Embedded Stellar Populations towards Young Massive Star Formation Regions I. G305.2+0.2

We present deep, wide-field J, H and Ks images taken with IRIS2 on the Anglo Australian Telescope, towards the massive star formation region G305.2+0.2. Combined with 3.6, 4.5, 5.8 and 8.0 micron data from the GLIMPSE survey on the Spitzer Space Telescope, we investigate the properties of the embedded stellar populations. After removing contamination from foreground stars we separate the sources based on their IR colour. Strong extended emission in the GLIMPSE images hampers investigation of the most embedded sources towards the known sites of massive star formation. However, we find a sizeable population of IR excess sources in the surrounding region free from these completeness effects. Investigation reveals the recent star formation activity in the region is more widespread than previously known. Stellar density plots show the embedded cluster in the region, G305.24+0.204, is offset from the dust emission. We discuss the effect of this cluster on the surrounding area and argue it may have played a role in triggering sites of star formation within the region. Finally, we investigate the distribution of IR excess sources towards the cluster, in particular their apparent lack towards the centre compared with its immediate environs.Comment: 16 pages, 16 figures (significantly size reduced), 2 tables, accepted MNRA

Stellar Kinematics of Young Clusters in Turbulent Hydrodynamic Simulations

The kinematics of newly-formed star clusters are interesting both as a probe of the state of the gas clouds from which the stars form, and because they influence planet formation, stellar mass segregation, cluster disruption, and other processes controlled in part by dynamical interactions in young clusters. However, to date there have been no attempts to use simulations of star cluster formation to investigate how the kinematics of young stars change in response to variations in the properties of their parent molecular clouds. In this letter we report the results of turbulent self-gravitating simulations of cluster formation in which we consider both clouds in virial balance and those undergoing global collapse. We find that stars in these simulations generally have velocity dispersions smaller than that of the gas by a factor of ~ 5, independent of the dynamical state of the parent cloud, so that subvirial stellar velocity dispersions arise naturally even in virialized molecular clouds. The simulated clusters also show large-scale stellar velocity gradients of ~0.2-2 km s$^{-1}$ pc$^{-1}$ and strong correlations between the centroid velocities of stars and gas, both of which are observed in young clusters. We conclude that star clusters should display subvirial velocity dispersions, large-scale velocity gradients, and strong gas-star velocity correlations regardless of whether their parent clouds are in virial balance, and, conversely, that observations of these features cannot be used to infer the dynamical state of the parent gas clouds.Comment: 5 pages, 4 figures, accepted to ApJ

PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation

Nanomaterials have been actively pursued for biological and medical applications in recent years. Here, we report the synthesis of several new poly(ethylene glycol) grafted branched-polymers for functionalization of various nanomaterials including carbon nanotubes, gold nanoparticles (NP) and gold nanorods (NRs), affording high aqueous solubility and stability for these materials. We synthesize different surfactant polymers based upon poly-(g-glutamic acid) (gPGA) and poly(maleic anhydride-alt-1-octadecene) (PMHC18). We use the abundant free carboxylic acid groups of gPGA for attaching lipophilic species such as pyrene or phospholipid, which bind to nanomaterials via robust physisorption. Additionally, the remaining carboxylic acids on gPGA or the amine-reactive anhydrides of PMHC18 are then PEGylated, providing extended hydrophilic groups, affording polymeric amphiphiles. We show that single-walled carbon nanotubes (SWNTs), Au NPs and NRs functionalized by the polymers exhibit high stability in aqueous solutions at different pHs, at elevated temperatures and in serum. Morever, the polymer-coated SWNTs exhibit remarkably long blood circulation (t1/2 22.1 h) upon intravenous injection into mice, far exceeding the previous record of 5.4 h. The ultra-long blood circulation time suggests greatly delayed clearance of nanomaterials by the reticuloendothelial system (RES) of mice, a highly desired property for in vivo applications of nanomaterials, including imaging and drug delivery

Encounters in the ONC - observing imprints of star-disc interactions

The external destruction of protoplanetary discs in a clustered environment acts mainly due to two mechanisms: gravitational drag by stellar encounters and evaporation by strong stellar winds and radiation. If encounters play a role in disc destruction, one would expect that stars devoid of disc material would show unexpectedly high velocities as an outcome of close interactions. We want to quantify this effect by numerical simulations and compare it to observations. As a model cluster we chose the Orion Nebula Cluster (ONC). We found from the observational data that 8 to 18 stars leave the ONC with velocities several times the velocity dispersion. The majority of these high-velocity stars are young low-mass stars, among them several lacking infrared excess emission. Interestingly, the high-velocity stars are found only in two separate regions of the ONC. Our simulations give an explanation for the location of the high-velocity stars and provide evidence for a strong correlation between location and disc destruction. The high-velocity stars can be explained as the outcome of close three-body encounters; the partial lack of disc signatures is attributed to gravitational interaction. The spatial distribution of the high-velocity stars reflects the initial structure and dynamics of the ONC. Our approach can be generalized to study the evolution of other young dense star clusters, like the Arches cluster, back in time.Comment: 12 pages, 9 figures, 1 table, accepted for publication in A&A, adopted changes after review by editor

