258 research outputs found
Belang van ondersteunende netwerken voor ouderen
__Abstract__
āEven Buurtenā is een Rotterdams initiatief. Hierin proberen professionals uit
zorg en welzijn via een integrale wijkaanpak de sociale netwerken rondom
thuiswonende ouderen te verstevigen. Doel van dit sociale netwerk is (vroeg)
signalering en het bieden van concrete hulp en ondersteuning aan kwetsbare
ouderen. Uit onderzoek naar het āEven Buurtenā-initiatief komt het belang van
een sterk sociaal buurtnetwerk duidelijk naar voren. Het succes van een integrale
wijkaanpak hangt in sterke mate af van een integraal formeel eĀ“n informeel
ondersteunend netwerk in de buurt. Formele en informele netwerken werken
echter nog niet goed samen. En ook binnen het formele netwerk (bijv. tussen
zorg en welzijn) wordt nog onvoldoende samengewerkt om kwetsbare ouderen
optimale ondersteuning te bieden. Deze klinische les beschrijft hoe integrale,
wijkgerichte ondersteuning beter tegemoetkomt aan de behoeften en wensen
van kwetsbare ouderen
Is synthetic hexaploid wheat a useful germplasm source for increasing grain size and yield in bread wheat breeding?
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Imaging the development of the human craniofacial arterial system - an experimental study
Background: The process of vascular development is essential for shaping complex craniofacial structures. Investigating the interplay between vascular development and orofacial morphogenesis holds critical importance in clinical practice and contributes to advancing our comprehension of (vascular) developmental biology. New insights into specific vascular developmental pathways will have far-reaching implications across various medical disciplines, enhancing clinical understanding, refining surgical techniques, and elucidating the origins of congenital abnormalities. Embryonic development of the craniofacial vasculature remains, however, under-exposed in the current literature. We imaged and created 3-dimensional (D) reconstructed images of the craniofacial arterial system from two early-stage human embryonic samples. Objective: The aim of this study was to investigate the vascular development of the craniofacial region in early-stage human embryos, with a focus on understanding the interplay between vascular development and orofacial morphogenesis. Materials and methods: Reconstructions (3-D) were generated from high-resolution diffusible iodine-based contrast-enhanced computed tomography (diceCT) images, enabling visualization of the orofacial arterial system in human embryonic samples of Carnegie stages (CS) 14 and 18 from the Dutch Fetal Biobank, corresponding to weeks 7 and 8.5 of gestation. Results: From two human embryonic samples (ages CS 14 and 18), the vascular development of the orofacial region at two different stages of development was successfully stained with B-Lugol and imaged using a micro-computed tomography (micro-CT) scanner with resolutions of 2.5-Ī¼m and 9-Ī¼m voxel sizes, respectively. Additionally, educational 3-D reconstructions of the orofacial vascular system were generated using AMIRA 2021.2 software. Conclusion: Micro-CT imaging is an effective strategy for high-resolution visualization of vascular development of the orofacial region in human embryonic samples. The generated interactive 3-D educational models facilitate better understanding of the development of orofacial structures. Graphical abstract: (Figure presented.)</p
Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer
TP53 has been implicated in regulation of the cell cycle, DNA repair, and
apoptosis. We studied, in primary breast tumors through direct cDNA
sequencing of exons 2-11, whether TP53 gene mutations can predict response
in patients with advanced disease to either first-line tamoxifen therapy
(202 patients, of whom 55% responded) or up-front (poly)chemotherapy (41
patients, of whom 46% responded). TP53 mutations were detected in 90 of
243 (37%) tumors, and one-fourth of these mutations resulted in a
premature termination of the protein. The mutations were observed in 32%
(65 of 202) of the primary tumors of tamoxifen-treated patients and in 61%
(25 of 41) of the primary tumors of the chemotherapy patients. TP53
mutation was significantly associated with a poor response to tamoxifen
[31% versu
Consensus parameter: research methodologies to evaluate neurodevelopmental effects of pubertal suppression in transgender youth
An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth.Pathways through Adolescenc
PD-L1 blockade in combination with carboplatin as immune induction in metastatic lobular breast cancer: the GELATO trial
Invasive lobular breast cancer (ILC) is the second most common histological breast cancer subtype, but ILC-specific trials are lacking. Translational research revealed an immune-related ILC subset, and in mouse ILC models, synergy between immune checkpoint blockade and platinum was observed. In the phase II GELATO trial (NCT03147040), patients with metastatic ILC were treated with weekly carboplatin (area under the curve 1.5āmgāmlā1 minā1) as immune induction for 12 weeks and atezolizumab (PD-L1 blockade; triweekly) from the third week until progression. Four of 23 evaluable patients had a partial response (17%), and 2 had stable disease, resulting in a clinical benefit rate of 26%. From these six patients, four had triple-negative ILC (TN-ILC). We observed higher CD8+ T cell infiltration, immune checkpoint expression and exhausted T cells after treatment. With this GELATO trial, we show that ILC-specific clinical trials are feasible and demonstrate promising antitumor activity of atezolizumab with carboplatin, particularly for TN-ILC, and provide insights for the design of highly needed ILC-specific trials. Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease
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