Updating database schemas without breaking the UI: Modeling using cognitive semantic categories

PublishedData management user interfaces are ubiquitous in information systems and web-based applications. From the oldest spreadsheet to the most modern database, end users and administrators alike have interacted with tabular data. Usually, each concept is represented by a table and columns. Change to the structure of each concept requires structural change to the tables and columns, which is costly. Tailor-made database and web applications may overcome this obstacle by designing UIs on top of the data layer, providing some degree of data independence. However, changes in their schemas do not automatically propagate into the user interface, and so their maintenance is expensive. In this paper we present a user interface that lets the end user alter the schema without the need for programming skills, eliminating the need for expensive software maintenance. To this end we propose an automatically generated user interface to include schema and data management functions. We built and evaluated an Adaptive Information System user interface (AIS UI), incorporating schema evolution functionality. In usability testing, firsttime users were able to perform various data management tasks equally fast or faster than users using Microsoft Access, and on average ̃43% faster than users using Microsoft Excel. Task completion rates using the AIS significantly exceeded those using Microsoft Access and were comparable (>95%) with those using Microsoft Excel. Copyright © 2014 ACM 978-1-4503-2725-1/14/06

Some Structural Changes Observed in the Transformation of Wood into Charcoal1

On the basis of measurements of microtomed cubes of white oak and on resultant charcoal, dimensional changes occurring on the conversion of wood into charcoal are: tangential, -25.68%, radial, -15.45%, and longitudinal, -11.43%. Light microscopic examination of charcoal reveals residues of combustion present in cell cavities. Electron microscopic examination indicates that the original fibrillar arrangement of the cell wall has been replaced with a smooth, "amorphous-appearing" wall structure

A Note on Effects of Sewage Effluent Irrigation on Specific Gravity and Growth Rate of White and Red Oaks

A 2.5-acre forested terrace of mixed hardwoods (predominately oak) in southern Missouri was sprinkler-irrigated with treated sewage effluent. Ninety-two oak trees were sampled (increment cores) at breast height. There were 41 white oaks and 52 red oaks. Growth rate increased significantly for white oaks and specific gravity increased significantly for red oaks

Growth-Quality Evaluation of Black Walnut Wood. Part II-Color Analyses of Veneer Produced on Different Sites

Heartwood color is an important wood quality parameter in the grading of black walnut veneer. One of the primary factors that causes a reduction in veneer grade is variability in heartwood color. This variability may be in the form of streaked heartwood or in coloration not of a uniform light chocolate brown nature. Black walnut trees from four distinctly different sites were selected to describe wood color of commercially prepared veneer sheets, using standard color measurement techniques, so that within-tree, between-tree, and between-site variations could be determined. Selected logs were sliced into veneer by a commercial process and the veneer was graded according to industrial standards. Reflectance data were obtained from selected veneer samples and these data were transformed into standard color parameters. Wide ranges in luminance and purity parameters were obtained. However, only the differences in luminance were detectable upon visual examination. This suggests that variability in luminance (i.e., darkness or lightness) is the primary cause of heartwood color variability. These analyses revealed statistically significant within-site differences in heartwood luminance, but within-tree differences were also observed. Between-site differences were considered less important than within-site differences

Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring

Respiratory syncytial virus (RSV) infection poses a significant risk for infants. Since the direct vaccination of infants is problematic, maternal vaccination may provide a safer, more effective approach to their protection. In the cotton rat (CR) model, we have compared the immunization of pregnant CR dams with virus-like particles assembled with the prototype mutation stabilized pre-fusion F protein, DS-Cav1, as well two alternative mutation stabilized pre-fusion proteins (UC-2 F, UC-3 F) and showed that the alternative pre-fusion F VLPs protected the offspring of immunized dams significantly better than DS-Cav1 F VLPs (Blanco, et al. J. Virol. 93: e00914). Here, we have addressed the reasons for this increased protection by characterizing the specificities of antibodies in the sera of both immunized dams and their offspring. The approach was to measure the levels of total anti-pre-F IgG serum antibodies that would block the binding of representative pre-fusion specific monoclonal antibodies to soluble pre-fusion F protein targets. Strikingly, we found that the sera in most offspring of DS-Cav1 F VLP-immunized dams had no mAb D25-blocking antibodies, although their dams had robust levels. In contrast, all offspring of UC-3 F VLP-immunized dams had robust levels of these D25-blocking antibodies. Both sets of pup sera had significant levels of mAb AM14-blocking antibodies, indicating that all pups received maternal antibodies. A lack of mAb D25-blocking antibodies in the offspring of DS-Cav1 F VLP-immunized dams may account for the lower protection of their pups from challenge compared to the offspring of UC-3 F VLP-immunized dams

