Lipolytic enzymes and hydrolytic rancidity

Lipolysis, the enzymic hydrolysis of milk lipids to free fatty acids and partial glycerides, is a constant concern to the dairy industry because of the detrimental effcts it can have on the flvor and other properties of milk and milk products. However, free fatty acids also contribute to the desirable flavor of milk and milk products when present at low concentrations and, in some cheeses, when present at high concentrations. The enzymes responsible for the detrimental effects of lipolysis are of two main types: those indigenous to milk, and those of microbial origin. The major indigenous milk enzyme is lipoprotein lipase. It is active on the fat in natural milk fat globules only after their disruption by physical treatments or if certain blood serum lipoproteins are present. The major microbial lipases are produced by psychrotrophic bacteria. Many of these enzymes are heat stable and are particularly significant in stored products. Human milk differs from cows' milk in that it contains two lipases, a lipoprotein lipase and a bile salt-stimulated lipase. The ability of the latter to cause considerable hydrolysis of ingested milk lipids has important nutritional implications

A highly virulent variant of HIV-1 circulating in the Netherlands.

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log <sub>10</sub> increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence

Test of CP invariance in vector-boson fusion production of the Higgs boson in the H → ττ channel in proton-proton collisions at √<i>s</i>=13TeV with the ATLAS detector

A test of CP invariance in Higgs boson production via vector-boson fusion is performed in the $H\rightarrow\tau\tau$ decay channel. This test uses the Optimal Observable method and is carried out using 36.1 $\mathrm{fb}^{-1}$ of $\sqrt{s}$ = 13 TeV proton$-$proton collision data collected by the ATLAS experiment at the LHC. Contributions from CP-violating interactions between the Higgs boson and electroweak gauge bosons are described by an effective field theory, in which the parameter $\tilde{d}$ governs the strength of CP violation. No sign of CP violation is observed in the distributions of the Optimal Observable, and $\tilde{d}$ is constrained to the interval $[-0.090, 0.035]$ at the 68% confidence level (CL), compared to an expected interval of $\tilde{d} \in [-0.035,0.033]$ based upon the Standard Model prediction. No constraints can be set on $\tilde{d}$ at 95% CL, while an expected 95% CL interval of $\tilde{d} \in [-0.21,0.15]$ for the Standard Model hypothesis was expected