934 research outputs found
Protein thiol oxidoreductas and allergic airways disease
Asthma is a chronic inflammatory disorder of the airways characterized by wheezing and difficulty breathing, affecting approximately 300 million people worldwide. Current therapies target specific manifestations of the disease, improving quality of life however, there remains a significant patient population for whom these treatments are ineffective. Popular belief holds that oxidants are harmful, contributing to disease pathogenesis; although, evidence suggests that oxidants possess diverse biological functions, including anti-inflammatory mechanisms. The goal of this thesis was to examine the functional significance of specific oxidative events in allergic airways disease, and results from these studies reveal potential novel therapeutic strategies for asthma and other disorders of the lung
Ionization of Infalling Gas
H-alpha emission from neutral halo clouds probes the radiation and
hydrodynamic conditions in the halo. Armed with such measurements, we can
explore how radiation escapes from the Galactic plane and how infalling gas can
survive a trip through the halo. The Wisconsin H-Alpha Mapper (WHAM) is one of
the most sensitive instruments for detecting and mapping optical emission from
the ISM. Here, we present recent results exploring the ionization of two
infallling high-velocity complexes. First, we report on our progress mapping
H-alpha emission covering the full extent of Complex A. Intensities are faint
(<100 mR; EM <0.2 pc cm^-6 but correlate on the sky and in velocity with 21-cm
emission. Second, we explore the ionized component of some Anti-Center Complex
clouds studied by Peek et al. (2007) that show dynamic shaping from interaction
with the Galactic halo.Comment: 4 pages, 2 figures; to appear in proceedings of "The Role of
Disk-Halo Interaction in Galaxy Evolution: Outflow vs Infall?" held in
Espinho, Portugal during 2008 Augus
Основные вехи деятельности Народного управления религиозными делами мусульман Крыма
В статье рассматривается история создания системы народного управления в
Крымской АССР, анализируется деятельность мусульманских съездов и уточняется политика советской
власти по отношению к мусульманам в рассматриваемый исторический период
"Dark energy" in the Local Void
The unexpected discovery of the accelerated cosmic expansion in 1998 has
filled the Universe with the embarrassing presence of an unidentified "dark
energy", or cosmological constant, devoid of any physical meaning. While this
standard cosmology seems to work well at the global level, improved knowledge
of the kinematics and other properties of our extragalactic neighborhood
indicates the need for a better theory. We investigate whether the recently
suggested repulsive-gravity scenario can account for some of the features that
are unexplained by the standard model. Through simple dynamical considerations,
we find that the Local Void could host an amount of antimatter
() roughly equivalent to the mass of a typical
supercluster, thus restoring the matter-antimatter symmetry. The antigravity
field produced by this "dark repulsor" can explain the anomalous motion of the
Local Sheet away from the Local Void, as well as several other properties of
nearby galaxies that seem to require void evacuation and structure formation
much faster than expected from the standard model. At the global cosmological
level, gravitational repulsion from antimatter hidden in voids can provide more
than enough potential energy to drive both the cosmic expansion and its
acceleration, with no need for an initial "explosion" and dark energy.
