Molecular Design Approach Managing Molecular Orbital Superposition for High Efficiency without Color Shift in Thermally Activated Delayed Fluorescent Organic Lightâ Emitting Diodes

Molecular design principles of thermally activated delayed fluorescent (TADF) emitters having a high quantum efficiency and a color tuning capability was investigated by synthesizing three TADF emitters with donors at different positions of a benzonitrile acceptor. The position rendering a large overlap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) enhances the quantum efficiency of the TADF emitter. Regarding the orbital overlap, donor attachments at 2â and 6â positions of the benzonitrile were more beneficial than 3â and 5â substitutions. Moreover, an additional attachment of a weak donor at the 4â position further increased the quantum efficiency without decreasing the emission energy. Therefore, the molecular design strategy of substituting strong donors at the positions allowing a large molecular orbital overlap and an extra weak donor is a good approach to achieve both high quantum efficiency and a slightly increased emission energy.Overlap to emit: The substitution of strong donors at the positions rendering a large HOMOâ LUMO overlap and the addition of a weak donor constitute an effective design approach to realize TADF emitters having high efficiency.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/1/chem201805616-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/2/chem201805616.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/3/chem201805616_am.pd

Integrated system for traction and battery charging of electric vehicles with universal interface to the power grid

This paper proposes an integrated system for traction and battery charging of electric vehicles (EVs) with universal interface to the power grid. In the proposed system, the power electronics converters comprising the traction drive system are also used for the battery charging system, reducing the required hardware, meaning the integrated characteristic of the system. Besides, this interface is universal, since it can be performed with the three main types of power grids, namely: (1) Single-phase AC power grids; (2) Three-phase AC power grids; (3) DC power grids. In these three types of interfaces with the power grid, as well as in the traction drive operation mode, bidirectional operation is possible, framing the integration of this system into an EV in the context of smart grids. Moreover, the proposed system endows an EV with an on-board fast battery charger, whose operation allows either fast or slow battery charging. The main contributes of the proposed system are detailed in the paper, and simulation results are presented in order to attain the feasibility of the proposed system.This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT -Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2013. This work has been supported by FCT within the Project Scope DAIPESEV - Development of Advanced Integrated Power Electronic Systems for Electric Vehicles: PTDC/EEI-EEE/30382/2017. Mr. Tiago Sousa is supported by the doctoral scholarship SFRH/BD/134353/2017 granted by the Portuguese FCT agency. This work is part of the FCT project 0302836 NORTE-01-0145-FEDER-030283

