89 research outputs found
Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA
- Author
- Aguilar C
- Aguinaco R
- Alonso N
- Altisent C
- Arribalzaga K
- Batlle J
- Bermejo N
- Berrueco R
- Bonanad S
- Borràs N
- Cabrera N
- Campos R
- Castro Quismondo N
- Cid AR
- Corrales I
- Cuesta J
- de Andrés-Jacob A
- Dobón M
- Fernández-Mosteirín N
- Ferreiro M
- Fidalgo T
- Fontanes E
- García-Candel F
- García-Frade J
- Herrero S
- Iñigo B
- Jiménez-Yuste V
- Lourés E
- López-Fernández MF
- Marcellini S
- Marco P
- Martinho P
- Martínez MP
- Mateo J
- Mingot-Castellano ME
- Moret A
- Moreto A
- Navarro N
- Nieto MM
- Orriols G
- Paloma MJ
- Palomo Á
- Parra R
- Pérez-Montes R
- Pérez-Rodríguez A
- Rodríguez-González R
- Rodríguez-Huerta AM
- Rodríguez-Trillo Á
- Soto I
- Tenorio JM
- Vidal F
- Vidal R
- Publication venue
- 'Ferrata Storti Foundation (Haematologica)'
- Publication date
- 25/10/2018
- Field of study
Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7473G>A (p.=) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of 3 mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that 4 of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease.info:eu-repo/semantics/publishedVersio
Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α
- Author
- A Contestabile
- A Inohara
- A Iwasaki
- A Lamb
- A Marshak-Rothstein
- A Sayi
- AM Torok
- AT Gewirtz
- B Bauer
- B Beutler
- B Schmausser
- C Kollewe
- CM Tato
- D Rothenbacher
- DB Polk
- DY Graham
- E Andersen-Nissen
- E Kurtoglu
- F Backhead
- J Viala
- JA Schmid
- JC Atherton
- JK Bell
- Joseph Madassery
- KJ Livak
- L Mandell
- L Sun
- LF Jiménez-Soto
- M Fukata
- M Hatakeyama
- M Karin
- M Selbach
- M Selbach
- M Yoneyama
- MF Smith Jr
- MM D'Elios
- R Rad
- R Rad
- R Shaykhiev
- S Akira
- S Backert
- S Backert
- S Backert
- S Brandt
- S Gieseler
- S Li
- S Maeda
- S Moese
- S Moese
- S Wessler
- S Yokota
- S Yokota
- Sabine Brandt
- SL Foster
- Steffen Backert
- Suneesh Kumar Pachathundikandi
- SZ Ding
- T Kawahara
- T Kawai
- T Kwok
- T Ogawa
- T Pédron
- T Watanabe
- Y Takeda
- Yoshio Yamaoka
- Publication venue
- Public Library of Science
- Publication date
- 01/05/2011
- Field of study
Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein. However, mechanisms of sensing this pathogen through Toll-like receptors (TLRs) and downstream signalling pathways in the development of different pathologies are widely unclear. Here, we explored the involvement of TLR-2 and TLR-5 in THP-1 cells and HEK293 cell lines (stably transfected with TLR-2 or TLR-5) during infection with wild-type H. pylori and isogenic cagPAI mutants. H. pylori triggered enhanced TLR-2 and TLR-5 expression in THP-1, HEK293-TLR2 and HEK293-TLR5 cells, but not in the HEK293 control. In addition, IL-8 and TNF-α cytokine secretion in THP-1 cells was induced in a cagPAI-dependent manner. Furthermore, we show that HEK293 cells are not competent for the uptake of T4SS-delivered CagA, and are therefore ideally suited for studying TLR signalling in the absence of T4SS functions. HEK293 control cells, which do not induce TLR-2 and TLR-5 expression during infection, only secreted cytokines in small amounts, in agreement with T4SS functions being absent. In contrast, HEK293-TLR2 and HEK293-TLR5 cells were highly competent for inducing the secretion of IL-8 and TNF-α cytokines in a cagPAI-independent manner, suggesting that the expression of TLR-2 or TLR-5 has profoundly changed the capability to trigger pro-inflammatory signalling upon infection. Using phospho-specific antibodies and luciferase reporter assays, we further demonstrate that H. pylori induces IRAK-1 and IκB phosphorylation in a TLR-dependent manner, and this was required for activation of transcription factor NF-κB. Finally, NF-κB activation in HEK293-TLR2 and HEK293-TLR5 cells was confirmed by expressing p65-GFP which was translocated from the cytoplasm into the nucleus. These data indicate that H. pylori-induced expression of TLR-2 and TLR-5 can qualitatively shift cagPAI-dependent to cagPAI-independent pro-inflammatory signalling pathways with possible impact on the outcome of H. pylori-associated diseases
