Gastric adenomyoma

Bacground. Gastric adenomyoma is a rare, hamartomatous tumor localized most frequently in the gastric antrum. Review of the available literature shows only sporadic reports or smaller series. Case reports. We presented a 72-year-old woman admitted due to epigastric pain with dyspeptic difficulties. Biochemical parameters and tumor markers were within the referential limits. Diagnostic procedures (upper endoscopy, endoscopic ultrasonography and computerized tomography) revealed an intramural tumor prominence with intact mucosa on the posterior wall of gastric antrum, not accessible for biopsy. Surgical treatment was performed with total extirpation of the tumor. Histopathological examination verified adenomyoma with focal low grade epithelial dysplasia. Cytologic immunophenotype was consistent with smooth muscle stromal and epithelial tumor (CK7 and CK20 ++ immunophenotype). Stromal component revealed low proliferative index (Ki-67 protein immunoexpression level 3%), and p53 less than 0.1% in both epithelial and stromal components. Following the operation, the patient remained in good condition. Conclusion. Uncertain malignant potential of the gastric adenomyoma in the presented case indicates that timely diagnostics with adequate surgical treatment is crucial for an adequate treatment

Liver actinomycosis mimicking liver tumor

Background. The liver actinomycosis is a rare disease associated with complex differentiation from the liver metastases or hepatocellular carcinoma. Case report. A 50-year old immunocompetent female patient was admitted to the Surgical Department in an exhausted condition, with dyspnea, significant weight loss and intermittent fever in the recent two months. Diagnostic procedures that followed, including abdominal ultrasound and computed tomography led us to the diagnosis of metastatic liver disease of unknown etiology with pleural and pericardial effusion. Intraoperatively, the presence of liver pseudotumor without malignancy in the liver was confirmed. Histological examination confirmed the diagnosis of liver actinomycosis. Prolonged treatment with high dose penicillin was performed and all signs and symptoms resolved completely without further problems. The control abdominal ultrasound finding was normal. Conclusion. Liver actinomycosis has a nonspecific presentation, often mimicking liver tumor. A timely diagnosis as well as a combined surgical and antibiotic therapy is necessary in the treatment of patients with primary disease and prevention of complications

Geophysical and geochemical constraints on geoneutrino fluxes from Earth's mantle

Knowledge of the amount and distribution of radiogenic heating in the mantle is crucial for understanding the dynamics of the Earth, including its thermal evolution, the style and planform of mantle convection, and the energetics of the core. Although the flux of heat from the surface of the planet is robustly estimated, the contributions of radiogenic heating and secular cooling remain poorly defined. Constraining the amount of heat-producing elements in the Earth will provide clues to understanding nebula condensation and planetary formation processes in early Solar System. Mantle radioactivity supplies power for mantle convection and plate tectonics, but estimates of mantle radiogenic heat production vary by a factor of more than 20. Recent experimental results demonstrate the potential for direct assessment of mantle radioactivity through observations of geoneutrinos, which are emitted by naturally occurring radionuclides. Predictions of the geoneutrino signal from the mantle exist for several established estimates of mantle composition. Here we present novel analyses, illustrating surface variations of the mantle geoneutrino signal for models of the deep mantle structure, including those based on seismic tomography. These variations have measurable differences for some models, allowing new and meaningful constraints on the dynamics of the planet. An ocean based geoneutrino detector deployed at several strategic locations will be able to discriminate between competing compositional models of the bulk silicate Earth.Comment: 34 pages, 6 tables, 5 figures, 2 supplementary figures; revised version submitted to Earth Planet. Sci. Let

Effects of different production methods on content of some microelements in spelt seed (Triticum spelta)

Numerous worldwide studies have shown that there is a difference in the mineral composition between organically and conventionally produced plants and their products. Spelt (Triticum spelta), alternative grain from the family Poaceae, occupies a very important place in the production of healthy food. Also, spelt represents commonly grown organic crops due to the ideally balanced ratio of nutrients. In addition to the macroelements, for the survival and normal plant function some microelements are also needed. The aim of this study was to determine the existence of differences in the content of microelements and (B, Ba, Cu, Li, Mn and Se) in organically and conventionally produced spelt seeds, in period of 2015-2017. The determination of these elements was conducted by using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) with previous digestion of samples and results were expressed as mg/kg of dry weight. In samples collected during 2015 and 2016, B and Ba were not detected. In conventional spelt seed, higher quantity of Ba (2.366 mg/kg), Cu (6.356 mg/kg) and Mn (55.878 mg/kg) was determined, while organic spelt seed contained higher content of B (0.875 mg/kg), Li (14.77 mg/kg) and Se (0.275 mg/kg) compared to conventionally grown sample. The obtained results for the examined elements revealed that the lowest content in analyzed seeds was for Li (conventional seed from 2017, 0,008 mg/kg), while Mn was quantified in the highest amount (conventional seed from 2017, 55.878 mg/kg)

THE SEED VIGOUR OF SPELT PRODUCED AT THE MAIZE RESEARCH INSTITUTE “ZEMUN POLJE”