Mean ergodicity and spectrum of the Cesàro operator on weighted c0 spaces

[EN] A detailed investigation is made of the continuity, the compactness and the spectrum of the Cesàro operator C acting on the weighted Banach sequence space c0(w) for a bounded, strictly positive weight w. New features arise in the weighted setting (e.g. existence of eigenvalues, compactness, mean ergodicity) which are not present in the classical setting of c0.The research of the first two authors was partially supported by the Projects MTM2013-43540-P, GVA Prometeo II/2013/013 and ACOMP/2015/186 (Spain).Albanese, AA.; Bonet Solves, JA.; Ricker, WJ. (2016). Mean ergodicity and spectrum of the Cesàro operator on weighted c0 spaces. Positivity. 20:761-803. https://doi.org/10.1007/s11117-015-0385-xS76180320Akhmedov, A.M., Başar, F.: On the fine spectrum of the Cesàro operator in $$c_0$$ c 0 . Math. J. Ibaraki Univ. 36, 25–32 (2004)Akhmedov, A.M., Başar, F.: The fine spectrum of the Cesàro operator $$C_1$$ C 1 over the sequence space $$bv_p, (1 \le p < \infty )$$ b v p , ( 1 ≤ p < ∞ ) . Math. J. Okayama Univ. 50, 135–147 (2008)Albanese, A.A., Bonet, J., Ricker, W.J.: Convergence of arithmetic means of operators in Fréchet spaces. J. Math. Anal. Appl. 401, 160–173 (2013)Albanese, A.A., Bonet, J., Ricker, W.J.: Spectrum and compactness of the Cesàro operator on weighted $$\ell _p$$ ℓ p spaces. J. Aust. Math. Soc. 99, 287–314 (2015)Albanese, A.A., Bonet, J., Ricker, W.J.: The Cesàro operator in the Fréchet spaces $$\ell ^{p+}$$ ℓ p + and $$L ^{p-}$$ L p - . Glasg. Math. J (to appear)Ansari, S.I., Bourdon, P.S.: Some properties of cyclic operators. Acta Sci. Math. Szeged 63, 195–207 (1997)Brown, A., Halmos, P.R., Shields, A.L.: Cesàro operators. Acta Sci. Math. Szeged 26, 125–137 (1965)Curbera, G.P., Ricker, W.J.: Spectrum of the Cesàro operator in $$\ell ^p$$ ℓ p . Arch. Math. 100, 267–271 (2013)Curbera, G.P., Ricker, W.J.: Solid extensions of the Cesàro operator on $$\ell ^p$$ ℓ p and $$c_0$$ c 0 . Integr. Equ. Oper. Theory 80, 61–77 (2014)Curbera, G.P., Ricker, W.J.: The Cesàro operator and unconditional Taylor series in Hardy spaces. Integr. Equ. Oper. Theory 83, 179–195 (2015)Diestel, J.: Sequences and Series in Banach Spaces. Springer, New York (1984)Dowson, H.R.: Spectral Theory of Linear Operators. Academic Press, London (1978)Dunford, N., Schwartz, J.T.: Linear Operators I: General Theory, 2nd Printing. Wiley Interscience Publ, New York (1964)Emilion, R.: Mean-bounded operators and mean ergodic theorems. J. Funct. Anal. 61, 1–14 (1985)Goldberg, S.: Unbounded Linear Operators: Theory and Applications. Dover Publ, New York (1985)Hille, E.: Remarks on ergodic theorems. Trans. Am. Math. Soc. 57, 246–269 (1945)Jarchow, H.: Locally Convex Spaces. Teubner, Stuttgart (1981)Krengel, U.: Ergodic Theorems. de Gruyter, Berlin (1985)Leibowitz, G.: Spectra of discrete Cesàro operators. Tamkang J. Math. 3, 123–132 (1972)Lin, M.: On the uniform ergodic theorem. Proc. Am. Math. Soc. 43, 337–340 (1974)Megginson, R.E.: An Introduction to Banach Space Theory. Springer, New York (1998)Mureşan, M.: A Concrete Approach to Classical Analysis. Springer, Berlin (2008)Okutoyi, J.I.: On the spectrum of $$C_1$$ C 1 as an operator on $$bv_0$$ b v 0 . J. Aust. Math. Soc. Ser. A 48, 79–86 (1990)Radjavi, H., Tam, P.-W., Tan, K.-K.: Mean ergodicity for compact operators. Studia Math. 158, 207–217 (2003)Reade, J.B.: On the spectrum of the Cesàro operator. Bull. Lond. Math. Soc. 17, 263–267 (1985)Rhoades, B.E., Yildirim, M.: The spectra and fine spectra of factorable matrices on $$c_0$$ c 0 . Math. Commun. 16, 265–270 (2011)Taylor, A.E.: Introduction to Functional Analysis. Wiley, New York (1958

Modelling the implications of stopping vector control for malaria control and elimination

Increasing coverage of malaria vector control interventions globally has led to significant reductions in disease burden. However due to its high recurrent cost, there is a need to determine if and when vector control can be safely scaled back after transmission has been reduced.; A mathematical model of Plasmodium falciparum malaria epidemiology was simulated to determine the impact of scaling back vector control on transmission and disease. A regression analysis of simulation results was conducted to derive predicted probabilities of resurgence, severity of resurgence and time to resurgence under various settings. Results indicate that, in the absence of secular changes in transmission, there are few scenarios where vector control can be removed without high expectation of resurgence. These, potentially safe, scenarios are characterized by low historic entomological inoculation rates, successful vector control programmes that achieve elimination or near elimination, and effective surveillance systems with high coverage and effective treatment of malaria cases.; Programmes and funding agencies considering scaling back or withdrawing vector control from previously malaria endemic areas need to first carefully consider current receptivity and other available interventions in a risk assessment. Surveillance for resurgence needs to be continuously conducted over a long period of time in order to ensure a rapid response should vector control be withdrawn

