Bienestar psicológico según género entre colaboradores de un centro de salud privado de la ciudad de Trujillo

La presente investigación tuvo como objetivo principal determinar las diferencias del bienestar psicológico según género entre colaboradores de un centro de salud privado de la ciudad de Trujillo. Así mismo, fue de tipo no experimental, de diseño descriptivo comparativo transversal, con una la población de 130 coolaboradores y una muestra de 120 trabajadores, a quiénes se les aplicó el cuestionario de bienestar psicológico en adultos (BIEPS-A), Casullo (2002). Los resultados mostraron que no existen diferencias estadísticamente significativas (p>.05) de bienestar psicológico entre los colaboradores según género, concluyendo que el bienestar psicológico es percibido o experimentado de la misma manera en mujeres y varones, siendo el bienestar psicológico similar para ambos géneros de los colaboradores de un centro de salud privado de la ciudad de Trujill

Influencia de las prácticas preventivas de la familia del paciente pediátrico frente al contagio de COVID-19 en el Hospital III Goyeneche, Arequipa 2022

Esta investigación tiene como objetivo determinar la INFLUENCIA DE LAS PRÁCTICAS PREVENTIVAS DE LA FAMILIA DEL PACIENTE PEDIÁTRICO FRENTE AL CONTAGIO DE COVID – 19 EN EL HOSPITAL III GOYENECHE, AREQUIPA 2022. La población de estudio estuvo conformado de 50 familiares del paciente pediátrico que cumplieron con los criterios de selección. Para la estadística inferencial se aplicó la prueba de chi cuadrado con un nivel de significancia del 5%. Los resultados mostraron que los familiares de los pacientes pediátricos presentan las 3 áreas de prácticas preventivas frente el contagio de Covid – 19. El 70.0% de los familiares del paciente pediátrico frente al contagio de Covid – 19 presentaron practicas interpersonales en proceso, el 44.0% tuvieron prácticas de protección personal adecuadas, mientras que el 44.0% de los familiares tuvieron prácticas de control de ambiente en proceso y adecuadas. El 96.0% de los familiares del paciente pediátrico no contrajeron la enfermedad durante su estancia hospitalaria; mientras que solo el 4.0% de los familiares si presentaron contagio por Covid – 19, siendo éstos los padres del paciente pediátrico. El 50.0% de los familiares del paciente pediátrico que participaron de la investigación son madres, seguido del 22.0% de padres, el 10.0% son abuelas y tías, mientras que solo el 8.0% de los familiares son tíos de los pacientes. Después de aplicar la prueba estadística se determinó que las prácticas preventivas de la familia del paciente pediátrico frente al contagio de COVID – 19 no presentaba relación estadística significativa con la dosis, parentesco y contagio de COVID

Microstructural Characterization of Silver Nanoparticles for Bioimaging Applications

Junta de Andalucía FQM-6615, PI0070, FQM31

Programa de avaliação e acompanhamento do trauma de cabeça no futebol

A concussão cerebral é uma lesão muito comum na prática de esportes de contato etem uma alta prevalência no futebol. Palavra derivada da palavra latina “concutere”,que significa tremer violentamente, é um subtipo de traumatismo cranianofrequentemente usado na literatura como sinônimo de traumatismo craniano leve.Com base no IV Consenso sobre Concussão Cerebral no Esporte realizado peloComitê Olímpico Internacional (COI) e pela Federação Internacional de Futebol(FIFA), a concussão cerebral pode resultar em alterações neuropatológicas edistúrbios funcionais com sintomas clínicos agudos, sem demonstrar uma lesãoestrutural. Portanto, nenhuma alteração será identificada nos estudos tradicionais deneuroimagem. Dessa forma, a concussão é uma condição mal diagnosticada noBrasil e na América do Sul. Seu diagnóstico tem como base a investigação de sinaise sintomas clínicos. Embora muitas técnicas inovadoras demonstrem ser boasferramentas complementares, nenhum marcador foi caracterizado como ótimo edeve ser adotado como padrão-ouro para detectar e acompanhar a evolução daconcussão. Esse estudo objetiva estabelecer um programa sistematizado paraconcussão cerebral no futebol, pela primeira vez no Brasi

Interlocuções, trajetos e fluxos: Ana Salazar e a moda de autor em Portugal

Entrevistas realizadas utilizando a Plataforma Zoom, coordenadas entre Lisboa, Múrcia, Porto e Paris, em 28 de agosto de 2021 e 28 de janeiro de 2022, respetivamente. A primeira foi realizada a Ana Salazar e a segunda a Cristina L. Duarte. [...

