55 research outputs found
Fish, docosahexaenoic acid and Alzheimer’s disease
Cognitive decline in the elderly, particularly Alzheimer’s disease (AD), is a major socio-economic and healthcare concern. We review here the literature on one specific aspect of diet affecting AD, that of the ω3 fatty acids, particularly the brain’s principle ω3 fatty acid – docosahexaenoic acid (DHA). DHA has deservedly received wide attention as a nutrient supporting both optimal brain development and for cardiovascular health. Our aim here is to critically assess the quality of the present literature as well as the potential of ω3 fatty acids to treat or delay the onset of AD. We start with a brief description of cognitive decline in the elderly, followed by an overview of well recognized biological functions of DHA. We then turn to epidemiological studies, which are largely supportive of protective effects of fish and DHA against risk of AD. However, biological studies, including blood and brain DHA analyses need careful interpretation and further investigation, without which the success of clinical trials with DHA may continue to struggle. We draw attention to some of the methodological issues that need resolution as well as an emerging mechanism that may explain how DHA could be linked to protecting brain function in the elderly
(Pharmacol. Biochem. Behavior, 26:1285-1292)Dietary manipulation of ethanol preference in the Syrian golden hamster
Mechanism of Inhibition of Bovine Pineal Gland Hydroxyindole-O-Methyltransferase (EC 2.1.1.4) by Divalent Cations
(Biochim. Biophys. Acta, 876:183-186)Triacylglycerol content of arachidonic acid varies inversely with total triacylglycerol in liver and plasma
(Proc. Soc. Exp. Biol. Med., 181:399-403)Effect of different dietary proteins on plasma and liver fatty acid compositions in growing rats
Effect of Various Cations on the Activity of Pineal Gland N-Acetyltransferase (EC 2.3.1.5) and Hydroxyindole-O-Methyl Transferase (EC2.1.1.4) In Vitro
(Atherosclerosis, 41:193-207)Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18:3n-6) but not by linoleic acid (18:2n-6)
(Ann. Nutr. Metab., 30:081-086)Influence of different dietary fatty acid sources on erythrocyte lipids and plasma and liver essential fatty acids in hamster fed ethanol
(Nutr. Res., 06:549-558)Effect of cholesterol supplementation on plasma and liver cholesteryl ester fatty acids in rats fed casein or soy protein
(Prog. Lipid Res., 20:157-160)Role of zinc in linoleic acid desaturation and prostaglandin synthesis
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