Gas Sensors Based on Semiconducting Metal Oxide One-Dimensional Nanostructures

This article provides a comprehensive review of recent (2008 and 2009) progress in gas sensors based on semiconducting metal oxide one-dimensional (1D) nanostructures. During last few years, gas sensors based on semiconducting oxide 1D nanostructures have been widely investigated. Additionally, modified or doped oxide nanowires/nanobelts have also been synthesized and used for gas sensor applications. Moreover, novel device structures such as electronic noses and low power consumption self-heated gas sensors have been invented and their gas sensing performance has also been evaluated. Finally, we also point out some challenges for future investigation and practical application

An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy

The extracellular matrix comprises a network of macromolecules such as collagens, proteoglycans and glycoproteins. VWA1 (von Willebrand factor A domain containing 1) encodes a component of the extracellular matrix that interacts with perlecan/collagen VI, appears to be involved in stabilizing extracellular matrix structures, and demonstrates high expression levels in tibial nerve. Vwa1-deficient mice manifest with abnormal peripheral nerve structure/function; however, VWA1 variants have not previously been associated with human disease. By interrogating the genome sequences of 74 180 individuals from the 100K Genomes Project in combination with international gene-matching efforts and targeted sequencing, we identified 17 individuals from 15 families with an autosomal-recessive, non-length dependent, hereditary motor neuropathy and rare biallelic variants in VWA1. A single disease-associated allele p.(G25Rfs*74), a 10-bp repeat expansion, was observed in 14/15 families and was homozygous in 10/15. Given an allele frequency in European populations approaching 1/1000, the seven unrelated homozygote individuals ascertained from the 100K Genomes Project represents a substantial enrichment above expected. Haplotype analysis identified a shared 220 kb region suggesting that this founder mutation arose >7000 years ago. A wide age-range of patients (6–83 years) helped delineate the clinical phenotype over time. The commonest disease presentation in the cohort was an early-onset (mean 2.0 ± 1.4 years) non-length-dependent axonal hereditary motor neuropathy, confirmed on electrophysiology, which will have to be differentiated from other predominantly or pure motor neuropathies and neuronopathies. Because of slow disease progression, ambulation was largely preserved. Neurophysiology, muscle histopathology, and muscle MRI findings typically revealed clear neurogenic changes with single isolated cases displaying additional myopathic process. We speculate that a few findings of myopathic changes might be secondary to chronic denervation rather than indicating an additional myopathic disease process. Duplex reverse transcription polymerase chain reaction and immunoblotting using patient fibroblasts revealed that the founder allele results in partial nonsense mediated decay and an absence of detectable protein. CRISPR and morpholino vwa1 modelling in zebrafish demonstrated reductions in motor neuron axonal growth, synaptic formation in the skeletal muscles and locomotive behaviour. In summary, we estimate that biallelic variants in VWA1 may be responsible for up to 1% of unexplained hereditary motor neuropathy cases in Europeans. The detailed clinical characterization provided here will facilitate targeted testing on suitable patient cohorts. This novel disease gene may have previously evaded detection because of high GC content, consequential low coverage and computational difficulties associated with robustly detecting repeat-expansions. Reviewing previously unsolved exomes using lower QC filters may generate further diagnoses

Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization

Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected macaques, whereas natural reservoir hosts exhibit limited disease and pathology. It is, however, unclear how natural hosts can sustain high viral loads, comparable to those observed in the pathogenic model, without developing severe disease. We performed transcriptional profiling on lymph node, blood, and colon samples from African green monkeys (natural host model) and Asian pigtailed macaques (pathogenic model) to directly compare gene expression patterns during acute pathogenic versus non-pathogenic SIV infection. The majority of gene expression changes that were unique to either model were detected in the lymph nodes at the time of peak viral load. Results suggest a shift toward cellular stress pathways and Th1 profiles during pathogenic infection, with strong and sustained type I and II interferon responses. In contrast, a strong type I interferon response was initially induced during non-pathogenic infection but resolved after peak viral load. The natural host also exhibited controlled Th1 profiles and better preservation of overall cell homeostasis. This study identified gene expression patterns that are specific to disease susceptibility, tissue compartmentalization, and infection duration. These patterns provide a unique view of how host responses differ depending upon lentiviral infection outcome

