44 research outputs found
The Swimmer's view: does it really show what it is supposed to show? A retrospective study
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>One of the basic principles in the primary survey of a trauma patient is immobilisation of the cervical spine till cleared of any injury. Lateral cervical spine radiograph is one of the important initial radiographic assessments. More than often additional radiographs like the Swimmer's view are necessary for adequate visualisation of the cervical spine. How good is the Swimmer's view in visualisation of the cervical spine after an inadequate lateral cervical spine radiograph?</p> <p>Methods</p> <p>100 Swimmer's view radiographs randomly selected over a 2 year period in trauma patients were included for the study. All the patients had inadequate lateral cervical spine radiographs. The radiographs were assessed with regards to their adequacy by a single observer. The criteria for adequacy were adequate visualisation of the C7 body, C7/T1 junction and the soft tissue shadow.</p> <p>Results</p> <p>Only 55% of the radiographs were adequate. None of the inadequate radiographs provided adequate visualisation of the C7 body and the C7/T1 junction. In 42.2% radiographs the soft tissue shadow was unclear. Poor exposure accounted for 53% of the inadequacies while overlapping bones accounted for the rest.</p> <p>Conclusion</p> <p>Clearing the cervical spine prior to removing triple immobilisation is essential in a trauma patient. This needs adequate visualisation from C1 to C7/T1 junction. In our study Swimmer's views did not satisfactorily provide adequate visualisation of the cervical spine in trauma patients. We recommend screening the cervical spine by a CT scan when the cervical spine lateral radiographs and Swimmer's views are inadequate.</p
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
- Grassi Veronica
- Grover Kartikae
- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
- Gvaramadze Anzors
- Hallam Kelly
- Hamad Ahmed
- Hamed Hisham
- Hamilton Stephen
- Hamnett Kathryn
- Hamo Ishrak
- Haq Anwar
- Harcourt Ruth
- Harding-MacKean Claudia
- Harnett Adrian
- Harnett Adrian
- Harnett Adrian
- Harris Chad
- Harris Kevin
- Harris Paul
- Harvey James
- Harvey Kate L
- Haywood Richard M
- Healy Samuel
- Henderson Julia
- Henry Francis P
- Hernan Izaro
- Heys Steven
- Hignett Susan
- Hill Arnold DK
- Hogan Brian
- Holcombe Chris
- Holcombe Chris
- Holcombe Chris
- Hollywood Ciaran
- Holt Simon
- Horgan Kieran
- Howes Rachel
- Hu Jennifer
- Humphreys Laura
- Hunter Judith
- Hussien Maged I
- Ihsan Naila
- Iqbal Azhar
- Irakleidis Foivos
- Irwin Gareth
- Irwin Michael S
- Isherwood Jennifer
- Ives Charlotte
- Jafferbhoy Sadaf
- Jafferbhoy Sadaf
- Jain Yogesh
- Jallali Navid
- James Karen
- James Ruth
- James Stuart
- Jibril Jibril A
- Jiwa Natasha
- Johns Neil
- Johnson Laura
- Johnson Richard
- Jones Ben Mancey
- Jones Robin
- Kalles Vasileios
- Kalra Loraine
- Kaushik Monika
- Kearns Marie
- Kelsall Jennett
- Kennedy Katy
- Kenny Frances
- Khalil Haitham
- Khan Mansoor
- Khan Shazia M
- Khattak Ilyas
- Khawaja Saira
- Khout Hazem
- Kirby Robert
- Kirchhoff Chris
- Kirkpatrick Katharine
- Kiruparan Pasupathy
- Kirwan Cliona C
- Kleidi Eleftheria
- Kneeshaw Peter
- Kokan Jalal
- Koris Jacob
- Kothari Ashutosh
- Kovacs Tibor
- Krupa Jaroslaw
- Krupa Katerine
- Kryjak Zbigniew
- Kulkarni Dhananjay
- Lai Lee Min