Spelt (Triticum spelta L.) has been increasingly attracting producers due to the biological properties and chemical composition of its seeds. As high-quality seeds are necessary for successful production, the vigour of organically and conventionally produced spelt seeds has been studied and results are presented in this paper. The seeds of the variety Nirvana produced by both methods at the Maize Research Institute “Zemun Polje” in 2015 were observed. According to the results, the germination energy of conventionally and organically produced seeds amounted to 30% and 69%, respectively. The total germination of conventionally and organically produced spelt seeds amounted to 99% and 93%, respectively. The percentage of abnormal seedlings of spelt produced by both methods amounted to 1% on average. The participation of diseased and dead seeds was higher in organically produced seeds (6%) than in conventionally produced seeds (0%). After the seed accelerated ageing test, a higher germination was observed in conventionally produced seeds (75%) than in organically produced seeds (68%). The electric conductivity of conventionally produced seeds amounted to 189.4 μS/cm and 195.2 μS/cm in the first and the second replication, respectively, while the values of organically produced seeds amounted to 95.5 μS/cm and 98.6 μS/cm, in the first and the second replication, respectively. The results obtained by the electrical conductivity test indicated that the conventionally produced spelt seeds (32.33 µS/cm g) were classified into the category of low vigour seeds in comparison to organically produced spelt seeds (27.65 µS/cm g). © 2022 University of Belgrade - Faculty of Agriculture. All Rights Reserved

Ocjena radne sposobnosti pacijenta s Wilsonovom bolesti - prikaz bolesnika

Wilson’s disease (WD) is a rare, progressive autosomal recessive disorder characterised by impaired transport and excessive accumulation of copper in the liver, brain, and other tissues. The disease is diagnosed based on clinical manifestations and screening tests results. Work ability assessment of patients with WD is based on the analysis of liver, kidney, neurological, and cognitive impairments, and takes into account patient’s level of education. This article presents a case with a 48-year-old male patient, who was admitted for work ability assessment due to polymorphic symptoms. The patient had been working as a salesman for 28 years. A detailed interview and examination by occupational health and other medical specialists revealed that the patient had been suffering from Wilson’s disease from the age of 13, and had now developed hepatic manifestations (compensated liver cirrhosis with portal hypertension), neurological manifestations (dystonia, dysarthria, muscle weakness, vertigo), and psychiatric manifestations (depression, insomnia, cognitive impairment) of the disease, including problems partially caused by long-lasting treatment with copper chelating agents (neurological and haematological manifestations). There were no ocular manifestations of Wilson’s disease (Kayser-Fleischer rings or sunflower cataract). The patient was assessed as having drastically diminished general work ability, dominantly due to neurological and psychiatric impairments caused by Wilson’s disease.Wilsonova je bolest rijetka, progresivna autosomno recesivna bolest karakterizirana poremećajem transporta bakra i posljedičnim prekomjernim nakupljanjem bakra u jetri, mozgu i drugim tkivima i organima. Dijagnoza bolesti postavlja se na osnovi kliničkih manifestacija bolesti i nalaza laboratorijskih ispitivanja. Ocjena radne sposobnosti pacijenata s Wilsonovom bolesti zasniva se na analizi postojanja oštećenja i stupnja oštećenja hepatičkih, neuroloških, bubrežnih i kognitivnih funkcija, kao i na analizi stupnja obrazovanja pacijenata. Prikazan je slučaj D. M., 48-godišnjeg pacijenta, koji je primljen zbog polimorfnih tegoba na bolničko ispitivanje radi ocjene radne sposobnosti. Pacijent je radio kao prodavač posljednjih 28 godina. Nakon detaljne anamneze i pregleda koje su obavili specijalisti medicine rada i drugi specijalisti utvrđeno je da pacijent boluje od Wilsonove bolesti od 13. godine života i da u ovom trenutku ima izražene hepatične manifestacije (kompenzirana ciroza jetre s portalnom hipertenzijom), neurološke manifestacije (distonija, dizartrija, mišićna slabost, vrtoglavica) i psihijatrijske manifestacije (depresija, nesanica, kognitivno oštećenje) Wilsonove bolesti, kao i da su prisutne tegobe djelomično uzrokovane dugotrajnom upotrebom kelatne terapije (neurološki i hematološki poremećaji). Nisu uočene karakteristične očne promjene Wilsonove bolesti (Kayser-Fleischerov prsten, katarakta u obliku suncokreta). Ocjenom radne sposobnosti utvrđeno je da pacijent ima drastično smanjenu radnu sposobnost pretežno zbog neuroloških i psihičkih poremećaja u sklopu Wilsonove bolesti

Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically

The present work determined complete mineral profile of four different types of grains (spelt, soybean, maize, and buckwheat) grown under two growing systems – conventional and organic. The contents of 20 macro-, micro- and trace elements were analysed in the examined grains by inductively coupled plasma-optical emission spectrometry (ICP-OES). In most samples, nine elements were present in concentrations higher than 10 mg/kg. The remaining elements were present at lower concentrations or in traces or not detected in certain samples. Aluminium and arsenic, as two toxic elements, were detected only in organic buckwheat grains. Based on the obtained results for the mineral contents, a nutritive assessment of the quality of grains of spelt, soybean, maize, and buckwheat were made. Results of nutritional assessment showed that spelt, soybean, and buckwheat grains could potentially be good sources of several minerals for human diet. On the other hand, the presence of some toxic elements, such as cadmium and strontium, should be monitored. Results of principal component analysis (PCA) and hierarchical cluster analysis (HCA) shown that the mineral composition, to a much greater extent, depended on the botanical origin of grains as compared to the production system