Moreover, the discrete distribution of these dark repulsors, in contrast to the
uniformly permeating dark energy, can also explain dark flows and other
recently observed excessive inhomogeneities and anisotropies of the Universe.Comment: 6 pages, accepted as a Letter to the Editor by Astrophysics and Space
Scienc
Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study
Organophosphate esters (OPEs) are a class of chemicals commonly used as flame retardants and plasticizers. OPEs are applied to a wide variety of consumer products and have a propensity to leach from these products. Consequently, OPEs are ubiquitous contaminants in many human environments and human exposure is pervasive. Accumulating evidence suggests that OPEs are capable of interfering with childhood cognitive development through both neurologic- and endocrine-mediated mechanisms. However, observational evidence of cognitive effects is limited. We used data collected in the third phase of the Pregnancy, Infection, and Nutrition Study to investigate cognitive effects of prenatal exposure to OPEs. In a spot prenatal maternal urine sample, we measured the following OPE metabolites: diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl phosphate) (BDCIPP), isopropyl-phenyl phenyl phosphate (ip-PPP), and 1-hydroxyl-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP). We assessed children's language and multi-faceted and overall cognitive development between two and three years of age using the MacArthur-Bates Communicative Development Inventories (MB-CDI) and the Mullen Scales of Early Learning (MSEL). We used linear regression to estimate the change in children's scores on these developmental assessments per interquartile range (IQR) increase in log-transformed, specific-gravity-corrected prenatal OPE metabolite concentrations, adjusted for maternal age, education, income, race/ethnicity, BMI, and child's sex. A total of 149 children had both OPE metabolite measurements and MB-CDI scores, and 227 children had both OPE metabolite measurements and MSEL scores. We observed that higher concentrations of ip-PPP (ng/ml) were associated with lower scores on the MSEL Cognitive Composite Score (β = −2.61; 95% CI: −5.69, 0.46), and separately on two of the four MSEL Scales that comprise the Cognitive Composite, specifically the Fine Motor Scale (β = −3.08; 95% CI: −5.26, −0.91) and the Expressive Language Scale (β = −1.21; 95% CI: −2.91, 0.49). We similarly observed that prenatal ip-PPP concentrations were inversely associated with age-standardized scores on the MB-CDI Vocabulary assessment (β = −1.19; 95% CI: −2.53, 0.16). Other OPE metabolites were not strongly associated with performance on either assessment. Our results suggest that isopropylated triarylphosphate isomers, the presumed parent compounds of ip-PPP, may adversely impact cognitive development, including fine motor skills and early language abilities. Our study contributes to the growing body of observational evidence that suggests prenatal exposure to OPEs may adversely affect cognitive development
Prenatal exposure to organophosphate esters and behavioral development in young children in the Pregnancy, Infection, and Nutrition Study
Organophosphate esters (OPEs) are commonly used as plasticizers and flame retardants in consumer products, and exposure is relatively ubiquitous in most populations studied. This may be of concern as some OPEs may be neurotoxic, endocrine-disrupting, and interfere with behavioral development; however, observational evidence is limited. We used data from the Pregnancy, Infection, and Nutrition Study, a prospective birth cohort study, to investigate associations between maternal OPE metabolite concentrations during pregnancy and behavioral development in offspring. Women provided a urine sample during pregnancy that was analyzed for concentrations of OPE metabolites, including diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl phosphate) (BDCIPP), isopropyl-phenyl phenyl phosphate (ip-PPP), and 1-hydroxyl-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP). Offspring's behavioral development was assessed by the Behavioral Assessment System for Children (2nd Edition) (BASC-2) at approximately 36 months. Linear regression was used to estimate associations between tertiles in specific gravity-corrected OPE metabolite concentrations and children's scores on the BASC-2, adjusted for maternal age, maternal BMI, maternal race, maternal education, familial income, maternal depression, quality of the home environment, and sex. Higher BDCIPP concentrations were associated with higher scores on the Behavioral Symptoms Index (1st vs. 3rd tertile: β = 3.03; 95% CI = 0.40, 5.67) and Externalizing Problems (1st vs. 3rd tertile: β = 2.49; 95% CI: −0.12, 5.10) composites. Among BASC-2 scales, BDCIPP was most strongly associated with Withdrawal, Attention Problems, Depression, Hyperactivity, and Aggression. DPHP concentrations were also associated with higher scores on the Externalizing Problems and Behavioral Symptoms Index composites, but not as strongly as BDCIPP. Conversely, higher concentrations of ip-PPP were associated with fewer adverse behavioral symptoms, including an inverse association with the Internalizing Problems composite (1st vs. 3rd tertile: β = −3.74; 95% CI = −6.75, −0.74) and constituent scales. BCIPHIPP was not strongly associated with any measured behavioral outcomes. Our results suggest that greater maternal exposure to tris(1,3-dichloro-2-propyl phosphate) (TDCIPP, parent compound of BDCIPP) and, to a lesser degree, triphenyl phosphate (TPHP, parent compound of DPHP) during pregnancy is associated with adverse behavioral development in children. Our study contributes to the growing body of evidence pertaining to adverse developmental effects of prenatal OPE exposure and highlights the need for further research to characterize risks associated with this ubiquitous family of chemicals