- Lambert Kelly
- Lampropoulos Pavlos
- Lane Risha
- Langlands Fiona
- Lansdown Mark
- Laurence Nicola
- Lawlor Catriona
- Laws Siobhan
- Ledwidge Serena
- Lee Jason
- Lewis Rebecca
- Li Alessandro Quattrini
- Liccardo Raffaele
- Limite Gennaro
- Lo Michelle
- Lund Jonathan
- Lymperopoulos N
- Maalo Joseph
- Mackay Iain
- MacLean Gael
- MacLennan Louise
- Macmillan Douglas
- MacNeill Fiona
- Mahapatra Tapan
- Majeed Yousef
- Malata Charles M
- Mallon Peter
- Malyon Andy
- Mansfield Lucy
- Mariniello Maria Donatella
- Marsh Daniel
- Marzia Lo Russo
- Masannat Yazan A
- Masood Mohammad
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathew Tom
- Mazari Fayyaz
- McCartan Damian
- McCulley Stephen
- McDermott Enda
- McEvoy Kat
- McGill David
- McGuiness Caroline
- McIntosh Jamie
- McIntosh Stuart A
- Mckenzie Shireen
- McManus Penelope
- Mehmood Iftikhar
- Mehta Disha
- Michalakis Ioannis
- Michieletto Silvia
- Milligan Robert
- Misky Adam
- Mitchell Geraldine
- Monib Sherif
- Morgan Mary
- Morrison Colin
- Mortimer Caroline
- Mosahebi Afshin
- Moss Sarah
- Muhibullah Nazli
- Mullan Michelle
- Munot Kailas
- Murali Kothandaraman
- Murphy Claire
- Murphy Declan C
- Murphy John
- Mustafa Mohammed
- Mylvaganam Senthurun
- Nagachandra Geerthan
- Narayanan Sankaran
- Naseem Salma
- Nasr Rana
- Navin Channegowda
- Nguyen Dai
- Nizamoglu Metin
- O'Brien Ciara
- O'Brien Ciara
- O'Brien James
- O'Connell Rachel
- O'Connell Rachel L
- O'Donoghue Joe
- O'Leary Peter
- Okwemba Sylvia
- Oliver James
- Olsen Sisse
- Oluwajana Michael
- Otieno Charlene
- Pain Simon J
- Park Alan
- Parvanta Laila
- Patel Ashraf
- Patel Krupali
- Peel Anthony
- Pereira Bernadette
- Pereira Jerome
- Pikoulas Panagiotis
- Pilgrim Simon
- Piper Jenny
- Poonawala Shabbir
- Popa Elena
- Pope Vanessa
- Potter Shelley
- Potter Shelley
- Potter Shelley
- Power Kieran
- Prichard Ruth
- Prousskaia Elena
- Pujji Ojas
- Rainsbury Dick
- Ramakrishnan Venkat
- Ramsey Kelvin
- Rasheed Tuabin
- Rattay Tim
- Rattay Tim
- Ravichandran Duraisamy
- Ray Biswajit
- Rayter Zenon
- Refsum Sigi
- Reissis Dimitris
- Remoundos Dionysios Dennis
- Ribas Maria Dalmau
- Rizkalla Maged
- Rizki Hirah
- Rocco Nicola
- Roche Nicola
- Roncella Manuela
- Roshanlall Chandeena
- Rossetti Elena
- Rothwell Jane
- Roy Pankaj
- Rusby Jennifer
- Sahu Ajay
- Saibene Tania
- Saleem Talha
- Sami AS
- Sassoon EM
- Scott John
- Seetharam Seema
- Sethu Claire
- Seward Joanna
- Shanks Lindsay
- Shariaha Yousef
- Sherwin Liz
- Shetty Geeta
- Shokuhi Sheila
- Shrestha Deepak
- Sircar Tapan
- Sirianni Chiara
- Sirianni Chiara
- Sjokvist Olivia
- Skillman Joanna
- Skillman Joanna
- Slade-Sharman Diana
- Sloan Samantha
- Smyth Elizabeth
- Sojitra Nilesh
- Soulsby Rachel
- Soumian Soni
- Sowdi Ravi
- Stebbing Anne
- Sundaramoorthy Souganthy
- Sutton Richard
- Svenning Matilda
- Syed Farah
- Tadros Amir
- Taghizadeh Rieka
- Tansley Anne
- Tasoulis Marios
- Tayeh Salim
- Taylor Amanda
- Taylor Jevan
- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
- Thekkinkattil Dinesh
- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
- Tillett Rachel
- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
- Wilson Rebecca
- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
- Amit B.
- Anand A.
- Anantapatnaikuni S.
- Anderson L.
- Anderson M.
- Anderson M.
- Anderson N.
- Anderson R.
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- Ang A.
- Anguvaa L.
