Comparative Account on Proliferation Rate of Microalgae Used in Biodiesel Production by Indigenously Prepared Bioreactors

Algae as a feedstock is emerging at the forefront of biofuel research due to increasing awareness of global energy issues in conjunction with the production limitation of agriculture based oilseed crops. In this concern, India is lagging behind with respect to research emphasis. The long term Research and development strategies were implemented in the developing countries for biofuels from different sources. One of the most fascinating areas of researcher always remained with algae as a source of biofuel. All the above the more research than development will be required in this field. This paper focuses the comparative Proliferation rate of Chlorophycean algae in indigenously prepared bioreactors as well as drinking bottled models

Private 5G, “Not As Private As You May Think”

As the need grows for mobile solutions that can offer more data throughput with ultra-reliable low-latency communications and better connection density—albeit at risk—private 5G networks and the shift to Industry 4.0 are gaining pace. As 5G technology develops and enterprises start implementing it, they need to be cautious during this transitional phase to make sure they are cognizant of and control risk as their attack surface changes. Many private 5G deployments use 4G/LTE Core networks in Non-Stand-Alone mode, which keeps many of the same vulnerabilities that have been there for years. As a result, private 5G is frequently not fully 5G pure. In this research paper, a few of the present-day weaknesses in the Stream Control Transmission and GPRS Tunnelling protocols—as well as the Industrial Control System protocols—that businesses need to be aware of and safeguard while using these technologies are discussed and shown

Comparative Account on Proliferation Rate of Microalgae Used in Biodiesel Production by Indigenously Prepared Bioreactors

Algae as a feedstock is emerging at the forefront of biofuel research due to increasing awareness of global energy issues in conjunction with the production limitation of agriculture based oilseed crops. In this concern, India is lagging behind with respect to research emphasis. The long term Research and development strategies were implemented in the developing countries for biofuels from different sources. One of the most fascinating areas of researcher always remained with algae as a source of biofuel. All the above the more research than development will be required in this field. This paper focuses the comparative Proliferation rate of Chlorophycean algae in indigenously prepared bioreactors as well as drinking bottled models

Overview of GINIX and Top-k Method

In today’s life more applications are web based and peoples may communicate with each other by using Internet. It involves more and more data retrieval from database system as per user demand. Inverted Index is a system use for searching in which searching is takes place as per index sequentially. So it require more time for searching. While Ginix can search as per word in which all files or related document that word is search appropriately. But it only search documents file which are save in database system but not search multimedia files. Hence the more competent technique for searching is top-k method in which all database is scan for finding appropriate result for given data. Also data is search on web pages. It provides more perfect result within less time as compare to Ginix. DOI: 10.17762/ijritcc2321-8169.15011

Impact of Occupational Stress and Its Associated Factors on Cognitive, Hormonal and Stress Responsive Protein in Mining Based Industrial Workers

Rapid globalization and technological advances have transformed the way of working. Occupational stress is psychological and physical condition that has potential to worsen a person’s health in any workplace. Stress related productivity impairment were common in mining industries. Lack of skills, organizational issues, and a social support at workplace can all cause workers to experience stress. Therefore, hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system are activated as part of the body’s physiological reaction. Hence chronic stress were linked to digestive, cardiovascular, atherosclerosis, and neurological issues. Numerous studies reported, several biochemical and pathophysiological factors were responsible for occupational, environmental, and workplace depression. This review chapter were included studied from PubMed, Google, book chapters, case reports, and other electronic databases, etc. Total (n = 104) articles were selected related to occupational stress and its impact on biochemical and pathophysiological were experienced in them. Workers who experienced occupational stress underwent pathophysiological changes that leads to changes in the stress hormones, sensitive stress protein and other significant variables. Finally, cortisol, stress hormones, PTH, HO-1, cytokines used as a panel of marker for stressful conditions evaluation in occupational settings. These findings, advice interventions that will be reduce, or eradicate some of these stressors in occupational settings

