487 research outputs found
Impaired regulation of emotion: Neural correlates of reappraisal and distraction in bipolar disorder and unaffected relatives
Deficient emotion regulation has been proposed as a crucial pathological mechanism in bipolar disorder (BD). We therefore investigated emotion regulation impairments in BD, the related neural underpinnings and their etiological relevance for the disorder. Twenty-two euthymic patients with bipolar-I disorder and 17 unaffected first-degree relatives of BD-I patients, as well as two groups of healthy gender-, age- and education-matched controls (N=22/17, respectively) were included. Participants underwent functional magnetic resonance imaging while applying two different emotion regulation techniques, reappraisal and distraction, when presented with emotional images. BD patients and relatives showed impaired downregulation of amygdala activity during reappraisal, but not during distraction, when compared with controls. This deficit was correlated with the habitual use of reappraisal. The negative connectivity of amygdala and orbitofrontal cortex (OFC) observed during reappraisal in controls was reversed in BD patients and relatives. There were no significant differences between BD patients and relatives. As being observed in BD patients and unaffected relatives, deficits in emotion regulation through reappraisal may represent heritable neurobiological abnormalities underlying BD. The neural mechanisms include impaired control of amygdala reactivity to emotional stimuli and dysfunctional connectivity of the amygdala to regulatory control regions in the OFC. These are, thus, important aspects of the neurobiological basis of increased vulnerability for BD
Spectral constraints on unidentified EGRET gamma-ray sources from COMPTEL MeV observations
We investigated the MeV properties of 173 unidentified or only tentatively
identified EGRET sources listed in the third EGRET catalogue, by analyzing the
simultaneously collected COMPTEL MeV data for each individual source. The
sources can generally be divided into 4 groups. In this paper we focus on one
of these, a group of 22 EGRET sources for which we can provide additional
constraining information: their spectral extrapolations from the energy range
above 100 MeV towards lower energies overshoot the fluxes or upper limits
derived simultaneously at MeV energies. This means that for these sources a
spectral turnover/break between 1 MeV and 100 MeV is required. At least two of
these sources, but most likely the majority of this sample, have the maxima of
their gamma-ray luminosities in this energy band. The sources have rather soft
EGRET spectra (average photon index: 2.72), and seem to spatially cluster in
the inner Galaxy. Variability analyses revealed 11 out of the 22 sources to be
significantly variable. Object classes proposed as possible counterparts for
the unidentified EGRET sources are discussed in the light of these additional
constraints.Comment: 9 pages including 4 figures; A&A accepte
An Unidentified Variable Gamma-Ray Source near the Galactic Plane Detected by COMPTEL
We report the detection of an unidentified gamma-ray source near the Galactic plane by the COMPTEL experiment aboard the Compton Gamma-Ray Observatory. The source is detected at a significance level of ~ 7.2 sigma in the energy range 1-3 MeV and at ~ 4.6 sigma in the lower 0.75-1 MeV band in the time period March to July 1995. At energies above 3 MeV are only marginal hints or upper limits obtained. The MeV spectrum has a soft shape. Strong flux variability is found within one year at energies below 3 MeV. Possible counterparts of galactic and extragalactic nature are discussed
The COMPTEL instrumental line background
The instrumental line background of the Compton telescope COMPTEL onboard the
Compton Gamma-Ray Observatory is due to the activation and/or decay of many
isotopes. The major components of this background can be attributed to eight
individual isotopes, namely 2D, 22Na, 24Na, 28Al, 40K, 52Mn, 57Ni, and 208Tl.