To be or not to be: reassessing the origins of portable art in the Cantabrian Region (Northern Spain)

[EN] The characterization of the first portable artistic depictions in Cantabrian Spain is crucial for comprehension of the symbolic development of Neandertals and Homo sapiens in the context of the passage from the Middle to the Upper Paleolithic. However, despite the importance of these first graphic representations, their study has tended to lack the application of suitable methodologies to be able to discriminate between graphic activity and other kind of alterations (use-wear, taphonomic, or post-depositional). The present study has examined a significant sample of Middle and Upper Paleolithic lithic and osseous objects from Cantabrian Spain that have been cited as evidence of graphic activity in the literature. The contexts in which the objects were found have been considered, and the objects have been analyzed through the microscopic observation of the marks to distinguish between incisions, pecking, and engraving made for a non-functional purpose (graphic activity) and those generated by diverse functional actions or taphonomic processes (cutmarks, trampling, root marks, percussion scars, and use-wear). The results show that some regional Middle Paleolithic osseous objects display incisions that are neither functional nor taphonomic and whose characteristics are similar to graphic evidence attributed to Neandertals in Europe and the Near East. In turn, the first portable art produced by Homo sapiens in the Cantabrian Spain seems to be limited mostly to linear signs, and no figurative representation can be recognized until the Gravettian. This appears to indicate a particular idiosyncrasy of the region in the Early Upper Paleolithic, which, in comparison with other regions such as south-west France and the Swabian Jura, shows a later and less abundant production of portable art.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The study presented in this paper was funded by the research project of the Spanish Science Ministry “Learning and developing artistic skills in anatomically modern humans: a multidisciplinary approach”Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

To be or not to be: reassessing the origins of portable art in the Cantabrian Region (Northern Spain)

The characterization of the frist portable artistic depictions in Cantabrian Spain is crucial for comprehension of the symbolic development of Neandertals and Homo sapiens in the context of the passage from the Middle to the Upper Paleolithic. How ever, despite the importance of these frst graphic representations, their study has tended to lack the application of suitable methodologies to be able to discriminate between graphic activity and other kind of alterations (use-wear, taphonomic, or post-depositional). The present study has examined a significant sample of Middle and Upper Paleolithic lithic and osseous objects from Cantabrian Spain that have been cited as evidence of graphic activity in the literature. The contexts in which the objects were found have been considered, and the objects have been analyzed through the microscopic observation of the marks to distinguish between incisions, pecking, and engraving made for a non-functional purpose (graphic activity) and those generated by diverse functional actions or taphonomic processes (cutmarks, trampling, root marks, percussion scars, and use-wear). The results show that some regional Middle Paleolithic osseous objects display incisions that are neither functional nor taphonomic and whose characteristics are similar to graphic evidence attributed to Neandertals in Europe and the Near East. In turn, the frst portable art produced by Homo sapiens in the Cantabrian Spain seems to be limited mostly to linear signs, and no figurative representation can be recognized until the Gravettian. This appears to indicate a particular idiosyncrasy of the region in the Early Upper Paleolithic, which, in comparison with other regions such as south-west France and the Swabian Jura, shows a later and less abundant production of portable art.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The study presented in this paper was funded by the research project of the Spanish Science Ministry “Learning and developing artistic skills in anatomically modern humans: a multidisciplinary approach” HAR2017-87739-P, led by Olivia River

Maternal prenatal hair cortisol is associated with prenatal depressive symptom trajectories

