Mobile phones and wrong numbers: how Maasai agro-pastoralists form and use accidental social ties in East Africa

Mobile phones are recognized as important new tools for rural development in the Global South, but few studies have examined how phones can shape social networks. This study documents a new type of social tie, enabled by mobile phones, that to our knowledge has not previously been discussed in academic literature. In 2018, we discovered that Maasai pastoralists in northern Tanzania create new social ties through wrong numbers, a phenomenon with implications for theory on social networks and path dependency. We used a mixed ethnographic and survey-based design to examine the following: (1) the conditions under which wrong number connections (WNCs) are made; (2) the incidence of these connections in the study area; and (3) the association between WNCs and multiple livelihood strategies. Working in 10 rural communities in Tanzania, we conducted 16 group interviews with men about their phone use and found that WNCs are diverse and can provide households with important information, resources, and opportunities from an expansive geographic area. (Nine separate interviews with groups of women revealed that women do not create WNCs.) Based on early qualitative findings, we designed and conducted a standardized survey with 317 household heads. We found that 46% of respondents have had WNCs. Furthermore, multivariate regression models show a significant association between WNCs and the controversial practice of leasing land in one district. Taken together, our findings show that WNCs can be seen as innovations in social networking that reduce path dependency, increase the range of potential outcomes, and hold important implications for rural livelihoods in East Africa

Kritisi Desain Pseudo Elastis Pada Bangunan Beraturan 6- Dan 10- Lantai Dengan Denah Persegi Di Wilayah 6 Peta Gempa Indonesia

Pseudo Elastis adalah metode alternatif yang dikembangkan dalam perencanaan bangunan terhadap gempa dengan menggunakan pola keruntuhan Partial Side Sway Mechanism. Beberapa kolom didesain dengan suatu faktor pengali (FP) sebagai pembesar gaya untuk menjaga agar kolom tetap elastis selama terkena beban gempa, sedangkan kolom lainnya dan balok diijinkan mengalami sendi plastis. Metode ini tidak lagi berdasarkan desain kapasitas seperti pada umumnya, melainkan berdasarkan beban kombinasi yang bekerja. Tujuan dari penelitian ini adalah mengkritisi apakah asumsi pada konsep Pseudo Elastis mengenai distribusi gaya geser pada kolom interior ke kolom eksterior sudah benar dan bangunan memenuhi pola keruntuhan Partial Side Sway Mechanism. Bangunan yang diteliti adalah bangunan beraturan berbentuk persegi, 6- dan 10-lantai di wilayah 6 peta gempa Indonesia. Tulangan balok direncanakan sedekat mungkin dengan perhitungan teoritis. Distribusi gaya geser dan kinerja bangunan diuji dengan analisis Time History Nonlinear menggunakan program SAP2000v.11. Hasil penelitian menunjukkan bahwa distribusi gaya geser pada kolom interior tidak tersalurkan ke kolom eksterior dan pola keruntuhan Partial Side Sway Mechanism masih belum tercapai

A method for sensitivity analysis to assess the effects of measurement error in multiple exposure variables using external validation data

Measurement error in self-reported dietary intakes is known to bias the association between dietary intake and a health outcome of interest such as risk of a disease. The association can be distorted further by mismeasured confounders, leading to invalid results and conclusions. It is, however, difficult to adjust for the bias in the association when there is no internal validation data

Sampling constrained probability distributions using Spherical Augmentation

Statistical models with constrained probability distributions are abundant in machine learning. Some examples include regression models with norm constraints (e.g., Lasso), probit, many copula models, and latent Dirichlet allocation (LDA). Bayesian inference involving probability distributions confined to constrained domains could be quite challenging for commonly used sampling algorithms. In this paper, we propose a novel augmentation technique that handles a wide range of constraints by mapping the constrained domain to a sphere in the augmented space. By moving freely on the surface of this sphere, sampling algorithms handle constraints implicitly and generate proposals that remain within boundaries when mapped back to the original space. Our proposed method, called {Spherical Augmentation}, provides a mathematically natural and computationally efficient framework for sampling from constrained probability distributions. We show the advantages of our method over state-of-the-art sampling algorithms, such as exact Hamiltonian Monte Carlo, using several examples including truncated Gaussian distributions, Bayesian Lasso, Bayesian bridge regression, reconstruction of quantized stationary Gaussian process, and LDA for topic modeling.Comment: 41 pages, 13 figure

A family of thermostable fungal cellulases created by structure-guided recombination

SCHEMA structure-guided recombination of 3 fungal class II cellobiohydrolases (CBH II cellulases) has yielded a collection of highly thermostable CBH II chimeras. Twenty-three of 48 genes sampled from the 6,561 possible chimeric sequences were secreted by the Saccharomyces cerevisiae heterologous host in catalytically active form. Five of these chimeras have half-lives of thermal inactivation at 63°C that are greater than the most stable parent, CBH II enzyme from the thermophilic fungus Humicola insolens, which suggests that this chimera collection contains hundreds of highly stable cellulases. Twenty-five new sequences were designed based on mathematical modeling of the thermostabilities for the first set of chimeras. Ten of these sequences were expressed in active form; all 10 retained more activity than H. insolens CBH II after incubation at 63°C. The total of 15 validated thermostable CBH II enzymes have high sequence diversity, differing from their closest natural homologs at up to 63 amino acid positions. Selected purified thermostable chimeras hydrolyzed phosphoric acid swollen cellulose at temperatures 7 to 15°C higher than the parent enzymes. These chimeras also hydrolyzed as much or more cellulose than the parent CBH II enzymes in long-time cellulose hydrolysis assays and had pH/activity profiles as broad, or broader than, the parent enzymes. Generating this group of diverse, thermostable fungal CBH II chimeras is the first step in building an inventory of stable cellulases from which optimized enzyme mixtures for biomass conversion can be formulated