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Aktas S
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Alegria ZL
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amirie KJ
- Amor Dos Santos SP
- Amos KR
- An S
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Arbiol Val SJ
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Astrand KSV
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Baer TM
- Bagnaia P
- Bahmani M
- Bahner D
- Bai K
- Bailey AJ
- Baines JT
- Baines L
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beaucamp JY
- Beauchemin PH
- Bechtle P
- Beck HP
- Becker K
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Benchekroun D
- Bendebba F
- Benhammou Y
- Benkendorfer KC
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berrocal Guardia A
- Berry T
- Berta P
- Berthold A
- Bethke S
- Betti A
- Bevan AJ
- Bhalla NK
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhide KD
- Bhopatkar VS
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Billingsley CS
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
- Biros M
- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- Bjørke K
- Bloch I
- Blue A
- Blumenschein U
- Blumenthal J
- Bobrovnikov VS
- Boehler M
- Boehm B
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Brüers B
- Buanes T
- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burlayenko O
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabrera Urbán S
- Cadamuro L
- Caforio D
- Cai H
- Cai Y
- Cai Y
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
- Calvet S
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canbay AC
- Canonero E
- Cantero J
- Cao Y
- Capocasa F
- Capua M
- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlotto JI
- Carlson BT
- Carlson EM
- Carminati L
- Carnelli A
- Carnesale M
- Caron S
- Carquin E
- Carratta G
- Carroll AM
- Carrá S
- Carter TM
- Casado MP
- Caspar M
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cavaliere T
- Cavaliere V
- Cavalli N
- Cekmecelioglu YC
- Celebi E
- Cella S
- Celli F
- Centonze MS
- Cepaitis V
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervato B
- Cervelli A
- Cesarini G
- Cetin SA
- Chakraborty D
- Chan J
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- Chapman JD
- Chapon E
- Chargeishvili B
- Charlton DG
- Chatterjee M
- Chauhan C
- Che Y
- Chekanov S
- Chekulaev SV
- Chelkov GA
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- Cheong S
- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiedde N
- Chiodini G
- Chisholm AS
- Chitan A
- Chitishvili M
- Chizhov MV
- Choi K
- Chou Y
- Chow EYS
- Chu KL
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Clark A
- Clark PJ
- Clarry C
- Clavijo Columbie JM
- Clawson SE
- Clement C
- Clercx J
- Coadou Y
- Cobal M
- Coccaro A
- Coelho Barrue RF
- Coelho Lopes De Sa R
- Coelli S
- Cole B
- Collot J
- Conde Muiño P
- Connell MP
- Connell SH
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cordeiro Oudot Choi A
- Corpe LD
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Cowan G
- Cranmer K
- Cremonini D
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosby JE
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cui H
- Cui Z
- Cunningham WR
- Curcio F
- Curran JR
- Czodrowski P
- Czurylo MM
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dal Santo D
- Dallapiccola C
- Dam M
- Damp J
- Dandoy JR
- Danninger M
- Dao V
- Darbo G
- Das SJ
- Dattola F
- David C
- Davidek T
- Davis-Purcell B
- Dawson I
- Day-hall HA
- De Asmundis R
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- De Groot N
- de Jong P
- De la Torre H
- De Maria A
- De Salvo A
- De Sanctis U
- De Santis F
- De Santo A
- De Vivie De Regie JB
- De K
- Dedovich DV
- Degens J
- Deiana AM
- Del Corso F
- Del Peso J
- Del Rio F
- Delagrange L
- Deliot F
- Delitzsch CM
- Della Pietra M
- Della Volpe D
- Dell’Acqua A
- Dell’Asta L
- Delmastro M
- Delsart PA
- Demers S
- Demichev M
- Denisov SP
- Derendarz D
- Derue F
- Dervan P
- Desch K
- Deutsch C
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Luca A
- Di Micco B
