Gibt es eine Normbewegung im heterogenen Bewegungsablauf des linken Ventrikels

Ziel dieser Arbeit ist es, den Bewegungsablauf aller Wandregionen nach Maß und Zeit zu kartographisieren, um eine Grundlage für eine Bewertung eines gestörten Bewegungsablaufes in der Krankheitslehre zu schaffen. Für eine bessere Analyse der Kraftausbreitung innerhalb der Myokardwand scheint eine genaue Beobachtung der Verkürzungswege sinnvoller zu sein, um im Sinne der „Inversen Mechanik“, von “strain“ (Verkürzungsstrecke) auf “stress“ (Spannung) zu schließen und nicht umgekehrt. Somit wurde in der vorliegenden Arbeit untersucht, wie gut die Aussage von MRT mit Blick auf die Verkürzungswege in der Myokardwand des linken Ventrikels ist. Die von uns mit der Magnetresonanztomographie an drei Schweinen erhobenen Befunde lassen erhebliche Heterogenitäten im Bewegungsablauf des linken Ventrikels in drei Ebenen nach Maß und Geschwindigkeit erkennen. Eine Normbewegung konnten wir nicht beobachten. Diese in der Arbeit belegten Beobachtungen können eine wichtige Rolle in der Energetik des Herzens und der langfristigen Funktion des Ventrikels sein

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Activity of the Digestive Protease, Chymotrypsin, in Larvae of the Cultured Sharpsnout Sea Bream (Diplodus puntazzo)

Specific and total activity of the digestive protease, chymotrypsin, was studied in cultured sharp- snout sea bream larvae (Diplodus puntazzo) for 35 days from hatching and in a variety of pH lev- els. Activity was detected upon hatching (2.8±0.34 mm total length), before the onset of exoge- nous feeding. Specific chymotrypsin activity exponentially increased from mouth opening on day 3 until day 25, then dropped until the end of the experiment. Total chymotrypsin activity sharply increased to day 10, then continued to increase, but slightly, until the end of the experiment. As expected, pH strongly affected both specific and total chymotryptic activity in the digestive tracts of larvae. Both were significantly lower when pH was acidic (1.5, 3.0, 4.0) than when it was alka- line (8.0, 9.0, 10.0) although there were no significant differences within either the acidic or the alkaline range. Our results indicate that chymotrypsin activity is capable of digesting protein before mouth opening and may be a valuable tool for better understanding the nutritional capa- bilities of young larvae

First-line treatment posterior tibial nerve stimulation in patients with interstitial cystitis/bladder pain syndrome

Introduction The aim of this study was to determine the effects of first-line treatment posterior tibial nerve stimulation (PTNS), applied once a week for a 12 week period, as a treatment modality for patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Purification and characterization of alpha-L-arabinofuranosidases from Geobacillus stearothermophilus strain 12

WOS: 000410907000002In order to characterize two alpha-L-arabinofuranosidases (alpha-L-AFases), Abf1Geo12 and Abf2Geo12, produced by Geobacillus stearothermophilus strain 12, the genes (abf 1 and abf 2) coding for these enzymes were cloned and sequenced. Based on the protein sequence similarities, approximately 57 kDa two alpha-L-AFases were assigned to the glycoside hydrolase family 51. To obtain pure enzymes, the abf 1 and abf 2 genes were cloned into pET28a+ expression vector and recombinant alpha-L-AFases were produced in E. coli BL21(DE3): pLysS. Characterization of recombinant alpha-L-AFases revealed that Abf1Geo12 and Abf2Geo12 were active in a broad temperature range from 50 to 85 degrees C and from 40 to 80 degrees C, respectively. Also, the Abf1Geo12 was active in a broad pH range from 5.0 to 9.0. The optimum pH and temperature for Abf1Geo12 were determined as pH 6.0 and 65 degrees C, respectively, whereas the optimum pH and temperature for Abf2Geo12 were determined as pH 5.5 and 60 degrees C, respectively. Based on characterization studies, it was determined that the Abf1Geo12 was more stable than Abf2Geo12 and previously identified alpha-L-AFases from G. stearothermophilus. Using p-nitrophenyl alpha-L-arabinofuranoside as a substrate, the Km and Vmax values for Abf1Geo12 and Abf2Geo12 were determined as 0.31 mM and 290 U/mg for the former enzyme and 0.19 mM and 213.2 U/mg for the latter enzyme, respectively. The activities of Abf1Geo12 and Abf2Geo12 were strongly inhibited by 1 mM Hg2+. Interestingly, Cu2+ and Co2+ stimulated the activity of Abf1Geo12, but they reduced the activity of Abf2Geo12. The recombinant enzymes released L-arabinose from sugar beet arabinan, arabinobiose, arabinotriose, arabinotetraose and arabinopentaose. Consequently, these characterized two enzymes may be used in industrial fields since they are stable at high temperatures.Scientific and Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [211T116]This work was supported by The Scientific and Research Council of Turkey (TUBITAK, Grant No.: 211T116)