Maternal prenatal cortisol levels have been inconsistently associated with self-reports of prenatal psychological distress (PD). Previous research has linked hair cortisol concentration (HCC) evaluating cumulatively the previous months with cross-sectional PD measures that usually cover the past week(s), which may lead to misleading conclusions on their relations. We aimed to investigate how maternal HCC relates to cumulative PD measures across pregnancy. Maternal prenatal cortisol levels have been inconsistently associated with self-reports of prenatal psychological distress (PD). Previous research has linked hair cortisol concentration (HCC) evaluating cumulatively the previous months with cross-sectional PD measures that usually cover the past week(s), which may lead to misleading conclusions on their relations. We aimed to investigate how maternal HCC relates to cumulative PD measures across pregnancy. Methods Subjects (N = 595) were drawn from the FinnBrain Birth Cohort Study. Maternal HCC was measured from hair samples collected at gestational week (gwk) 24 (HCC1, n = 467) and at delivery (HCC2, n = 222). As HCC1 and HCC2 comprised mostly of different subjects, they were considered as independent populations. Maternal PD assessments at gwks 14, 24, and 34 were the Edinburgh Postnatal Depression Scale (EPDS), the anxiety subscale of the Symptom Checklist (SCL-90), the Pregnancy-Related Anxiety Questionnaire -Revised2 (PRAQ-R2), and a daily hassles scale. Cumulative PD comprised of the mean scores of two consecutive assessments (mean1 = gwks 14 and 24; mean2 = gwks 24 and 34). In addition, EPDS and SCL scores were modelled by using growth mixture modelling to identify symptom trajectory categories. Regression models were adjusted for age, body mass index, education and use of selective serotonin/serotonin-norepinephrine reuptake inhibitor medication. Results In the adjusted regression model, higher HCC2 was related to the “consistently elevated” prenatal depressive symptoms trajectory in comparison to “consistently low” (β =.71, p =.021) and “low and increasing” (β =.82, p = .011) symptom trajectories. Additionally, the cumulative mean (mean 1) of daily hassles in relationships was associated with HCC1 (β = 0.25, p = .004). General or pregnancy-related anxiety symptoms were unrelated to HCC after adjustment for the covariates. Conclusions The assessment of cumulative or trajectory measures of PD can reveal important associations with maternal prenatal HCC, even though the associations are generally weak. Of the different dimensions of PD, prenatal trajectories of depressive symptoms were most consistently linked with end-pregnancy HCC levels.Academy of Finland (grant #134950 to HK and grant #308176 to LK), Jane and Aatos Erkko Foundation, Signe and Ane Gyllenberg Foundation, and State Research Grants. Preparation of the manuscript has been funded by Juho Vainio Foundation (PM), Finnish Brain Foundation (PM), and Yrjö Jahnsson Foundation (LK, grants #6976 and #6847). AJR is an FCT Investigator Fellow (IF/00883/2013) and is funded by projects POCI-01-0145-FEDER-016428; POCI-01-0145-FEDER-029071 and POCI-01-0145-FEDER-00703

Hair cortisol concentrations are associated with dental anxiety during pregnancy

Dental anxiety (DA) and hair cortisol concentrations (HCC) are associated with psychological symptoms and vary during pregnancy. We aimed to examine the association between HCC and DA at two points of pregnancy. Participants were pregnant mothers (n = 533) drawn from the FinnBrain Birth Cohort Study donating a hair sample at gestational week (gwk) 24 (n = 442) and/or at delivery (n = 176) and completed questionnaires on DA. Two groups, HCC1 and HCC2, treated as separate in the analyses, were formed according to the hair sample donation time i.e., gwk24 and delivery. 85 subjects were included in both groups. MDAS, EPDS, and SCL-90 were used to measure DA, depressive and anxiety symptoms, respectively, at gwk14 for the HCC1 group and gwk34 for the HCC2 group. The association between DA and HCC was studied with a binary logistic regression model, adjusted for anxiety and depressive symptoms, age, BMI, and smoking status. Individuals with high DA had lower HCC levels at gwk24 (OR = 0.548; 95% CI = 0.35–0.86; p = 0.009), but the association was not statistically significant at the delivery (OR = 0.611; 95% CI = 0.28–1.33; p = 0.216). The independent association between HCC and DA in pregnant women suggests that long-term cortisol levels could play a role in the endogenous etiology of DA. Further studies are however, needed.This research was funded by the Academy of Finland (grant #134950 to HK and grant #308176 to LK), Jane and Aatos Erkko Foundation, Signe and Ane Gyllenberg Foundation, and State Research Grants. AJR is funded by FCT under the project PTDC/MED-NEU/29071/2017

Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad

Funding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019.The authors further thank FCT/MCTES for supporting Research Units LAQV-REQUIMTE (UIDB/50006/2020), GHTM (UID/Multi/04413/2020). Publisher Copyright: © 2023 The AuthorsMalaria, leishmaniasis and Chagas disease are vector-borne protozoal infections with a disproportionately high impact on the most fragile societies in the world, and despite malaria-focused research gained momentum in the past two decades, both trypanosomiases and leishmaniases remain neglected tropical diseases. Affordable effective drugs remain the mainstay of tackling this burden, but toxicicty, inneficiency against later stage disease, and drug resistance issues are serious shortcomings. One strategy to overcome these hurdles is to get new therapeutics or inspiration in nature. Indeed, snake venoms have been recognized as valuable sources of biomacromolecules, like peptides and proteins, with antiprotozoal activity. This review highlights major snake venom components active against at least one of the three aforementioned diseases, which include phospholipases A2, metalloproteases, L-amino acid oxidases, lectins, and oligopeptides. The relevance of this repertoire of biomacromolecules and the bottlenecks in their clinical translation are discussed considering approaches that should increase the success rate in this arduous task. Overall, this review underlines how venom-derived biomacromolecules could lead to pioneering antiprotozoal treatments and how the drug landscape for neglected diseases may be revolutionized by a closer look at venoms. Further investigations on poorly studied venoms is needed and could add new therapeutics to the pipeline.publishersversionepub_ahead_of_prin