Mesoscopic structure conditions the emergence of cooperation on social networks

We study the evolutionary Prisoner's Dilemma on two social networks obtained from actual relational data. We find very different cooperation levels on each of them that can not be easily understood in terms of global statistical properties of both networks. We claim that the result can be understood at the mesoscopic scale, by studying the community structure of the networks. We explain the dependence of the cooperation level on the temptation parameter in terms of the internal structure of the communities and their interconnections. We then test our results on community-structured, specifically designed artificial networks, finding perfect agreement with the observations in the real networks. Our results support the conclusion that studies of evolutionary games on model networks and their interpretation in terms of global properties may not be sufficient to study specific, real social systems. In addition, the community perspective may be helpful to interpret the origin and behavior of existing networks as well as to design structures that show resilient cooperative behavior.Comment: Largely improved version, includes an artificial network model that fully confirms the explanation of the results in terms of inter- and intra-community structur

Reversible linkage of two distinct small molecule inhibitors of myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines

We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules.We synthesized two directed libraries of monomers, each comprised of a ligand, a connector, and a bioorthogonal linker element, to identify the optimal dimer configuration required to inhibit Myc. We identified combinations of monomers, termed self-assembling dimeric inhibitors, which displayed synergistic inhibition of Myc-dependent cell growth. We confirmed that these dimeric inhibitors directly bind to Myc blocking its interaction with Max and affect transcription of MYC dependent genes. Control combinations that are unable to form a dimer do not show any synergistic effects in these assays. Collectively, these data validate our new approach to generate more potent and selective inhibitors of Myc by self-assembly from smaller, lower affinity components. This approach provides an opportunity for developing novel therapeutics against Myc and other challenging protein:protein interaction (PPI) target classes. © 2015 Wanner et al

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs). Analysis of these EV miRNAs in the bio-fluids of afflicted patients represents a potential platform for biomarker development. However, the analytic algorithm for quantitative assessment of EV miRNA remains under-developed. Here, we demonstrate that the reference transcripts commonly used for quantitative PCR (including GAPDH, 18S rRNA, and hsa-miR-103) were unreliable for assessing EV miRNA. In this context, we quantitated EV miRNA in absolute terms and normalized this value to the input EV number. Using this method, we examined the abundance of miR-21, a highly over-expressed miRNA in glioblastomas, in EVs. In a panel of glioblastoma cell lines, the cellular levels of miR-21 correlated with EV miR-21 levels (p<0.05), suggesting that glioblastoma cells actively secrete EVs containing miR-21. Consistent with this hypothesis, the CSF EV miR-21 levels of glioblastoma patients (n=13) were, on average, ten-fold higher than levels in EVs isolated from the CSF of non-oncologic patients (n=13, p<0.001). Notably, none of the glioblastoma CSF harbored EV miR-21 level below 0.25 copies per EV in this cohort. Using this cut-off value, we were able to prospectively distinguish CSF derived from glioblastoma and non-oncologic patients in an independent cohort of twenty-nine patients (Sensitivity=87%; Specificity=93%; AUC=0.91, p<0.01). Our results suggest that CSF EV miRNA analysis of miR-21 may serve as a platform for glioblastoma biomarker development

Mutation-enrichment next-generation sequencing for quantitative detection of KRAS mutations in urine cell-free DNA from patients with advanced cancers

Purpose: Tumor-derived cell-free DNA (cfDNA) from urine of patients with cancer offers noninvasive biological material for detection of cancer-related molecular abnormalities such as mutations in Exon 2 of KRASExperimental Design: A quantitative, mutation-enrichment next-generation sequencing test for detecting KRASG12/G13 mutations in urine cfDNA was developed, and results were compared with clinical testing of archival tumor tissue and plasma cfDNA from patients with advanced cancer.Results: With 90 to 110 mL of urine, the KRASG12/G13 cfDNA test had an analytical sensitivity of 0.002% to 0.006% mutant copies in wild-type background. In 71 patients, the concordance between urine cfDNA and tumor was 73% (sensitivity, 63%; specificity, 96%) for all patients and 89% (sensitivity, 80%; specificity, 100%) for patients with urine samples of 90 to 110 mL. Patients had significantly fewer KRASG12/G13 copies in urine cfDNA during systemic therapy than at baseline or disease progression (P = 0.002). Compared with no changes or increases in urine cfDNA KRASG12/G13 copies during therapy, decreases in these measures were associated with longer median time to treatment failure (P = 0.03).Conclusions: A quantitative, mutation-enrichment next-generation sequencing test for detecting KRASG12/G13 mutations in urine cfDNA had good concordance with testing of archival tumor tissue. Changes in mutated urine cfDNA were associated with time to treatment failure