798 research outputs found
Impact of the Sun on Remote Sensing of Sea Surface Salinity from Space
The sun is a sufficiently strong source of radiation at L-band to be an important source of interference for radiometers on future satellite missions such as SMOS, Aquarius, and Hydros designed to monitor soil moisture and sea surface salinity. Radiation from the sun can impact passive remote sensing systems in several ways, including line-of-sight radiation that comes directly from the sun and enters through antenna side lobes and radiation that is reflected from the surface to the radiometer. Examples are presented in the case of Aquarius, a pushbroom radiometer with three beams designed to monitor sea surface salinity. Near solar minimum, solar contamination is not a problem unless the sun enters near the main beam. But near solar maximum, contamination from the sun equivalent to a change of salinity on the order of 0.1 psu can occur even when the signal enters in sidelobes far from the main beam
‘It was nothing that you would think was anything’:qualitative analysis of appraisal and help seeking preceding brain cancer diagnosis
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease
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Impact of different El Niño types on the El Niño/IOD relationship
Previous studies reported that positive phases of the Indian Ocean Dipole (IOD) tend to accompany El Niño during boreal autumn. Here we show that the El Niño/IOD relationship can be better understood when considering the two different El Niño flavors. Eastern-Pacific (EP) El Niño events exhibit a strong correlation with the IOD dependent on their magnitude. In contrast, the relationship between Central-Pacific (CP) El Niño events and the IOD depends mainly on the zonal location of the sea surface temperature anomalies rather than their magnitude. CP El Niño events lying further west than normal are not accompanied by significant anomalous easterlies over the eastern Indian Ocean along the Java/Sumatra coast, which is unfavorable for the local Bjerknes feedback and correspondingly for an IOD development. The El Niño/IOD relationship has experienced substantial changes due to the recent decadal El Niño regime shift, which has important implications for seasonal prediction
The evolving role of oestrogen receptor beta in clinical breast cancer
Controversy surrounds the potential clinical importance of oestrogen receptor (ER)β in breast cancer, and three recent papers have sought to resolve this. In the present issue of Breast Cancer Research Novelli and colleagues explored the significance of ERβ1 expression in 936 breast cancer patients, and they showed diverse relationships according to lymph node status. A second paper examined 442 breast cancers in which ERβ1 was an independent predictor of recurrence, disease-free survival and overall survival. Finally a third paper showed that ERβ2 was a powerful prognostic indicator in 757 breast cancers but this was dependent on cellular location, with nuclear ERβ2 expression predicting good survival whilst cytoplasmic expression predicted worse outcome. These papers point to a clinical role for ERβ in breast cancer and shall be discussed
Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques
Styryl-congutated BODIPY dyes which are structurally similar to known Aβ peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of Aβ plaques. © 2014 the Partner Organisations
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