The investigation of work-related musculoskeletal disorders among female workers in a hazelnut factory: Prevalence, working posture, work-related and psychosocial factors

WOS: 000503086000004Background: Work-related musculoskeletal disorders (WMSDs) are the most common occupational health problems in the industrialized world. The identification of WMSDs specific to occupation is essential to plan and implement preventative programs. This study investigated the prevalence of WMSDs and determined the factors related to the severity of the most common disorders among female workers in a hazelnut factory. Methods: A total of 114 female workers were examined in this cross-sectional study using the Nordic Musculoskeletal Questionnaire, the Dutch Musculoskeletal Questionnaire, and an author-developed questionnaire (for socio-demographic characteristics and psychosocial factors). Working posture, craniovertebral angle, thoracic kyphosis angle (TKA), and lumbar lordosis angle were evaluated based on a photogrammetry method using the ImageJ program. Results: The prevalence of WMSDs in at least one body part during the last 12 months was 92.1%, The highest prevalence of WMSDs was in the lower back (61.4%), neck (57.9%), shoulder (53.6%), and upper back (45.6%). The least affected part was the elbow. Lower back, shoulder, and neck disorders were the most common causes of activity limitation. The severity of lower back pain was associated with stress in the workplace and work-related factors. The neck pain severity was related to craniovertebral angle and work-related factors. The shoulder pain severity increased with TKA and employment duration. TKA was related to upper back pain severity. Conclusions: WMSDs are common among female workers in a hazelnut factory. Reorganizing of working posture, work-related factors, and stress at work may be beneficial to decrease the prevalence of WMSDs and pain severity. Relevance to Industry; The female workers in the hazelnut factory are vulnerable to the work-related musculoskeletal disorders, particularly in the spinal region. The employers should endeavor to improve the health of the workers by the adjustment of the working posture and environmental factors

The study of MIG weldability of heat-treated aluminum alloys

Sevim, Ibrahim/0000-0003-0582-4992; kaya, yakup/0000-0002-9951-2844WOS: 000319557200056In this article, Metal Inert Gas (MIG) weldability of commercially received and aged samples of 6061-T-6 and 7075-T-651 aluminum alloys was investigated. The welding joints were prepared in ten different combinations. Microstructure, microhardness, EDX, energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD) analyses were used in order to evaluate the effect of aged heat treatment on the performance of welded joints. In addition, the mechanical properties of welding joints were characterized using the tensile and microhardness tests. In conclusion, it was shown that prewelding aging heat treatment improves the mechanical properties of welding joints

Silver nanowire decorated heatable textiles

The modification of insulating fabrics with electrically conductive nanomaterials has opened up a novel application field. With the help of Joule heating mechanism, conductive fabrics can be used as mobile heaters. In this work, heatable textiles are fabricated using silver nanowires (Ag NWs). Cotton fabrics are decorated with polyol synthesized Ag NWs via a simple dip-and-dry method. The time-dependent thermal response of the fabrics under different applied voltages is investigated. It is found that the fabrics can be heated to 50 degrees C under an applied power density of as low as 0.05Wcm(-2). Uniform deposition of Ag NWs resulted in the homogeneous generation of heat. In addition, the stability of the fabrics with time and under different bending and washing conditions is examined. Moreover, a simple control circuit is fabricated and integrated in order to demonstrate the high potential of the fabrics for mobile applications. This work provides a roadmap for researchers who would like to work on heatable textiles with metallic NWs