- Aniruddhan K.
- Antonina Z.
- Araujo M.
- Archer A.
- Archer S.
- Arimoto R.
- Arkley C.
- Armah C.
- Armistead J.
- Armstrong C.
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- Arora D.
- Arya A.
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- Asher G.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Hanci O.
- Handrean S.
- Handzewniak N.
- Haney S.
- Hanison E.
- Hannington A.
- Hanrath A.
- Hanson A.
- Hanson H.
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- Headon E.
- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
- Henshall D.
- Hernandez F.
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- Hester S.
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- Hum R.
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- Hurditch E.
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- Hyslop M.
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- Ijaz M.
- Ilyas F.
- Ingham J.
- Ingram T.
- Ionita A.
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- Irons R.
- Irving R.
- Islam S.
- Islim A.
- Ismail O.
- Iwanikiw S.
- Jack C.
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- Jafar A.
- Jagannathan V.
- Jaime F.
- Jaki Thomas
- Jaly Y.
- Jama R.
- Jamal A.
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- James L.
- Jameson J.
- Janes K.
- Japp D.
- Jarman C.
- Jarvis C.
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- Jastrzebska P.
- Jeebun V.
- Jeffery Katie
- Jeffreys N.
- Jeffs B.
- Jenkins P.
- Jennings F.
- Jennings V.
- Jerry D.
- Jimenez Gil A.
- Johal S.
- John A.
- John M.
- Johnson G.
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- Johnstone E.
- Jones A.
- Jones B.
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- Jordache R.
- Jose S.
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- Joseph R.
- Josiah B.
- Ju Wen Kwek A.
- Judge P.
- Juszczak Edmund
- Kailey A.
- Kalayi R.
- Kamath P.
- Kamfose M.
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- Kavanagh S.
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- Kennedy A.
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- Khin H.
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- Lipscomb G.
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- Liu P.
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- Lloyd A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
- Locke T.
- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
- Lomme K.
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- Mackay L.
- MacKenzie J.
- Mackey A.
- Mackintosh C.
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- Madden A.
- Madeja N.
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- Maharajh A.
- Mahaveer A.
- Mahdi H.
- Maheswaran A.
- Mahmood W.
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- Mahony E.
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- Mair L.
- Majekdunmi T.
- Majumdar Jaydip
- Malein Flora
- Mancinelli R.
- Mandal S.
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- Mandeville J.
- Mane T.
- Manso K.
- Mansour M.
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- Maria del Rocio F.
- Mariano V.
- Marks B.
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- Marriott C.
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- Marsden P.
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- Mather N.
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- Matovu E.
- Matthews C.
- May P.
- Mayanagao I.
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- McBrearty C.
- McBride E.
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- McCorkindale A.
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- McCullagh L.
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- McEvoy E.
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- McLachlan H.
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- Mears K.
- Mediana A.
- Medine R.
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- Melville A.
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- Mendonca C.
- Mentzer A.
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- Metryka A.
- Mew L.
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- Michalak N.
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- Mohamed O.
- Mohammed O.
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- Montasser M.
- Montgomery Alan
- Moon A.
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- Morrissey M.
- Morrow A.
- Moss S.
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- Motherwell N.
- Moulton H.
- Mounce G.
- Mtuwa S.
- Muazzam A.
- Mudawi D.
- Mulcahy M.
- Mulligan S.
- Mumford Andrew
- Munavvar Mohammed
- Munt S.
- Murphy S.
- Murray C.
- Murray D.
- Murray I.
- Murray K.
- Murray L.
- Murthy M.
- Mutch C.
- Muzengi N.
- Mwaura E.
- Nafei M.
- Nagarajan T.
- Naglik L.
- Naguib M.
- Naicker K.
- Naisbitt J.
- Nandani A.
- Nandwani T.
- Nasa S.
- Natarajan N.
- Nathvani M.
- Navarra H.
- Naveed S.
- Naz M.
- Neal A.
- Nelson B.
- Nelson S.
- Nethercott D.
- Newby D.
- Newman T.
- Newport R.
- Ng S.
- Ngumo A.
- Nicholas N.
- Nicholas P.
- Nickson I.
- Nicol R.
- Nightingale T.
- Nilsson A.
- Ninan P.
- Nirmalan M.
- Nixon J.
- Nizam Ud Din K.
- Noe H.
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- Oliver A.
