Transformations of Logic Programs on Infinite Lists

We consider an extension of logic programs, called \omega-programs, that can be used to define predicates over infinite lists. \omega-programs allow us to specify properties of the infinite behavior of reactive systems and, in general, properties of infinite sequences of events. The semantics of \omega-programs is an extension of the perfect model semantics. We present variants of the familiar unfold/fold rules which can be used for transforming \omega-programs. We show that these new rules are correct, that is, their application preserves the perfect model semantics. Then we outline a general methodology based on program transformation for verifying properties of \omega-programs. We demonstrate the power of our transformation-based verification methodology by proving some properties of Buechi automata and \omega-regular languages.Comment: 37 pages, including the appendix with proofs. This is an extended version of a paper published in Theory and Practice of Logic Programming, see belo

Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach

Background: Identifying candidates for left ventricular assist device surgery at risk of right ventricular failure remains difficult. The aim was to identify the most accurate predictors of right ventricular failure among clinical, biological, and imaging markers, assessed by agreement of different supervised machine learning algorithms. Methods: Seventy-four patients, referred to HeartWare left ventricular assist device since 2010 in two Italian centers, were recruited. Biomarkers, right ventricular standard, and strain echocardiography, as well as cath-lab measures, were compared among patients who did not develop right ventricular failure (N = 56), those with acute–right ventricular failure (N = 8, 11%) or chronic–right ventricular failure (N = 10, 14%). Logistic regression, penalized logistic regression, linear support vector machines, and naïve Bayes algorithms with leave-one-out validation were used to evaluate the efficiency of any combination of three collected variables in an “all-subsets” approach. Results: Michigan risk score combined with central venous pressure assessed invasively and apical longitudinal systolic strain of the right ventricular–free wall were the most significant predictors of acute–right ventricular failure (maximum receiver operating characteristic–area under the curve = 0.95, 95% confidence interval = 0.91–1.00, by the naïve Bayes), while the right ventricular–free wall systolic strain of the middle segment, right atrial strain (QRS-synced), and tricuspid annular plane systolic excursion were the most significant predictors of Chronic-RVF (receiver operating characteristic–area under the curve = 0.97, 95% confidence interval = 0.91–1.00, according to naïve Bayes). Conclusion: Apical right ventricular strain as well as right atrial strain provides complementary information, both critical to predict acute–right ventricular failure and chronic–right ventricular failure, respectively

The place of vericiguat in the landscape of treatment for heart failure with reduced ejection fraction

The significant morbidity and mortality associated with heart failure with reduced (HFrEF) or preserved ejection fraction (HFpEF) justify the search for novel therapeutic agents. The nitric oxide (NO)–soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays an important role in the regulation of cardiovascular function. This pathway is disrupted in HF resulting in decreased protection against myocardial injury. The sGC activator cinaciguat increases cGMP levels by direct, NO-independent activation of sGC, and may be particularly effective in conditions of increased oxidative stress and endothelial dysfunction, and then reduced NO levels, but this comes at the expense of a greater risk of hypotension. Conversely, sGC stimulators (riociguat and vericiguat) enhance sGC sensitivity to endogenous NO, and then exert a more physiological action. The phase 3 VICTORIA trial found that vericiguat is safe and effective in patients with HFrEF and recent HF decompensation. Therefore, adding vericiguat may be considered in individual patients with HFrEF, particularly those at higher risk of HF hospitalization; the efficacy of the sacubitril/valsartan-vericiguat combination in HFrEF is currently unknown

How cardiologists can manage excess body weight and related cardiovascular risk. An expert opinion

Obesity is an important independent cardiovascular (CV) risk factor and a chronic inflammatory disease related to the development of insulin resistance, type 2 diabetes, dyslipidaemia, coronary artery disease, hypertension, heart failure, atrial fibrillation and obstructive sleep apnoea. Body Mass Index (BMI) values >27 kg/m2 are associated with an exponential increase in the risk for Major Adverse Cardiac Events (MACE). On the other hand, weight reduction can significantly reduce metabolic, CV and oncological risk. Orlistat, bupropion/naltrexone, liraglutide and semaglutide, combined with lifestyle changes, have proven to be effective in weight loss; the last two have been tested in randomized clinical trials (RCTs) with CV outcomes only in diabetic patients, and not in obese patients. To fill a fundamental gap of knowledge, the SELECT trial on patients with obesity and CV disease treated with semaglutide is ongoing, aiming at MACE as the primary endpoint. The battle against the social and clinical stigma towards obesity must be counteracted by promoting an awareness that elevates obesity to a complex chronic disease. Several actions should be implemented to improve the management of obesity, and cardiologists have a key role for achieving a global approach to patients with excess weight also through the correct implementation of available treatment strategies

Fatty Hepatocytes Induce Skeletal Muscle Atrophy In Vitro: A New 3D Platform to Study the Protective Effect of Albumin in Non-Alcoholic Fatty Liver

