Design and Development of a Mini-Orange Magnetic Spectrometer with Multichannel Facility for Conversion Electron Spectroscopy

Background: Conventional magnetic spectrometers used for conversion electron detection are very cumbersome, require strong magnetic fields and the spectra have to be scanned point by point and have very low transmission. A magnetic filter using permanent magnets and an Si(Li) detector would facilitate multichannel analysis with high transmission. The mini-orange is a new type of spectrometer for conversion electrons combining a solid state Si(Li) detector with a filter of permanent magnets around a central absorber of lead.Purpose: An indigenously developed magnetic spectrometer if optimized properly would be of great use in conversion electron spectroscopy for both online and offline experiments. Methods: A Mini-Orange magnetic spectrometer made of small permanent magnets has been designed and developed indigenously and optimized for its best performance condition. The transmission curves for different energy regions are plotted using the conversion electron spectra from the standard gamma transitions from 153Gd, 169Yb and 131Ba decays. The optimized spectrometer facilitates multichannel acquisition of conversion electron spectra for precision electron spectroscopy. The system also can be used in in-beam experiments with minor modifications of the vacuum chamber.Results: The optimized spectrometer was used for precision electron spectroscopy. Experimental transmission curves are then obtained by plotting Transmission (T) against the corresponding electron energy for low energy, medium energy and a broad energy range. Out of the several experiments done the optimum settings for f and g, that resulted in this curve, is identified at f = 7.5 cm and g = 4.5 cm. Conclusions: The optimized spectrometer facilitates multichannel acquisition of conversion electron spectra for precision electron spectroscopy. The system also can be used in in-beam experiments with minor modifications of the vacuum chamber

4-Hydr­oxy-3-meth­oxy-5-nitro­aceto­phenone (5-nitro­apocynin)

The title mol­ecule, C9H9NO5, is close to planar (r.m.s. deviation from the mean plane of the non-H atoms = 0.058 Å). The OH group forms a bifurcated O—H⋯(O,O) hydrogen bond, with the intra­molecular component to a nitro O atom and the inter­molecular component to a keto O atom, the latter resulting in chains along [20]. A C—H⋯O inter­action reinforces the packing

Modular Domain Adaptation for Conformer-Based Streaming ASR

Speech data from different domains has distinct acoustic and linguistic characteristics. It is common to train a single multidomain model such as a Conformer transducer for speech recognition on a mixture of data from all domains. However, changing data in one domain or adding a new domain would require the multidomain model to be retrained. To this end, we propose a framework called modular domain adaptation (MDA) that enables a single model to process multidomain data while keeping all parameters domain-specific, i.e., each parameter is only trained by data from one domain. On a streaming Conformer transducer trained only on video caption data, experimental results show that an MDA-based model can reach similar performance as the multidomain model on other domains such as voice search and dictation by adding per-domain adapters and per-domain feed-forward networks in the Conformer encoder.Comment: Accepted to Interspeech 202

Smart System for Document Verification

Traffic control device is one of the vital sectors in any united states for its smooth travel. In India, Communication innovation in social coverage location has now no longer been altogether actualized to enhance its nature of administration. Growing use of verbal exchange era many nations have applied e-card device. At gift there may be no present digital site visitors control device in India aside from Digi-locker. The factor of this proposed e-clever card framework is to enhance effectiveness, get right of entry to of drivers record verification offerings and administrations. Using the e-clever card all drivers’ records, car details, car beyond records and car beyond violations may be accessed via an internet web page with the aid of using the legal parties. Our proposed concept conveys the advantages of stable transportation offerings in India using records and correspondence advancements. Digital data permit for higher monitoring and extra standardized documentation of drivers and vehicles, which has the ability to lessen error

3,3′-Dinitro­bis­phenol A

The title compound [systematic name: 2,2′-dinitro-4,4′-(propane-2,2-di­yl)diphenol], C15H14N2O6, crystallizes with two mol­ecules in the asymmetric unit. Both have a trans conformation for their OH groups, and in each, the two aromatic rings are nearly orthogonal, with dihedral angles of 88.30 (3) and 89.62 (2)°. The nitro groups are nearly in the planes of their attached benzene rings, with C—C—N—O torsion angles in the range 1.21 (17)–4.06 (17)°, and they each accept an intra­molecular O—H⋯O hydrogen bond from their adjacent OH groups. One of the OH groups also forms a weak inter­molecular O—H⋯O hydrogen bond