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- Oomatia A.
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- Osadcow A.
- Osanlou R.
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- Osborne R.
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- Osei-Bobie J.
- Oxlade R.
- O’Brien R.
- O’Callaghan C.
- O’Connor G.
- O’Donovan C.
- O’Farrell S.
- O’Riordan D.
- O’Sullivan E.
- Padden G.
- Page I.
- Page S.
- Pagett K.
- Pajak S.
- Pakou G.
- Palacios A.
- Palfrey H.
- Pandya T.
- Panes A.
- Pantin C.
- Parambil V.
- Parashar S.
- Parekh A.
- Parekh D.
- Parker B.
- Parker J.
- Parker S.
- Parkinson A.
- Passby L.
- Passey S.
- Patachako J.
- Patel M.
- Patel P.
- Patel S.
- Patience A.
- Patten S.
- Patterson C.
- Patterson L.
- Pauls L.
- Paulus S.
- Payne B.
- Payne E.
- Payne R.
- Peacock L.
- Pearce J.
- Pearson K.
- Peasley A.
- Peggie H.
- Pelham C.
- Penman C.
- Penman J.
- Penman R.
- Percival R.
- Perez E.
- Periyasamy L.
- Perry A.
- Perry M.
- Pessoa-Amorim Guilherme
- Peters C.
- Peterson A.
- Peto Leon
- Petrova B.
- Pezard-Snell M.
- Phelan P.
- Philbin J.
- Phillips N.
- PI M.
- Pick S.
- Pickard J.
- Pickering G.
- Piercy C.
- Pinches H.
- Pine K.
- Pinjala M.
- Pitchford M.
- Pleass R.
- Plowright M.
- Plumptre C.
- Pomery F.
- Poole L.
- Porter D.
- Porter L.
- Potter A.
- Potts J.
- Poustie V.
- Power N.
- Poyner E.
- Pradhan V.
- Prady H.
- Prasath S.
- Pratt A.
- Pratt S.
- Preiss D.
- Prest C.
- Price A.
- Price C.
- Price D.
- Price K.
- Price L.
- Price V.
- Price-Eland R.
- Priest A.
- Prince C.
- Pringle S.
- Pristopan V.
- Priyash V.
- Prudon Benjamin
- Pugh L.
- Purdue C.
- Purdy R.
- Pursell M.
- Purvis S.
- Putensen D.
- Pyart E.
- Quek E.
- Quigley J.
- Quindoyos J.
- Quinn T.
- Rabinowicz S.
- Rafique J.
- Rahman M.
- Rai S.
- Raithatha A.
- Rajasri A.
- Ramanan A.
- Ramasamy M.
- Ramchandani A.
- Ramirez J.
- Rampling T.
- Ramsay J.
- Ramshaw A.
- Rana G.
- Rand J.
- Rank H.
- Rankhelawon R.
- Rasheed A.
- Ratcliffe S.
- Raw J.
- Razvi Z.
- RECOVERY Collaborative Group
- Redknap I.
- Redman N.
- Rees A.
- Rees M.
- Rees S.
- Rehman Z.
- Reilly M.
- Reith C.
- Renshaw S.
- Rey S.
- Reynard C.
- Reynolds H.
- Rhodes J.
- Rice E.
- Rice M.
- Rice N.
- Richardson E.
- Richardson N.
- Rigby L.
- Riley M.
- Riley P.
- Ripley D.
- Rishton C.
- Riste M.
- Ritchings A.
- Rivera Ortega P.
- Robbins E.
- Roberts V.
- Robertson C.
- Robertson J.
- Robertson N.
- Robinson J.
- Robinson L.
- Robinson S.
- Robson S.
- Roderick M.
- Rodger A.
- Rodgers A.
- Rodgers N.
- Rodgers P.
- Roehr C.
- Rogers J.
- Rogers S.
- Rogers T.
- Rook C.
- Rooney L.
- Rosby E.
- Rose A.
- Rose Z.
- Ross I.
- Rothman A.
- Rothwell J.
- Roughley L.
- Rowan Kathryn
- Rowan N.
- Rowe A.
- Rowe N.
- Rowley M.
- Rudenko A.
- Rule R.
- Rushmer J.
- Ryan A.
- Ryan L.
- Ryan P.
- Rybka E.
- Ryder S.
- Salberg A.
- Saleh M.
- Salih H.