The liver neutralizes endogenous and exogenous toxins and metabolites, being metabolically interconnected with many organs. Numerous clinical and experimental studies show a strong association between Non-alcoholic fatty liver disease (NAFLD) and loss of skeletal muscle mass known as sarcopenia. Liver transplantation solves the hepatic-related insufficiencies, but it is unable to revert sarcopenia. Knowing the mechanism(s) by which different organs communicate with each other is crucial to improve the drug development that still relies on the two-dimensional models. However, those models fail to mimic the pathological features of the disease. Here, both liver and skeletal muscle cells were encapsulated in gelatin methacryloyl and carboxymethylcellulose to recreate the disease’s phenotype in vitro. The 3D hepatocytes were challenged with non-esterified fatty acids (NEFAs) inducing features of Non-alcoholic fatty liver (NAFL) such as lipid accumulation, metabolic activity impairment and apoptosis. The 3D skeletal muscle tissues incubated with supernatant from fatty hepatocytes displayed loss of maturation and atrophy. This study demonstrates the connection between the liver and the skeletal muscle in NAFL, narrowing down the players for potential treatments. The tool herein presented was employed as a customizable 3D in vitro platform to assess the protective effect of albumin on both hepatocytes and myotubes

The use of pulse-compression thermography for detecting defects in paintings

Interest in the conservation of paintings grows year by year. Their periodic inspection is essential for their conservation over the time. Thermographic non-destructive inspection is one technique useful for paintings, but it is essential to be able to detect buried defects while minimising the level of thermal stimulus. This paper describes a pulse-compression infrared thermography technique whereby defect detection is optimized while minimising the rise in temperature. To accomplish this task, LED lamps driven by a coded waveform based on a linear frequency modulated chirp signal have been used on paintings on both a wooden panel and a canvas layer. These specimens contained artificially fabricated defects. Although the physical condition of each painting was different, the experimental results show that the proposed signal processing procedure is able to detect defects using a low temperature contrast

Monitoring of biomarkers in heart failure.

The role of biomarkers is increasingly recognized in heart failure (HF) management, for diagnosis, prognostication, and screening of high-risk patients. Beyond natriuretic peptides and troponins, the utility of novel, emerging biomarkers is less established. This document reflects the key points of a Heart Failure Association of the European Society of Cardiology (ESC) consensus meeting on biomarker monitoring in HF

Songs and Writings : Oral and Literary Cultures in Early-Modern Finland

Laulut ja kirjoitukset: suullinen ja kirjallinen kulttuuri uuden ajan alun Suomessa (Songs and writings: oral and literary culture in early-modern Finland) has been written at the crossroads of historical and folkloristic studies. Our purpose is to study the interface of literary and oral cultures in early modern Finland, focusing on the sixteenth and seventeenth centuries. The book renews the understanding of exchange between the learned culture of clergymen and the culture of commoners, or “folk”. What happened when the Reformation changed the position of the vernacular language to literary and ecclesiastical, and when folk beliefs seem to have become an object for more intensive surveillance and correction? How did clergymen understand and use the versatile labels of popular belief, paganism, superstition and Catholic fermentation? Why did they choose particular song languages, poetic modes and melodies for their Lutheran hymns and literary poems, and why did they avoid oral poetics in certain contexts while accentuating it in others? How were the hagiographical traditions representing the international medieval literary or “great” tradition adapted to “small” folk traditions, and how did they persist and change after the Reformation? What happened to the cult of the Virgin Mary in local oral traditions? This book studies the relations and mutual influences of oral and literary cultures in Finland during the long period stretching from late Middle Ages to the nineteenth century. The Reformation, the process of turning vernacular languages into literary ones, the rise of new early-modern territorial principalities, and the reorganisation of the whole Baltic Sea area in the sixteenth century and after all affected both people’s everyday lives and the spheres of the sacred. The learned elites became interested in folk beliefs and practices as they started to argue about and order their own religious practices in a new way. Lutheran congregational singing spread from the German area to the northern Baltic Sea regions. The first Finnish sixteenth-century reformers admired the new Germanic models and avoided the Finnic vernacular Kalevala-metre idiom, while their successors picked up many vernacular traits, most notably alliteration, in their ecclesiastical poetry and hymns. Over the following centuries, the new features introduced via new Lutheran hymns such as accentual metres, end-rhymes and strophic structures were infusing into oral folk poetry, although this took place also via secular oral and literary routes. On the other hand, seventeenth-century scholars cultivated a new academic interest in what they understood as “ancient Finnish poetry”. The main source materials studied in this book are from the Reformation period and immediately after, when Finnish clergymen wrote their first comments and depictions of folk beliefs and worked to create Lutheran hymns in Finnish, and also largely from the nineteenth century, when most Finnish folk poetry and older oral traditions were collected. These later folklore materials are used here to shed light on the transformations of folk beliefs and poetic forms during the centuries that followed the Reformation. The emphasis is on the areas which formed the old medieval diocese of Turku (Swedish Åbo) or what the Swedish rulers called the province of Österland (Lat. Osterlandia, later Finlandia) west from the border of Nöteborg (Finnish Pähkinäsaari) between Sweden and the Grand Duchy of Novgorod in 1323. In addition, some other sources, especially from the Finnic and Scandinavian areas, are used as comparative material.Peer reviewe

Predicting heart failure outcome from cardiac and comorbid conditions: The 3C-HF score

Background: Prognostic stratification in heart failure (HF) is crucial to guide clinical management and treatment decision-making. Currently available models to predict HF outcome have multiple limitations. We developed a simple risk stratification model, based on routinely available clinical information including comorbidities, the Cardiac and Comorbid Conditions HF (3C-HF) Score, to predict all-cause 1-year mortality in HF patients. Methods: We recruited in a cohort study 6274 consecutive HF patients at 24 Cardiology and Internal Medicine Units in Europe. 2016 subjects formed the derivation cohort and 4258 the validation cohort.Weentered information on cardiac and comorbid candidate prognostic predictors in amultivariablemodel to predict 1-year outcome