336 research outputs found

    Four essays on modelling asset returns in the Chinese financial market

    Get PDF
    Firstly, we employ a three-state hidden semi-Markov model (HSMM) to explain the time-varying distribution of the Chinese stock market returns. Our results indicate that the time-varying distribution depends on the hidden states, represented by three market conditions, namely the bear, sidewalk, and bull markets. Secondly, we further employ the three-state HSMM to the daily returns of the Chinese stock market and seven developed markets. Through the comparison, three unique characteristics of the Chinese stock market are found, namely “Crazy Bull”, “Frequent and Quick Bear”, and “No Buffer Zone”. Thirdly, we propose a new diffusion process referred to as the ``camel process'' to model the cumulative return of a financial asset. Its steady state probability density function could be unimodal or bimodal, depending on the sign of the market condition parameter. The overreaction correction is realised through the non-linear drift term. Lastly, we take the tools in functional data analysis to understand the term structure of Chinese commodity futures and forecast their log returns at both short and long horizons. The FANOVA has been applied to examine the calendar effect of the term structure. An h-step functional autoregressive model is employed to forecast the log return of the term structure

    The Cytoplasmic Tail of FPC Antagonizes the Full-Length Protein in the Regulation of mTOR Pathway

    Get PDF
    FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like cleavage and subsequently the cleaved carboxy(C)-terminal fragment translocates to the nucleus. To study the functions of the isolated C-tail, we expressed the intracellular domain of human FPC (hICD) in renal epithelial cells. By 3-dimensional (3D) tubulogenesis assay, we found that in contrast to tubule-like structures formed from control cells, hICD-expressing cells exclusively formed cyst-like structures. By western blotting, we showed that the Akt/mTOR pathway, indicated by increased phosphorylation of Akt at serine 473 and S6 kinase 1 at threonine 389, was constitutively activated in hICD-expressing cells, similar to that in FPC knockdown cells and ARPKD kidneys. Moreover, application of mTOR inhibitor rapamycin reduced the size of the cyst-like structures formed by hICD-expressing cells. Application of either LY294002 or wortmannin inhibited the activation of both S6K1 and Akt. Expression of full-length FPC inhibited the activation of S6 and S6 kinase whereas co-expression of hICD with full-length FPC antagonized the inhibitory effect of full-length FPC on mTOR. Taken together, we propose that FPC modulates the PI3K/Akt/mTOR pathway and the cleaved C-tail regulates the function of the full-length protein
    corecore