RNA secondary structure formation: a solvable model of heteropolymer folding

The statistical mechanics of heteropolymer structure formation is studied in the context of RNA secondary structures. A designed RNA sequence biased energetically towards a particular native structure (a hairpin) is used to study the transition between the native and molten phase of the RNA as a function of temperature. The transition is driven by a competition between the energy gained from the polymer's overlap with the native structure and the entropic gain of forming random contacts. A simplified Go-like model is proposed and solved exactly. The predicted critical behavior is verified via exact numerical enumeration of a large ensemble of similarly designed sequences.Comment: 4 pages including 2 figure

Simple models of protein folding and of non--conventional drug design

While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learned how to extract this information to predict the three--dimensional, biologically active, native conformation of a protein whose sequence is known. Using insight obtained from simple model simulations of the folding of proteins, in particular of the fact that this phenomenon is essentially controlled by conserved (native) contacts among (few) strongly interacting ("hot"), as a rule hydrophobic, amino acids, which also stabilize local elementary structures (LES, hidden, incipient secondary structures like $\alpha$--helices and $\beta$--sheets) formed early in the folding process and leading to the postcritical folding nucleus (i.e., the minimum set of native contacts which bring the system pass beyond the highest free--energy barrier found in the whole folding process) it is possible to work out a succesful strategy for reading the native structure of designed proteins from the knowledge of only their amino acid sequence and of the contact energies among the amino acids. Because LES have undergone millions of years of evolution to selectively dock to their complementary structures, small peptides made out of the same amino acids as the LES are expected to selectively attach to the newly expressed (unfolded) protein and inhibit its folding, or to the native (fluctuating) native conformation and denaturate it. These peptides, or their mimetic molecules, can thus be used as effective non--conventional drugs to those already existing (and directed at neutralizing the active site of enzymes), displaying the advantage of not suffering from the uprise of resistance

On the stability of renormalizable expansions in three-dimensional gravity

Preliminary investigations are made for the stability of the $1/N$ expansion in three-dimensional gravity coupled to various matter fields, which are power-counting renormalizable. For unitary matters, a tachyonic pole appears in the spin-2 part of the leading graviton propagator, which implies the unstable flat space-time, unless the higher-derivative terms are introduced. As another possibility to avoid this spin-2 tachyon, we propose Einstein gravity coupled to non-unitary matters. It turns out that a tachyon appears in the spin-0 or -1 part for any linear gauges in this case, but it can be removed if non-minimally coupled scalars are included. We suggest an interesting model which may be stable and possess an ultraviolet fixed point.Comment: 32 pages. (A further discussion to avoid tachyons is included. To be Published in Physical Review D.

Cardiac Biomarkers and Risk of Atrial Fibrillation in Chronic Kidney Disease: The CRIC Study.

Background We tested associations of cardiac biomarkers of myocardial stretch, injury, inflammation, and fibrosis with the risk of incident atrial fibrillation (AF) in a prospective study of chronic kidney disease patients. Methods and Results The study sample was 3053 participants with chronic kidney disease in the multicenter CRIC (Chronic Renal Insufficiency Cohort) study who were not identified as having AF at baseline. Cardiac biomarkers, measured at baseline, were NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity troponin T, galectin-3, growth differentiation factor-15, and soluble ST-2. Incident AF ("AF event") was defined as a hospitalization for AF. During a median follow-up of 8 years, 279 (9%) participants developed a new AF event. In adjusted models, higher baseline log-transformed NT-proBNP (N-terminal pro-B-type natriuretic peptide) was associated with incident AF (adjusted hazard ratio [HR] per SD higher concentration: 2.11; 95% CI, 1.75, 2.55), as was log-high-sensitivity troponin T (HR 1.42; 95% CI, 1.20, 1.68). These associations showed a dose-response relationship in categorical analyses. Although log-soluble ST-2 was associated with AF risk in continuous models (HR per SD higher concentration 1.35; 95% CI, 1.16, 1.58), this association was not consistent in categorical analyses. Log-galectin-3 (HR 1.05; 95% CI, 0.91, 1.22) and log-growth differentiation factor-15 (HR 1.16; 95% CI, 0.96, 1.40) were not significantly associated with incident AF. Conclusions We found strong associations between higher NT-proBNP (N-terminal pro-B-type natriuretic peptide) and high-sensitivity troponin T concentrations, and the risk of incident AF in a large cohort of participants with chronic kidney disease. Increased atrial myocardial stretch and myocardial cell injury may be implicated in the high burden of AF in patients with chronic kidney disease