Adzhubei

Ait-Ali

Al-Haddawi

Asif

Atapattu

Bacon

Bakker

Barillet

Barrow

Bishop

Boyd

Briles

Brisbin

Bumstead

Callaway

Carlén

Caverly

Cheng

Chiodini

Cole

Cutlip

Dassanayake

Davies

Diez-Tascon

Dileepan

Dominik

E. Giuffra

Ewart

Flori

Fragkou

Friars

G. Davies

Gasbarre

Gauly

Gavora

Gibbons

Gonda

Gordon

Gougoulis

Gyles

Haesebrouck

Hala

Halbur

Hassan

Hayes

Heringstad

Hickford

Houston

Jackwood

Jensen

Jiao

Juul-Madsen

Kaiser

Kaufman

Keane

Khatkar

Koets

Kramer

Lamont

Lavi

Legarra

Lewis

Longenecker

Lund

Lundeheim

MacKinnon

Mackintosh

Malek

Mariani

Martin

Mavrogianni

Mays

Meijerink

Minion

Mirsky

Moen

Mortensen

Muggli-Cockett

Nakajima

Nieuwhof

Niewold

Noormohammadi

Opriessnig

Peng

Permin

Perry

Petry

English

S. Genini

S.C. Bishop

Crossref

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

This paper reviews the evidence for host genetic variation in resistance to infectious diseases for a wide variety of diseases of economic importance in poultry, cattle, pig, sheep and Atlantic salmon. Further, it develops a method of ranking each disease in terms of its overall impact, and combines this ranking with published evidence for host genetic variation and information on the current state of genomic tools in each host species. The outcome is an overall ranking of the amenability of each disease to genomic studies that dissect host genetic variation in resistance. Six disease-based assessment criteria were defined: industry concern, economic impact, public concern, threat to food safety or zoonotic potential, impact on animal welfare and threat to international trade barriers. For each category, a subjective score was assigned to each disease according to the relative strength of evidence, impact, concern or threat posed by that particular disease, and the scores were summed across categories. Evidence for host genetic variation in resistance was determined from available published data, including breed comparison, heritability studies, quantitative trait loci (QTL) studies, evidence of candidate genes with significant effects, data on pathogen sequence and on host gene expression analyses. In total, 16 poultry diseases, 13 cattle diseases, nine pig diseases, 11 sheep diseases and three Atlantic salmon diseases were assessed. The top-ranking diseases or pathogens, i.e. those most amenable to studies dissecting host genetic variation, were Salmonella in poultry, bovine mastitis, Marek's disease and coccidiosis, both in poultry. The top-ranking diseases or pathogens in pigs, sheep and Atlantic salmon were Escherichia coli, mastitis and infectious pancreatic necrosis, respectively. These rankings summarise the current state of knowledge for each disease and broadly, although not entirely, reflect current international research efforts. They will alter as more information becomes available and as genome tools become more sophisticated for each species. it is suggested that this approach could be used to rank diseases from other perspectives as well, e.g. in terms of disease control strategies.</p

Davies, G.

Genini, S.

Bishop, S. C.

Giuffra, E.

Edinburgh Research Explorer

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An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

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