(In)Consistencies in responses to sodium bicarbonate supplementation: a randomised, repeated measures, counterbalanced and double-blind study

Objectives: Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. We determined the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods: 15 physically active males (age 25 ± 4 y; body mass 76.0 ± 7.3 kg; height 1.77 ± 0.05 m) completed six cycling capacity tests at 110% of maximum power output (CCT 110% ) following ingestion of either 0.3 g.kg -1 BM of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) was recorded as the exercise outcome. Results: SB supplementation increased blood pH, bicarbonate and base excess prior to every trial (all p ≤0.001); absolute changes in pH, bicarbonate and base excess from baseline to pre-exercise were similar in all SB trials (all p > 0.05). Blood lactate was elevated following exercise in all trials (p ≤ 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 +0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4. Individual analysis showed ten participants improved in at least one SB trial above the normal variation of the test although five improved in none. Conclusions: The mechanism for improved exercise with SB was consistently in place prior to exercise, although this only resulted in a likely improvement in one trial. SB does not consistently improve high intensity cycling capacity, with results suggesting that caution should be taken when interpreting the results from single trials as to the efficacy of SB supplementation. Trial Registration: ClinicalTrials.gov NCT0247462

Entropic Entanglement Criteria for Continuous Variables

We derive several entanglement criteria for bipartite continuous variable quantum systems based on the Shannon entropy. These criteria are more sensitive than those involving only second-order moments, and are equivalent to well-known variance product tests in the case of Gaussian states. Furthermore, they involve only a pair of quadrature measurements, and will thus should prove extremely useful the experimental identification of entanglement.Comment: 4 pages, 2 figure

Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.

The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents

Comprehensive Overview on HVDC Converter Transformer Design: Additional Discussions to the IEC/IEEE 60076-57-129 Standard

HVDC has been chosen as an economical and technical solution for power transmission through long distances, asynchronous interconnections and long submarine cables crossing. Despite DC transmission benefits to power systems, the converters non-linearity produces undesirable effects to the converter transformer in service, mainly listed in the technical standard IEC/IEEE 60076-57-129. However, additional discussions and complementary information can be found in a plurality of references, which are brought in the article under a comprehensive overview perspective. Some design solutions deal with these effects increasing the technical margins, which have direct influence on manufacturing costs and transformer reliability and availability levels. This article goes through the main topics pointed by the standard and the references, investigating their consequences in the converter transformer operation, in order to provide a comprehensive tutorial on design solutions and considerations to deal with those undesirable effects

The Promethean: Fall 2012

Fall 2012 edition of The Promethean. Contents: From the Director 2 Honors Study Abroad 4 Tips for Writing Your Senior Thesis 6 Collected Poetry 8 Freshman Experience Articles 9 Remembering Alex Kogut 10https://digitalcommons.brockport.edu/promethean/1007/thumbnail.jp

Synthesis and Characterization of Advanced Carbon-Based Nanowires – Study of Composites Actuation Capabilities Containing These Nanowires as Fillers

International audienc

Controle de capim-amargoso com diferentes misturas.

A dificuldade no controle de capim amargoso com o herbicida glyphosate gera a necessidade da utilização de outros herbicidas para um manejo adequado da espécie. Assim sendo, objetivou-se com o presente trabalho avaliar o controle de Digitaria insularis (capim-amargoso) por meio de combinações de herbicidas de diferentes mecanismos de ação. O delineamento experimental foi o de blocos ao acaso, com 22 tratamentos e 4 repetições. Os herbicidas foram aplicados quando as plantas estavam com altura próxima a 80 cm. Os resultados mostraram que o herbicida Select foi o graminicida que apresentou melhor níveis de controle para a espécie. Com relação às misturas dos graminicidas com os latifolicidas, verificou-se que pode haver antagonismo entre eles. A possibilidade desta ocorrência foi mais evidente para as misturas Targa + Finale; Targa + Gramocil e Podium + Gramocil; Panther + Gramocil e Podium + Classic

Investigation of DFIG with Fault RideThrough Capability

Abstract--In this paper, the ability of doubly fed induction generators to provide voltage stability support in weak transmission networks is investigated. Specifically, the response of wind turbines to voltage dips at the point of common coupling and its effects on system stability are analyzed. A control strategy for the operation of the grid and rotor side converters is developed in order to support the grid voltage by injecting reactive power during and after grid fault events. The performance of the strategy is analyzed for different voltage dips at the point of common coupling of a wind farm and compared with the case when the converters do not provide any voltage support. Simulations are performed using a simplified model of the Chilean transmission network. This system is considered to be a good example of weak power system, because of its radial configuration