The Effect of Probabilistic Context on Implicit Temporal Expectations in Down Syndrome

One of the most important sources of predictability that human beings can exploit to create an internal representation of the external environment is the ability to implicitly build up subjective statistics of events\u2019 temporal structure and, consequently, use this knowledge to prepare for future actions. Stimulus expectancy can be subjectively shaped by hierarchically nested sources of prediction, capitalizing on either local or global probabilistic rules. In order to better understand the nature of local-global proactive motor control in Down Syndrome, in the present study a group of participants with Down Syndrome (DS group; n = 28; mean age 29.5 \ub1 13 years; range 10\u201354) and a group of typically developing participants matched by either gender or mental age (TD-MA group; n = 28; 5.6 \ub1 1 years; range 4\u20138) were administered a novel motor preparation task, defined as the Dynamic Temporal Prediction (DTP) task. In the DTP, the temporal preparation to imperative stimuli is implicitly shaped by the local increase of expectancy. This is manipulated trial-by-trial as a function of the preparatory foreperiod interval (Stimulus-Onset Asynchrony or SOA). In addition, temporal preparation can be also implicitly adjusted as a function of global predictive context, so that a block-wise SOA-distribution bias toward a given preparatory interval might determine a high-order source of expectancy, with functional consequences on proactive motor control adjustment. Results showed that in both groups motor preparation was biased by temporal expectancy when this was locally manipulated within-trials. By contrast, only the TD-MA group was sensitive to global rule changes: only in this cohort was behavioral performance overall impacted by the SOA probabilistic distribution manipulated between-blocks. The evidence of a local-global dissociation in DS suggests that the use of flexible cognitive mechanisms to implicitly extract high-order probabilistic rules in order to build-up an internal model of the temporal properties of events is disrupted in this developmental disorder. Moreover, since the content of the information to be processed in the DTP task was neither verbal nor spatial, we suggest that atypical global processing in Down Syndrome is a domain-general rather than specific aspect characterizing the cognitive profile of this population

Multidimensional natal isotopic niches refect migratory patterns in birds

7openInternationalBothNaturally occurring stable isotope ratios in animal tissues allow estimation of species trophic position and ecological niche. Measuring multiple isotopes of migratory species along flyway bottlenecks offers the opportunity to sample multiple populations and species whose tissues carry information at continental scales. We measured δ2H, δ18O, δ13C, δ15N in juvenile feathers of 21 bird species captured at a migratory bottleneck in the Italian Alps. We examined if trends in individual isotopes reflected known migratory strategies and whether dietary (δ13C–δ15N) and spatially-explicit breeding origin (δ2H–δ18O) niche breadth (NB) differed among long-distance trans-Saharan (TS), short-distance (IP) and irruptive (IR) intra-Palearctic migrants, and whether they correlated with reported populations long-term trends. In both TS and IP groups, species δ2H declined with capture date, indicating that northern populations reached the stopover site later in the season, following a Type-I migration strategy. Values of δ2H indicated that breeding range of TS migrants extended farther north than IP and IR migrants. The breeding season was longer for IP migrants whose δ13C and δ15N values declined and increased, respectively, with time of capture. Average species dietary NB did not differ among migratory groups, but TS migrants displayed wider breeding origin niches, suggesting that long-distant migration is linked to broader ecological niches. Isotope origin NB well reflected species geographic range extent, while dietary NB did not correlate with literature accounts of species’ diet. We found no relationship between species breeding NB and population trends in Europe, suggesting that conditions in the breeding grounds, as inferred by stable isotopes, are not the only determinant of species’ long-term persistence. We demonstrate that ringing activities and isotopic measurements of passerines migrating through a bottleneck represents a unique opportunity to investigate large-scale life-history phenomena relevant to conservation.openFranzoi, A.; Larsen, S.; Franceschi, P.; Hobson, K. A.; Pedrini, P.; Camin, F.; Bontempo, L.Franzoi, A.; Larsen, S.; Franceschi, P.; Hobson, K.A.; Pedrini, P.; Camin, F.; Bontempo, L

Ecosystem functioning and ecological status in the Venice lagoon, which relationships?

