Extremely low long‐term erosion rates around the Gamburtsev Mountains in interior East Antarctica

The high elevation and rugged relief (>3 km) of the Gamburtsev Subglacial Mountains (GSM) have long been considered enigmatic. Orogenesis normally occurs near plate boundaries, not cratonic interiors, and large‐scale tectonic activity last occurred in East Antarctica during the Pan‐African (480–600 Ma). We sampled detrital apatite from Eocene sands in Prydz Bay at the terminus of the Lambert Graben, which drained a large pre‐glacial basin including the northern Gamburtsev Mountains. Apatite fission‐track and (U‐Th)/He cooling ages constrain bedrock erosion rates throughout the catchment. We double‐dated apatites to resolve individual cooling histories. Erosion was very slow, averaging 0.01–0.02 km/Myr for >250 Myr, supporting the preservation of high elevation in interior East Antarctica since at least the cessation of Permian rifting. Long‐term topographic preservation lends credence to postulated high‐elevation mountain ice caps in East Antarctica since at least the Cretaceous and to the idea that cold‐based glaciation can preserve tectonically inactive topography

Three-State Feshbach Resonances Mediated By Second-Order Couplings

We present an analytical study of three-state Feshbach resonances induced by second-order couplings. Such resonances arise when the scattering amplitude is modified by the interaction with a bound state that is not directly coupled to the scattering state containing incoming flux. Coupling occurs indirectly through an intermediate state. We consider two problems: (i) the intermediate state is a scattering state in a distinct open channel; (ii) the intermediate state is an off-resonant bound state in a distinct closed channel. The first problem is a model of electric-field-induced resonances in ultracold collisions of alkali metal atoms [Phys. Rev. A 75, 032709 (2007)] and the second problem is relevant for ultracold collisions of complex polyatomic molecules, chemical reaction dynamics, photoassociation of ultracold atoms, and electron - molecule scattering. Our analysis yields general expressions for the energy dependence of the T-matrix elements modified by three-state resonances and the dependence of the resonance positions and widths on coupling amplitudes for the weak-coupling limit. We show that the second problem can be generalized to describe resonances induced by indirect coupling through an arbitrary number of sequentially coupled off-resonant bound states and analyze the dependence of the resonance width on the number of the intermediate states.Comment: 27 pages, 4 figures; added a reference; journal reference/DOI refer to final published version, which is a shortened and modified version of this preprin

Polypill for prevention of cardiovascular disease in an Urban Iranian population with special focus on nonalcoholic steatohepatitis: A pragmatic randomized controlled trial within a cohort (PolyIran - Liver) – Study protocol

Background: Cardiovascular disease (CVD) is among the most common causes of mortality in all populations. Nonalcoholic steatohepatitis is a common finding in patients with CVD. Prevention of CVD in individual patients typically requires periodic clinical evaluation, as well as diagnosis and management of risk factors such as hypertension and hyperlipidemia. However, this is resource consuming and hard to implement, especially in developing countries. We designed a study to investigate the effects of a simpler strategy: a fixed-dose combination pill consisting of aspirin, valsartan, atorvastatin and hydrochlorthiazide (PolyPill) in an unselected group of persons aged over 50 years. Design: The PolyIran-Liver study was performed in Gonbad city as an open label pragmatic randomized controlled trial nested within the Golestan Cohort Study. We randomly selected 2,400 cohort study participants aged above 50 years, randomly assigned them to intervention or usual care and invited them to participate in an additional measurement study (if they met the eligibility criteria) to measure liver related outcomes. Those agreeing and randomized to the intervention arm were offered a daily single dose of PolyPill. We will follow participants for 5 years. The primary outcome is major cardiovascular events, secondary outcomes include all-cause mortality and liver related outcomes: liver stiffness and liver enzyme levels. Cardiovascular outcomes and mortality will be determined from the cohort study and liver-related outcomes in those consenting to follow up. Analysis will be by allocated group. Trial Status: Between October and December 2011, 1,320 intervention and 1,080 control participants were invited to participate in the additional measurement study. For all these participants, the major cardiovascular events will be determined using blind assessment of outcomes through the cohort study. In the intervention and control arms, 875 (66%) and 721 (67%) respectively, met the eligibility criteria and agreed to participate in the additional measurement study. Liver related outcomes will be measured in these participants. Of the 1,320 participants randomized to the intervention, 787 (60%) accepted the PolyPill. Conclusion: The PolyIran-liver urban study will provide us with important information on the effectiveness of PolyPill on major cardiovascular events, all-cause mortality and liver related outcomes. (ClinicalTrials.gov ID: NCT01245608). © 2015, Academy of Medical Sciences of I.R. Iran. All rights reserved