Phenotypic Plasticity of Leaf Shape along a Temperature Gradient in Acer rubrum

Both phenotypic plasticity and genetic determination can be important for understanding how plants respond to environmental change. However, little is known about the plastic response of leaf teeth and leaf dissection to temperature. This gap is critical because these leaf traits are commonly used to reconstruct paleoclimate from fossils, and such studies tacitly assume that traits measured from fossils reflect the environment at the time of their deposition, even during periods of rapid climate change. We measured leaf size and shape in Acer rubrum derived from four seed sources with a broad temperature range and grown for two years in two gardens with contrasting climates (Rhode Island and Florida). Leaves in the Rhode Island garden have more teeth and are more highly dissected than leaves in Florida from the same seed source. Plasticity in these variables accounts for at least 6–19 % of the total variance, while genetic differences among ecotypes probably account for at most 69–87 %. This study highlights the role of phenotypic plasticity in leaf-climate relationships. We suggest that variables related to tooth count and leaf dissection in A. rubrum can respond quickly to climate change, which increases confidence in paleoclimate methods that use these variables

Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors

The cancer stem cell (CSC) concept is a highly debated topic in cancer research. While experimental evidence in favor of the cancer stem cell theory is apparently abundant, the results are often criticized as being difficult to interpret. An important reason for this is that most experimental data that support this model rely on transplantation studies. In this study we use a novel cellular Potts model to elucidate the dynamics of established malignancies that are driven by a small subset of CSCs. Our results demonstrate that epigenetic mutations that occur during mitosis display highly altered dynamics in CSC-driven malignancies compared to a classical, non-hierarchical model of growth. In particular, the heterogeneity observed in CSC-driven tumors is considerably higher. We speculate that this feature could be used in combination with epigenetic (methylation) sequencing studies of human malignancies to prove or refute the CSC hypothesis in established tumors without the need for transplantation. Moreover our tumor growth simulations indicate that CSC-driven tumors display evolutionary features that can be considered beneficial during tumor progression. Besides an increased heterogeneity they also exhibit properties that allow the escape of clones from local fitness peaks. This leads to more aggressive phenotypes in the long run and makes the neoplasm more adaptable to stringent selective forces such as cancer treatment. Indeed when therapy is applied the clone landscape of the regrown tumor is more aggressive with respect to the primary tumor, whereas the classical model demonstrated similar patterns before and after therapy. Understanding these often counter-intuitive fundamental properties of (non-)hierarchically organized malignancies is a crucial step in validating the CSC concept as well as providing insight into the therapeutical consequences of this model

Dietary advice for muscularity, leanness and weight control in Men's Health magazine: a content analysis

Background: The dietary content of advice in men’s lifestyle magazines has not been closely scrutinised. Methods: We carried out an analysis of such content in all 2009 issues (n = 11) of Men’s Health (MH) focusing on muscularity, leanness and weight control. Results: Promotion of a mesomorphic body image underpinned advice to affect muscle building and control weight. Diet advice was underpinned by a strong pseudo-scientific discourse, with citation of expert sources widely used to legitimise the information. Frequently multiple dietary components were advocated within one article e.g. fat, omega-3 fatty acids, thiamine, zinc and high-glycaemic index foods. Furthermore advice would cover numerous nutritional effects, e.g. strengthening bones, reducing stress and boosting testosterone, with little contextualisation. The emphasis on attainment of a mesomorphic body image permitted promotion of slimming diets. Advice to increase calorie and protein intake to augment muscle mass was frequent (183 and 262 references, respectively). Such an anabolic diet was advised in various ways, including consumption of traditional protein foods (217 references) and sports foods (107 references), thereby replicating muscle magazines’ support for nutritional supplements. Although advice to increase consumption of red meat was common (52 references), fish and non-flesh sources of protein (eggs, nuts & pulses, and soy products) together exceeded red meat in number of recommendations (206 references). Advice widely asserted micronutrients and phytochemicals from plant food (161 references) as being important in muscle building. This emphasis diverges from stereotypical gender-based food consumption patterns. Dietary advice for control of body weight largely replicated that of muscularity, with strong endorsement to consume fruits and vegetables (59 references), diets rich in nuts and pulses and fish (66 references), as well as specific micronutrients and phytochemicals (62 references). Notably there was emphasis on fat-burning, good fats and consumption of single foods, with relatively little mention of dietary restriction. Conclusions: Despite the widespread use of scientific information to endorse dietary advice, the content, format and scientific basis of dietary content of MH leaves much to be desired. The dietary advice as provided may not be conducive to public health

Circadian function in patients with advanced non-small-cell lung cancer

This study aimed to evaluate whether patients with advanced non-small-cell lung cancer experience disrupted rest–activity daily rhythms, poor sleep quality, weakness, and maintain attributes that are linked to circadian function such as fatigue. This report describes the rest–activity patterns of 33 non-small-cell lung cancer patients who participated in a randomised clinical trial evaluating the benefits of melatonin. Data are reported on circadian function, health-related quality of life (QoL), subjective sleep quality, and anxiety/depression levels prior to randomisation and treatment. Actigraphy data, an objective measure of circadian function, demonstrated that patients' rest–activity circadian function differs significantly from control subjects. Our patients reported poor sleep quality and high levels of fatigue. Ferrans and Powers QoL Index instrument found a high level of dissatisfaction with health-related QoL. Data from the European Organization for Research and Treatment for Cancer reported poor capacity to fulfil the activities of daily living. Patients studied in the hospital during or near chemotherapy had significantly more abnormal circadian function than those studied in the ambulatory setting. Our data indicate that measurement of circadian sleep/activity dynamics should be accomplished in the outpatient/home setting for a minimum of 4–7 circadian cycles to assure that they are most representative of the patients' true condition. We conclude that the daily sleep/activity patterns of patients with advanced lung cancer are disturbed. These are accompanied by marked disruption of QoL and function. These data argue for investigating how much of this poor functioning and QoL are actually caused by this circadian disruption, and, whether behavioural, light-based, and or pharmacologic strategies to correct the circadian/sleep activity patterns can improve function and QoL