- Salman R.
- Salmon R.
- Sam M.
- Sam S.
- Saminathan S.
- Sammons E.
- Sammut D.
- Sampson J.
- Samuel M.
- Samuel Y.
- Sanchez Gonzalez A.
- Sanchez V.
- Sandercock Peter
- Sangombe M.
- Sanju M.
- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
- Scarratt L.
- Scattergood S.
- Schadenberg A.
- Schafers J.
- Schneblen W.
- Schofield E.
- Schumacher N.
- Schunke N.
- Scobie A.
- Scoones T.
- Scott A.
- Scott C.
- Scullion A.
- Seaton I.
- Sedano J.
- Segovia M.
- Selby F.
- Sellers K.
- Sen N.
- Sengupta A.
- Sewdin T.
- Seymour J.
- Shah H.
- Shah R.
- Shah S.
- Shaibu A.
- Shanahan T.
- Sharaf H.
- Sharma B.
- Sharma O.
- Sharma S.
- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
- Shioi C.
- Shirley K.
- Shurlock J.
- Shurmer Jack
- Siamia L.
- Siddle E.
- Sime R.
- Simpson A.
- Simpson D.
- Simpson J.
- Simpson M.
- Simpson P.
- Sinclair S.
- Singh C.
- Singh S.
- Singhal P.
- Sithiravel S.
- Sivanadarajah S.
- Skaria A.
- Skehan N.
- Skinner T.
- Skinner V.
- Skorko A.
- Slack A.
- Slade H.
- Small E.
- Smallridge A.
- Smart B.
- Smith C.
- Smith E.
- Smith H.
- Smith J.
- Smith L.
- Smith M.
- Smith N.
- Smith P.
- Smith R.
- Smith S.
- Smith T.
- Smith V.
- Snell D.
- Sobande T.
- Sobrino Diaz A.
- Solly R.
- Soni G.
- Soor P.
- Soothill G.
- Soren J.
- Spiller W.
- Spring O.
- Squires G.
- Squires J.
- Squires R.
- Srinivasan R.
- Stagg W.
- Stanton A.
- Staplin Natalie
- Starnes D.
- Steer J.
- Stefania V.
- Stefanowska P.
- Stephens A.
- Stephensen D.
- Stephenson E.
- Sterrenburg M.
- Stevens W.
- Stevenson A.
- Stevenson S.
- Steward M.
- Stewart C.
- Stewart K.
- Stewart Richard
- Stickley J.
- Stirrup S.
- Stock S.
- Stockdale A.
- Stone B.
- Stone S.
- Storey I.
- Stratton E.
- Stratton J.
- Stubbs A.
- Stuttard M.
- Subudhi C.
- Sugden P.
- Sukumaran A.
- Sundar S.
- Surtees M.
- Sutherland R.
- Sutherland S.
- Sutu M.
- Swanson-Low C.
- Swart T.
- Swift E.
- Swist-Szulik K.
- Sykes D.
- Sykes E.
- Symon D.
- Syndercombe A.
- T-Michael H.
- Tadros M.
- Tague L.
- Tahir H.
- Tait J.
- Talbot P.
- Tallent R.
- Tallon B.
- Tanney C.
- Tanton E.
- Taribagil P.
- Tarr E.
- Tasiou A.
- Tate A.
- Taylor C.
- Taylor J.
- Taylor K.
- Taylor L.
- Taylor R.
- Taylor-Siddons M.
- Teasdale F.
- Teasdale J.
- Teasdale K.
- Tebbutt J.
- Telfer A.
- Tempany J.
- Tereszkowski-Kaminski R.
- Tewkesbury D.
- Thake M.
- Thakker M.
- Thamu B.
- Thet P.
- Thomas A.
- Thomas E.
- Thomas K.
- Thomas R.
- Thomas S.
- Thompson E.
- Thompson J.
- Thompson K.
- Thompson R.
- Thornton D.
- Thornton J.
- Thornton S.
- Thorpe S.
- Thrasyvoulou L.
- Thraves H.
- Thu-Ta P.
- Thwaites Guy
- Tilbey S.
- Timerick J.
- Timmins A.
- Tinkler H.
- Tipper J.
- Tivenan H.
- Todd S.
- Tohfa M.
- Toohey C.
- Topham K.
- Topping M.
- Tousis R.
- Trevelyan M.
- Trewick N.