Paleointensity Record From the 2.7 Ga Stillwater Complex, Montana

The record of geomagnetic intensity captured in the 2.7 Ga Stillwater Complex (Montana, USA) provides a statistical description of the Archean geodynamo. We present results of modified Thellier paleointensity experiments on 441 core specimens, 114 of which pass strict reliability criteria. The specimens are from 53 sites spanning most of the Banded Series rocks in the Stillwater Complex. On the basis of thermochronologic and petrologic evidence, we interpret the highest temperature component of remanence to be a late Archean thermoremanence, though the possibility remains that it is a thermochemical remanence. Thermal models indicate that the highest temperature magnetization component at each of the sites averages ∼20–200 ka of geomagnetic secular variation. The suite of sites as distributed through the Banded Series samples a roughly a 1 Ma time interval. The average of the most reliable paleointensity measurements, uncorrected for the effects of anisotropy or cooling rate, is 38.2 ± 11.3 μT (1σ). Remanence anisotropy, cooling rate, and the nonlinear relationship between applied field and thermoremanence have a significant effect on paleointensity results; a corrected average of 30.6 ± 8.8 μT is likely a more appropriate value. Earth\u27s average dipole moment during the late Archean (5.05 ± 1.46 × 1022Am2, λpmag = 44.5°) was well within the range of estimates from Phanerozoic rocks. The distribution of site-mean paleointensities around the mean is consistent with that expected from slow cooling over timescales expected from thermal models and with secular variation comparable to that of the Phanerozoic field

Beyond the veil: Inner horizon instability and holography

We show that scalar perturbations of the eternal, rotating BTZ black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship. Because of backscattering from the geometry, plane wave modes have a divergent stress tensor at the event horizon, but suitable wavepackets avoid this difficulty, and are dominated at late times by quasinormal behavior. The wavepackets have cuts in the complexified coordinate plane that are controlled by requirements of continuity, single-valuedness and positive energy. Due to a focusing effect, regular wavepackets nevertheless have a divergent stress-energy at the inner horizon, signaling an instability. This instability, which is localized behind the event horizon, is detected holographically as a breakdown in the semiclassical computation of dual CFT expectation values in which the analytic behavior of wavepackets in the complexified coordinate plane plays an integral role. In the dual field theory, this is interpreted as an encoding of physics behind the horizon in the entanglement between otherwise independent CFTs.Comment: 40 pages, LaTeX, 3 eps figures, v2: references adde

Stratigraphy of the Pleistocene, phonolitic Cão Grande Formation on Santo Antão, Cape Verde

Highlights: • Two new phonolitic tephra units complementing the two previously known. • First radiometric ages of the CGF. • Contemporaneously evolution of the CGF and the Tope de Coroa. • Marine correlations improve tephra volume estimations for CG I and II. Abstract: The Cão Grande Formation (CGF) on the western plateau of Santo Antão Island is part of the younger volcanic sequence that originated from both, basanitic and nephelinitic magmatic suites, respectively called COVA and COROA suites. Based on our detailed revised stratigraphy of the CGF, including two yet unknown tephra units, we can show that both suites produced multiple, highly differentiated eruptions over a contemporaneous period. Correlations of CGF tephras with marine ash layers provide distal dispersal data for Cão Grande I (CG I) and also identify two highly explosive, phonolitic eruptions that pre-date the CGF tephra deposits known on land. Within the CGF, the lowermost, 220±7 ka old unit Canudo Tephra (CT; COVA suite) comprises phonolitic fall deposits and ignimbrites; it is partly eroded and overlain by debris flow deposits marking a hiatus in highly differentiated eruptions. The phonolitic CG I Tephra (COROA suite) consists of an initial major plinian fall deposit and associated ignimbrite and terminal surge deposits. This is immediately overlain by the phonolitic to phono-tephritic Cão Grande II (CG II; COVA suite), a complex succession of numerous fallout layers and density-current deposits. CG I and CG II have radiometric ages of 106±3 ka and 107±15 ka, respectively, that are identical within their error limits. The youngest CGF unit, the Furninha Tephra (FT; COROA suite), consists of three foidic-phonolitic fall deposits interbedded with proximal scoria deposits from a different vent. The phonolitic eruptions switched to and fro between both magmatic suites, in each case with a stronger first followed by a weaker second eruption. Each eruption evolved from stable to unstable eruption columns. During their terminal phases, both magma systems also leaked evolved dome-forming lavas next to the tephras. Distal ashes increase the CG I tephra volume to ~ 10 km3, about twice the previously published estimate. The tephra volume of CG II is ~ 3 km3; CT and FT are too poorly exposed for volume estimation. The characteristics of the CGF tephra units outline hazard conditions that may be expected from future evolved explosive eruptions on the western plateau of Santo Antão

