The conservation project and archaeological excavation of the old Parish Church at Siggiewi - an intermediate report

Until December 2007 the old parish church of Siggiewi, dating back to the late medieval period, and occupying a central location within the village core, had been in a neglected and dilapidated state for a very long time, so much so that the remaining ruins were almost totally covered with debris and thick vegetation (Plates 2; 9A; 9D; colour plate 2A; Fig. 4 and colour plate 3). While passing by the walled up and highly degraded site, the inhabitants of Siggiewi barely knew that beneath the soil and vegetation were the remains of their first parish church and the cemetery where most of their ancestors had been buried.peer-reviewe

Simulación de la migración de hidrógeno en aleaciones de zirconio

En este trabajo se estudia el fenómeno de migración de hidrógeno y formación de blisters de hidruro ante el contacto entre tubos de presión y tubos calandria en reactores tipo CANDU. Este fenómeno es actualmente admitido como uno de los principales factores limitantes de la vida Útil de este tipo de reactores, desde que ocasionara el incidente de Pickering en 1983. Se desarrolla un método numérico basado en la regularización de las ecuaciones constitutivas que, con el tratamiento usual de elementos finitos y con un esquema de Newton-Raphson, permite resolver el citado problema sobre redes generales. Se incluyen resultados unidimensionales y bidimensionales, que muestran buen acuerdo con soluciones cuasi-analíticas disponibles (caso l-D) e ilustran la capacidad del método empleado.Peer Reviewe

Effect of EGF-Receptor Tyrosine Kinase Inhibitor on Rab5 Function During Endocytosis

Tyrosine autophosphorylation within the cytoplasmic tail of EGF-receptor is a key event, which in turn recruits several factors including Shc, Grb2 and Rin1 that are essential activities for receptor-mediated endocytosis and signaling. In this study, we demonstrated that treatment with AG1478, an EGF-receptor kinase inhibitor, blocked the formation of Rab5-positive endosomes as well as the activation of Rab5 upon addition of EGF. We also found that EGF-receptor catalytically inactive mutant failed to activate Rab5 upon EGF stimulation. Additionally, endosomal co-localization of Rab5 and EGF-receptor was inhibited by AG1478. Interestingly, AG1478 inhibitor did not block the formation of enlarged Rab5-positive endosomes in cells expressing Rab5 GTP hydrolysis defective mutant (Rab5:Q79L). AG1478 inhibitor also blocked the in vitroendosome fusion in a concentration-dependent manner, and more importantly, Rab5:Q79L mutant rescued it. Furthermore, addition of Rin1, a Rab5 guanine nucleotide exchange factor, partially restored endosome fusion in the presence of AG1478 inhibitor. Consistent with these observations, we also observed that Rin1 was unable to localize to membranes upon EGF-stimulation in the presence of AG1478 inhibitor. These results constitute first evidence that the enzymatic activity of a tyrosine kinase receptor is required endosome fusion via the activation of Rab5

UK parents' attitudes towards meningococcal group B (MenB) vaccination: a qualitative analysis

OBJECTIVES: (1) To explore existing knowledge of, and attitudes, to group B meningococcal disease and serogroup B meningococcal (MenB) vaccine among parents of young children. (2) To seek views on their information needs. DESIGN: Cross-sectional qualitative study using individual and group interviews conducted in February and March 2015, prior to the introduction of MenB vaccine (Bexsero) into the UK childhood immunisation schedule. SETTING: Community centres, mother and toddler groups, parents’ homes and workplaces in London and Yorkshire. PARTICIPANTS: 60 parents of children under 2 years of age recruited via mother and baby groups and via an advert posted to a midwife-led Facebook group. RESULTS: Although recognising the severity of meningitis and septicaemia, parents’ knowledge of group B meningococcal disease and MenB vaccine was poor. While nervous about fever, most said they would take their child for MenB vaccination despite its link to fever. Most parents had liquid paracetamol at home. Many were willing to administer it after MenB vaccination as a preventive measure, although some had concerns. There were mixed views on the acceptability of four vaccinations at the 12-month booster visit; some preferred one visit, while others favoured spreading the vaccines over two visits. Parents were clear on the information they required before attending the immunisation appointment. CONCLUSIONS: The successful implementation of the MenB vaccination programme depends on its acceptance by parents. In view of parents’ recognition of the severity of meningitis and septicaemia, and successful introduction of other vaccines to prevent bacterial meningitis and septicaemia, the MenB vaccination programme is likely to be successful. However, the need for additional injections, the likelihood of post-immunisation fever and its management are issues about which parents will need information and reassurance from healthcare professionals. Public Health England has developed written information for parents, informed by these findings