The identification of instrumental lines with specific isotopes is based on the
line energies as well as on the variation of the event rate with time,
cosmic-ray intensity, and deposited radiation dose during passages through the
South-Atlantic Anomaly. The characteristic variation of the event rate due to a
specific isotope depends on its life-time, orbital parameters such as the
altitude of the satellite above Earth, and the solar cycle. A detailed
understanding of the background contributions from instrumental lines is
crucial at MeV energies for measuring the cosmic diffuse gamma-ray background
and for observing gamma-ray line emission in the interstellar medium or from
supernovae and their remnants. Procedures to determine the event rate from each
background isotope are described, and their average activity in spacecraft
materials over the first seven years of the mission is estimated.Comment: accepted for publication in A&A, 22 pages, 21 figure
INTEGRAL and XMM-Newton observations towards the unidentified MeV source GRO J1411-64
The COMPTEL unidentified source GRO J1411-64 was observed by INTEGRAL, and
its central part, also by XMM-Newton. The data analysis shows no hint for new
detections at hard X-rays. The upper limits in flux herein presented constrain
the energy spectrum of whatever was producing GRO J1411-64, imposing, in the
framework of earlier COMPTEL observations, the existence of a peak in power
output located somewhere between 300-700 keV for the so-called low state. The
Circinus Galaxy is the only source detected within the 4 location error
of GRO J1411-64, but can be safely excluded as the possible counterpart: the
extrapolation of the energy spectrum is well below the one for GRO J1411-64 at
MeV energies. 22 significant sources (likelihood ) were extracted and
analyzed from XMM-Newton data. Only one of these sources, XMMU
J141255.6-635932, is spectrally compatible with GRO J1411-64 although the fact
the soft X-ray observations do not cover the full extent of the COMPTEL source
position uncertainty make an association hard to quantify and thus risky. The
unique peak of the power output at high energies (hard X-rays and gamma-rays)
resembles that found in the SED seen in blazars or microquasars. However, an
analysis using a microquasar model consisting on a magnetized conical jet
filled with relativistic electrons which radiate through synchrotron and
inverse Compton scattering with star, disk, corona and synchrotron photons
shows that it is hard to comply with all observational constrains. This and the
non-detection at hard X-rays introduce an a-posteriori question mark upon the
physical reality of this source, which is discussed in some detail
The all-sky distribution of 511 keV electron-positron annihilation emission
We present a map of 511 keV electron-positron annihilation emission, based on
data accumulated with the SPI spectrometer aboard ESA's INTEGRAL gamma-ray
observatory, that covers approximately 95% of the celestial sphere. 511 keV
line emission is significantly detected towards the galactic bulge region and,
at a very low level, from the galactic disk. The bulge emission is highly
symmetric and is centred on the galactic centre with an extension of 8 deg. The
emission is equally well described by models that represent the stellar bulge
or halo populations. The disk morphology is only weakly constrained by the
present data, being compatible with both the distribution of young and old
stellar populations. The 511 keV line flux from the bulge and disk components
is 1.05e-3 ph cm-2 s-1 and 0.7e-3 ph cm-2 s-1, respectively, corresponding to a
bulge-to-disk flux ratio in the range 1-3. Assuming a positronium fraction of
0.93 this translates into annihilation rates of 1.5e43 s-1 and 3e42 s-1,
respectively. The ratio of the bulge luminosity to that of the disk is in the
range 3-9. We find no evidence for a point-like source in addition to the
diffuse emission, down to a typical flux limit of 1e-4 ph cm-2 s-1. We also
find no evidence for the positive latitude enhancement that has been reported
from OSSE measurements; our 3 sigma upper flux limit for this feature is 1.5e-4
ph cm-2 s-1. The disk emission can be attributed to the beta+ decay of the
radioactive species 26Al and 44Ti. The bulge emission arises from a different
source which has only a weak or no disk component. We suggest that Type Ia
supernovae and/or low-mass X-ray binaries are the prime candidates for the
source of the galactic bulge positrons. Light dark matter annihilation could
also explain the observed 511 keV bulge emission characteristics.Comment: accepted for publication in A&
INTEGRAL/XMM views on the MeV source GRO J1411-64
The COMPTEL unidentified source GRO J 1411-64 was observed by INTEGRAL and
XMM-Newton in 2005. The Circinus Galaxy is the only source detected within the
4 location error of GRO J1411-64, but in here excluded as the possible
counterpart. At soft X-rays, 22 reliable and statistically significant sources
(likelihood ) were extracted and analyzed from XMM-Newton data. Only one
of these sources, XMMU J141255.6 -635932, is spectrally compatible with GRO
J1411-64 although the fact the soft X-ray observations do not cover the full
extent of the COMPTEL source position uncertainty make an association hard to
quantify and thus risky. At the best location of the source, detections at hard
X-rays show only upper limits, which, together with MeV results obtained by
COMPTEL suggest the existence of a peak in power output located somewhere
between 300-700 keV for the so-called low state. Such a spectrum resembles
those in blazars or microquasars, and might suggest at work by a similar
scenario.
However, an analysis using a microquasar model consisting on a magnetized
conical jet filled with relativistic electrons, shows that it is hard to comply
with all observational constrains. This fact and the non-detection at hard
X-rays introduce an a-posteriori question mark upon the physical reality of
this source, what is discussed here.Comment: Accepted for publication in Astrophysics and Space Science, as
proceedings of "The Multi-Messenger Approach to High-Energy Gamma-Ray
Sources", Barcelona, July 4-7, 2006, J. M. Paredes, O. Reimer, and D. F.
Torres, editor
Внедрение корпоративной системы управления проектами для реализации стратегических проектов компании
В целях реализации Восточной газовой программы ООО "Газпром трансгаз Томск" разработало Стратегию развития до 2020 г. и План организационно-технических мероприятий. Для успешного выполнения перспективных задач в организации формируется новая, современная система управления - корпоративная система управления проектами. Разработана методика внедрения корпоративной системы управления проектами, состав системы, определены ключевые участники и критические факторы успеха, выполнен расчет экономической эффективности проекта
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