Computational neurorehabilitation: modeling plasticity and learning to predict recovery

Despite progress in using computational approaches to inform medicine and neuroscience in the last 30 years, there have been few attempts to model the mechanisms underlying sensorimotor rehabilitation. We argue that a fundamental understanding of neurologic recovery, and as a result accurate predictions at the individual level, will be facilitated by developing computational models of the salient neural processes, including plasticity and learning systems of the brain, and integrating them into a context specific to rehabilitation. Here, we therefore discuss Computational Neurorehabilitation, a newly emerging field aimed at modeling plasticity and motor learning to understand and improve movement recovery of individuals with neurologic impairment. We first explain how the emergence of robotics and wearable sensors for rehabilitation is providing data that make development and testing of such models increasingly feasible. We then review key aspects of plasticity and motor learning that such models will incorporate. We proceed by discussing how computational neurorehabilitation models relate to the current benchmark in rehabilitation modeling – regression-based, prognostic modeling. We then critically discuss the first computational neurorehabilitation models, which have primarily focused on modeling rehabilitation of the upper extremity after stroke, and show how even simple models have produced novel ideas for future investigation. Finally, we conclude with key directions for future research, anticipating that soon we will see the emergence of mechanistic models of motor recovery that are informed by clinical imaging results and driven by the actual movement content of rehabilitation therapy as well as wearable sensor-based records of daily activity

The challenges of constraining shelf sea tidal models using seabed sediment grain size as a proxy for tidal currents

This is the final version. Available from Elsevier via the DOI in this record.Past major changes in sea level have had a significant influence on global- and shelf sea tidal dynamics. Some of these changes are preserved in sedimentary records from the shelf seas, and so appropriate proxy data have the potential to constrain tidal model outputs over the recent geological past. Tidal models which simulate the evolution of tide-dependent parameters over geological timescales are fundamental to understanding the response of the tides to sea-level rise and climate change. This study explores a potential new sedimentary proxy for validating past shelf sea tidal dynamics, interrogating the relationship between tidally-modulated bed shear stress and seabed sediment grain size at discrete sediment core locations over the northwest European shelf seas. Radiocarbon-dated sediment grain size profiles were generated for four British Geological Survey UK shelf sediment vibrocores, spanning a range of physical environments. Changes in observed sediment grain size through time were compared with simulated changes in tidal-induced bed shear through time, using temporal and spatial outputs from the most recently developed palaeotidal model of the Northwest European shelf seas. Although a positive correlation between observed grain size and simulated bed shear stress was observed at three of the four sediment cores sites, no robust relationship could be quantified. The palaeotidal model output failed to resolve the details of the actual sediment dynamics, since only tidal-induced bed shear stresses were considered. Wave processes were neglected, and the model was not sensitive enough to constrain simulated past tidal conditions at point locations; rather it is suitable for examining general trends. There remains a need to develop new proxies for past shelf sea hydrodynamic conditions which can be used to constrain numerical model output of tidal currents at regional scales.Natural Environment Research Council (NERC

Classifying seabed sediment type using simulated tidal-induced bed shear stress

This is the author accepted manuscript. The final version is freely available from Elsevier via the DOI in this record.An ability to estimate the large-scale spatial variability of seabed sediment type in the absence of extensive observational data is valuable for many applications. In some physical (e.g., morphodynamic) models, knowledge of seabed sediment type is important for inputting spatially-varying bed roughness, and in biological studies, an ability to estimate the distribution of seabed sediment benefits habitat mapping (e.g., scallop dredging). Although shelf sea sediment motion is complex, driven by a combination of tidal currents, waves, and wind-driven currents, in many tidally energetic seas, such as the Irish Sea, long-term seabed sediment transport is dominated by tidal currents. We compare observations of seabed sediment grain size from 242 Irish Sea seabed samples with simulated tidal-induced bed shear stress from a three-dimensional tidal model (ROMS) to quantitatively define the relationship between observed grain size and simulated bed shear stress. With focus on the median grain size of well-sorted seabed sediment samples, we present predictive maps of the distribution of seabed sediment classes in the Irish Sea, ranging from mud to gravel. When compared with the distribution of well-sorted sediment classifications (mud, sand and gravel) from the British Geological Survey digital seabed sediment map of Irish Sea sediments (DigSBS250), this 'grain size tidal current proxy' (GSTCP) correctly estimates the observed seabed sediment classification in over 73% of the area.Funding was provided by the Natural Environment Research Council (NERC) through grant NE/I527853/1 (Ph.D. studentship to SLW). The authors are grateful for access to the seabed sediment sample data and would like to acknowledge colleagues collecting and preparing these data through the projects HABMAP, SWISS, IMAGIN, ADFISH, and various projects led by the JNCC, as well as Hilmar Hinz, Lee Murray and Gwladys Lambert for work undertaken on a project funded by the Isle of Man Government (Department of Environment, Food and Agriculture). The author acknowledges modelling support from Patrick Timko and Reza Hashemi. The digital seabed sediment map (DigSBS250) was kindly made available by the BGS. The model simulations were undertaken on High Performance Computing (HPC) Wales, a collaboration between Welsh universities, the Welsh Government and Fujitsu

