315 research outputs found
Влияние различных методов седации у больных с острой тяжелой черепно-мозговой травмой на перекисное окисление липидов
Objective: to study the impact of various sedation methods on lipid peroxidation in patients with acute severe brain injury. Subjects and methods. For this, 44 victims with this condition were examined. According the option of posttraumatic sedation therapy, the victims were divided into 3 groups: 1) 12 patients in whom sodium oxybutyrate was used for sedation; 2) 12 received thiopental sodium; 3) 20 patients were given propofol. The lipid peroxidation and antioxidant system were judged from the serum levels of fatty acid hydroperoxides and secondary lipid peroxidation products (malonic dialdehyde) and from the content of the endogenous antioxidant a-tocopherol. Results. The study performed indicated that the highest concentrations of fatty acid hydroperoxides were observed in Groups 1 and 2 within the first 24 posttraumatic hours. In Group 3 where propofol was used for sedation, the concentration of the hydroperoxides remained in the normal range although there was a tendency for their rise. Conclusion. Thus, propofol is the agent of choice for sedation that prevents the activation of lipid peroxidation and stabilizes some indices of the antioxidant system in patients with acute severe brain injury. Key words: brain injury, lipid peroxidation, sedation, sodium oxybutyrate, thiopental sodium, propofol.Цель исследования — изучить влияние различных методов седации у больных с острой тяжелой черепно-мозговой травмой на перекисное окисление липидов. Материал и методы. Для достижения указанной цели обследованы 44 пострадавших с острой тяжелой черепно-мозговой травмой. В зависимости от вида седационной терапии, проводившейся в посттравматическом периоде, больные были разделены на 3 группы. В I группу (12 чел.) вошли больные, которым с целью седации использовался оксибутират натрия, во II группе (12 чел.) больных применялся тиопентал натрия, и в III группе больных (20 чел.) вводился пропофол. О состоянии перекисного окисления липидов и антиоксидантной системы судили по уровню в сыворотке крови гидроперекисей жирных кислот и вторичных продуктов перекисного окисления липидов — малонового диальдегида, содержанию эндогенного антиоксиданта альфа-токоферола. Результаты. Проведенное исследование показало, что в 1-е сутки посттравматического периода наиболее высокие концентрации гидроперекисей жирных кислот отмечались в I и II группах больных. В III же группе больных, где для седации использовался пропофол, концентрация гидроперекисей оставались в пределах нормальных значений, хотя также оставалась тенденция к их росту. Заключение. Таким образом, наиболее благоприятным вариантом седации, предупреждающей активацию перекисного окисления липидов и стабилизирующей некоторые показатели антиоксидантной системы у больных с острой тяжелой черепно-мозговой травмой является пропофол. Ключевые слова: черепно-мозговая травма, перекисное окисление липидов, седация, оксибутират натрия, тиопентал натрия, пропофол
Recommended from our members
Spectroscopy of geo-neutrinos from 2056 days of Borexino data
We report an improved geo-neutrino measurement with Borexino from 2056 days
of data taking. The present exposure is
protonyr. Assuming a chondritic Th/U mass ratio of 3.9, we obtain geo-neutrino events. The null
observation of geo-neutrinos with Borexino alone has a probability of (5.9). A geo-neutrino signal from the mantle is
obtained at 98\% C.L. The radiogenic heat production for U and Th from the
present best-fit result is restricted to the range 23-36 TW, taking into
account the uncertainty on the distribution of heat producing elements inside
the Earth.Comment: 4 pages, 4 figure
Recent Borexino results and prospects for the near future
The Borexino experiment, located in the Gran Sasso National Laboratory, is an
organic liquid scintillator detector conceived for the real time spectroscopy
of low energy solar neutrinos. The data taking campaign phase I (2007 - 2010)
has allowed the first independent measurements of 7Be, 8B and pep fluxes as
well as the first measurement of anti-neutrinos from the earth. After a
purification of the scintillator, Borexino is now in phase II since 2011. We
review here the recent results achieved during 2013, concerning the seasonal
modulation in the 7Be signal, the study of cosmogenic backgrounds and the
updated measurement of geo-neutrinos. We also review the upcoming measurements
from phase II data (pp, pep, CNO) and the project SOX devoted to the study of
sterile neutrinos via the use of a 51Cr neutrino source and a 144Ce-144Pr
antineutrino source placed in close proximity of the active material.Comment: 8 pages, 11 figures. To be published as proceedings of Rencontres de
Moriond EW 201
Recommended from our members
Solar neutrino with Borexino: results and perspectives
