Ligand conjugated liposomal drug delivery system for enhanced brain uptake of ampicillin

Targeting of antimicrobial agents by means of liposomes may be of great value in the treatment of intra or extracellular infections compare to conventional forms of antimicrobial therapy. In the present study Ampicillin loaded non-targeted Polyethylene glycolated liposomes and targeted Glutathione Polyethylene glycollated liposomes of about 132.14 nm size were prepared with 80 % of drug entrapment. Prepared liposomes were evaluated for in vitro, in vivo release profile and brain uptake studies. Results of these studies revealed more absorption of drug than standard Ampicillin solution and non targeted liposomes (Auc0-6h 1858.908 µg h/ml) and 3.5 times increase in brain uptake. Incorporation of polyethylene glycol in the liposomes increased the drug concentration and circulation time in plasma as well as in the extracellular fluid of brain thus improved therapeutic availability of Ampicillin trihydrate

Ethnic Identity Formation in Local Political Economic Arena

Pembentukan identitas etnik di arena ekonomi politik lokal penting untuk dikaji dalam rangka memahami pluralisme di Indonesia. Tujuan dari tulisan ini adalah untuk mempelajari pembentukan identitas etnik di arena ekonomi politik lokal. Penelitian ini menggunakan metodologi kualitatif dengan paradigma non-positivistik perspektif struktural-konstruktivisme. Unit analisis dalam penelitian ini adalah masyarakat yang tinggal di Kendari, Sulawesi Tenggara. Data dikumpulkan melalui wawancara mendalam, wawancara tertruktur dan Focus Grup Discussion (FGD) yang dilakukan aktor dari latar belakang berbagai etnis (Tolaki, Muna, Buton, dan Bugis) dan berbagai profesi (politisi, birokrasi, akademisi, and aktivis LSM). Hasil penelitian menunjukkan bahwa pembentukan identitas etnik di arena politik lokal dipengaruhi oleh sejarah kelompok etnis (posisi) dan pengalaman aktor (disposisi). Dari keduanya, bentuk garis yang berkelanjutan membentuk suatu interaksi (kesenangan) yang dinamakan pembentukan identitas etnik. Struktur ini mengacu pada dua bentuk: (1) bentuk identitas etnik dengan skala besar dan (2) pembentukan batas identitas etnik. Kedua struktur tersebut merupakan penentu arena ekonomi politik lokal. Psinsip hirarki ganda (prinsip hirarki heteronomus dan autonomus) memberikan kontribusi pada pembentukan identitas etnik yang disebabkan oleh mobilisasi [identitas], positif atau negatif

SOLID LIPID NANOPARTICLES: A PROMISING APPROACH FOR COMBINATIONAL DRUG THERAPY IN CANCER

Combination therapy for cancer treatment is accepted worldwide due to the generation of synergistic anticancer effects; restrain in multidrug resistance (MDR) or tumor resistance by different mechanisms of action and minimization of dose-dependent toxicity. Recently developed Solid lipid nanoparticles (SLNs) are matrix composed of lipid which is solid at both room and body temperature and hence it is as an alternative to other nanocarrier systems. SLNs after oral administration get absorbed by lymphatic pathway due to stimulation of chylomicron formation. Thus, it avoids all consequences related to an oral drug delivery system and improves oral bioavailability. SLNs based combination drug delivery to tumor tissues reduces the problems associated with chemotherapy. The targeted and sustained delivery of chemotherapeutic agents reduces the dose by achieving high concentrations at the target site, without altering the normal tissues. In this article, we have reviewed and focused on SLNs as a drug delivery system; ingredients used in formulating SLNs and developed two or more drugs in a single formulation of SLNs as drug delivery. This article also focuses on the fact that SLNs as a combination drug delivery provides an attractive approach in future prevention and beneficial for the treatment of cancer by increasing its therapeutic efficacy

Advanced information processing system for advanced launch system: Avionics architecture synthesis

The Advanced Information Processing System (AIPS) is a fault-tolerant distributed computer system architecture that was developed to meet the real time computational needs of advanced aerospace vehicles. One such vehicle is the Advanced Launch System (ALS) being developed jointly by NASA and the Department of Defense to launch heavy payloads into low earth orbit at one tenth the cost (per pound of payload) of the current launch vehicles. An avionics architecture that utilizes the AIPS hardware and software building blocks was synthesized for ALS. The AIPS for ALS architecture synthesis process starting with the ALS mission requirements and ending with an analysis of the candidate ALS avionics architecture is described

(Conflict Resolution of Irrigation Development: Case Study in Ibu Subdistrict of West Halmahera District)

