Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial

Peer reviewedPostprin

Contribution of deformation to sea-ice mass balance: a case study from an N-ICE2015 storm

The fastest and most efficient process of gaining sea ice volume is through the mechanical redistribution of mass as a consequence of deformation events. During the ice growth season divergent motion produces leads where new ice grows thermodynamically, while convergent motion fractures the ice and either piles the resultant ice blocks into ridges or rafts one floe under the other. Here we present an exceptionally detailed airborne dataset from a 9km2 area of first and second year ice in the Transpolar Drift north of Svalbard that allowed us to estimate the redistribution of mass from an observed deformation event. To achieve this level of detail we analyzed changes in sea ice freeboard acquired from two airborne laser scanner surveys just before and right after a deformation event brought on by a passing low pressure system. A linear regression model based on divergence during this storm can explain 64% of freeboard variability. Over the survey region we estimated that about 1.3% of level sea ice volume was pressed together into deformed ice and the new ice formed in leads in a week after the deformation event would increase the sea ice volume by 0.5%. As the region is impacted by about 15 storms each winter a simple linear extrapolation would result in about 7% volume increase and 20% deformed ice fraction at the end of the seaso

On Linear Information Systems

Scott's information systems provide a categorically equivalent, intensional description of Scott domains and continuous functions. Following a well established pattern in denotational semantics, we define a linear version of information systems, providing a model of intuitionistic linear logic (a new-Seely category), with a "set-theoretic" interpretation of exponentials that recovers Scott continuous functions via the co-Kleisli construction. From a domain theoretic point of view, linear information systems are equivalent to prime algebraic Scott domains, which in turn generalize prime algebraic lattices, already known to provide a model of classical linear logic

The relationship between habitual physical activity status and executive function in individuals with Alzheimer’s disease: a longitudinal, cross-lagged panel analysis

To determine whether habitual physical activity status specifically influences executive function change in Alzheimer’s disease (AD) over 1 year. In this longitudinal cohort study, 45 participants with AD were recruited and provided follow-up data approximately 1 year later. Executive function measures (map search task, digit symbol substitution task, controlled oral word association task, verbal fluency task) and habitual physical activity measures (Physical Activity Scale for the Elderly (PASE) and handgrip strength) were taken at baseline and follow-up. Individual composites were subsequently created. Additional demographic, lifestyle, and neuropsychiatric measures were also taken. In a structural equation model (χ2(26) = 9.84, p = .998, comparative fit index = 1.00, root mean square error of approximation = .00), a significant association was found between habitual physical activity and executive function change (β = .27, p = .04). In a cross-lagged panel analysis, a significant path was found between the PASE score and executive change (β = .22, p = .01). As higher habitual physical activity levels were associated with reduced executive function change, the promotion of low-intensity habitual physical activities in individuals with a diagnosis of AD may be warranted. Further research is needed, however, to explore the impact of habitual physical activity on the trajectory of change across cognitive domains, and how this relates to the progression of the underlying pathology associated with this disease

The structure of social influence in recommender networks

People’s ability to influence others’ opinion on matters of taste varies greatly—both offline and in recommender systems. What are the mechanisms underlying these striking differences? Using the weighted k-nearest neighbors algorithm (k-nn) to represent an array of social learning strategies, we show—leveraging methods from network science—how the k-nn algorithm gives rise to networks of social influence in six real-world domains of taste. We show three novel results that apply both to offline advice taking and online recommender settings. First, influential individuals have mainstream tastes and high dispersion in their taste similarity with others. Second, the fewer people an individual or algorithm consults (i.e., the lower k is) or the larger the weight placed on the opinions of more similar others, the smaller the group of people with substantial influence. Third, the influence networks emerging from deploying the k-nn algorithm are hierarchically organized. Our results shed new light on classic empirical findings in communication and network science and can help improve the understanding of social influence offline and online

Influence of music therapy on coping skills and anger management in forensic psychiatric patients: An exploratory study

The effect of music therapy on anger management and coping skills is an innovative subject in the field of forensic psychiatry. This study explores the following research question: Can music therapy treatment contribute to positive changes in coping skills, anger management, and dysfunctional behavior of forensic psychiatric patients? To investigate this question, first a literature review is offered on music therapy and anger management in forensic psychiatry. Then, an explorative study is presented. In the study, a pre- and post-test design was used with a random assignment of patients to either treatment or control condition. Fourteen participants’ complete datasets were collected. All participants received “treatment as usual.” Nine of the participants received a standardized, music therapy anger management program; the five controls received, unplanned, an aggression management program. Results suggested that anger management skills improved for all participants. The improvement of positive coping skills and diminishing of avoidance as a coping skill were measured to show greater changes in music therapy participants. When controlling for the exact number of treatment hours, the outcomes suggested that music therapy might accelerate the process of behavioral changes

Accelerating dynamics of collective attention

The impacts of technological development on social sphere lack strong empirical foundation. Here the authors presented quantitative analysis of the phenomenon of social acceleration across a range of digital datasets and found that interest appears in bursts that dissipate on decreasing timescales and occur with increasing frequency

Intuitive geometry and visuospatial working memory in children showing symptoms of nonverbal learning disabilities.

Visuospatial working memory (VSWM) and intuitive geometry were examined in two groups aged 11-13, one with children displaying symptoms of nonverbal learning disability (NLD; n = 16), and the other, a control group without learning disabilities (n = 16). The two groups were matched for general verbal abilities, age, gender, and socioeconomic level. The children were presented with simple storage and complex-span tasks involving VSWM and with the intuitive geometry task devised by Dehaene, Izard, Pica, and Spelke (2006 ). Results revealed that the two groups differed in the intuitive geometry task. Differences were particularly evident in Euclidean geometry and in geometrical transformations. Moreover, the performance of NLD children was worse than controls to a larger extent in complex-span than in simple storage tasks, and VSWM differences were able to account for group differences in geometry. Finally, a discriminant function analysis confirmed the crucial role of complex-span tasks involving VSWM in distinguishing between the two groups. Results are discussed with reference to the relationship between VSWM and mathematics difficulties in nonverbal learning disabilities

Persoonlijkheidspathologie, slachtofferschap vóór het 18e levensjaar, huiselijk geweld en delict informatie in een klinische groep terbeschikkinggestelden

Dit is een vervolgonderzoek op het landelijk onderzoek huiselijk geweld in 2010 (zie: Meer informatie) om nog openstaande vragen te beantwoorden. Dit zijn de onderzoeksvragen die in deze deelrapportage beantwoord worden:Is er sprake van slachtofferschap (mishandeling en verwaarlozing) in de jeugd bij tbs-patiënten?Welke psychopathologie vinden we bij psychotische patiënten en patiënten met persoonlijkheidsstoornissen?Is er een verband tussen slachtofferschap vóór het 18e levensjaar en huiselijk geweld in de volwassenheid? Differentieert slachtofferschap naar type delict en differentieert het plegen van huiselijk geweld met het persoonlijkheidsprofiel?Is er verband tussen het indexdelict en het plegen van huiselijk geweld en tussen het indexdelict en slachtofferschap? De andere deelonderzoeksrapportages zijn te vinden bij: Meer informatie