- Truell R.
- Tsakiridou K.
- Tsang C.
- Tucker S.
- Tufail A.
- Tuff J.
- Tully R.
- Turbitt K.
- Turgut T.
- Turner G.
- Turner K.
- Turner S.
- Turner-Bone I.
- Turney S.
- Tyer A.
- UK National Institute for Health Research Clinical Research Network (for the RECOVERY Collaborative Group)
- Ul Haq M.
- Ul Hassan W.
- Underwood C.
- Unsworth A.
- Uriel Alison
- Usher R.
- Ustianowski A.
- Vankayalapati P.
- Van’t Hoff W.
- Varghese M.
- Varnier G.
- Vasu V.
- Vatish M.
- Veerasamy S.
- Velankar S.
- Vella N.
- Velugupati A.
- Venables I.
- Venditti M.
- Veres M.
- Vergnano S.
- Vernall R.
- Verula J.
- Vethanayagam N.
- Vettikumaran S.
- Victoria S.
- Vinay S.
- Vincent O.
- Vincent R.
- Vyras E.
- Wade P.
- Waite A.
- Walden A.
- Walker I.
- Walker K.
- Walker S.
- Wallace G.
- Wallendszus K.
- Wallis G.
- Walsh D.
- Walters J.
- Walton E.
- Walton O.
- Wang N.
- Wang R.
- Wang S.
- Warburton S.
- Ward J.
- Ward L.
- Ward R.
- Wardle S.
- Warmington J.
- Warner C.
- Warran S.
- Warren R.
- Warren Y.
- Warris Adilia
- Wasson E.
- Waterfall H.
- Waters D.
- Watson A.
- Watson E.
- Watson J. G. R.
- Watson L.
- Watson R.
- Watterson D.
- Watts M.
- Waugh V.
- Wayman E.
- Weatherhead M.
- Webb C.
- Webster I.
- Weerakoon R.
- Weetman M.
- Wei S.
- Welch J.
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- Wels R.
- Welters I.
- Welton R.
- Wentworth L.
- West R.
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- Weston H.
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- Whitehead C.
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- Xavier B.
- Yaqoob N.
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- Zayed M.
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- Zuhra N.
- Zullo C.
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study
- Author
- Abbas Abeera
- Abbas Imran
- Abbott Nick
- Abdalla El-Rasheed
- Absar Mohammed
- Achuthan Raj
- Adwani Asha
- Agabiti Ennio
- Agrawal Amit
- Ainsworth Rachel
- Aitken Jane
- Akolekar Deepika
- Al-Ishaq Zaid
- Al-Mufti Ragheed
- AL-Zawi Abdalla Saad Abdalla
- Alder Louise
- Alkistawi Firas Eddin Bachir
- Allen Michael J.
- Allum William H.
- Amin Khalid
- Ansari Aonghus
- Asgeirsson Kristjan
- Athanasiou Irene
- Athwal Ruvinder
- Azmy Iman
- Bakri Nur Amalina Che
- Banerjee Dibyesh
- Banks Jenny
- Barkeji Musa
- Barker Sarah
- Barnes Nicola
- Barry Peter A.
- Barua Ellora
- Bathla Sonia
- Batt Jeremy
- Benson John
- Bentley James
- Betal Dibendu
- Betambeau Nadine
- Bezzaa Sabrina
- Bichoo Raouef Ahmed
- Bonomi Riccardo
- Bosch Karen
- Boundouki George
- Bramley Maria
- Brown Iain
- Bunza Ralia
- Burrah Rajaram
- Byrne Gerard
- Cain Henry
- Callaghan Maria
- Camacho Elizabeth M.
- Cariati Massimiliano
- Carmichael Amtul
- Cartlidge Christopher W. J.
- Chagla Leena
- Chalmers Ritchie
- Chambers Alice
- Chandrasekharan Sankaran
- Chandrashekar Mysore
- Charalampoudis Petros
- Chatterjee Sumohan
- Chaudhry Anushka
- Cheung Kwok-Leung
- Chong Kelvin
- Chopra Sharat
- Chouhan Ashok
- Chrysafi Ada
- Clayton Elizabeth
- Clayton Gillian
- Coles Charlotte E.
- Cook James
- Cook Lorna
- Coombs Nathan
- Copson Ellen
- Courtney Alona
- Courtney Carol-Ann
- Cox Karina
- Critchley Adam
- Cuffolo Giulio
- Cutress Ramsey I.
