150 research outputs found
Thermal diagnostic of the Optical Window on board LISA Pathfinder
Vacuum conditions inside the LTP Gravitational Reference Sensor must comply
with rather demanding requirements. The Optical Window (OW) is an interface
which seals the vacuum enclosure and, at the same time, lets the laser beam go
through for interferometric Metrology with the test masses. The OW is a
plane-parallel plate clamped in a Titanium flange, and is considerably
sensitive to thermal and stress fluctuations. It is critical for the required
precision measurements, hence its temperature will be carefully monitored in
flight. This paper reports on the results of a series of OW characterisation
laboratory runs, intended to study its response to selected thermal signals, as
well as their fit to numerical models, and the meaning of the latter. We find
that a single pole ARMA transfer function provides a consistent approximation
to the OW response to thermal excitations, and derive a relationship with the
physical processes taking place in the OW. We also show how system noise
reduction can be accomplished by means of that transfer function.Comment: 20 pages, 14 figures; accepted for publication in Class. Quantum Gra
Neural network interpolation of the magnetic field for the LISA Pathfinder Diagnostics Subsystem
LISA Pathfinder is a science and technology demonstrator of the European
Space Agency within the framework of its LISA mission, which aims to be the
first space-borne gravitational wave observatory. The payload of LISA
Pathfinder is the so-called LISA Technology Package, which is designed to
measure relative accelerations between two test masses in nominal free fall.
Its disturbances are monitored and dealt by the diagnostics subsystem. This
subsystem consists of several modules, and one of these is the magnetic
diagnostics system, which includes a set of four tri-axial fluxgate
magnetometers, intended to measure with high precision the magnetic field at
the positions of the test masses. However, since the magnetometers are located
far from the positions of the test masses, the magnetic field at their
positions must be interpolated. It has been recently shown that because there
are not enough magnetic channels, classical interpolation methods fail to
derive reliable measurements at the positions of the test masses, while neural
network interpolation can provide the required measurements at the desired
accuracy. In this paper we expand these studies and we assess the reliability
and robustness of the neural network interpolation scheme for variations of the
locations and possible offsets of the magnetometers, as well as for changes in
environmental conditions. We find that neural networks are robust enough to
derive accurate measurements of the magnetic field at the positions of the test
masses in most circumstances
The LISA PathFinder DMU and Radiation Monitor
The LISA PathFinder DMU (Data Management Unit) flight model was formally
accepted by ESA and ASD on 11 February 2010, after all hardware and software
tests had been successfully completed. The diagnostics items are scheduled to
be delivered by the end of 2010. In this paper we review the requirements and
performance of this instrumentation, specially focusing on the Radiation
Monitor and the DMU, as well as the status of their programmed use during
mission operations, on which work is ongoing at the time of writing.Comment: 11 pages, 7 figures, prepared for the Proceedings of the 8th
International LISA Symposium, Classical and Quantum Gravit
Formal [4 + 1] Cycloadditions of ,-Diaryl-Substituted ortho-(Alkynyl)styrenes through Gold(I)-Catalyzed Cycloisomerization Reactions
LISA and LISA PathFinder, the endeavour to detect low frequency GWs
This is a review about LISA and its technology demonstrator, LISA PathFinder.
We first describe the conceptual problems which need to be overcome in order to
set up a working interferometric detector of low frequency Gravitational Waves
(GW), then summarise the solutions to them as currently conceived by the LISA
mission team. This will show that some of these solutions require new
technological abilities which are still under development, and which need
proper test before being fully implemented. LISA PathFinder (LPF) is the the
testbed for such technologies. The final part of the paper will address the
ideas and concepts behind the PathFinder as well as their impact on LISA.Comment: 25 pages, 21 figures, presented at the Spanish Relativity Meeting,
Mallorca September 2006. Will be published in Journal of Physics: Conference
Series, IOP. To be published in Journal of Physics: Conference Series, IO
The diagnostics subsystem on board LISA PathFinder and LISA
The Data and Diagnostics Subsystem of the LTP hardware and software are at
present essentially ready for delivery. In this presentation we intend to
describe the scientific and technical aspects of this subsystem, which includes
thermal diagnostics, magnetic diagnostics and a Radiation Monitor, as well as
the prospects for their integration within the rest of the LTP. We also sketch
a few lines of progress recently opened up towards the more demanding
diagnostics requirements which will be needed for LISA.Comment: 11 pages, 5 figures, pdflatex, prepared for the Proceedings of the
7th International LISA Symposium (Barcelona, Spain, 16-20 June-2008),
submitted to Classical and Quantum Gravit
Quasispecies Spatial Models for RNA Viruses with Different Replication Modes and Infection Strategies
Empirical observations and theoretical studies suggest that viruses may use different replication strategies to amplify their genomes, which impact the dynamics of mutation accumulation in viral populations and therefore, their fitness and virulence. Similarly, during natural infections, viruses replicate and infect cells that are rarely in suspension but spatially organized. Surprisingly, most quasispecies models of virus replication have ignored these two phenomena. In order to study these two viral characteristics, we have developed stochastic cellular automata models that simulate two different modes of replication (geometric vs stamping machine) for quasispecies replicating and spreading on a two-dimensional space. Furthermore, we explored these two replication models considering epistatic fitness landscapes (antagonistic vs synergistic) and different scenarios for cell-to-cell spread, one with free superinfection and another with superinfection inhibition. We found that the master sequences for populations replicating geometrically and with antagonistic fitness effects vanished at low critical mutation rates. By contrast, the highest critical mutation rate was observed for populations replicating geometrically but with a synergistic fitness landscape. Our simulations also showed that for stamping machine replication and antagonistic epistasis, a combination that appears to be common among plant viruses, populations further increased their robustness by inhibiting superinfection. We have also shown that the mode of replication strongly influenced the linkage between viral loci, which rapidly reached linkage equilibrium at increasing mutations for geometric replication. We also found that the strategy that minimized the time required to spread over the whole space was the stamping machine with antagonistic epistasis among mutations. Finally, our simulations revealed that the multiplicity of infection fluctuated but generically increased along time
The presence of both HLA-DRB1[*]04:01 and HLA-B[*]15:01 increases the susceptibility to cranial and extracranial giant cell arteritis.