Functional divergence in the role of N-linked glycosylation in smoothened signaling

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active sub-cellular localization, and the ability of vertebrate Smo to induce distinct G protein-dependent and independent signals in response to ligand. Whereas the canonical Smo signal to Gli transcriptional effectors occurs in a G protein-independent manner, its non-canonical signal employs Gαi. Whether vertebrate Smo can selectively bias its signal between these routes is not yet known. N-linked glycosylation is a post-translational modification that can influence GPCR trafficking, ligand responsiveness and signal output. Smo proteins in Drosophila and vertebrate systems harbor N-linked glycans, but their role in Smo signaling has not been established. Herein, we present a comprehensive analysis of Drosophila and murine Smo glycosylation that supports a functional divergence in the contribution of N-linked glycans to signaling. Of the seven predicted glycan acceptor sites in Drosophila Smo, one is essential. Loss of N-glycosylation at this site disrupted Smo trafficking and attenuated its signaling capability. In stark contrast, we found that all four predicted N-glycosylation sites on murine Smo were dispensable for proper trafficking, agonist binding and canonical signal induction. However, the under-glycosylated protein was compromised in its ability to induce a non-canonical signal through Gαi, providing for the first time evidence that Smo can bias its signal and that a post-translational modification can impact this process. As such, we postulate a profound shift in N-glycan function from affecting Smo ER exit in flies to influencing its signal output in mice

Vaccine Potential of Nipah Virus-Like Particles

Nipah virus (NiV) was first recognized in 1998 in a zoonotic disease outbreak associated with highly lethal febrile encephalitis in humans and a predominantly respiratory disease in pigs. Periodic deadly outbreaks, documentation of person-to-person transmission, and the potential of this virus as an agent of agroterror reinforce the need for effective means of therapy and prevention. In this report, we describe the vaccine potential of NiV virus-like particles (NiV VLPs) composed of three NiV proteins G, F and M. Co-expression of these proteins under optimized conditions resulted in quantifiable amounts of VLPs with many virus-like/vaccine desirable properties including some not previously described for VLPs of any paramyxovirus: The particles were fusogenic, inducing syncytia formation; PCR array analysis showed NiV VLP-induced activation of innate immune defense pathways; the surface structure of NiV VLPs imaged by cryoelectron microscopy was dense, ordered, and repetitive, and consistent with similarly derived structure of paramyxovirus measles virus. The VLPs were composed of all the three viral proteins as designed, and their intracellular processing also appeared similar to NiV virions. The size, morphology and surface composition of the VLPs were consistent with the parental virus, and importantly, they retained their antigenic potential. Finally, these particles, formulated without adjuvant, were able to induce neutralizing antibody response in Balb/c mice. These findings indicate vaccine potential of these particles and will be the basis for undertaking future protective efficacy studies in animal models of NiV disease

Small Angle X-ray Scattering Study of Oak Charcoals

Small angle X-ray scattering data have been used to characterize the microscopic and submicroscopic structure of oak charcoals produced at different temperatures. The specific surface has been calculated for each sample. The observed scattering is ascribed to voids in a carbon matrix. The scattering data suggest that these voids have average dimensions that fall into two groups: (1) a relatively large-scale structure that is similar to the structure of the original wood and that has dimensions of the order of microns, and (2) a much finer structure, with dimensions about 15Å. In samples prepared at low temperature, only the large-scale structure is detectable. When charcoals are prepared at temperatures above approximately 1000 F, additional voids are generated. As a result, the average dimensions of the large-scale voids are apparently reduced and a small-scale structure develops