Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis

BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide meta‐analysis of individual participant data from 20 634 hospitalised patients with laboratory‐confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. RESULTS: Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. CONCLUSIONS: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support

Investigating the mechanical performance and characteristics of nitrile butadiene rubber date palm fiber reinforced composites for sustainable bio-based materials

The recent focus on enhancing sustainability has emphasized the proper utilization of natural fibers and waste materials. Natural fiber reinforced composites have emerged as a promising solution for future bio-based products. This study aims to investigate the synergistic effects between date palm fiber (DPF) and Nitrile Butadiene Rubber (NBR) in order to develop innovative bio-based composites suitable for diverse industrial applications. The composites were produced through a mixing process using a Brabender internal mixer, followed by rolling. Various reinforcement materials and processing conditions were employed to characterize and analyze the mechanical properties of the composites. These properties included tensile strength, tensile modulus, strain, tear resistance, mechanical hardness, and compression behavior, assessed according to ASTM standards. The results revealed that the composites with a 40 wt% fiber loading exhibited the highest elastic modulus and tear resistance, indicating good compatibility and adhesion between the fibers and rubber. Additionally, the composites displayed increased brittleness and strain with higher fiber content. The mechanical hardness of the composites suggested their potential for various industrial applications, with the best results obtained at a 30 wt% fiber loading. Furthermore, the compression strength of the composites, evaluated using the ASTM D395 standard and a compression molding method, displayed significant improvement at a 40 wt% fiber content, indicating favorable characteristics and potential for industrial applications requiring oil, fuel, abrasion, and heat resistance in the form of bio-based products

Determining the appropriate natural fibers for intelligent green wearable devices made from biomaterials via multi-attribute decision making model

Intelligent and green wearable technology becomes essential for new modern societies. This work introduces a multi criteria decision making model to properly assess and compare relative desired criteria for selecting the most suitable constituents for green body wearable bio-products made from bio-based materials. It aims to enhance the sustainability of intelligent green wearable devices by providing support in the selection process of lightweight, eco-friendly materials suitable for personal body wearable bio-products made of natural fiber composites to improve qualities that may help in better monitoring human vital signs and thereby address the health care concern. The relative intrinsic characteristic and merits of various natural fibers were utilized to compare and evaluate their relative performance in bio-composites. The model considered several evaluation factors like mechanical performance including tensile strength and modulus of elasticity, comfortability including size and weight, availability, fiber orientation, cellulose content, and cost. Results have demonstrated different priorities of the considered natural fibers relative to each evaluation factor. However, the model was capable of properly evaluating and ranking the best fibers relative to the whole conflicting evaluation criteria simultaneously. The closeness of priorities in several cases emphasizes upon using such decision making models to be able to judge the relative merits of natural fibers for such applications. It can also help designers to avoid bias during determining the best alternatives considering several conflicting evaluation criteria

Thermal regulation of photovoltaic panels using PCM with multiple fins configuration:Experimental study with analysis

This paper presents an experimental and theoretical analysis of thermal regulation of solar panels using Phase change materials (PCM). Three different materials; RT31, RT35, and RT42 were investigated using different fins inserts. The presented theoretical model predicts the solar panel's temperature with a PCM underneath it. The experimental work was divided into two stages. Initial phase: intended to select the best phase change material amongst the tested and compare its cooling performance to the uncooled panel. The outcomes from the initial stage were that RT31 melting point is too low to be used under the test conditions. The second phase examined how semi-cylindrical, triangular, and rectangular fins affect heat transfer through the material’s layers. In this stage, RT35 and RT42 were used under radiation intensities of 510, 680, and 850 W/m2. RT42 with triangular fins showed that it can reduce the panel’s temperature by 24 % and 19.4 % at the lowest and highest tested radiation intensities, respectively compared to the uncooled one. This could lead to increase the solar panel’s efficiency by 7 to 8.4 % between the lowest and the highest tested solar intensity. RT42 demonstrated two advantages over RT35. Firstly, it had a longer lifetime, making it more durable. Secondly, it solidifies faster during nighttime, which is beneficial for the heat sink's performance.<br/

Evidence of sustained reductions in the relative risk of acute hepatitis B and C virus infections, and the increasing burden of hepatitis a virus infection in Egypt: comparison of sentinel acute viral hepatitis surveillance results, 2001–17

Abstract Background Egypt ranks fifth for the burden of viral hepatitis worldwide. As part of Egypt’s renewed national strategy for the elimination of viral hepatitis, surveillance for acute viral hepatitis (AVH) was re-established during 2014–2017 to describe the current epidemiology and associated risk factors, and changes from surveillance conducted during 2001–2004. Methods Patients with suspected AVH were enrolled, completed a questionnaire, and provided blood for testing for hepatitis viruses A (HAV), B (HBV), C (HCV), D, and E (HEV) infections by enzyme-linked immunosorbent assay. Odds ratios and Chi2 were used to detect differences between hepatitis types by patient characteristics and exposures. Newcombe-Wilson method was used to compare results between surveillance periods 2001–2004 and 2014–2017. Results Between 2014 and 2017, among 9321 patients enrolled, 8362 (89.7%) had one or more markers of AVH including 7806 (93.4%) HAV, 252 (3.0%) HCV, 238 (2.8%) HBV, and 31 (0.4%) HEV infection. HAV infection occurred most commonly among children < 16 years age, while HBV infection occurred among ages 16–35 years and HCV infection in ages greater than 45 years. Healthcare-associated exposures were significantly associated with HBV and HCV infections compared to HAV infection including receiving therapeutic injections, surgery, wound suture, or urinary catheter and IV line insertions, while significant lifestyle exposures included exposure to blood outside the healthcare system, IV drug use, or incarceration. Exposures significantly associated with HAV infection were attending nursery or pre-school, contact with person attending nursery or pre-school, having meals outside the home, or contact with HAV case. Compared with AVH surveillance during 2001–2004, there was a significant increase in the proportion of HAV infections from 40.2 to 89.7% (RR = 2.3) with corresponding reductions in the proportions of HBV and HCV infections from 30.0 to 2.8% (RR = 0.1) and 29.8 to 3.0% (RR = 0.1), respectively. Conclusions Healthcare-associated exposures were significantly association with and remain the greatest risk for HBV and HCV infections in Egypt. Additional studies to evaluate factors associated with the reductions in HBV and HCV infections, and cost effectiveness of routine HAV immunization might help Egypt guide and evaluate control measures

Avian Influenza A(H5N1) Virus in Egypt

In Egypt, avian influenza A subtype H5N1 and H9N2 viruses are enzootic in poultry. The control plan devised by veterinary authorities in Egypt to prevent infections in poultry focused mainly on vaccination and ultimately failed. Recently, widespread H5N1 infections in poultry and a substantial increase in the number of human cases of H5N1 infection were observed. We summarize surveillance data from 2009 through 2014 and show that avian influenza viruses are established in poultry in Egypt and are continuously evolving genetically and antigenically. We also discuss the epidemiology of human infection with avian influenza in Egypt and describe how the true burden of disease is underestimated. We discuss the failures of relying on vaccinating poultry as the sole intervention tool. We conclude by highlighting the key components that need to be included in a new strategy to control avian influenza infections in poultry and humans in Egypt