The implementation of management measures for improving the ecological status within an Ecosystem Based Management approach represents one the of the main challenges in coastal and transitional water environments. In general terms, ecological status and ecosystem functioning are expected to be positively associated, being good ecological processes a sort of prerequisite for the ecosystem health, but often relationships between ecosystem functioning indicators and the metrics used to define ecological status resulted to be rather puzzling. Moreover, the Biological Quality Elements (BQEs) do not show a consistent response to the changes in the ecosystem. This situation does not allow to recognize where interventions are really needed, hindering the definition of effective management strategies. In the present paper, a spatially explicit food web model of the Venice lagoon (with the resolution of 300 m) is used to simulate changes in the ecological status and related them to different management scenarios. Functional changes in the food web were investigated by comparing values of a set of 12 indicators derived by the ecological network analysis. In general, results highlighted on one hand the need for more discussion about the implementation of the WFD, at least in complex and spatially heterogeneous transitional waters environments, as the Venice lagoon; on the other, results remark the opportunity to support the BQEs monitoring with an ecological modelling approach. These models are certainly not the panacea for addressing questions about the environmental management, as they have inherent uncertainties (on parameters, structure, processes etc.); however, they can prove useful for selecting among different policy choices, since they offer the opportunity to simulate the mean effects, preliminarily verifying the efficacy of the proposed interventions

In-situ health monitoring of IGBT power modules in EV applications

Power electronics are an enabling technology and play a critical role in the establishment of an environmentally-friendly and sustainable low carbon economy. The electrification of passenger vehicles is one way of achieving this goal. It is well acknowledged that Electric vehicles (EVs) have inherent advantages over the conventional internal combustion engine (ICE) vehicles owing to the absence of emissions, high efficiency, and quiet and smooth operation. Over the last 20 years, EVs have improved significantly in their system integration, dynamic performance and cost. It has attracted much attention in research communities as well as in the market. In 2011 electric vehicle sales were estimated to reach about 20,000 units worldwide, increasing to more than 500,000 units by 2015 and 1.3 million by 2020 which accounts for 1.8 per cent of the total number of passenger vehicles expected to be sold that year. In general, electric vehicles use electric motors for traction drive, power converters for energy transfer and control, and batteries, fuel cells, ultracapacitors, or flywheels for energy storage. These are the core elements of the electric power drive train and thus are desired to provide high reliability over the lifetime of the vehicle. One of the vulnerable components in an electric power drive train is the IGBT switching devices in an inverter. During the operation, IGBT power modules will experience high mechanical and thermal stresses which lead to bond wire lift-off and solder joint fatigue faults. Theses stresses can lead to malfunctions of the IGBT power modules. A short-circuit or open-circuit in any of the power modules may result in an instantaneous loss of traction power, which is dangerous for the driver and other road users. These reliability issues are very complex in their nature and demand for the development of analytical models and experimental validation. This work is set out to develop an online measurement technique for health monitoring of IGBT and freewheeling diodes inside the power modules. The technique can provide an early warning prior to a power device failure. Bond wire lift-off and solder fatigue are the two most frequently occurred faults in power electronic modules. The former increases the forward voltage drop across the terminals of the power device while the latter increase the thermal resistance of the solder layers. As a result, bond wire lift-off can be detected by a highly sensitive and fast operating in-situ monitoring circuit. Solder joint fatigue is detected by measuring the thermal impedance of the power modules. This thesis focuses on the design and optimisation of the in-situ health monitoring circuit in an attempt to reducing noise, temperature variations and measurement uncertainties. Experimental work is carried out on a set of various IGBT power modules that have been modified to account for different testing requirements. Then the lifetime of the power module can be estimated on this basis. The proposed health monitoring system can be integrated into the existing IGBT driver circuits and can also be applied to other applications such as industrial drives, aerospace and renewable energy.EThOS - Electronic Theses Online ServiceORSSchool of EEEGBUnited Kingdo

