796 research outputs found
Higgs Messengers
We explore the consequences of the Higgs fields acting as messengers of
supersymmetry breaking. The hidden-sector paradigm in the gauge mediation
framework is relaxed by allowing two types of gauge-invariant, renormalizable
operators that are typically discarded: direct coupling between the Higgses and
supersymmetry breaking singlets, and Higgs-messenger mixing terms. The most
important phenomenological consequence is a flavor-dependent shift in sfermion
masses. This is from a one-loop contribution, which we compute for a general
set of weak doublet messengers. We also study a couple of explicit models in
detail, finding that precision electroweak constraints can be satisfied with a
spectrum significantly different from that of gauge mediation.Comment: 20 pages, 5 figure
Healthcare resource utilisation and related costs of patients with CKD from the UK: a report from the DISCOVER CKD retrospective cohort
Background
Chronic kidney disease (CKD) is widely reported to decrease quality of life, increase morbidity and mortality and cause increased healthcare resource utilisation (HCRU) as the disease progresses. However, there is a relative paucity of accurate and recent estimates of HCRU in this patient population. Our aim was to address this evidence gap by reporting HCRU and related costs in patients with CKD from the UK primary and secondary care settings.
Methods
HCRU and cost estimates of CKD were derived for UK patients included in the DISCOVER CKD cohort study using clinical records from the Clinical Practice Research Datalink linked to external databases. Patients with a history of transplant or undergoing dialysis were not included. HCRU and costs were stratified by CKD severity using the urinary albumin:creatinine ratio (UACR) and estimated glomerular filtration rate.
Results
Hospitalisation rates more than tripled between low (A1) and high (A3) UACR categories and the mean annual per-patient costs ranged from ÂŁ4966 (A1) to ÂŁ9196 (A3) and from ÂŁ4997 (G2) to ÂŁ7595 (G5), demonstrating that a large healthcare burden can be attributed to a relatively small number of patients with later stage CKD, including those with kidney failure and/or albuminuria.
Conclusions
HCRU and costs associated with CKD impose a substantial burden on the healthcare system, particularly in the more advanced stages of CKD. New interventions that can delay the progression of CKD to kidney failure may not only prolong the patientâs life, but would also provide significant resource and cost savings to healthcare providers
Probing Colored Particles with Photons, Leptons, and Jets
If pairs of new colored particles are produced at the Large Hadron Collider,
determining their quantum numbers, and even discovering them, can be
non-trivial. We suggest that valuable information can be obtained by measuring
the resonant signals of their near-threshold QCD bound states. If the particles
are charged, the resulting signatures include photons and leptons and are
sufficiently rich for unambiguously determining their various quantum numbers,
including the charge, color representation and spin, and obtaining a precise
mass measurement. These signals provide well-motivated benchmark models for
resonance searches in the dijet, photon+jet, diphoton and dilepton channels.
While these measurements require that the lifetime of the new particles be not
too short, the resulting limits, unlike those from direct searches for pair
production above threshold, do not depend on the particles' decay modes. These
limits may be competitive with more direct searches if the particles decay in
an obscure way.Comment: 39 pages, 9 figures; v2: more recent searches include
Perceived confidence in the FAST exam before and after an educational intervention in a developing country
Integrating evolution into ecological modelling: accommodating phenotypic changes in agent based models.
PMCID: PMC3733718This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Evolutionary change is a characteristic of living organisms and forms one of the ways in which species adapt to changed conditions. However, most ecological models do not incorporate this ubiquitous phenomenon. We have developed a model that takes a 'phenotypic gambit' approach and focuses on changes in the frequency of phenotypes (which differ in timing of breeding and fecundity) within a population, using, as an example, seasonal breeding. Fitness per phenotype calculated as the individual's contribution to population growth on an annual basis coincide with the population dynamics per phenotype. Simplified model variants were explored to examine whether the complexity included in the model is justified. Outputs from the spatially implicit model underestimated the number of individuals across all phenotypes. When no phenotype transitions are included (i.e. offspring always inherit their parent's phenotype) numbers of all individuals are always underestimated. We conclude that by using a phenotypic gambit approach evolutionary dynamics can be incorporated into individual based models, and that all that is required is an understanding of the probability of offspring inheriting the parental phenotype
Prompt Decays of General Neutralino NLSPs at the Tevatron
Recent theoretical developments have shown that gauge mediation has a much
larger parameter space of possible spectra and mixings than previously
considered. Motivated by this, we explore the collider phenomenology of gauge
mediation models where a general neutralino is the lightest MSSM superpartner
(the NLSP), focusing on the potential reach from existing and future Tevatron
searches. Promptly decaying general neutralino NLSPs can give rise to final
states involving missing energy plus photons, Zs, Ws and/or Higgses. We survey
the final states and determine those where the Tevatron should have the most
sensitivity. We then estimate the reach of existing Tevatron searches in these
final states and discuss new searches (or optimizations of existing ones) that
should improve the reach. Finally we comment on the potential for discovery at
the LHC.Comment: 41 pages, minor changes, added refs and discussion of previous
literatur
Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy?
BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data from private retailers. METHODS: Parallel studies were conducted in Tanzania, in which patients obtaining artemether-lumefantrine (AL) at 40 randomly selected public health facilities and 37 accredited drug dispensing outlets (ADDOs) were visited at home and questioned about doses taken. The effect of sector on adherence, controlling for potential confounders was assessed using logistic regression with a random effect for outlet. RESULTS: Of 572 health facility patients and 450 ADDO patients, 74.5% (95% CI: 69.8, 78.8) and 69.8% (95% CI: 64.6, 74.5), respectively, completed treatment and 46.0% (95% CI: 40.9, 51.2) and 34.8% (95% CI: 30.1, 39.8) took each dose at the correct time ('timely completion'). ADDO patients were wealthier, more educated, older, sought care later in the day, and were less likely to test positive for malaria than health facility patients. Controlling for patient characteristics, the adjusted odds of completed treatment and of timely completion for ADDO patients were 0.65 (95% CI: 0.43, 1.00) and 0.69 (95% CI: 0.47, 1.01) times that of health facility patients. Higher socio-economic status was associated with both adherence measures. Higher education was associated with completed treatment (adjusted OR = 1.68, 95% CI: 1.20, 2.36); obtaining AL in the evening was associated with timely completion (adjusted OR = 0.35, 95% CI: 0.19, 0.64). Factors associated with adherence in each sector were examined separately. In both sectors, recalling correct instructions was positively associated with both adherence measures. In health facility patients, but not ADDO patients, taking the first dose of AL at the outlet was associated with timely completion (adjusted OR = 2.11, 95% CI: 1.46, 3.04). CONCLUSION: When controlling for patient characteristics, there was some evidence that the adjusted odds of adherence for ADDO patients was lower than that for public health facility patients. Better understanding is needed of which patient care aspects are most important for adherence, including the role of effective provision of advice
D-branes at Toric Singularities: Model Building, Yukawa Couplings and Flavour Physics
We discuss general properties of D-brane model building at toric
singularities. Using dimer techniques to obtain the gauge theory from the
structure of the singularity, we extract results on the matter sector and
superpotential of the corresponding gauge theory. We show that the number of
families in toric phases is always less than or equal to three, with a unique
exception being the zeroth Hirzebruch surface. With the physical input of three
generations we find that the lightest family of quarks is massless and the
masses of the other two can be hierarchically separated. We compute the CKM
matrix for explicit models in this setting and find the singularities possess
sufficient structure to allow for realistic mixing between generations and CP
violation.Comment: 55 pages, v2: typos corrected, minor comments adde
General Gauge Mediation with Gauge Messengers
We generalize the General Gauge Mediation formalism to allow for the
possibility of gauge messengers. Gauge messengers occur when charged matter
fields of the susy-breaking sector have non-zero F-terms, which leads to
tree-level, susy-breaking mass splittings in the gauge fields. A classic
example is that SU(5) / SU(3) x SU(2) x U(1) gauge fields could be gauge
messengers. We give a completely general, model independent, current-algebra
based analysis of gauge messenger mediation of susy-breaking to the visible
sector. Characteristic aspects of gauge messengers include enhanced
contributions to gaugino masses, (tachyonic) sfermion mass-squareds generated
already at one loop, and also at two loops, and significant one-loop A-terms,
already at the messenger scale.Comment: 79 pages, 5 figure
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