Objectives: To determine if patients with the predominant extracranial large-vessel-vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLA-DRB1 alleles confers an increased risk for GCA susceptibility, either for the cranial and extracranial LVV phenotypes.
Methods: A total of 184 patients with biopsy-proven cranial GCA, 105 with LVV-GCA and 486 healthy controls were included in our study. We compared HLA-B phenotype frequencies between the three groups.
Results: HLA-B*15 phenotype was significantly increased in patients with classic cranial GCA compared to controls (14.7% versus 5.8%, respectively; p<0.01; OR [95% CI] =2.81 [1.54-5.11]). It was mainly due to the HLA-B*15:01 allele (12.5% versus 4.0%, respectively; p<0.01; OR [95% CI] =3.51 [1.77-6.99]) and remained statistically significant after Bonferroni correction. Similar HLA-B*15 association was observed in patients with the LVV-GCA (11.4% versus 5.8%, p=0.04, OR [95% CI] =2.11 [1.04-4.30]). This association was also mainly due to the HLA-B*15:01 allele (10.5% versus 4.0%, respectively; p=0.0054; OR [95% CI] =2.88 [1.19-6.59]). Noteworthy, the presence of HLA-B*15:01 together with HLA-DRB1*04:01 led to an increased risk of developing both cranial and extracranial LVV-GCA.
Conclusions: Susceptibility to GCA is strongly related to the HLA region, regardless of the clinical phenotype of expression of the disease.This work was partially supported by RETICS Programs, RD08/0075 (RIER), RD12/0009/0013 and
RD16/0012 from ââInstituto de Salud Carlos IIIââ (ISCIII) (Spain). However, this research did not receive any specific
grant from funding agencies in the commercial or not-for-profit sectors
Sub-femto-g free fall for space-based gravitational wave observatories: LISA pathfinder results
We report the first results of the LISA Pathfinder in-flight experiment. The results demonstrate that two free-falling reference test masses, such as those needed for a space-based gravitational wave observatory like LISA, can be put in free fall with a relative acceleration noise with a square root of the power spectral density of 5.2 Âą 0.1 fm sâ2/âHz or (0.54 Âą 0.01) Ă 10â15 g/âHz, with g the standard gravity, for frequencies between 0.7 and 20 mHz. This value is lower than the LISA Pathfinder requirement by more than a factor 5 and within a factor 1.25 of the requirement for the LISA mission, and is compatible with Brownian noise from viscous damping due to the residual gas surrounding the test masses. Above 60 mHz the acceleration noise is dominated by interferometer displacement readout noise at a level of (34.8 Âą 0.3) fm/âHz, about 2 orders of magnitude better than requirements. At f ⤠0.5 mHz we observe a low-frequency tail that stays below 12 fm sâ2/âHz down to 0.1 mHz. This performance would allow for a space-based gravitational wave
observatory with a sensitivity close to what was originally foreseen for LISA
Genomic transformation and social organization during the Copper Age-Bronze Age transition in southern Iberia
The emerging Bronze Age (BA) of southeastern Iberia saw marked social changes. Late Copper Age (CA) settlements were abandoned in favor of hilltop sites, and collective graves were largely replaced by single or double burials with often distinctive grave goods indirectly reflecting a hierarchical social organization, as exemplified by the BA El Argar group. We explored this transition from a genomic viewpoint by tripling the amount of data available for this period. Concomitant with the rise of El Argar starting âź2200 cal BCE, we observe a complete turnover of Y-chromosome lineages along with the arrival of steppe-related ancestry. This pattern is consistent with a founder effect in male lineages, supported by our finding that males shared more relatives at sites than females. However, simple two-source models do not find support in some El Argar groups, suggesting additional genetic contributions from the Mediterranean that could predate the BA.This work was supported by the Max Planck Society (V.V.-M. and W.H.); European Research Council (ERC) grant 771234âPALEoRIDER (W.H.); Spanish Ministry of Economy, Industry and Competitiveness project HAR2017-85962-P (C.O., C.R.-H., M.I.F., E.C.B., C.V.-F., V.L., R.M., and R.R.); AGAUR 2017SGR1044 (C.O., C.R.-H., M.I.F., E.C.B., C.V.-F., V.L., R.M., and R.R.); ICREA Academia program (R.R.); John Templeton Foundation grant 61220 (D.R.); and Paul Allen Family Foundation (D.R.). D.R. is an Investigator of the Howard Hughes Medical Institute
- âŚ