Assessing Walking Ability in People with HTLV-1-Associated Myelopathy Using the 10 Meter Timed Walk and the 6 Minute Walk Test

Five to ten million persons, are infected by HTLV-1 of which 3% will develop HTLV-1-associated myelopathy (HAM) a chronic, disabling inflammation of the spinal cord. Walking, a fundamental, complex, multi-functional task is demanding of multiple body systems. Restricted walking ability compromises activity and participation levels in people with HAM (pwHAM). Therapy aims to improve mobility but validated measures are required to assess change.Prospective observational study.To explore walking capacity in pwHAM, walking endurance using the 6 minute walk (6MW), and gait speed, using the timed 10m walk (10mTW).Out-patient setting in an inner London Teaching hospital.Prospective documentation of 10mTW and 6MW distance; walking aid usage and pain scores measured twice, a median of 18 months apart.Data analysis was completed for twenty-six pwHAM, (8♂; 18♀; median age: 57.8 years; median disease duration: 8 years). Median time at baseline to: complete 10m was 17.5 seconds, versus 21.4 seconds at follow up; 23% completed the 6MW compared to 42% at follow up and a median distance of 55m was covered compared to 71m at follow up. Using the 10mTW velocity to predict the 6MW distance, overestimated the distance walked in 6 minutes (p<0.01). Functional decline over time was captured using the functional ambulation categories.The 10mTW velocity underestimated the degree of disability. Gait speed usefully predicts functional domains, shows direction of functional change and comparison with published healthy age matched controls show that these patients have significantly slower gait speeds. The measured differences over 18 months were sufficient to reliably detect change and therefore these assessments can be useful to detect improvement or deterioration within broader disability grades. Walking capacity in pwHAM should be measured using the 10mTW for gait speed and the 6MW for endurance

Remote mental health care interventions during the COVID-19 pandemic: an umbrella review

Mitigating the COVID-19 related disruptions in mental health care services is crucial in a time of increased mental health disorders. Numerous reviews have been conducted on the process of implementing technology- based mental health care during the pandemic. The research question of this umbrella review was to examine what the impact of COVID-19 was on access and delivery of mental health services and how mental health services have changed during the pandemic. A systematic search for systematic reviews and meta-analyses was conducted up to August 12, 2022, and 38 systematic reviews were identified. Main disruptions during COVID-19 were reduced access to outpatient mental health care and reduced admissions and earlier discharge from inpatient care. In response, synchronous telemental health tools such as videoconferencing were used to provide remote care similar to pre-COVID care, and to a lesser extent asynchronous virtual mental health tools such as apps. Implementation of synchronous tools were facilitated by time-efficiency and flexibility during the pandemic but there was a lack of accessibility for specific vulnerable populations. Main barriers among prac- titioners and patients to use digital mental health tools were poor technological literacy, particularly when preexisting inequalities existed, and beliefs about reduced therapeutic alliance particularly in case of severe mental disorders. Absence of organizational support for technological implementation of digital mental health interventions due to inadequate IT infrastructure, lack of funding, as well as lack of privacy and safety, chal- lenged implementation during COVID-19. Reviews were of low to moderate quality, covered heterogeneously designed primary studies and lacked findings of implementation in low- and middle-income countries. These gaps in the evidence were particularly prevalent in studies conducted early in the pandemic. This umbrella review shows that during the COVID-19 pandemic, practitioners and mental health care institutions mainly used synchronous telemental health tools, and to a lesser degree asynchronous tools to enable continued access to mental health care for patients. Numerous barriers to these tools were identified, and call for further improve- ments. In addition, more high quality research into comparative effectiveness and working mechanisms may improve scalability of mental health care in general and in future infectious disease outbreaks

The evolution of ecological specialization across the range of a broadly distributed marine species