- Di Nardo R
- Diamantopoulou M
- Dias Do Vale T
- Dias FA
- Diaz Capriles FG
- Diaz MA
- Didenko M
- Diehl EB
- Diez Pardos C
- Dimitriadi C
- Dimitrievska A
- Dingfelder J
- Dinu I-M
- Dittmeier SJ
- Dittus F
- Divisek M
- Djama F
- Djobava T
- Doglioni C
- Dohnalova A
- Dolejsi J
- Dolezal Z
- Dona KM
- Donadelli M
- Dong B
- Donini J
- Dopke J
- Doria A
- Dos Santos Fernandes N
- Dougan P
- Dova MT
- Doyle AT
- Draguet MA
- Dreyer E
- Drivas-koulouris I
- Drnevich M
- Drozdova M
- du Pree TA
- Du D
- Dubinin F
- Dubovsky M
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Duden ER
- Duflot L
- Duminica I
- Dumitriu AE
- Dunford M
- Dungs S
- Dunne K
- Duperrin A
- Duran Yildiz H
- Durglishvili A
- Dwyer BL
- Dyckes GI
- Dyndal M
- Dziedzic BS
- Díez Cornell S
- Dührssen M
- Düren M
- D’amen G
- D’Amico V
- D’Auria S
- D’avanzo A
- D’Eramo L
- D’Onofrio A
- D’Onofrio M
- D’uffizi M
- Earnshaw ZO
- Eberwein GH
- Eckerova B
- Eggebrecht S
- Egidio Purcino De Souza E
- Ehrke LF
- Eigen G
- Einsweiler K
- Ekelof T
- Ekman PA
- El Farkh S
- El Ghazali Y
- El Jarrari H
- El Moussaouy A
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Ellis N
- Elmsheuser J
- Elsawy M
- Elsing M
- Emeliyanov D
- Enari Y
- Ene I
- Epari S
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Etzion E
- Evans G
- Evans H
- Evans LS
- Ezhilov A
- Ezzarqtouni S
- Fabbri F
- Fabbri L
- Facini G
- Fadeyev V
- Fakhrutdinov RM
- Fakoudis D
- Falciano S
- Falda Ulhoa Coelho LF
- Falke PJ
- Fallavollita F
- Faltova J
- Fan C
- Fan Y
- Fang Y
- Fanti M
- Faraj M
- Farazpay Z
- Farbin A
- Farilla A
- Farooque T
- Farrington SM
- Fassi F
- Fassouliotis D
- Faucci Giannelli M
- Fawcett WJ
- Fayard L
- Federic P
- Federicova P
- Fedin OL
- Feickert M
- Feligioni L
- Fellers DE
- Feng C
- Feng M
- Feng Z
- Fenton MJ
- Ferencz L
- Ferguson RAM
- Fernandez Luengo SI
- Fernandez Martinez P
- Fernoux MJV
- Ferrando J
- Ferrari A
- Ferrari P
- Ferrari R
- Ferrere D
- Ferretti C
- Fiedler F
- Fiedler P
- Filipčič A
- Filmer EK
- Filthaut F
- Fiolhais MCN
- Fiorini L
- Fisher WC
- Fitschen T
- Fitzhugh PM
- Fleck I
- Fleischmann P
- Flick T
- Flores Castillo LR
- Flores Sanz De Acedo L
- Flores M
- Follega FM
- Fomin N
- Foo JH
- Formica A
- Forti AC
- Fortin E
- Fortman AW
- Foti MG
- Fountas L
- Fournier D
- Fox H
- Francavilla P
- Francescato S
- Franchellucci S
- Franchini M
- Franchino S
- Francis D
- Franco Lima V
- Franco L
- Franconi L
- Franklin M
- Frattari G
- Freund WS
- Frid YY
- Friend J
- Fritzsche N
- Froch A
- Froidevaux D
- Frost JA
- Fu Y
- Fuenzalida Garrido S
- Fujimoto M
- Fung KY
- Furtado De Simas Filho E
- Furukawa M
- Fuster J
- Gabrielli A
- Gabrielli A
- Gadow P
- Gagliardi G
- Gagnon LG
- Galantzan S
- Gallas EJ
- Gallop BJ
- Gan KK
- Ganguly S
- Gao Y
- Garay Walls FM
- Garcia Alonso A
- Garcia Caffaro AG
- Garcia B
- Garcia-Sciveres M
- García Navarro JE
- García C
- Gardner GL
- Gardner RW
- Garelli N
- Garg D
- Garg RB
- Gargan JM
- Garner CA
- Garvey CM
- Gaspar P
- Gassmann VK
- Gaudio G
- Gautam V
- Gauzzi P
- Gavrilenko IL
- Gavrilyuk A
- Gay C
- Gaycken G
- Gazis EN
- Geanta AA
- Gee CM
- Gekow A
- Gemme C
- Genest MH
- Gentry AD
- George S
- George WF
- Geralis T
- Gessinger-Befurt P
- Geyik ME
- Ghani M
- Ghorbanian K
- Ghosal A
- Ghosh A
- Ghosh A
- Giacobbe B
- Giagu S
- Giani T
- Giannetti P
- Giannini A
- Gibson SM
- Gignac M
- Gil DT
- Gilbert AK
- Gilbert BJ
- Gillberg D
- Gilles G
- Ginabat L
- Gingrich DM
- Giordani MP
- Giraud PF
- Giugliarelli G
- Giugni D
- Giuli F
- Gkialas I
- Gladilin LK
- Glasman C
- Gledhill GR
- Glemža G
- Glisic M
- Gnesi I
- Go Y
- Goblirsch-Kolb M
- Gocke B
- Godin D
- Gokturk B
- Goldfarb S
- Golling T
- Gololo MGD
- Golubkov D
- Gombas JP
- Gomes Da Silva G
- Gomes A
- Gomez Delegido AJ
- Gonella L
- Gongadze A
- Gonnella F
- Gonski JL
- Gonzalez Lopez R
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- Zhao T
- Zhao Y
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- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
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- Zhong D
