63 research outputs found
Implications of Flavor Dynamics for Fermion Triplet Leptogenesis
We analyze the importance of flavor effects in models in which leptogenesis
proceeds via the decay of Majorana electroweak triplets. We find that depending
on the relative strengths of gauge and Yukawa reactions the asymmetry can
be sizably enhanced, exceeding in some cases an order of magnitude level. We
also discuss the impact that such effects can have for TeV-scale triplets
showing that as long as the asymmetry is produced by the dynamics of the
lightest such triplet they are negligible, but open the possibility for
scenarios in which the asymmetry is generated above the TeV scale by heavier
states, possibly surviving the TeV triplet related washouts. We investigate
these cases and show how they can be disentangled at the LHC by using Majorana
triplet collider observables and, in the case of minimal type III see-saw
models even through lepton flavor violation observables.Comment: 22 pages, 9 figures, extended discussion on collider phenomenology,
references added. Version matches publication in JHE
A realistic pattern of fermion masses from a five-dimensional SO(10) model
We provide a unified description of fermion masses and mixing angles in the
framework of a supersymmetric grand unified SO(10) model with anarchic Yukawa
couplings of order unity. The space-time is five dimensional and the extra flat
spatial dimension is compactified on the orbifold ,
leading to Pati-Salam gauge symmetry on the boundary where Yukawa interactions
are localised. The gauge symmetry breaking is completed by means of a rather
economic scalar sector, avoiding the doublet-triplet splitting problem. The
matter fields live in the bulk and their massless modes get exponential
profiles, which naturally explain the mass hierarchy of the different fermion
generations. Quarks and leptons properties are naturally reproduced by a
mechanism, first proposed by Kitano and Li, that lifts the SO(10) degeneracy of
bulk masses in terms of a single parameter. The model provides a realistic
pattern of fermion masses and mixing angles for large values of . It
favours normally ordered neutrino mass spectrum with the lightest neutrino mass
below 0.01 eV and no preference for leptonic CP violating phases. The right
handed neutrino mass spectrum is very hierarchical and does not allow for
thermal leptogenesis. We analyse several variants of the basic framework and
find that the results concerning the fermion spectrum are remarkably stable.Comment: 30 pages, 7 figures, 4 table
Perceived threat predicts the neural sequelae of combat stress
Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amygdala is a key brain region involved in threat detection and fear regulation, and previous animal studies have suggested that stress sensitizes amygdala responsivity and reduces its regulation by the prefrontal cortex. In this study, we used a prospective design to investigate the consequences of severe stress in soldiers before and after deployment to a combat zone. We found that combat stress increased amygdala and insula reactivity to biologically salient stimuli across the group of combat-exposed individuals. In contrast, its influence on amygdala coupling with the insula and dorsal anterior cingulate cortex was dependent on perceived threat, rather than actual exposure, suggesting that threat appraisal affects interoceptive awareness and amygdala regulation. Our results demonstrate that combat stress has sustained consequences on neural responsivity, and suggest a key role for the appraisal of threat on an amygdala-centered neural network in the aftermath of severe stress
Marine fish traits follow fast-slow continuum across oceans
A fundamental challenge in ecology is to understand why species are found where they are and predict
where they are likely to occur in the future. Trait-based approaches may provide such understanding,
because it is the traits and adaptations of species that determine which environments they can inhabit.
It is therefore important to identify key traits that determine species distributions and investigate
how these traits relate to the environment. Based on scientific bottom-trawl surveys of marine fish
abundances and traits of >1,200 species, we investigate trait-environment relationships and project
the trait composition of marine fish communities across the continental shelf seas of the Northern
hemisphere. We show that traits related to growth, maturation and lifespan respond most strongly to
the environment. This is reflected by a pronounced “fast-slow continuum” of fish life-histories, revealing
that traits vary with temperature at large spatial scales, but also with depth and seasonality at more
local scales. Our findings provide insight into the structure of marine fish communities and suggest that
global warming will favour an expansion of fast-living species. Knowledge of the global and local drivers
of trait distributions can thus be used to predict future responses of fish communities to environmental
change.Postprint2,92
A cytomorphological and immunohistochemical profile of aggressive B-cell lymphoma: high clinical impact of a cumulative immunohistochemical outcome predictor score
We analyzed morphological and immunohistochemical features in 174 aggressive B-cell lymphomas of nodal and extranodal origin. Morphological features included presence or absence of a follicular component and cytologic criteria according to the Kiel classification, whereas immunohistochemical studies included expression of CD10, BCL-2, BCL-6, IRF4/MUM1, HLA-DR, p53, Ki-67 and the assessment of plasmacytoid differentiation. Patients were treated with a CHOP-like regimen. While the presence or absence of either CD10, BCL-6 and IRF4/MUM1 reactivity or plasmacytoid differentiation did not identify particular cytomorphologic or site-specific subtypes, we found that expression of CD10 and BCL-6, and a low reactivity for IRF4/MUM1 were favourable prognostic indicators. In contrast, BCL-2 expression and presence of a monotypic cytoplasmic immunoglobulin expression was associated with an unfavourable prognosis in univariate analyses. Meta-analysis of these data resulted in the development of a cumulative immunohistochemical outcome predictor score (CIOPS) enabling the recognition of four distinct prognostic groups. Multivariate analysis proved this score to be independent of the international prognostic index. Such a cumulative immunohistochemical scoring approach might provide a valuable alternative in the recognition of defined risk types of aggressive B-cell lymphomas
Evolutionarily Conserved Protein Sequences of Influenza A Viruses, Avian and Human, as Vaccine Targets
10.1371/journal.pone.0001190PLoS ONE21
The Effects of Handling and Anesthetic Agents on the Stress Response and Carbohydrate Metabolism in Northern Elephant Seals
Free-ranging animals often cope with fluctuating environmental conditions such as weather, food availability, predation risk, the requirements of breeding, and the influence of anthropogenic factors. Consequently, researchers are increasingly measuring stress markers, especially glucocorticoids, to understand stress, disturbance, and population health. Studying free-ranging animals, however, comes with numerous difficulties posed by environmental conditions and the particular characteristics of study species. Performing measurements under either physical restraint or chemical sedation may affect the physiological variable under investigation and lead to values that may not reflect the standard functional state of the animal. This study measured the stress response resulting from different handling conditions in northern elephant seals and any ensuing influences on carbohydrate metabolism. Endogenous glucose production (EGP) was measured using [6-3H]glucose and plasma cortisol concentration was measured from blood samples drawn during three-hour measurement intervals. These measurements were conducted in weanlings and yearlings with and without the use of chemical sedatives—under chemical sedation, physical restraint, or unrestrained. We compared these findings with measurements in adult seals sedated in the field. The method of handling had a significant influence on the stress response and carbohydrate metabolism. Physically restrained weanlings and yearlings transported to the lab had increased concentrations of circulating cortisol (F11, 46 = 25.2, p<0.01) and epinephrine (F3, 12 = 5.8, p = 0.01). Physical restraint led to increased EGP (t = 3.1, p = 0.04) and elevated plasma glucose levels (t = 8.2, p<0.01). Animals chemically sedated in the field typically did not exhibit a cortisol stress response. The combination of anesthetic agents (Telazol, ketamine, and diazepam) used in this study appeared to alleviate a cortisol stress response due to handling in the field without altering carbohydrate metabolism. Measures of hormone concentrations and metabolism made under these conditions are more likely to reflect basal values
Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective.
Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events
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