Evolving a DSL implementation

Domain Specific Languages (DSLs) are small languages designed for use in a specific domain. DSLs typically evolve quite radically throughout their lifetime, but current DSL implementation approaches are often clumsy in the face of such evolution. In this paper I present a case study of an DSL evolving in its syntax, semantics, and robustness, implemented in the Converge language. This shows how real-world DSL implementations can evolve along with changing requirements

Neurons characterization in the cerebral ganglia of the green-lipped mussel, Perna canaliculus, using antibodies raised against neuropeptides and neurotransmitters involved in gastropod egg-laying behaviour and bivalve reproduction and spawning

Immunohistochemical techniques were used to characterise central neurons in the cerebral ganglia of both male and female Perna canaliculus. We used mollusc antibodies raised against neuropeptides and neurotransmitters known to control reproduction and spawning. Anti-ELH and anti-APGWamide showed very strong immunoreactivity in small type of neurons. Anti-5-HT and anti-DA immunoreactivity was mostly in large type of neurons. The labelled neurons are consistent with descriptions of neurosecretory cells implicated in the control of reproduction and spawning on the basis of earlier histological staining techniques used in this species. The use of selective immunological markers for peptides and amines appears to be a promising tool for further characterisation of neurosecretory cells, and to isolate and characterise neuropeptides and other biologically active materials involved in the control of reproduction in Perna canaliculus

Understanding the lived experience of Long Covid: A rapid literature review

Long-Covid (LC), as a patient-defined illness, has rapidly emerged as both a medical and social issue since 2020, drawing headlines in the public and global domain. In the UK, people experiencing ongoing symptoms of Covid after the initial infection came together online to try to make sense and gain recognition of their condition. Academic research into LC is constantly evolving and seeks to understand the illness from the perspective of those suffering from it. We conducted a rapid literature review to explores existing studies into LC (up to August 2021), capturing the narratives of people who have adapted to live with LC. The literature largely focuses on providing an initial understanding of LC, how the illness emerged, and the fluctuating symptoms managed by those with LC. Although the literature is predominantly descriptive and has a lack of focus on the ongoing experiences of LC, narratives of making sense of, managing, and living with the illness over time are brought forward. In this briefing paper, we will present such narratives to shed light on the stories of those living with LC, and further to think more theoretically to understand the lived experiences of LC and their impact on the multifaceted aspects of LC patients’ lives

EOM sideband phase characteristics for the spaceborne gravitational wave detector LISA

The Laser Interferometer Space Antenna (LISA) is a joint ESA/NASA mission proposed to observe gravitational waves. One important noise source in the LISA phase measurement will be on-board reference oscillators. An inter-spacecraft clock tone transfer chain will be necessary to remove this non-negligible phase noise in post processing. One of the primary components of this chain are electro-optic modulators (EOMs). At modulation frequencies of 2 GHz, we characterise the excess phase noise of a fibre-coupled integrated EOM in the LISA measurement band (0.1 mHz to 1 Hz). The upper phase noise limit was found to be almost an order of magnitude better than required by the LISA mission. In addition, the EOM's phase dependence on temperature and optical power was determined. The measured coefficients are within a few milliradians per kelvin and per watt respectively and thereby negligible with the expected on-board temperature and laser power stability.DLR/50 OQ 0601DFG/EXC/QUES

Phase noise contribution of EOMs and HF cables

Two key components of LISA's inter-spacecraft clock tone transfer chain are electro-optic modulators (EOMs) and high-frequency (HF) cable assemblies. At modulation frequencies of 2 GHz, we characterized the excess phase noise of these components in the LISA frequency range (0.1 mHz to 1 Hz). The upper phase noise limit was found to be almost an order of magnitude better than required. In addition, phase dependencies on temperature were determined. The measured coefficients are within a few milliradians per Kelvin and thereby negligible due to the specified on-board temperature stability

Nucleosomes in colorectal cancer patients during radiochemotherapy

Apoptotic markers and tumor-associated antigens might be suitable to indicate the response to radiochemotherapy early. We analyzed the courses of nucleosomes, CEA, CA 19-9 and CYFRA 21-1 in 25 colorectal cancer patients during radiochemotherapy (4 postoperative, 13 preoperative, 8 local relapse therapy). Blood was taken before therapy, daily during the first week, once weekly during the following weeks, and at the end of the radiochemotherapy. After a temporary decline 6 h after the first irradiation, nucleosomes rose in most patients rapidly reaching a maximum during the first days which was followed by a subsequent decrease. In patients receiving postoperative therapy after complete resection of tumor, nucleosome levels generally were lower than in patients with preoperative or relapse therapy. Correspondingly, CEA, CA 19-9 and CYFRA 21-1 levels of postoperatively treated patients were the lowest whereas those with tumor relapse had the highest ones. During preoperative therapy, lower nucleosome concentrations were found in patients with response to therapy resulting in a smaller area under the curve of days 1-3 (AUC) than in those with progressive disease (p = 0.028). The other parameters did not indicate the response to therapy at the initial treatment phase. In conclusion, the course of nucleosomes (AUC) might be valuable for the early prediction of therapy response in preoperatively treated colorectal cancer patients. Copyright (c) 2006 S. Karger AG, Basel

A Demonstration of LISA Laser Communication

Over the past few years questions have been raised concerning the use of laser communications links between sciencecraft to transmit phase information crucial to the reduction of laser frequency noise in the LISA science measurement. The concern is that applying medium frequency phase modulations to the laser carrier could compromise the phase stability of the LISA fringe signal. We have modified the table-top interferometer presented in a previous article by applying phase modulations to the laser beams in order to evaluate the effects of such modulations on the LISA science fringe signal. We have demonstrated that the phase resolution of the science signal is not degraded by the presence of medium frequency phase modulations.Comment: minor corrections found in the CQG versio

Creation of solitons and vortices by Bragg reflection of Bose-Einstein condensates in an optical lattice

We study the dynamics of Bose-Einstein condensates in an optical lattice and harmonic trap. The condensates are set in motion by displacing the trap and initially follow simple semiclassical paths, shaped by the lowest energy band. Above a critical displacement, the condensate undergoes Bragg reflection. For high atom densities, the first Bragg reflection generates a train of solitons and vortices, which destabilize the condensate and trigger explosive expansion. At lower densities, soliton and vortex formation requires multiple Bragg reflections, and damps the center-of-mass motion.Comment: 5 pages including 5 figures (for higher resolution figures please email the authors