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- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
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- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
The contribution of heavy metal pollution derived from highway runoff to Guanabara Bay sediments: Rio de Janeiro / Brazil
- Author
- ACKEMAN F
- AMADOR ES
- ANDERSSON M
- BAPTISTA NETO JA
- BAPTISTA NETO JA
- BARROCAS PRG
- Bernard J. Smith
- BODUR MN
- BOTHNER MH
- BRICKER SB
- CHARLESWORTH SM
- CHECK LM
- CHON H
- CORDERY I
- DE MIQUEL E
- DUZGOREN-AYDIN NS
- Edisio Pereira
- ELLIS JB
- ELLIS JB
- ELLIS JB
- ELLIS JB
- ELLIS JB
- ERGIN M
- FARIA MM
- FEELY RA
- FERGUSON JE
- GODOY JM
- GROMAIRE MC
- GROUSSET FE
- HUANG K
- JENNE FA
- John J. Mcallister
- José A. Baptista-Neto
- KACKSTAETTER UR
- KJERFVE B
- LACERDA LD
- LEAL M
- MACHADO W
- MASON Y
- MCALLISTER JJ
- MCALLISTER JJ
- MCALLISTER JJ
- MCBRIDE MB
- NAQEROTTE SM
- NIMER E
- ODUN WE
- PAGOTTO C
- PERIN G
- POPE W
- REBELLO A
- RICHARDS BK
- ROBERTS AH
- RULE JH
- SALOMONS W
- SARTOR JD
- SELVARAJ K
- SHAHEEN DG
- SMITH BJ
- SOTO-JIMÉNEZ MF
- SUTHERLAND RA
- SUTHERLAND RA
- SZEFER P
- TOSSAVAINEN M
- TUREKIAN KK
- TURER D
- VAN DER SLOOT HA
- VANDENBERG C
- WALKLEY A
- WATTS S
- WEEKS CR
- WILKINSON R
- WINDOM HL
- WONG CSC
- ZONTA R
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A proposal for a CT driven classification of left colon acute diverticulitis
- Author
- A Chabok
- A Perathoner
- A Toro
- Abdelkarim H Omari
- Aleksandar Karamarkovic
- AM Kaiser
- AM Morris
- Andras Vereczkei
- Arda Isik
- Ashraf Abbas
- Athanasios Marinis
- AV Weizman
- B Siewert
- Boris Sakakushev
- BR Klarenbeek
- C Ordoñez
- Carlos A Ordoñez
- Carlos Augusto Gomes
- CE Oberkofler
- Charalampos Spyropoulos
- Cristian Tranà
- CS Andeweg
- CS Andeweg
- D Brandt
- D Feingold
- DA Etzioni
- Damien Massalou
- Daniel Rios-Cruz
- Darija Soldatenkova
- David Costa Navarro
- DG Weber
- Diego Piazza
- DM Shabanzadeh
- Dmitry Smirnov
- E Angenete
- E Myers
- E Myers
- EJ Hinchey
- Elif Çolak
- Emanuele Caproli
- ES Yeo
- Ewen A Griffiths
- F Agresta
- F McDermott
- FA Moore
- Fausto Catena
- Federico Coccolini
- Ferdinando Agresta
- Fikri M Abu-Zidan
- FJ Fleming
- Francesco Corcione
- Frederick A Moore
- Gabriele Anania
- Georgios Gkiokas
- Gerson Alves Pereira
- Gianluca Baiocchi
- Giovanni Bellanova
- GL Rossi
- Goran Augustin
- H Masoomi
- H Wasvary
- HA Swank
- HA Swank
- Helmut A Segovia Lohse
- Imtiaz Wani
- Ioannis Nikolopoulos
- Ionut Negoi
- Isidoro Di Carlo
- Jaan Tepp
- Jae Il Kim
- Jakub Kenig
- Jan Ulrych
- JB Puylaert
- JC Andersen
- JD Jackson
- JJ Atema
- Kenneth Y Kok
- Konstantinos Bouliaris
- Koray Das
- L Kohler
- L Köhler
- L Salem
- L Trenti
- Luca Ansaloni
- M Jiménez
- M Karoui
- M Rodrìguez-Cerrillo
- M Sartelli
- M Sartelli
- M Tadlock
- MA Mazzei
- Mahir Gachabayov
- Marco Catani
- Mario Paulo Faro
- Massimo Sartelli
- Matej Skrovina
- ME Kreis
- ME Sher
- MF Rotondo
- Michael McFarlane
- Miklosh Bala
- Miran Rems
- N de Korte
- Norio Sato
- O Hansen
- Offir Ben-Ishay
- P Ambrosetti
- P Ambrosetti
- P Ambrosetti
- P Ambrosetti
- R Kafka-Ritsch
- R Ricciardi
- Raul Coimbra
- Renato B Melo
- Roberto Bini
- Rodolfo Soto
- RR Kumar
- S Abbas
- S Afshar
- S Alonso
- S Biondo
- S Biondo
- S Dharmarajan
- Salomone Di Saverio
- Sanjay Marwah
- Sanoop K Zachariah
- SE Regenbogen
- T Herzog
- Tadaja Pintar
- U Zingg
- V Sallinen
- Varut Lohsiriwat
- Victor Kong
- Vishal G Shelat
- VJ Sallinen
- W Laméris
- W Laméris
- Y Durmishi
- Yunfeng Cui
- Zaza Demetrashvili
- Zurabs Kecbaja
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
- Abi B
- Abud A Abed
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adamowski M
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Alba J Bazo
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso MJ Rodriguez
- AlRashed M
- Alt C
- Alton A
- Alvarez R
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews M
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arellano L
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Astiz IL De Icaza