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

ABSTRACT We aimed to evaluate the performance of Oxford Nanopore Technologies (ONT) sequencing from positive blood culture (BC) broths for bacterial identification and antimicrobial susceptibility prediction. Patients with suspected sepsis in four intensive care units were prospectively enrolled. Human-depleted DNA was extracted from positive BC broths and sequenced using ONT (MinION). Species abundance was estimated using Kraken2, and a cloud-based system (AREScloud) provided in silico predictive antimicrobial susceptibility testing (AST) from assembled contigs. Results were compared to conventional identification and phenotypic AST. Species-level agreement between conventional methods and AST predicted from sequencing was 94.2% (49/52), increasing to 100% in monomicrobial infections. In 262 high-quality AREScloud AST predictions across 24 samples, categorical agreement (CA) was 89.3%, with major error (ME) and very major error (VME) rates of 10.5% and 12.1%, respectively. Over 90% CA was achieved for some taxa (e.g.,Staphylococcus aureus) but was suboptimal for Pseudomonas aeruginosa. In 470 AST predictions across 42 samples, with both high quality and exploratory-only predictions, overall CA, ME, and VME rates were 87.7%, 8.3%, and 28.4%. VME rates were inflated by false susceptibility calls in a small number of species/antibiotic combinations with few representative resistant isolates. Time to reporting from sequencing could be achieved within 8–16 h from BC positivity. Direct sequencing from positive BC broths is feasible and can provide accurate predictive AST for some species. ONT-based approaches may be faster but significant improvements in accuracy are required before it can be considered for clinical use. IMPORTANCE Sepsis and bloodstream infections carry a high risk of morbidity and mortality. Rapid identification and susceptibility prediction of causative pathogens, using Nanopore sequencing direct from blood cultures, may offer clinical benefit. We assessed this approach in comparison to conventional phenotypic methods and determined the accuracy of species identification and susceptibility prediction from genomic data. While this workflow holds promise, and performed well for some common bacterial species, improvements in sequencing accuracy and more robust predictive algorithms across a diverse range of organisms are required before this can be considered for clinical use. However, results could be achieved in timeframes that are faster than conventional phenotypic methods

In-stent thrombosis after 68 months of implantation inspite of continuous dual antiplatelet therapy: a case report

Lately, there has been an increased incidence of late stent thrombosis; especially following Drug eluting stent (DES) implantation. Several factors are associated with an increased risk of stent thrombosis, including the procedure itself, patient and lesion characteristics, stent design, and premature cessation of anti-platelet drugs. We present a case of late stent thrombosis (LST) following DES implantation after a period of 68 months, making it the longest reported case of LST reported in the literature, despite the use of dual anti-platelet therapy

Indian community health insurance schemes provide partial protection against catastrophic health expenditure

BACKGROUND: More than 72% of health expenditure in India is financed by individual households at the time of illness through out-of-pocket payments. This is a highly regressive way of financing health care and sometimes leads to impoverishment. Health insurance is recommended as a measure to protect households from such catastrophic health expenditure (CHE). We studied two Indian community health insurance (CHI) schemes, ACCORD and SEWA, to determine whether insured households are protected from CHE. METHODS: ACCORD provides health insurance cover for the indigenous population, living in Gudalur, Tamil Nadu. SEWA provides insurance cover for self employed women in the state of Gujarat. Both cover hospitalisation expenses, but only upto a maximum limit of US$23 and US$45, respectively. We reviewed the insurance claims registers in both schemes and identified patients who were hospitalised during the period 01/04/2003 to 31/03/2004. Details of their diagnoses, places and costs of treatment and self-reported annual incomes were obtained. There is no single definition of CHE and none of these have been validated. For this research, we used the following definition; "annual hospital expenditure greater than 10% of annual income," to identify those who experienced CHE. RESULTS: There were a total of 683 and 3152 hospital admissions at ACCORD and SEWA, respectively. In the absence of the CHI scheme, all of the patients at ACCORD and SEWA would have had to pay OOP for their hospitalisation. With the CHI scheme, 67% and 34% of patients did not have to make any out-of-pocket (OOP) payment for their hospital expenses at ACCORD and SEWA, respectively. Both CHI schemes halved the number of households that would have experienced CHE by covering hospital costs. However, despite this, 4% and 23% of households with admissions still experienced CHE at ACCORD and SEWA, respectively. This was related to the following conditions: low annual income, benefit packages with low maximum limits, exclusion of some conditions from the benefit package, and use of the private sector for admissions. CONCLUSION: CHI appears to be effective at halving the incidence of CHE among hospitalised patients. This protection could be further enhanced by improving the design of the CHI schemes, especially by increasing the upper limits of benefit packages, minimising exclusions and controlling costs

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

PURPOSE: Early recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit (ICU) setting. We describe the feasibility of the Bayesian dosing software Individually Designed Optimum Dosing Strategies (ID-ODS™), to reduce time to effective antibiotic exposure in children and adults with sepsis in ICU. METHODS: A multi-centre prospective, non-randomised interventional trial in three adult ICUs and one paediatric ICU. In a pre-intervention Phase 1, we measured the time to target antibiotic exposure in participants. In Phase 2, antibiotic dosing recommendations were made using ID-ODS™, and time to target antibiotic concentrations were compared to patients in Phase 1 (a pre-post-design). RESULTS: 175 antibiotic courses (Phase 1 = 123, Phase 2 = 52) were analysed from 156 participants. Across all patients, there was no difference in the time to achieve target exposures (8.7 h vs 14.3 h in Phase 1 and Phase 2, respectively, p = 0.45). Sixty-one courses in 54 participants failed to achieve target exposures within 24 h of antibiotic commencement (n = 36 in Phase 1, n = 18 in Phase 2). In these participants, ID-ODS™ was associated with a reduction in time to target antibiotic exposure (96 vs 36.4 h in Phase 1 and Phase 2, respectively, p < 0.01). These patients were less likely to exhibit subtherapeutic antibiotic exposures at 96 h (hazard ratio (HR) 0.02, 95% confidence interval (CI) 0.01-0.05, p < 0.01). There was no difference observed in in-hospital mortality. CONCLUSIONS: Dosing software may reduce the time to achieve target antibiotic exposures. It should be evaluated further in trials to establish its impact on clinical outcomes