Ecological specialization is an important engine of evolutionary change and adaptive radiation, but empirical evidence of local adaptation in marine environments is rare, a pattern that has been attributed to the high dispersal ability of marine taxa and limited geographic barriers to gene flow. The broad-nosed pipefish, Syngnathus typhle, is one of the most broadly distributed syngnathid species and shows pronounced variation in cranial morphology across its range, a factor that may contribute to its success in colonizing new environments. We quantified variation in cranial morphology across the species range using geometric morphometrics, and tested for evidence of trophic specialization by comparing individual-level dietary composition with the community of prey available at each site. Although the diets of juvenile pipefish from each site were qualitatively similar, ontogenetic shifts in dietary composition resulted in adult populations with distinctive diets consistent with their divergent cranial morphology. Morphological differences found in nature are maintained under common garden conditions, indicating that trophic specialization in S. typhle is a heritable trait subject to selection. Our data highlight the potential for ecological specialization in response to spatially variable selection pressures in broadly distributed marine species.Swiss Academy of SciencesSwiss National Science FoundationSwiss National Science Foundation (SNSF)European CommissionUniversity of ZurichBrooklyn CollegeCity University of New Yorkinfo:eu-repo/semantics/acceptedVersio

Environmental restoration by aquatic angiosperm transplants in transitional water systems: The Venice Lagoon as a case study

The paper reports the results obtained after 4 years of aquatic angiosperm transplants in areas of the Venice Lagoon (North Adriatic Sea, Mediterranean) where meadows almost disappeared due to eutrophication, pollution and overexploitation of clam resources. The project LIFE12 NAT/IT/000331-SeResto, funded by the European Union, allowed to recolonize the Habitat 1150* (coastal lagoons) in the northernmost part of the lagoon, by extensive manual transplants of small sods or single rhizomes of Zostera marina, Zostera noltei, Ruppia cirrhosa and, in some stations also of Cymodocea nodosa. Over the 4 years of the project more than 75,000 rhizomes were transplanted in 35 stations with the support of local stakeholders (fishermen, hunters and sport clubs). Plants took root in 32 stations forming extensive meadows on a surface of approx. 10 km2 even if some failures were recorded in areas affected by outflows of freshwater rich in nutrients and suspended particulate matter. The rapid recovery of the ecological status of the involved areas was the result of this meadow restoration, which was in compliance with Water Framework Directive (WFD 2000/60/EC) objectives. Moreover, the monitoring of environmental parameters in the water column and in surface sediments allowed to identify the best conditions for successful transplants. Small, widespread interventions and the participation of local stakeholders in the environmental recovery, make this action economically cheap and easily transposable in other similar environments

A meta-analytic review of stand-alone interventions to improve body image

Objective Numerous stand-alone interventions to improve body image have been developed. The present review used meta-analysis to estimate the effectiveness of such interventions, and to identify the specific change techniques that lead to improvement in body image. Methods The inclusion criteria were that (a) the intervention was stand-alone (i.e., solely focused on improving body image), (b) a control group was used, (c) participants were randomly assigned to conditions, and (d) at least one pretest and one posttest measure of body image was taken. Effect sizes were meta-analysed and moderator analyses were conducted. A taxonomy of 48 change techniques used in interventions targeted at body image was developed; all interventions were coded using this taxonomy. Results The literature search identified 62 tests of interventions (N = 3,846). Interventions produced a small-to-medium improvement in body image (d+ = 0.38), a small-to-medium reduction in beauty ideal internalisation (d+ = -0.37), and a large reduction in social comparison tendencies (d+ = -0.72). However, the effect size for body image was inflated by bias both within and across studies, and was reliable but of small magnitude once corrections for bias were applied. Effect sizes for the other outcomes were no longer reliable once corrections for bias were applied. Several features of the sample, intervention, and methodology moderated intervention effects. Twelve change techniques were associated with improvements in body image, and three techniques were contra-indicated. Conclusions The findings show that interventions engender only small improvements in body image, and underline the need for large-scale, high-quality trials in this area. The review identifies effective techniques that could be deployed in future interventions