Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and impair glucose homeostasis. Here, we investigated the effect of over-expression of PGC-1α on metabolic control and generation of insulin desensitizing agents in extensor digitorum longus (EDL), a muscle that exhibits low levels of PGC-1α in the untrained state and minimally relies on oxidative metabolism. We demonstrate that PGC-1α induces a strictly balanced substrate oxidation in EDL by concomitantly promoting the transcription of activators and inhibitors of lipid oxidation. Moreover, we show that PGC-1α enhances the potential to uncouple oxidative phosphorylation. Thereby, PGC-1α boosts elevated, yet tightly regulated oxidative metabolism devoid of side products that are detrimental for glucose homeostasis. Accordingly, PI3K activity, an early phase marker for insulin resistance, is preserved in EDL muscle. Our findings suggest that PGC-1α coordinately coactivates the simultaneous transcription of gene clusters implicated in the positive and negative regulation of oxidative metabolism and thereby increases metabolic flexibility. Thus, in mice fed a normal chow diet, over-expression of PGC-1α does not alter insulin sensitivity and the metabolic adaptations elicited by PGC-1α mimic the beneficial effects of endurance training on muscle metabolism in this context

Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones

The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route. This is demonstrated by the synthesis of highly substituted tetrahydropyran-4-ones and is quantified by a series of recognised metrics, which demonstrate the efficiency of combining PASE over conventional synthetic strategies

Spectroscopic direct detection of reflected light from extra-solar planets

At optical wavelengths, an exoplanet's signature is essentially reflected light from the host star - several orders of magnitude fainter. Since it is superimposed on the star spectrum its detection has been a difficult observational challenge. However, the development of a new generation of instruments like ESPRESSO and next generation telescopes like the E-ELT put us in a privileged position to detect these planets' reflected light as we will have access to extremely high signal-to-noise ratio spectra. With this work, we propose an alternative approach for the direct detection of the reflected light of an exoplanet. We simulated observations with ESPRESSO@VLT and HIRES@E-ELT of several star+planet systems, encompassing 10h of the most favourable orbital phases. To the simulated spectra we applied the Cross Correlation Function to operate in a much higher signal-to-noise ratio domain than when compared with the spectra. The use of the Cross-Correlation Function permitted us to recover the simulated the planet signals at a level above 3 \sigma_{noise} significance on several prototypical (e.g., Neptune type planet with a 2 days orbit with the VLT at 4.4 \sigma_{noise} significance) and real planetary systems (e.g., 55 Cnc e with the E-ELT at 4.9 \sigma_{noise} significance). Even by using a more pessimistic approach to the noise level estimation, where systematics in the spectra increase the noise 2-3 times, the detection of the reflected light from large close-orbit planets is possible. We have also shown that this kind of study is currently within reach of current instruments and telescopes (e.g., 51 Peg b with the VLT at 5.2 \sigma_{noise} significance), although at the limit of their capabilities.Comment: Accepted for Publication on MNRAS: 2013 August 29; Online Article: http://mnras.oxfordjournals.org/content/early/2013/09/27/mnras.stt1642; 5 Figures, 11 page

Area Quantization in Quasi-Extreme Black Holes

We consider quasi-extreme Kerr and quasi-extreme Schwarzschild-de Sitter black holes. From the known analytical expressions obtained for their quasi-normal modes frequencies, we suggest an area quantization prescription for those objects.Comment: Final version to appear in Mod. Phys. Lett.

Study of the effect of pH, salinity and DOC on fluorescence of synthetic mixtures of freshwater and marine salts

In order to provide support for the discussion of the fate of organic matter in estuaries, a laboratory simulation was performed by changing freshwater ionic strength, pH and organic matter content. The change in spectroscopic characteristics caused by variations in salinity, pH and organic matter concentration in the filtered samples was observed by UV-Vis and fluorescence spectroscopy. The increase in emission fluorescence intensity of dissolved organic matter (DOM) due to increasing salinity (in the range 0 to 5 g l−1) is affected by the pH of the samples. The emission fluorescence intensity at the three maxima observed in the fluorescence spectra, is linearly correlated with dissolved organic carbon (DOC) concentration at several salinity values in the same sample. The increase in organic matter concentration caused a shift in the emission peak wavelength at 410 nm for several salinity values.We concluded that it is necessary to take into account the influence of salinity and pH on emission fluorescence of dissolved organic matter if it is to be used as a tracer in estuarine or near shore areas

Further constraints on the optical transmission spectrum of HAT-P-1b

We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting Hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo (TNG). Our measurements imply an average planet to star radius ratio equal to $\rm R_p/R_{\star}$=(0.1159$\pm$0.0005). This result is consistent with the value obtained from recent near infrared measurements of this object but differs from previously reported optical measurements being lower by around 4.4 exoplanet scale heights. Analyzing the data over 5 different spectral bins 600\AA$\,$ wide we observed a single peaked spectrum (3.7 $\rm\sigma$ level) with a blue cut-off corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in between 6180-7400\AA. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower than the one implied by solar abundance clear atmospheric models. We interpret the result as evidence that HAT-P-1b has a partially clear atmosphere at optical wavelengths with a more modest contribution from an optical absorber than previously reported.Comment: Accepted by Ap

The CORALIE survey for southern extra-solar planets. X. A Hot Jupiter orbiting HD73256

Recent radial-velocity measurements obtained with the CORALIE spectrograph on the 1.2-m Euler Swiss telescope at La Silla unveil the presence of a new Jovian-mass Hot Jupiter around HD 73256. The 1.85-M_Jup planet moves on an extremely short-period (P=2.5486 d), quasi-circular orbit. The best Keplerian orbital solution is presented together with an unsuccessful photometric planetary-transit search performed with the SAT Danish telescope at La Silla. Over the time span of the observations, the photometric follow-up of the candidate has nevertheless revealed a P=14-d photometric periodicity corresponding to the rotational period of the star. This variation as well as the radial-velocity jitter around the Keplerian solution are shown to be related to the fair activity level known for HD 73256.Comment: 7 pages, 7 figures. Accepted in A&