68 research outputs found
Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks
BACKGROUND: The lumpy skin disease virus (LSDV) is a dsDNA virus belonging to the Poxviridae family and the Capripoxvirus genus. Lumpy skin diseases (LSD) is a highly contagious transboundary disease in cattle producing major economic losses. In 2014, the disease was first reported in the European Union (in Cyprus); it was then reported in 2015 (in Greece) and has spread through different Balkan countries in 2016. Indirect vector transmission is predominant at small distances, but transmission between distant herds and between countries usually occurs through movements of infected cattle or through vectors found mainly in animal trucks. METHODS AND PRINCIPAL FINDINGS: In order to estimate the threat for France due to the introduction of vectors found in animal trucks (cattle or horses) from at-risk countries (Balkans and neighbours), a quantitative import risk analysis (QIRA) model was developed according to the international standard. Using stochastic QIRA modelling and combining experimental/field data and expert opinion, the yearly risk of LSDV being introduced by stable flies (Stomoxys calcitrans), that travel in trucks transporting animals was between 6 x 10-5 and 5.93 x 10-3 with a median value of 89.9 x 10-5; it was mainly due to the risk related to insects entering farms in France from vehicles transporting cattle from the at-risk area. The risk related to the transport of cattle going to slaughterhouses or the transport of horses was much lower (between 2 x 10-7 and 3.73 x 10-5 and between 5 x 10-10 and 3.95 x 10-8 for cattle and horses, respectively). The disinsectisation of trucks transporting live animals was important to reduce this risk. CONCLUSION AND SIGNIFICANCE: The development of a stochastic QIRA made it possible to quantify the risk of LSD being introduced in France through the import of vectors that travel in trucks transporting animals. This tool is of prime importance because the LSD situation in the Balkans is continuously changing. Indeed, this model can be updated to process new information on vectors and the changing health situation, in addition to new data from the TRAde Control and Expert System (TRACES, EU database). This model is easy to adapt to different countries and to other vectors and diseases
A simple method to estimate the number of doses to include in a bank of vaccines. The case of Lumpy Skin Disease in France
A simple method to estimate the size of the vaccine bank needed to control an epidemic of an exotic infectious disease in case of introduction into a country is presented. The method was applied to the case of a Lumpy Skin disease (LSD) epidemic in France. The size of the stock of vaccines needed was calculated based on a series of simple equations that use some trigonometric functions and take into account the spread of the disease, the time required to obtain good vaccination coverage and the cattle density in the affected region. Assuming a 7-weeks period to vaccinate all the animals and a spread of the disease of 7.3 km/week, the vaccination of 740 716 cattle would be enough to control an epidemic of LSD in France in 90% of the simulations (608 196 cattle would cover 75% of the simulations). The results of this simple method were then validated using a dynamic simulation model, which served as reference for the calculation of the vaccine stock required. The differences between both models in different scenarios, related with the time needed to vaccinate the animals, ranged from 7% to 10.5% more vaccines using the simple method to cover 90% of the simulations, and from 9.0% to 13.8% for 75% of the simulations. The model is easy to use and may be adapted for the control of different diseases in different countries, just by using some simple formulas and few input data
Ground penetrating radar data used in discovery of the early Christian church of Notre Dame de Baudes near Labastide-du-Temple, France
Data on ground-penetrating radar transect files are provided that support the research presented in ''Discovery and Appraisal of the Early Christian Church of Notre Dame de Baudes near Labastide-du-Temple, France'' [1]. Data consist of 102 transect files obtained with a GSSI SIR-3000 controller and a 400 MHz center frequency antenna in two grid blocks covering ca. 2700 m2. The data are distributed raw without post-processing in SEG-Y rev. 1 format (little endian). Keywords: Southwest France, Tarn River, Ground-penetrating radar, Medieval archeology, Site discover
Failure model for heterogeneous structures using structured meshes and accounting for probability aspects
GSTs, NATs, SULT1A1, CYP1B1 genetic polymorphisms, interaction with environmental exposures and bladder cancer risk in Brescia, Italy
Genetic polymorphism of MPO, COMT, MnSOD, NQO1 and DNA repair genes, interaction with environmental exposures and bladder cancer risk in Brescia, Italy
GSTs, NATs, SULT1A1, CYP1B1 genetic polymorphisms, interaction with environmental exposures and bladder cancer risk in Brescia, Italy
Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity
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