- Daltrey Ian
- Dani Mohsin
- Dash Isabella
- Dave Rajiv V.
- Davies Eleri
- de Silva Tania S.
- Dent Helen
- Devalia Haresh
- Dimopoulos Nikitas
- Dodwell David
- Douek Michael
- Doughty Julie
- Drew Philip
- Dua Sascha
- Dumitru Dorin
- Dunn Julie
- Egbeare Donna
- Eid Raja
- Elahi M. Bilal
- Elamass Mohamed
- Elfadl Dalia
- Elkorety Mohamed
- Elsberger Beatrix
- English Rachel Elizabeth
- Exarchos Georgios
- Fafemi Oladapo
- Fairbrother Patricia
- Fairhurst Katherine
- Fatayer Hiba
- Ferguson Douglas
- Forouhi Parto
- Franks Joanna
- Fuller Mairi
- Gahir Jasdeep
- Gallegos Nicholas
- Gandamihardja Tasha
- Gandhi Ashu
- Garreffa Emanuele
- Gathani Toral
- Gill Jasper
- Girgis Mina
- Goh Ngee-Ming
- Gopalan Vallipuran
- Govindarajulu Sasi
- Gowda Manoj
- Goyal Amit
- Goyal Sumit
- Gui Gerald
- Gvaramadze Anzors
- Hadjiminas Demetrios
- Hague Matthew
- Hamad Ahmed
- Hamed Hisham
- Harborough Kathryn E.
- Harding-Mackean Claudia
- Hardy Rob
- Hargreaves Anita
- Harries Simon
- Harvey James
- Hawkins Simon
- Heeney Anna
- Henderson Julia
- Highton Lyndsey
- Hill Arnold D. K.
- Hogan Brian
- Hogben Katy
- Holcombe Chris
- Hollywood Ciaran
- Horgan Kieran
- Horne Sarah
- Horsnell Jonathan D.
- Hurley Anna R.
- Hussien Maged
- Imran Abbas
- Irvine Tracey
- Irwin Gareth W.
- Isgar Brian
- Ives Charlotte
- Jacklin Rosamond
- Jafferbhoy Sadaf
- Jain Urvashi
- James Karen
- James Ruth
- Jenkins Stephanie C.
- Jibril Jibril
- Johnson Richard
- Jones Lucie
- Joshi Sanjay
- Kalakouti Eliana
- Kallaway Charlotte
- Kalra Loraine
- Kantola Venla
- Karagiannidis Georgios
- Kattakayam Arjun
- Kaushik Monika
- Kenny Frances
- Khalifa Eiman
- Khan Lucy R.
- Khout Hazem
- Kiernan Tamara
- Kim Baek
- King Polly
- Kirkham Jamie J.
- Kirkpatrick Katharine
- Kirwan Cliona C.
- Knight Alex
- Knowles Hannah
- Kothari Ashutosh
- Krupa Jaroslaw
- Krupa Katherine
- Krzyzanowska Catherine
- Laban Christiana
- Lafi Mohamed
- Lai Lee-Min
- Lambert Kelly
- Laurence Nicola
- Law Rebekah
- Lee Rachel Xue Ning
- Leff Daniel R.
- Liptay-Wagner Peter
- Lobo Cheryl
- Lund Jonathan
- Maalo Joseph
- Macinnes Emma
- MacLean Gael
- Macmillan Robert
- Mallidis Evangelos
- Mallon Peter
- Marla Sekhar
- Marsh Simon
- Martin Lee
- Masannat Yazan
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathers Helen
- Mazari Fayyaz
- McCulley Stephen
- McEvoy Kat
- McGoldrick Ciara
- McIntosh Jamie
- McIntosh Stuart A.
