290 research outputs found
Should I stay or should I go? Modelling year-round habitat suitability for fin whales in the California Current
Aim
Understanding the spatial ecology of endangered species is crucial to predicting habitat use at scales relevant to conservation and management. Here, we aim to model the influence of biophysical conditions on habitat suitability for endangered fin whales Balaenoptera physalus, with a view to informing management in a heavily impacted ocean region.
Location
We satellite-tracked the movements of 67 fin whales through the California Current System (CCS), a dynamic eastern boundary upwelling ecosystem in the Northeast Pacific.
Methods
We use a multi-scale modelling framework to elucidate biophysical influences on habitat suitability for fin whales in the CCS. Using Generalised Additive Mixed Models, we quantify the influence of a suite of remotely-sensed variables on broad-scale patterns of occupancy, and present the first year-round, high-resolution predictions of seasonal habitat suitability. Further, we model the influence of contemporaneous biophysical conditions on individual-level residence times in high-use habitat.
Results
We present evidence of year-round habitat suitability in the southern California Current System, robust to inter-annual variability, establishing that North Pacific fin whales do not follow the canonical baleen whale migration model. Within the high-use habitat in the Southern California Bight (SCB), individual-level residency to localised areas (n=16 for >30 days; n=4 for >6 months) was associated with warm, shallow, nearshore waters (>18°C, <500m); with cool waters (14-15°C) occurring over complex seafloor topographies and convergent (sub-)mesoscale structures at the surface.
Main Conclusions
Biophysical conditions in the southern CCS generate productive foraging habitats that can support the fin whale population year-round and allow for extended periods of residency in localised areas. High-use habitats for fin whales are co-located with areas of intense human use, including international shipping routes and a major naval training range. Seasonal habitat suitability maps presented here could inform the management of anthropogenic threats to an endangered baleen whales in this globally significant biodiversity hotspot
Cryopreservation of individually selected sperm: methodology and case report of a clinical pregnancy
model predictive control tools for evolutionary plants
The analysis and design of control system configurations for automated production systems is generally a challenging problem, in particular given the increasing number of automation devices and the amount of information to be managed. This problem becomes even more complex when the production system is characterized by a fast evolutionary behaviour in terms of tasks to be executed, production volumes, changing priorities, and available resources. Thus, the control solution needs to be optimized on the basis of key performance indicators like flow production, service level, job tardiness, peak of the absorbed electrical power and the total energy consumed by the plant. This paper proposes a prototype control platform based on Model Predictive Control (MPC) that is able to impress to the production system the desired functional behaviour. The platform is structured according to a two-level control architecture. At the lower layer, distributed MPC algorithms control the pieces of equipment in the production system. At the higher layer an MPC coordinator manages the lower level controllers, by taking full advantage of the most recent advances in hybrid control theory, dynamic programming, mixed‐integer optimization, and game theory. The MPC-based control platform will be presented and then applied to the case of a pilot production plant
Guaranteed optimal reachability control of reaction-diffusion equations using one-sided Lipschitz constants and model reduction
We show that, for any spatially discretized system of reaction-diffusion, the
approximate solution given by the explicit Euler time-discretization scheme
converges to the exact time-continuous solution, provided that diffusion
coefficient be sufficiently large. By "sufficiently large", we mean that the
diffusion coefficient value makes the one-sided Lipschitz constant of the
reaction-diffusion system negative. We apply this result to solve a finite
horizon control problem for a 1D reaction-diffusion example. We also explain
how to perform model reduction in order to improve the efficiency of the
method
Recent Results from the VERITAS Collaboration