Lay support for pregnant women with social risk: a randomised controlled trial

Objectives We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families. Design Prospective, pragmatic, individually randomised controlled trial. Setting 3 Maternity Trusts in West Midlands, UK. Participants Following routine midwife systematic assessment of social risk factors, 1324 nulliparous women were assigned, using telephone randomisation, to standard maternity care, or addition of referral to a Pregnancy Outreach Worker (POW) service. Those under 16 years and teenagers recruited to the Family Nurse Partnership trial were excluded. Interventions POWs were trained to provide individual support and case management for the women including home visiting from randomisation to 6 weeks after birth. Standard maternity care (control) included provision for referring women with social risk factors to specialist midwifery services, available to both arms. Main outcome measures Primary outcomes were antenatal visits attended and Edinburgh Postnatal Depression Scale (EPDS) 8–12 weeks postpartum. Prespecified, powered, subgroup comparison was among women with 2 or more social risks. Secondary outcomes included maternal and neonatal birth outcomes; maternal self-efficacy, and mother-to-infant bonding at 8–12 weeks; child development assessment at 6 weeks, breastfeeding at 6 weeks, and immunisation uptake at 4 months, all collected from routine child health systems. Results Antenatal attendances were high in the standard care control and did not increase further with addition of the POW intervention (10.1 vs 10.1 (mean difference; MD) −0.00, 95% CI (95% CI −0.37 to 0.37)). In the powered subgroup of women with 2 or more social risk factors, mean EPDS (MD −0.79 (95% CI −1.56 to −0.02) was significantly better, although for all women recruited, no significant differences were seen (MD −0.59 (95% CI −1.24 to 0.06). Mother-to-infant bonding was significantly better in the intervention group for all women (MD −0.30 (95% CI −0.61 to −0.00) p=0.05), and there were no differences in other secondary outcomes. Conclusions This trial demonstrates differences in depressive symptomatology with addition of the POW service in the powered subgroup of women with 2 or more social risk factors. Addition to existing evidence indicates benefit from lay interventions in preventing postnatal depression. This finding is important for women and their families given the known effect of maternal depression on longer term childhood outcomes

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Acknowledgements The authors wish to thank the women who participated in the PROSPECT study. We also thank Margaret MacNeil for her secretarial support and data management; Dawn McRae and Lynda Constable for their trial management support; the programming team in CHaRT, led by Gladys McPherson; members of the Project Management Group for their ongoing advice and support of the study; and the staff at the recruitment sites who facilitated the recruitment, treatment and follow up of study participants.Peer reviewedPublisher PD

Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1-dioxides

Sixteen new isothiazoloisoxazole 1,1-dioxides, one new isothiazolotriazole and one new isothiazolopyrazole have been synthesised by using 1,3-dipolar cycloadditions to isothiazole 1,1-dioxides. One sub-set of these isothiazoloisoxazoles showed low μM activity against a human breast carcinoma cell line, whilst a second sub-set plus the isothiazolotriazole demonstrated an interesting restricted rotation of sterically hindered bridgehead substituents. A thiazete 1,1-dioxide produced from one of the isothiazole 1,1-dioxides underwent conversion into an unknown 1,2,3-oxathiazolin-2-oxide upon treatment with Lewis acids, but was inert towards 1,3-dipoles and cyclopropenones. Six supporting crystal structures are included

Strings in extremal BTZ black holes

We study the spectrum of the worldsheet theory of the bosonic closed string in the massless and extremal rotating BTZ black holes. We use a hyperbolic Wakimoto representation of the SL(2,R) currents to construct vertex operators for the string modes on these backgrounds. We argue that there are tachyons in the twisted sector, but these are not localised near the horizon. We study the relation to the null orbifold in the limit of vanishing cosmological constant. We also discuss the problem of extending this analysis to the supersymmetric case.Comment: 20 pages, no figure