- Mckenzie Shireen
- McManus Penelope
- Mehta Disha
- Merker Louise
- Mikhael Youhana
- Mirshekar-Syahkal Bahar
- Mitchell Geraldine
- Mondani Giuseppina
- Monib Sherif
- Moody Alice
- Mortimer Caroline
- Mullan Michelle
- Mullen Russell
- Murphy John
- Mylvaganam Senthurun
- Nair Rajive
- Najeeb Erum
- Narayanan Sankaran
- Nasir Nabila
- Navin Channegowda
- Noor Lubna
- Noronha Jarin Louis
- Ntakomyti Eleni
- Odofin Olubunmi
- Olsen Sisse
- Oni Georgette
- Ooi Jane
- O’Connell Rachel
- Pain Simon
- Pakzad Farrokh
- Parmeshwar Rishikesh
- Partlett Polly
- Patani Neill
- Peck Jennifer
- Peerlink Inga
- Pereira Bernadette
- Phyu Saung Hnin
- Pieri Andrew
- Pilgrm Simon
- Podesta Carl
- Pogson Caroline
- Poonawala Shabbir
- Potter Shelley
- Potter Shelley
- Power Colm
- Prusty Lydia
- Quinn Edel
- Ralph Jane
- Ramzi Sa’ed
- Rana Dheer Singh
- Rapisarda Fabio
- Rasheed Tuabin
- Rathinaezhil Rathi
- Rattay Tim
- Ravichandran Duraisamy
- Ray Atanu
- Rayter Zenon
- Remoundos Dennis
- Rew David
- Robb Henry Douglas
- Robertson Stuart
- Roche Nicola
- Romics Laszlo
- Rowland Matthew
- Roy Pankaj
- Rusby Jennifer E.
- Rutherford Claire Louise
- Saha Sunita
- Sahu Ajay
- Sait Mohamed Razick
- Sakellariou Vasileios
- Salem Fathi
- Salih Ali
- Salman Muhammad
- Salman Reem
- Salvador Reginald
- Sami Amtul
- Sarakbi Wail Al
- Sardar Mini V.
- Sarker Masuma
- Sasi Walid
- Satpathy Anjana
- Scally Norah
- Segaran Ashvina
- Sein Tin Aung
- Seward Joanna
- Shaheed Samy
- Sharif Mohammad Amir
- Sharma Anita
- Sharma Anup
- Sharma Nisha
- Shere Mike
- Shin Hyunjin
- Shokuhi Sheila
- Shrotri Anu
- Sibbering David Mark
- Simonca Claudiu
- Sircar Tapan
- Sloan Samantha A.
- Smith Simon
- Smyth Elizabeth
- Somasundaram Santosh
- Sotheran Wendy
- Soulsby Rachel
- Soumian Soni
- Sousa Emma de
- St John Edward R. C.
- Stallard Sheila
- Stanilov Noyko
- Suleiman Usama
- Sulieman Mona
- Sutton Richard
- Sweetland Helen M.
- Tabbakh Rami
- Tanhueco Angeline
- Tansley Anne
- Taraki Zarghuna
- Taxiarchi Vicky P.
- Taylor Amanda
- Thekkinkattil Dinesh
- Thiruchelvam Paul
- Thomas Robert
- Thomson Simon
- Thorne Amanda
- Tillett Rachel
- Touqan Nader
- Tuffaha Hussein
- Turner Jane
- Turton Philip
- Urquhart Gordon
- Valassiadou Kalliope
- Vashisht Rajiv
- Vatish Jamie
- Verroiotou Maria
- Vidya Raghavan
- Vinayagam Raman
- Wahedna Yasmin
- Waheed Shamaela
- Wallace Sharon
- Walsh Adam
- Wardle Stacy
- Whisker Lisa
- Whitehead Ian
- Wignarajah Primeera
- Williams Chloe
- Williams Kate E.
- Williams Samantha K.
- Williams-Jones Susan
- Wilson Christopher
- Young Ian
- Youssef Mina M. G.
- Zammit Charles
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- British Journal of Cancer
- Publication date
- 10/12/2020
- Field of study
Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods: This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings: Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used (n = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided (n = 299). Where adjuvant chemotherapy was omitted (n = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy (n = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions: The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown
Outpatient management of Gitelman's syndrome in pregnancy
- Publication venue
- 'BMJ'
- Publication date
- Field of study
Transgendered Persons and Feminist Strategy
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Diisopropylaminoisocyanide and DMAD in multiple component reactions (MCRs): novel synthesis of substituted 1-amino-3-pyrrolin-2-ones by reaction with aldehydes and dicarbonyl compounds
- Publication venue
- Elsevier Science
- Publication date
- Field of study
The zwitterion generated from diisopropylaminoisocyanide and dimethyl acetylenedicarboxylate (DMAD) reacts with a variety of carbonyl and dicarbonyl compounds affording substituted 1-aminopyrrolin-2-ones