187 research outputs found
Propiverinium picrate
The title compound [systematic name: 4-(2,2-diphenyl-2-propoxyacetoxy)-1-methylpiperidin-1-ium picrate], C23H30NO3
+·C6H2N3O7
−, crystallizes as a salt with one cation–anion (propiverinium picrate) pair in the asymmetric unit. A significant number of conformational changes are observed between the crystalline environment of this cation–anion salt and that of a density functional theory (DFT) calculation of the geometry-optimized structure. The angle between the dihedral planes of the two benzyl rings in the propiverinium cation increases by 14.4 (0)° from that of the crystalline environment. The dihedral angles between the mean planes of each of the benzyl rings and the mean plane of the piperidine increase by 2.0 (8) and 12.3 (5)°. The angles between the mean plane of the acetate group and the mean planes of the interconnected piperidine group and the two benzyl rings decrease by 0.2 (1), 7.4 (6) and 3.2 (2)°, respectively. The mean plane of the phenolate group in the anion changes by +22.6 (9), +22.1 (1) and −2.8 (6)° from the mean planes of the piperidine and benzyl rings in the cation, respectively. In the crystal, a bifurcated N—H⋯(O,O) hydrogen bond and a weak C—H⋯π ring interaction help to establish the packing. The two O atoms of the p-NO2 group are disordered with occupancies 0.825 (10):0.175 (10)
The Interspersed Spin Boson Lattice Model
We describe a family of lattice models that support a new class of quantum
magnetism characterized by correlated spin and bosonic ordering [Phys. Rev.
Lett. 112, 180405 (2014)]. We explore the full phase diagram of the model using
Matrix-Product-State methods. Guided by these numerical results, we describe a
modified variational ansatz to improve our analytic description of the
groundstate at low boson frequencies. Additionally, we introduce an
experimental protocol capable of inferring the low-energy excitations of the
system by means of Fano scattering spectroscopy. Finally, we discuss the
implementation and characterization of this model with current circuit-QED
technology.Comment: Submitted to EPJ ST issue on "Novel Quantum Phases and Mesoscopic
Physics in Quantum Gases
The sensitivity and specificity of a diagnostic test of sequence-space synesthesia
People with sequence-space synaesthesia (SSS) report stable visuo-spatial forms corresponding to numbers, days and months (amongst others). This type of synaesthesia has intrigued scientists for over 130 years but the lack of an agreed upon tool for assessing it has held back research on this phenomenon. The present study builds on previous tests by measuring the consistency of spatial locations that is known to discriminate controls from synaesthetes. We document, for the first time, the sensitivity and specificity of such a test and suggest a diagnostic cut-off point for discriminating between the groups based on the area bounded by different placement attempts with the same item
Microsecond Time-Resolved Absorption Spectroscopy Used to Study CO Compounds of Cytochrome bd from Escherichia coli
Cytochrome bd is a tri-heme (b558, b595, d) respiratory oxygen reductase that is found in many bacteria including pathogenic
species. It couples the electron transfer from quinol to O2 with generation of an electrochemical proton gradient. We
examined photolysis and subsequent recombination of CO with isolated cytochrome bd from Escherichia coli in oneelectron
reduced (MV) and fully reduced (R) states by microsecond time-resolved absorption spectroscopy at 532-nm
excitation. Both Soret and visible band regions were examined. CO photodissociation from MV enzyme possibly causes fast
(t,1.5 ms) electron transfer from heme d to heme b595 in a small fraction of the protein, not reported earlier. Then the
electron migrates to heme b558 (t,16 ms). It returns from the b-hemes to heme d with t,180 ms. Unlike cytochrome bd in
the R state, in MV enzyme the apparent contribution of absorbance changes associated with CO dissociation from heme d is
small, if any. Photodissociation of CO from heme d in MV enzyme is suggested to be accompanied by the binding of an
internal ligand (L) at the opposite side of the heme. CO recombines with heme d (t,16 ms) yielding a transient
hexacoordinate state (CO-Fe2+
-L). Then the ligand slowly (t,30 ms) dissociates from heme d. Recombination of CO with a
reduced heme b in a fraction of the MV sample may also contribute to the 30-ms phase. In R enzyme, CO recombines to
heme d (t,20 ms), some heme b558 (t,0.2–3 ms), and finally migrates from heme d to heme b595 (t,24 ms) in ,5% of the
enzyme population. Data are consistent with the recent nanosecond study of Rappaport et al. conducted on the
membranes at 640-nm excitation but limited to the Soret band. The additional phases were revealed due to differences in
excitation and other experimental conditions
Identificación y análisis de los recursos económicos asignados a la segunda locomotora. Evolución, aciertos y desaciertos
Con la elaboración del presente documento, se pretende identificar y analizar los recursos económicos asignados a una de las locomotoras del gobierno del presidente Juan Manuel Santos en el marco de su plan de desarrollo Prosperidad para todos y el impacto social de esta asignación de recursos en el agro Colombiano, Así mismo evaluar el cumplimiento de dicha política publica y la generación de bienestar social en la población."With the production of the present document, one tries to identify and to analyze the economic resources assigned to one of the locomotives of the government of the president Juan Manuel Santos in the frame of his plan of development "" Prosperity for all "" and the social impact of this assignment of resources in the Colombian agro, Likewise to evaluate the fulfillment of the above mentioned politics publishes and the generation of social well-being in the population.