- Aurisano A
- Aushev V
- Autiero D
- Ayala-Torres M
- Azfar F
- Babicz M
- Back A
- Back H
- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
- Baldi P
- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker G
- Barkhouse W
- Barnes C
- Barr G
- Barros A
- Barros N
- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Batchelor C
- Battat J
- Battisti F
- Bay F
- Bazetto MCQ
- Beacom JF
- Bechetoille E
- Behera B
- Beigbeder C
- Bellantoni L
- Bellettini G
- Bellini V
- Beltramello O
- Benekos N
- Berg R Van
- Berger J
- Berkman S
- Bermeo L Gomez
- Bernardini P
- Berner RM
- Bersani A
- Bertolucci S
- Betancourt M
- Bevan A
- Bezawada Y
- Bezerra TS
- Bhardwaj A
- Bhatnagar V
- Bhattacharjee M
- Bhattarai D
- Bhuller S
- Bhuyan B
- Biagi S
- Bian J
- Biassoni M
- Biery K
- Bilki B
- Bishai M
- Bitadze A
- Blake A
- Blaszczyk F
- Blazey G
- Blucher E
- Boissevain J
- Bolognesi S
- Bolton T
- Bomben L
- Bonesini M
- Bongrand M
- Bonilla E Rodriguez
- Bonilla-Diaz C
- Bonini F
- Bonis I De
- Booth A
- Boran F
- Bordoni S
- Borkum A
- Bostan N
- Bour P
- Bourgeois C
- Boyden D
- Bracinik J
- Braga D
- Brailsford D
- Branca A
- Brandt A
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between data and simulation
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
- Abed Abud A
- Abi B
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adamowski M
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso Monsalve S
- AlRashed M
- Alt C
- Alton A
- Alvarez R
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews M
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arellano L
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Aurisano A
- Aushev V
- Autiero D
- Ayala Lara V
- Ayala-Torres M
- Azfar F
- Babicz M
- Back A
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- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
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- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker G
- Barkhouse W
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- Barranco Monarca J
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- Barrow JL
- Basharina-Freshville A
- Bashyal A
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- Batchelor C
- Batista das Chagas E
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- Bazetto MCQ
- Bazo Alba J
- Beacom JF
- Bechetoille E
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- Beigbeder C
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- Benitez Montiel C
- Bento Neves F
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- Berkman S
- Bernardini P
- Berner RM
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- Bertolucci S
- Betancourt M
- Betancur Rodríguez A
- Bevan A
- Bezawada Y
- Bezerra TS
- Bhardwaj A
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- Bhattacharjee M
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- Bilki B
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
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- Berry B
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- Beverstock A
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- Bhangu A. Nepogodiev D
- Bhangu A
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- Biancafarina A
- Bianchi Cl
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- Blackford Od
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- Bolton W
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- Botelho P
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- Branagan G
- Bravo-Gutiérrez Af
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- Brennan S
- Brett M
- Brewer H
- Brewer Hk
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- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
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- Brown Od
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- Brunelli Db
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- Bukhari W
- Bull C
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- Busuttil A
- Byrne Be
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- Campagnaro T