Sensitivity of palaeotidal models of the northwest European shelf seas to glacial isostatic adjustment since the Last Glacial Maximum

This is the final version of the article. Available from Elsevier via the DOI in this record.The spatial and temporal distribution of relative sea-level change over the northwest European shelf seas has varied considerably since the Last Glacial Maximum, due to eustatic sea-level rise and a complex isostatic response to deglaciation of both near- and far-field ice sheets. Because of the complex pattern of relative sea level changes, the region is an ideal focus for modelling the impact of significant sea-level change on shelf sea tidal dynamics. Changes in tidal dynamics influence tidal range, the location of tidal mixing fronts, dissipation of tidal energy, shelf sea biogeochemistry and sediment transport pathways. Significant advancements in glacial isostatic adjustment (GIA) modelling of the region have been made in recent years, and earlier palaeotidal models of the northwest European shelf seas were developed using output from less well-constrained GIA models as input to generate palaeobathymetric grids. We use the most up-to-date and well-constrained GIA model for the region as palaeotopographic input for a new high resolution, three-dimensional tidal model (ROMS) of the northwest European shelf seas. With focus on model output for 1 ka time slices from the Last Glacial Maximum (taken as being 21 ka BP) to present day, we demonstrate that spatial and temporal changes in simulated tidal dynamics are very sensitive to relative sea-level distribution. The new high resolution palaeotidal model is considered a significant improvement on previous depth-averaged palaeotidal models, in particular where the outputs are to be used in sediment transport studies, where consideration of the near-bed stress is critical, and for constraining sea level index points.Funding was provided by the Natural Environment Research Council through grant NE/I527853/1 (Ph.D. studentship to SLW). The author acknowledges modelling support from Patrick Timko and Reza Hashemi. The model simulations were undertaken on High Performance Computing (HPC) Wales, a collaboration between Welsh universities, the Welsh Government and Fujitsu Laboratories of Europe. The authors also thank one anonymous reviewer and Dayton Dove for their thoughtful comments, and thorough and constructive reviews

Zoo‐housed mammals do not avoid giving birth on weekends

There is evidence that zoo visitor presence can influence the behaviour and, in some cases, adrenal response of zoo animals, and can sometimes compromise animal welfare. In some laboratory studies, significantly more primate births have been reported on weekends, when fewer people are working there, compared with weekdays when staffing levels are at their highest. Here, we investigate whether there is evidence of a "weekend effect" on births in zoo animals as a result of visitor numbers. Unlike laboratories, zoos are typically busier with visitors on weekends than on weekdays, although staffing levels remain fairly consistent across days of the week. If zoo animal parturition is sensitive to human presence, then fewer births would be expected on weekends compared with weekdays. We tested this using birth data and visitor numbers on the entrance gate from zoo records across 16 species representing artiodactyls, perissodactyls, carnivores and primates at four British zoos, to see whether there is an association between mean daily birth rates and average visitor numbers. We predict that, if there is a visitor effect, daily births should be lower on weekends than weekdays and should correlate with mean daily visitor numbers. Results showed that births for all 16 species were randomly distributed through the week, and there was no significant decline in births on weekends. We conclude that the “weekend effect”, if such a thing exists, does not appear to be a feature of zoo births, suggesting that elevated weekend visitor numbers are not sufficiently stressful to trigger delayed parturition

Energy Dissipation during Diffusion at Metal Surfaces: Disentangling the Role of Phonons versus Electron-Hole Pairs

Helium spin echo experiments combined with $\textit{ab initio}$ based Langevin molecular dynamics simulations are used to quantify the adsorbate-substrate coupling during the thermal diffusion of Na atoms on Cu(111). An analysis of trajectories within the local density friction approximation allows the contribution from electron-hole pair excitations to be separated from the total energy dissipation. Despite the minimal electronic friction coefficient of Na and the relatively small mass mismatch to Cu promoting efficient phononic dissipation, about (20±5)% of the total energy loss is attributable to electronic friction. The results suggest a significant role of electronic nonadiabaticity in the rapid thermalization generally relied upon in adiabatic diffusion theories.S. P. R. acknowledges the support of the Technische Universität München—Institute for Advanced Study, funded by the German Excellence Initiative and the European Union Seventh Framework Programme under Grant Agreement No. 291763