WebCARMA: a web application for the functional and taxonomic classification of unassembled metagenomic reads
Gerlach W, Jünemann S, Tille F, Goesmann A, Stoye J. WebCARMA: a web application for the functional and taxonomic classification of unassembled metagenomic reads. BMC Bioinformatics. 2009;10(1):430.Background Metagenomics is a new field of research on natural microbial communities. High-throughput sequencing techniques like 454 or Solexa-Illumina promise new possibilities as they are able to produce huge amounts of data in much shorter time and with less efforts and costs than the traditional Sanger technique. But the data produced comes in even shorter reads (35-100 basepairs with Illumina, 100-500 basepairs with 454-sequencing). CARMA is a new software pipeline for the characterisation of species composition and the genetic potential of microbial samples using short, unassembled reads. Results In this paper, we introduce WebCARMA, a refined version of CARMA available as a web application for the taxonomic and functional classification of unassembled (ultra-)short reads from metagenomic communities. In addition, we have analysed the applicability of ultra-short reads in metagenomics. Conclusions We show that unassembled reads as short as 35 bp can be used for the taxonomic classification of a metagenome. The web application is freely available at http://webcarma.cebitec.uni-bielefeld.d
Impacts of chemical gradients on microbial community structure
Succession of redox processes is sometimes assumed to define a basic microbial community structure for ecosystems with oxygen gradients. In this paradigm, aerobic respiration, denitrification, fermentation and sulfate reduction proceed in a thermodynamically determined order, known as the ‘redox tower’. Here, we investigated whether redox sorting of microbial processes explains microbial community structure at low-oxygen concentrations. We subjected a diverse microbial community sampled from a coastal marine sediment to 100 days of tidal cycling in a laboratory chemostat. Oxygen gradients (both in space and time) led to the assembly of a microbial community dominated by populations that each performed aerobic and anaerobic metabolism in parallel. This was shown by metagenomics, transcriptomics, proteomics and stable isotope incubations. Effective oxygen consumption combined with the formation of microaggregates sustained the activity of oxygen-sensitive anaerobic enzymes, leading to braiding of unsorted redox processes, within and between populations. Analyses of available metagenomic data sets indicated that the same ecological strategies might also be successful in some natural ecosystems
Global conformal anomaly in N=2 string
We show the existence of a global anomaly in the one-loop graphs of N=2
string theory, defined by sewing tree amplitudes, unless spacetime
supersymmetry is imposed. The anomaly is responsible for the non-vanishing
maximally helicity violating amplitudes. The supersymmetric completion of the
N=2 string spectrum is formulated by extending the previous cohomological
analysis with an external spin factor; the target space-time spin-statistics of
these individual fields in a selfdual background are compatible with previous
cohomological analysis as fields of arbitrary spin may be bosonized into one
another. We further analyze duality relations between the open and closed
string amplitudes and demonstrate this in the supersymmetric extension of the
target space-time theory through the insertion of zero-momentum operators.Comment: 29 pages, LaTeX, one figur
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