Discourse Semantics for the Analysis of Change in Language
This paper purports to elaborate and address several issues which lie at the intersection of computational linguistics and psychology. The first issue addressed is that of the interaction between discourse and semantics by virtue of empirical linguistic and psychotherapeutic evidence. This paper then gives a formal account of the knowledge representation and reasoning processes involved in the construction of an XML knowledge base for use in the sematic analysis of psychotherapeutic transcripts. Computational methods for the automatic mark-up and inference of the psychotherapeutic phenomena under investigation are detailed in order to further develop intuitions behind a particular pragmatic theory of language known as the Metamodel. The work presented here ultimately aims to produce a sustainable system for the evaluation of the effectiveness of any given psychotherapeutic technique. The possibility exists for such a system to recognise successful therapeutic mechanisms and further still, to infer new ones, or suggest improvements, or offer novel explanations as to the success or failure of the therapy itself. The work discussed here stems from research in computational linguistics, psychotherapy, and philosophy. The corpus used is a culmination of client transcripts taken before, during, and after therapy. The particular therapeutic technique used here is known as the Metamodel (Bandler and Grinder, 1975). The Metamodel was originally proffered as a method of language analysis suitable for use by practitioners of any psychotherapeutic technique. It theorises that speech utterances are related to a clients deep structure through three primary mechanisms, namely generalisation, deletion, and distortion. Previous hand tagging of our data has proven support for such claims. It is our aim to automate the identification and reasoning process. The issues and processes involved in the automation of such tagging are discussed here. Architectural and philosophical issues relating syntax (or grammar), semantics (Larson and Segal, 1995), and pragmatics (Grice, 1989; Searle, 1969) are raised. Discourse Representation Theory (Kamp, 1981; Asher and Lascarides, 1995) is discussed and used here in order to infer discourse relations.Hosted by the Scholarly Text and Imaging Service (SETIS), the University of Sydney Library, and the Research Institute for Humanities and Social Sciences (RIHSS), the University of Sydney
Upper critical field for underdoped high-T_c superconductors. Pseudogap and stripe--phase
We investigate the upper critical field in a stripe--phase and in the
presence of a phenomenological pseudogap. Our results indicate that the
formation of stripes affects the Landau orbits and results in an enhancement of
. On the other hand, phenomenologically introduced pseudogap leads to a
reduction of the upper critical field. This effect is of particular importance
when the magnitude of the gap is of the order of the superconducting transition
temperature. We have found that a suppression of the upper critical field takes
place also for the gap that originates from the charge--density waves.Comment: 7 pages, 5 figure
Chemostratigraphy of Neoproterozoic carbonates: implications for 'blind dating'
The delta C-13(carb) and Sr-87/Sr-86 secular variations in Neoproteozoic seawater have been used for the purpose of 'isotope stratigraphy' but there are a number of problems that can preclude its routine use. In particular, it cannot be used with confidence for 'blind dating'. The compilation of isotopic data on carbonate rocks reveals a high level of inconsistency between various carbon isotope age curves constructed for Neoproteozoic seawater, caused by a relatively high frequency of both global and local delta C-13(carb) fluctuations combined with few reliable age determinations. Further complication is caused by the unresolved problem as to whether two or four glaciations, and associated negative delta C-13(carb) excursions, can be reliably documented. Carbon isotope stratigraphy cannot be used alone for geological correlation and 'blind dating'. Strontium isotope stratigraphy is a more reliable and precise tool for stratigraphic correlations and indirect age determinations. Combining strontium and carbon isotope stratigraphy, several discrete ages within the 590-544 Myr interval, and two age-groups at 660-610 and 740-690 Myr can be resolved
WKB approximation for inflationary cosmological perturbations
A new method for predicting inflationary cosmological perturbations, based on
the Wentzel-Kramers-Brillouin (WKB) approximation, is presented. A general
expression for the WKB scalar and tensor power spectra is derived. The main
advantage of the new scheme of approximation is that it is valid even if the
slow-roll conditions are violated. The method is applied to power-law
inflation, which allows a comparison with an exact result. It is demonstrated
that the WKB approximation predicts the spectral indices exactly and the
amplitude with an error lower than 10%, even in regimes far from
scale-invariance. The new method of approximation is also applied to a
situation where the slow-roll conditions hold. It is shown that the result
obtained bears close resemblance with the standard slow-roll calculation.
Finally, some possible improvements are briefly mentioned.Comment: 11 pages, 1 figure, RevTeX; minor changes, reference added (v2);
typos corrected (v3
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