induction of cytoprotective pathways is essential for lifespan extension or merely correlated. Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4). We then screened for other gene inactivations that disrupt the induction of these responses by xenobiotic or genetic triggers, identifying 29 gene inactivations required for cytoprotective gene expression. If cytoprotective responses contribute directly to lifespan extension, inactivation of these genes would be expected to compromise the extension of lifespan conferred by decreased insulin/IGF-1 signaling, caloric restriction, or the inhibition of mitochondrial function. We find that inactivation of 25 of 29 cytoprotection-regulatory genes shortens the extension of longevity normally induced by decreased insulin/IGF-1 signaling, disruption of mitochondrial function, or caloric restriction, without disrupting normal longevity nearly as dramatically. These data demonstrate that induction of cytoprotective pathways is central to longevity extension and identify a large set of new genetic components of the pathways that detect cellular damage and couple that detection to downstream cytoprotective effectors.National Institute on Aging (AG16636

    Self domestication and the evolution of language

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    We set out an account of how self-domestication plays a crucial role in the evolution of language. In doing so, we focus on the growing body of work that treats language structure as emerging from the process ofcultural transmission. We argue that a full recognition of the importance of cultural transmission fundamentally changes the kind ofquestionswe should be asking regarding the biological basis of language structure. If we think of language structure as reflecting an accumulated set of changes in our genome, then we might ask something like, "What are the genetic bases of language structure and why were they selected?" However, if cultural evolution can account for language structure, then this question no longer applies. Instead, we face the task of accounting for the origin of the traits that enabled that process of structure-creating cultural evolution to get started in the first place. In light of work on cultural evolution, then, the new question for biological evolution becomes, "How did those precursor traits evolve?" We identify two key precursor traits: (1) the transmission of the communication system throughlearning; and (2) the ability to infer thecommunicative intentassociated with a signal or action. We then describe two comparative case studies-the Bengalese finch and the domestic dog-in which parallel traits can be seen emerging followingdomestication. Finally, we turn to the role of domestication in human evolution. We argue that the cultural evolution of language structure has its origin in an earlier process of self-domestication.</p

    Relação entre a força propulsiva da braçada, composição corporal e indicadores de força muscular isocinética em surfistas

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    This study aimed to evaluate the potential relationship between body composition (percentage of fat mass (FM %), fat mass and lean mass), muscle function (e.g., muscles; deltoid side and front, pectoralis major and teres major) and the propulsive force of the arm (PFA). Sixteen competitive surfers (29.1 ± 7.3 years; 1.72 ± 0.06 m; 74.2 ± 1.4 kg) were assessed for height, body mass, body composition (dual-energy-DXA), muscle function and PFA. Pearson correlation analyses were used to verify the relationship between all variables. An inverse correlations were found between PFA and isokinetic parameters to 60o/s: external rotation (peak torque: r = -0.71; p = 0.014; total work: r = -0.75; p = 0.007; power: r = -0.72; p = 0.011) and internal rotation (peak torque: r = -0.61; p = 0.045; total work: r = -0.73; p = 0.010; power: r = -0.61; p = 0.045) and 300o/s: external rotation (peak torque: r = -0.79; p = 0.003; total work: r = -0.84; p&lt;0,001; power: r = -0.81; p = 0.002) and internal rotation (peak torque: r = -0.69; p = 0.017; total work: r = -0.72; p = 0.011; power: r = -0.69; p = 0.017). There was no significant correlation between body composition components and PFA (p&gt;0.05). Although correlations do not imply cause and effect, PFA is not correlated with body composition in surfers and these relationships are inversely related to the parameters of muscle function.Objetivou-se avaliar a potencial relação entre a composição corporal (percentual de gordura (% gord.), massa gorda e massa magra), função muscular (i.e., músculos; deltoide anterior, deltoide lateral, peitoral maior e redondo maior) e a força propulsiva da braçada (FPB). Dezesseis surfistas competitivos (29,1 ± 7,3 anos, 1,72 ± 0,06 m, 74,2 ± 1,4 kg) tiveram a altura, massa corporal, composição corporal (dual-energy-DXA), função muscular e FPB avaliados. O coeficiente de correlação de Pearson foi empregado para avaliar a relação entre todas as variáveis. Foram observadas relações inversas entre a FPB e os parâmetros isocinéticos a 60°/s: rotação externa (pico de torque: r = -0,71; p = 0,014; trabalho total: r = -0,75; p = 0,007; potência: r = -0,72; p = 0,011) e rotação interna (pico de torque: r = -0,61; p = 0,045; trabalho total= r = -0,73; p = 0,010; potência: r = -0,61; p = 0,045) e 300o/s: rotação externa (pico de torque: r = -0,79; p = 0,003; trabalho total: r = -0,84; p&lt;0,001; potência: r = -0,81; p = 0,002) e rotação interna (pico de torque: r = -0,69; p = 0,017; trabalho total: r = -0,72; p = 0,011; potencia: r = -0,69; p = 0,017). Não foram observadas correlações significativas entre os componentes da composição corporal e a FPB (p&gt;0,05). Embora as correlações não impliquem em causa e efeito, a FPB não está correlacionada com a composição corporal em surfistas e estas relações são inversas com os parâmetros da função muscular

    Ethical Issues in Engineering Models: An Operations Researcher’s Reflections

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    This article starts with an overview of the author’s personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; e.g., case-studies on nuclear waste, water management, sustainable ecology, military tactics, and animal welfare. All these case studies employ computer simulation models. In general, models are meant to solve practical problems, which may have ethical implications for the various stakeholders; namely, the modelers, the clients, and the public at large. The article further presents an overview of codes of ethics in a variety of disciples. It discusses the role of mathematical models, focusing on the validation of these models’ assumptions. Documentation of these model assumptions needs special attention. Some ethical norms and values may be quantified through the model’s multiple performance measures, which might be optimized. The uncertainty about the validity of the model leads to risk or uncertainty analysis and to a search for robust models. Ethical questions may be pressing in military models, including war games. However, computer games and the related experimental economics may also provide a special tool to study ethical issues. Finally, the article briefly discusses whistleblowing. Its many references to publications and websites enable further study of ethical issues in modeling
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