24 research outputs found
Time optimal information transfer in spintronics networks
Propagation of information encoded in spin degrees of freedom through networks of coupled spins enables important applications in spintronics and quantum information processing. We study control of information propagation in rings of -spins with uniform nearest neighbour couplings forming a ring with a single excitation in the network as simple prototype of a router for spin-based information. Specifically optimising spatially distributed potentials, which remain constant during information transfer, simplifies the implementation of the routing scheme. However, the limited degrees of freedom makes finding a control that maximises the transfer probability in a short time difficult. The structure of the eigenvalues and eigenvectors must fulfill a specific condition to be able to maximise the transfer fidelity. While there are many potential structures that fulfill this condition, we choose a specific one, which in turn significantly improves the solutions found by optimal control
Universal control of quantum subspaces and subsystems
We describe a broad dynamical-algebraic framework for analyzing the quantum
control properties of a set of naturally available interactions. General
conditions under which universal control is achieved over a set of
subspaces/subsystems are found. All known physical examples of universal
control on subspaces/systems are related to the framework developed here.Comment: 4 Pages RevTeX, Some typos fixed, references adde
An interleaved sampling scheme for the characterization of single qubit dynamics
In this paper, we demonstrate that interleaved sampling techniques can be
used to characterize the Hamiltonian of a qubit and its environmental
decoherence rate. The technique offers a significant advantage in terms of the
number of measurements that are required to characterize a qubit. When compared
to the standard Nyquist-Shannon sampling rate, the saving in the total
measurement time for the interleaved method is approximately proportional to
the ratio of the sample rates.Comment: 9 pages, 4 figure
Rotational Cooling of Polar Molecules by Stark-tuned Cavity Resonance
A general scheme for rotational cooling of diatomic heteronuclear molecules
is proposed. It uses a superconducting microwave cavity to enhance the
spontaneous decay via Purcell effect. Rotational cooling can be induced by
sequentially tuning each rotational transition to cavity resonance, starting
from the highest transition level to the lowest using an electric field.
Electrostatic multipoles can be used to provide large confinement volume with
essentially homogeneous background electric field.Comment: 10 pages, 6 figure
Optimal control theory for unitary transformations
The dynamics of a quantum system driven by an external field is well
described by a unitary transformation generated by a time dependent
Hamiltonian. The inverse problem of finding the field that generates a specific
unitary transformation is the subject of study. The unitary transformation
which can represent an algorithm in a quantum computation is imposed on a
subset of quantum states embedded in a larger Hilbert space. Optimal control
theory (OCT) is used to solve the inversion problem irrespective of the initial
input state. A unified formalism, based on the Krotov method is developed
leading to a new scheme. The schemes are compared for the inversion of a
two-qubit Fourier transform using as registers the vibrational levels of the
electronic state of Na. Raman-like transitions through the
electronic state induce the transitions. Light fields are found
that are able to implement the Fourier transform within a picosecond time
scale. Such fields can be obtained by pulse-shaping techniques of a femtosecond
pulse. Out of the schemes studied the square modulus scheme converges fastest.
A study of the implementation of the qubit Fourier transform in the Na
molecule was carried out for up to 5 qubits. The classical computation effort
required to obtain the algorithm with a given fidelity is estimated to scale
exponentially with the number of levels. The observed moderate scaling of the
pulse intensity with the number of qubits in the transformation is
rationalized.Comment: 32 pages, 6 figure
Quantum control and the Strocchi map
Identifying the real and imaginary parts of wave functions with coordinates
and momenta, quantum evolution may be mapped onto a classical Hamiltonian
system. In addition to the symplectic form, quantum mechanics also has a
positive-definite real inner product which provides a geometrical
interpretation of the measurement process. Together they endow the quantum
Hilbert space with the structure of a K\"{a}ller manifold. Quantum control is
discussed in this setting. Quantum time-evolution corresponds to smooth
Hamiltonian dynamics and measurements to jumps in the phase space. This adds
additional power to quantum control, non unitarily controllable systems
becoming controllable by ``measurement plus evolution''. A picture of quantum
evolution as Hamiltonian dynamics in a classical-like phase-space is the
appropriate setting to carry over techniques from classical to quantum control.
This is illustrated by a discussion of optimal control and sliding mode
techniques.Comment: 16 pages Late
Linear optics substituting scheme for multi-mode operations
We propose a scheme allowing a conditional implementation of suitably
truncated general single- or multi-mode operators acting on states of traveling
optical signal modes. The scheme solely relies on single-photon and coherent
states and applies beam splitters and zero- and single-photon detections. The
signal flow of the setup resembles that of a multi-mode quantum teleportation
scheme thus allowing the individual signal modes to be spatially separated from
each other. Some examples such as the realization of cross-Kerr nonlinearities,
multi-mode mirrors, and the preparation of multi-photon entangled states are
considered.Comment: 11 pages, 4 eps-figures, using revtex
Second order gradient ascent pulse engineering
We report some improvements to the gradient ascent pulse engineering (GRAPE)
algorithm for optimal control of quantum systems. These include more accurate
gradients, convergence acceleration using the BFGS quasi-Newton algorithm as
well as faster control derivative calculation algorithms. In all test systems,
the wall clock time and the convergence rates show a considerable improvement
over the approximate gradient ascent.Comment: Submitted for publicatio
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Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination
Multiple sclerosis (MS) is a progressive inflammatory-demyelinating disease of the central nervous system. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic hyperexcitability. Axonal Kv7 (outward rectifying) and oligodendroglial Kir4.1 (inward rectifying) potassium channels have important roles in regulating neuronal excitability at and around nodes of Ranvier. Here, we studied the spatial and functional relationship between neuronal Kv7 and oligodendroglial Kir4.1 channels and assessed the transcriptional and functional signatures of cortical and retinal projection neurons under physiological and inflammatory-demyelinating conditions. We found that both channels became dysregulated in MS and experimental autoimmune encephalomyelitis (EAE) with Kir4.1 channels being chronically downregulated and Kv7 channel subunits being transiently upregulated during inflammatory demyelination. Further, we observed that pharmacological Kv7 channel opening with retigabine reduced neuronal hyperexcitability in human and EAE neurons, improved clinical EAE signs and rescued neuronal pathology in oligodendrocyte-Kir4.1-deficient mice. In summary, our findings indicate that neuron-oligodendrocyte compensatory interactions promote resilience through Kv7 and Kir4.1 channels and suggest pharmacological activation of nodal Kv7 channels as a neuroprotective strategy against inflammatory demyelination
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362