The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation

Background: Testes-specific protease 50 (TSP50), a newly discovered threonine enzyme, has similar amino acid sequences and enzymatic structures to those of many serine proteases. It may be an oncogene. TSP50 is up-regulated in breast cancer epithelial cells, and ectopic expression of TSP50 in TSP50-deficient Chinese hamster ovary (CHO) cells has been found to promote cell proliferation. However, the mechanisms by which TSP50 exerts its growth-promoting effects are not yet fully understood. Methodology/Principal Findings: To delineate whether the threonine protease activity of TSP50 is essential to its function in cell proliferation, we constructed and characterized a mutant TSP50, called TSP50 T310A, which was identified as a protease-dead mutant of TSP50. By a series of proliferation analyses, colony formation assays and apoptosis analyses, we showed that T310A mutation significantly depresses TSP50-induced cell proliferation in vitro. Next, the CHO stable cell line expressing either wild-type or T310A mutant TSP50 was injected subcutaneously into nude mice. We found that the T310A mutation could abolish the tumorigenicity of TSP50 in vivo. A mechanism investigation revealed that the T310A mutation prevented interaction between TSP50 and the NF-kBIkBa complex, which is necessary for TSP50 to perform its function in cell proliferation. Conclusion: Our data highlight the importance of threonine 310, the most critical protease catalytic site in TSP50, to TSP50induce

Secular trends: a ten-year comparison of the amount and type of physical activity and inactivity of random samples of adolescents in the Czech Republic

BACKGROUND: An optimal level of physical activity (PA) in adolescence influences the level of PA in adulthood. Although PA declines with age have been demonstrated repeatedly, few studies have been carried out on secular trends. The present study assessed levels, types and secular trends of PA and sedentary behaviour of a sample of adolescents in the Czech Republic. METHODS: The study comprised two cross-sectional cohorts of adolescents ten years apart. The analysis compared data collected through a week-long monitoring of adolescents' PA in 1998-2000 and 2008-2010. Adolescents wore either Yamax SW-701 or Omron HJ-105 pedometer continuously for 7 days (at least 10 hours per day) excluding sleeping, hygiene and bathing. They also recorded their number of steps per day, the type and duration of PA and sedentary behaviour (in minutes) on record sheets. In total, 902 adolescents (410 boys; 492 girls) aged 14-18 were eligible for analysis. RESULTS: Overweight and obesity in Czech adolescents participating in this study increased from 5.5% (older cohort, 1998-2000) to 10.4% (younger cohort, 2008-2010). There were no inter-cohort significant changes in the total amount of sedentary behaviour in boys. However in girls, on weekdays, there was a significant increase in the total duration of sedentary behaviour of the younger cohort (2008-2010) compared with the older one (1998-2000). Studying and screen time (television and computer) were among the main sedentary behaviours in Czech adolescents. The types of sedentary behaviour also changed: watching TV (1998-2000) was replaced by time spent on computers (2008-2010).The Czech health-related criterion (achieving 11,000 steps per day) decreased only in boys from 68% (1998-2000) to 55% (2008-2010). Across both genders, 55%-75% of Czech adolescents met the health-related criterion of recommended steps per day, however less participants in the younger cohort (2008-2010) met this criterion than in the older cohort (1998-2000) ten years ago. Adolescents' PA levels for the monitored periods of 1998-2000 and 2008-2010 suggest a secular decrease in the weekly number of steps achieved by adolescent boys and girls. CONCLUSION: In the younger cohort (2008-2010), every tenth adolescent was either overweight or obese; roughly twice the rate when compared to the older cohort (1998-2000). Sedentary behaviour seems relatively stable across the two cohorts as the increased time that the younger cohort (2008-2010) spent on computers is compensated with an equally decreased time spent watching TV or studying. Across both cohorts about half to three quarters of the adolescents met the health-related criterion for achieved number of steps. The findings show a secular decrease in PA amongst adolescents. The significant interaction effects (cohort × age; and cohort × gender) that this study found suggested that secular trends in PA differ by age and gender