Stepping Up and Taking the Lead: School-Based SLPs\u27 Perceptions and Attitudes of Leadership

This research explores the personal perspectives of school-based SLPs regarding their training in, perceptions of, and experiences regarding leadership. Survey research was conducted, and school based SLPs acted as respondents. Results may inform education in leadership, both in student training and in continuing education. Leadership in the field of speech-language pathology is essential to not only advocate for better outcomes of clients and patients, but also to foster an environment for change and understanding for future generations of SLPs

The power of partnerships: State public health department multisector collaborations in major chronic disease programme areas in the United States

BACKGROUND: Multisector collaboration between state public health departments (SHDs) and diverse community partners is increasingly recognized as important for promoting positive public health outcomes, addressing social determinants of health, and reducing health inequalities. This study investigates collaborations between SHDs in the United States and different types of organizations addressing chronic disease in and outside of the health sector. METHODS: SHD employees were randomly selected from the National Association of Chronic Disease Directors membership list for participation in an online survey. Participants were asked about their primary chronic disease work unit (cancer, obesity, tobacco, diabetes, cardiovascular disease, and others), as well as their work unit collaborations (exchange of information/cooperation in activities) with organizations in health and non-health sectors. As a measure of the different organizations SHDs collaborated with in health and non-health sectors, a collaboration heterogeneity score for each programme area was calculated. One-way analysis of variance (ANOVA) with Tukey\u27s post hoc tests were used to assess differences in collaborator heterogeneity between programme areas. RESULTS: A total of 574 participants were surveyed. Results indicated that the cancer programme area, along with diabetes and cardiovascular disease, had significantly less collaboration heterogeneity with organizations outside of the health sector compared to the obesity and tobacco programme areas. CONCLUSIONS: While collaborations with health sector organizations are commonly reported, public health departments can increase collaboration with sectors outside of health to more fully address chronic disease prevention

Coherent Population Trapping with Controlled Interparticle Interactions

We investigate Coherent Population Trapping in a strongly interacting ultracold Rydberg gas. Despite the strong van der Waals interactions and interparticle correlations, we observe the persistence of a resonance with subnatural linewidth at the single-particle resonance frequency as we tune the interaction strength. This narrow resonance cannot be understood within a meanfield description of the strong Rydberg--Rydberg interactions. Instead, a many-body density matrix approach, accounting for the dynamics of interparticle correlations, is shown to reproduce the observed spectral features

Dexterous actuation

Methods that have been developed for actuation system evaluation are normally generic, and primarily intended to facilitate actuator selection. Here, we address specifically those engineering devices that exhibit multiple-degree-of-freedom motions under space and weight constraints, and focus on the evaluation of the total actuation solution. We suggest a new measure that we provisionally call ‘Actuation Dexterity’, which interrogates the effectiveness of this total solution and serves as a design support tool. The new concept is developed in the context of artificial hands, and the approach is based on the review and analysis of thirty-six different artificial hand projects described in the literature. We have identified forty-eight unique evaluation criteria that are relevant to the actuation of devices of this type, and have devised a scoring method that permits the quantification of the actuation dexterity of a given device. We have tested this approach by evaluating and quantifying the actuation dexterity of five different artificial hands from the literature. Finally, we discuss the implications of this approach to the design process, and the portability of the approach between different device types.peer-reviewe