The objective of this research is to understand the conflict resolution of dam and irrigation development in three subdistrict villages of Ibu Halmahera Barat district 2013. This research uses analysis of dispute style (AGATA) in the form of: avoidance, accommodating, compromise, competitive, and collaboration. The results showed that there are two styles of conflict that is avoid and competitive style. Both style of disputes are transformed into a compromise style after the opposing party offers negotiation of land compensation. Based on this it can reduce the two parties, so that the mediator easily deal with the conflict. The settlement path is through mediation and facilitation by bringing the two conflicting parties together with the mediator of West Halmahera people's parliament. The decision taken is to stop the construction of dam and irrigation channels under construction. The decision, in addition to reducing the escalation of tensions, also to anticipates violet conflict between the two parties (the pros and cons of development)

An evaluation of the quality of discharge summaries from the general paediatric wards at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa

Background. Hospital discharge summaries are deemed to be an essential part of the medical record in South Africa, but formal assessment of their quality is rarely undertaken. At Chris Hani Baragwanath Academic Hospital (CHBAH) in Johannesburg, medical admission notes (bedletters) are difficult to retrieve from the hospital archives and the discharge summary is often the only readily available medical record that documents details of the hospital admission.Objectives. To determine the proportion of discharge summaries that were appropriately completed for children admitted to the general paediatric wards at CHBAH.Methods. A retrospective review of discharge summaries completed for children admitted from 1 May to 31 July 2016 was undertaken. The completeness of the following demographic and clinical variables was assessed: patient identifiers, hospital outcome, HIV infection status and anthropometric status. The documentation of correct International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) codes was assessed in children diagnosed with any form of lower respiratory tract infection (LRTI), which is the commonest diagnosis recorded in hospitalised children at CHBAH.Results. Discharge summaries were available for 1 148 (78.3%) of 1 466 children admitted during the study period. For completed discharge summaries, 80.1 - 93.3% of patient identifiers and 91.4% of patient outcomes were appropriately completed. HIV exposure was documented in 84.7% of summaries. Anthropometric parameters, including weight and length/height at admission and discharge weight, were appropriately completed in 91.4%, 70.9% and 50.0% of summaries, respectively. The ICD-10 code for children with LRTI was appropriately recorded by medical staff in 338 (67.2%) of 503 cases. ICD‑10 codes and anthropometric parameters, which are important clinical parameters in the paediatric follow-up consultation, were both correctly recorded for only 21.6% of children who required follow-up clinical consultations at CHBAH.Conclusions. Compared with similar studies, both the rate of completion and the quality of completed discharge summaries were modest in this tertiary academic teaching hospital. As discharge summaries are crucial medical documents, interventions to improve their completeness rate and quality need to be developed

Aktivitas Harian dan Preferensi Burung Predator Lanius SP. terhadap Hama Sexava Spp.

The objective research is to know the daily activities and preference of predatory birds Lanius sp. to several stages of Sexava spp. Ten predatory birds 12 to 14 months of age were bought at merchant bird in Yogyakarta. The study was conducted naturally under controlled condition in cages. Before the study was conducted the predatory birds were acclimatized for three days by feeding them cricket and gradually changed to Sexava spp. The young nymphs, old nymphs, adult male, and adult female of Sexava spp. were found at coconut plantation in Dumagin village became the new dietary of the predator. The result showed that Lanius sp. is a diurnal bird; the activities were dominated by hunting and preying (16.52%), followed by flying (6.53%), jumping (5.70%), and walking (4.58%). The Lanius sp. preferred to prey on significantly more nymphs of Sexava spp. than the adult. The birds prey proportionally on the young nymphs, old nymphs, male, and adult females for 50%, 41%, 5%, and 4%, respectively. Penelitian bertujuan untuk mengetahui aktivitas harian burung predator Lanius sp. dan preferensinya terhadap berbagai fase hama Sexava spp. Burung berumur 1–1,2 tahun sebanyak 10 ekor diperoleh dari pedagang burung di Yogyakarta. Kajian preferensi burung predator Lanius sp. terhadap belalang Sexava spp. dilakukan di bawah kondisi fisik alami dan terkontrol dalam kandang uji. Sebelum kajian dilakukan burung predator diaklimatisasi selama 3 hari dengan pakan jangkrik dan berangsur-angsur diganti dengan belalang Sexava spp. Belalang Sexava spp. stadia nimfa muda, nimfa tua, imago jantan, dan imago betina diperoleh dari kebun kelapa desa Dumagin, dipakai sebagai mangsa burung predator. Hasil kajian menunjukkan bahwa Lanius sp. termasuk burung diurnal; aktivitas siang hari didominasi berburu mangsa dan makan (16,52%), diikuti terbang (6,53%), melompat (5,70%), dan berjalan (4,58%). Lanius sp. Secara signifikan lebih memilih stadia nimfa dibandingkan imago belalang Sexava spp. Proporsi nimfa muda, nimfa tua, imago jantan, dan imago betina yang dimangsa berturut-turut yaitu 50%, 41%, 5%, dan 4%