A decade after the discovery of TeV gamma-rays from the blazar Mrk 421 (Punch et al. 1992), the list of TeV blazars has increased to five BL Lac objects: Mrk 421 (Punch et al. 1992; Petry et al. 1996; Piron et al. 2001), Mrk 501 (Quinn et al. 1996; Aharonian et al. 1999; Djannati-Atai et al. 1999), 1ES2344+514 (Catanese et al. 1998), H1426+428 (Horan et al. 2000, 2002; Aharonian et al. 2002; Djannati-Atai et al. 2002) and 1ES1959+650 (Nishiyama et al. 1999; Konopelko et al. 2002; Holder et al. 2002). In this paper we report results from recent observations of Mrk 421, H1426+428 and 1ES1959+650 using the Whipple Observatory 10 m telescope
Study of the reaction e^{+}e^{-} -->J/psi\pi^{+}\pi^{-} via initial-state radiation at BaBar
We study the process with
initial-state-radiation events produced at the PEP-II asymmetric-energy
collider. The data were recorded with the BaBar detector at center-of-mass
energies 10.58 and 10.54 GeV, and correspond to an integrated luminosity of 454
. We investigate the mass
distribution in the region from 3.5 to 5.5 . Below 3.7
the signal dominates, and above 4
there is a significant peak due to the Y(4260). A fit to
the data in the range 3.74 -- 5.50 yields a mass value
(stat) (syst) and a width value (stat)(syst) for this state. We do not
confirm the report from the Belle collaboration of a broad structure at 4.01
. In addition, we investigate the system
which results from Y(4260) decay
Costs and Effects of Abdominal versus Laparoscopic Hysterectomy: Systematic Review of Controlled Trials
Objective: Comparative evaluation of costs and effects of laparoscopic hysterectomy (LH) and abdominal hysterectomy (AH). Data sources: Controlled trials from Cochrane Central register of controlled trials, Medline, Embase and prospective trial registers. Selection of studies: Twelve (randomized) controlled studies including the search terms costs, laparoscopy, laparotomy and hysterectomy were identified. Methods: The type of cost analysis, perspective of cost analyses and separate cost components were assessed. The direct and indirect costs were extracted from the original studies. For the cost estimation, hospital stay and procedure costs were selected as most important cost drivers. As main outcome the major complication rate was taken. Findings: Analysis was performed on 2226 patients, of which 1013 (45.5%) in the LH group and 1213 (54.5%) in the AH group. Five studies scored >= 10 points (out of 19) for methodological quality. The reported total direct costs in the LH group (60,114). The reported total indirect costs of the LH group (3,139). The estimated mean major complication rate in the LH group (14.3%) was lower than in the AH group (15.9%). The estimated total costs in the LH group were 3,312 in the AH group. The incremental costs for reducing one patient with major complication(s) in the LH group compared to the AH group was $35,750. Conclusions: The shorter hospital stay in the LH group compensates for the increased procedure costs, with less morbidity. LH points in the direction of cost effectiveness, however further research is warranted with a broader costs perspective including long term effects as societal benefit, quality of life and survival
Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer
BACKGROUND: The identification of molecular and genetic markers to predict or monitor the efficacy of bevacizumab (BV) represents a key issue in the treatment of metastatic colorectal cancer (mCRC).
METHODS: Plasma levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble VEGF receptor 2 (sVEGFR-2) and thrombospondin-1 (TSP-1) were assessed by ELISA assay at different time points in a cohort of 25 patients enroled in a phase II trial of GONO-FOLFOXIRI plus BV as first-line treatment of mCRC. VEGF: -2578A/C, -1498C/T, -1154A/G, -634C/G and 936C/T; and VEGFR-2: -604A/G, +1192C/T and +1719A/T, polymorphisms were assessed in a total of 54 patients.
RESULTS: Treatment with GONO-FOLFOXIRI plus BV determined a prolonged and significant reduction in plasma free, biologically active VEGF concentration. Interestingly, VEGF concentrations remained lower than at baseline also at the time of PD. Conversely, PlGF levels increased during the treatment if compared with baseline, suggesting a possible role in tumour resistance; moreover, sVEGFR-2 increased at the time of PD, as well as TSP-1. No association of assessed polymorphisms with outcome was found.
CONCLUSION: Our study suggested the possible mechanisms of resistance to combined therapy in those patients with a progressive disease to be tested in ongoing phase III randomised studies
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