Borexino is a unique detector able to perform measurement of solar neutrinos
fluxes in the energy region around 1 MeV or below due to its low level of
radioactive background. It was constructed at the LNGS underground laboratory
with a goal of solar Be neutrino flux measurement with 5\% precision. The
goal has been successfully achieved marking the end of the first stage of the
experiment. A number of other important measurements of solar neutrino fluxes
have been performed during the first stage. Recently the collaboration
conducted successful liquid scintillator repurification campaign aiming to
reduce main contaminants in the sub-MeV energy range. With the new levels of
radiopurity Borexino can improve existing and challenge a number of new
measurements including: improvement of the results on the Solar and terrestrial
neutrino fluxes measurements; measurement of pp and CNO solar neutrino fluxes;
search for non-standard interactions of neutrino; study of the neutrino
oscillations on the short baseline with an artificial neutrino source (search
for sterile neutrino) in context of SOX project.Comment: 15 pages, 4 figure
Measurement of neutrino flux from the primary proton--proton fusion process in the Sun with Borexino detector
Neutrino produced in a chain of nuclear reactions in the Sun starting from
the fusion of two protons, for the first time has been detected in a real-time
detector in spectrometric mode. The unique properties of the Borexino detector
provided an oppurtunity to disentangle pp-neutrino spectrum from the background
components. A comparison of the total neutrino flux from the Sun with Solar
luminosity in photons provides a test of the stability of the Sun on the
10 years time scale, and sets a strong limit on the power production in
the unknown energy sources in the Sun of no more than 4\% of the total energy
production at 90\% C.L.Comment: 15 pages, 2 tables, 3 figure
The Main Results of the Borexino Experiment
The main physical results on the registration of solar neutrinos and the
search for rare processes obtained by the Borexino collaboration to date are
presented.Comment: 8 pages, 8 figgures, To be published as Proceedings of the Third
Annual Large Hadron Collider Physics Conference, St. Petersburg, Russia, 201
Recommended from our members
Search for Solar Axions Produced in Reaction with Borexino Detector
A search for 5.5-MeV solar axions produced in the reaction was performed using the Borexino detector. The Compton
conversion of axions to photons, ; the
axio-electric effect, ; the decay of axions into
two photons, ; and inverse Primakoff conversion on
nuclei, , are considered. Model independent
limits on axion-electron (), axion-photon (), and
isovector axion-nucleon () couplings are obtained: and at 1 MeV (90% c.l.). These limits are
2-4 orders of magnitude stronger than those obtained in previous
laboratory-based experiments using nuclear reactors and accelerators.Comment: 11 pages, 7 figures, submitted to Phys.Rev.
Recommended from our members
Measurement of geo-neutrinos from 1353 days of Borexino
We present a measurement of the geo--neutrino signal obtained from 1353 days
of data with the Borexino detector at Laboratori Nazionali del Gran Sasso in
Italy. With a fiducial exposure of (3.69 0.16) proton
year after all selection cuts and background subtraction, we detected
(14.3 4.4) geo-neutrino events assuming a fixed chondritic mass Th/U
ratio of 3.9. This corresponds to a geo-neutrino signal = (38.8
12.0) TNU with just a 6 probability for a null geo-neutrino
measurement. With U and Th left as free parameters in the fit, the relative
signals are = (10.6 12.7) TNU and =
(26.5 19.5) TNU. Borexino data alone are compatible with a mantle
geo--neutrino signal of (15.4 12.3) TNU, while a combined analysis with
the KamLAND data allows to extract a mantle signal of (14.1 8.1) TNU. Our
measurement of a reactor anti--neutrino signal =
84.5 TNU is in agreement with expectations in the presence of
neutrino oscillations.Comment: 9 pages, 6 figure
Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun
The Sun is fueled by a series of nuclear reactions that produce the energy
that makes it shine. The primary reaction is the fusion of two protons into a
deuteron, a positron and a neutrino. These neutrinos constitute the vast
majority of neutrinos reaching Earth, providing us with key information about
what goes on at the core of our star. Several experiments have now confirmed
the observation of neutrino oscillations by detecting neutrinos from secondary
nuclear processes in the Sun; this is the first direct spectral measurement of
the neutrinos from the keystone proton-proton fusion. This observation is a
crucial step towards the completion of the spectroscopy of pp-chain neutrinos,
as well as further validation of the LMA-MSW model of neutrino oscillations.Comment: Proceedings from NOW (Neutrino Oscillation Workshop) 201
- …