Lung function indices for predicting mortality in COPD

Chronic obstructive pulmonary disease (COPD) is characterised by high morbidity and mortality. It remains unknown which aspect of lung function carries the most prognostic information and if simple spirometry is sufficient. Survival was assessed in COPD outpatients whose data had been added prospectively to a clinical audit database from the point of first full lung function testing including spirometry, lung volumes, gas transfer and arterial blood gases. Variables univariately associated with survival were entered into a multivariate Cox proportional hazard model. 604 patients were included (mean±sd age 61.9±9.7 years; forced expiratory volume in 1 s 37±18.1% predicted; 62.9% males); 229 (37.9%) died during a median follow-up of 83 months. Median survival was 91.9 (95% CI 80.8–103) months with survival rates at 3 and 5 years 0.83 and 0.66, respectively. Carbon monoxide transfer factor % pred quartiles (best quartile (>51%): HR 0.33, 95% CI 0.172–0.639; and second quartile (51–37.3%): HR 0.52, 95% CI 0.322–0.825; versus lowest quartile (<27.9%)), age (HR 1.04, 95% CI 1.02–1.06) and arterial oxygen partial pressure (HR 0.85, 95% CI 0.77–0.94) were the only parameters independently associated with mortality. Measurement of gas transfer provides additional prognostic information compared to spirometry in patients under hospital follow-up and could be considered routinely

Clinical guidelines for low back pain. A critical review of consensus and inconsistencies across three major guidelines.

Given the scale and cost of the problem of low back pain, it is imperative that healthcare professionals involved in the care of people with low back pain have access to up-to-date, evidenced based information to assist them in treatment decision making. Clinical guidelines exist to promote consistent best practice, to reduce unwarranted variation and the use of low value interventions in patient care. Recent decades have seen the publication of a number of such guidelines. In this narrative review we consider three selected international interdisciplinary guidelines for the management of low back pain. Guideline development methods, consistent recommendations and inconsistencies between these guidelines are critically discussed

Bekkenbanden voor acute stabilisatie van instabiele bekkenfracturen

Bekkenbanden zijn ontwikkeld voor de acute behandeling van instabiele bekkenringfracturen in de prehospitale fase. Deze behandeling is gericht op het beperken van het inwendig bloedverlies door het verkleinen van het bij bekkenfracturen toegenomen bekkenvolume en het stabiliseren van de fractuurdelen. Het effect van commercieel verkrijgbare bekkenbanden op de reductie van de symphysis pubisdiastase en de hemodynamische stabiliteit is aangetoond. Het langdurig gebruik van bekkenbanden wordt ontraden wegens toegenomen risico op het ontwikkelen van decubitus. Met name langdurige immobilisatie met een bekkenband op een traumaplank dient voorkomen te worden. In dit artikel wordt een aantal verschillende bekkenbanden besproken en wordt een casus gepresenteerd.Pelvic circumferential compression devices have been developed for initial treatment of unstable pelvic ring fractures in the prehospital situation. The treatment is aimed at achieving tamponade by reducing the increased pelvic volume and reducing the bleeding from fracture surfaces. The effect of commercially available pelvic circumferential compression devices on the reduction of symphysis pubis diastasis and the resuscitation has been proved. Prolonged use of these devices is complicated by the risk of development of pressure sores. Therefore prolonged immobilization on a spine board should be avoided. A number of different pelvic binders will be discussed in this article, which also presents a case

Balancing the dilution and oddity effects: Decisions depend on body size

Background Grouping behaviour, common across the animal kingdom, is known to reduce an individual's risk of predation; particularly through dilution of individual risk and predator confusion (predator inability to single out an individual for attack). Theory predicts greater risk of predation to individuals more conspicuous to predators by difference in appearance from the group (the ‘oddity’ effect). Thus, animals should choose group mates close in appearance to themselves (eg. similar size), whilst also choosing a large group. Methodology and Principal Findings We used the Trinidadian guppy (Poecilia reticulata), a well known model species of group-living freshwater fish, in a series of binary choice trials investigating the outcome of conflict between preferences for large and phenotypically matched groups along a predation risk gradient. We found body-size dependent differences in the resultant social decisions. Large fish preferred shoaling with size-matched individuals, while small fish demonstrated no preference. There was a trend towards reduced preferences for the matched shoal under increased predation risk. Small fish were more active than large fish, moving between shoals more frequently. Activity levels increased as predation risk decreased. We found no effect of unmatched shoal size on preferences or activity. Conclusions and Significance Our results suggest that predation risk and individual body size act together to influence shoaling decisions. Oddity was more important for large than small fish, reducing in importance at higher predation risks. Dilution was potentially of limited importance at these shoal sizes. Activity levels may relate to how much sampling of each shoal was needed by the test fish during decision making. Predation pressure may select for better decision makers to survive to larger size, or that older, larger fish have learned to make shoaling decisions more efficiently, and this, combined with their size relative to shoal-mates, and attractiveness as prey items influences shoaling decisions