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- Campbell U
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- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
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- Cavallo D
- Cavero A
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- Cerdán-Santacruz C
- Cerdán-Santacruz C
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- Cervellera M
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- Chan D
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- Chandratreya N
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- Chillitupa Cz
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- Choong Jh
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- Colombo F
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- Compagnoni B
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- García-Granero A
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- García-Novoa A
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- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Combined measurement of the Higgs boson mass from the H → γγ and H → ZZ∗ → 4ℓ decay channels with the ATLAS detector using √s = 7, 8, and 13 TeV pp collision data
- Author
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- Caforio D
- Cai H
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- Cairo VMM
- Cakir O
- Calace N
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- Caloba LP
- Calvet D
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- Camarero Munoz D
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- Camerlingo MT
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- Castillo Gimenez V
- Castillo FL
- Castro NF
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- Catmore JR
- Cavaliere V
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- Celebi E
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- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cherkaoui El Moursli R
- Cheu E
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- Ciesla KM
- Cindro V
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- Da Fonseca Pinto JV
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- Zeng H
- Zeng JC
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- Zenin O
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- Zerwas D
- Zhai M
- Zhang B
- Zhang DF
- Zhang J
- Zhang J
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- Zhang P
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- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
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- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2023
- Field of study
A measurement of the mass of the Higgs boson combining the
H
→
Z
Z
∗
→
4
ℓ
and
H
→
γ
γ
decay channels is presented. The result is based on
140
fb
−
1
of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of
125.11
±
0.09
(
stat
)
±
0.06
(
syst
)
=
125.11
±
0.11
GeV
. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics
Searching for solar KDAR with DUNE
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- Abi B
- Abud AA
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
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- Trzaska WH
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- Tsamalaidze Z
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- Tzanov M
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- Urheim J
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- Vahle P
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- Vazquez WP
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- Vermeulen MA
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- Wallbank M
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- Wisniewski W
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- Yonehara K
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- Zalesak J
- Zambelli L
- Zamorano B
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- Zazueta L
- Zeller GP
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- Zimmerman ED
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