Two-Semester Agile Systems Engineering Design Course: Investigation and Exploration of Immersive Training Technologies

The teaching of systems engineering is a daunting task that involves the development of curriculum capable of teaching students the systems engineering process, the design aspects of engineering, and the interdisciplinary knowledge of a variety of fields. Design is widely considered to be the central or the major distinguishing activity of engineering1. Design can be considered as the center of system engineering, in which engineers employ an interdisciplinary approach to design effective solutions to meet social needs. However, systems engineering requires that traditional academic boundaries be crossed and intertwined with other fields of engineering as well as business, socio-political, and other disciplines that clearly interacts with or are directly affected by the system under consideration. Systems engineering requires different design thinking, as it requires in depth knowledge often beyond the traditional engineering classification boundaries. For example, an electrical engineer must also in many cases have knowledge of software engineering, or safety engineering when designing a cell phone circuit

Automated cold vapour flow-injection analysis of mercury at high concentrations

Continuous-flow cold vapour- atomic fluorescence spectrometry is shown to be an extremely sensitive technique for the determination of mercury with detection limits typically below 0.01 μg l-1. Linear calibration ranges were found to be at least four orders of magnitude (i.e. up to 0.1 mg l-1). Samples with concentrations exceeding the linear range are susceptible to self-absorption, and may, in severe cases, cause carry-over problems between samples. The flow-injection approach has been utilized to extend the upper limit of the linear calibration range allowing determinations up to 10 mg l-1 of mercury. A range of certified reference materials and zinc battery anodes have been successfully analysed with a minimal number of sample dilutions

A REVIEW OF 3D GIS FOR USE IN CREATING VIRTUAL HISTORIC DUBLIN

This paper illustrates how BIM integration with GIS is approached as part of the workflow in creating Virtual Historic Dublin. A design for a WEB based interactive 3D model of historic buildings and centres in Dublin City (Virtual Historic Dublin City) paralleling smart city initiates is now under construction and led by the National Monuments at the Office of Public Works in Ireland. The aim is to facilitate the conservation and maintenance of historic infrastructure and fabric and the dissemination of knowledge for education and cultural tourism using an extensive Historic Building Information Model. Remote sensing data is now processed with greater ease to create 3D intelligent models in Historic BIM. While the use of remote sensing, HBIM and game engine platforms are the main applications used at present, 3D GIS has potential to form part of the workflow for developing the Virtual Historic City. 2D GIS is now being replaced by 3D spatial data allowing more complex analysis to be carried out, 3D GIS can define and depict buildings, urban rural centres in relation to their geometry topological, semantic and visualisation properties. The addition of semantic attributes allows complex analysis and 3D spatial queries for modelling city and urban elements. This analysis includes fabric and structural elements of buildings, relief, vegetation, transportation, water bodies, city furniture and land use

Determination of Arsenic, Mercury and Barium in herbarium mount paper using dynamic ultrasound-assisted extraction prior to atomic fluorescence and absorption spectrometry

A dynamic ultrasound-assisted extraction method using Atomic Absorption and Atomic Flourescence spectrometers as detectors was developed to analyse mercury, arsenic and barium from herbarium mount paper originating from the herbarium collection of the National Museum of Wales. The variables influencing extraction were optimised by a multivariate approach. The optimal conditions were found to be 1% HNO3 extractant solution used at a flow rate of 1 mL min-1. The duty cycle and amplitude of the ultrasonic probe was found to be 50% in both cases with an ultrasound power of 400 W. The optimal distance between the probe and the top face of the extraction chamber was found to be 0 cm. Under these conditions the time required for complete extraction of the three analytes was 25 min. Cold vapour and hydride generation coupled to atomic fluorescence spectrometry was utilized to determine mercury and arsenic, respectively. The chemical and instrumental conditions were optimized to provide detection limits of 0.01ng g-1 and 1.25 ng g-1 for mercury and arsenic, respectively. Barium was determined by graphite-furnace atomic absorption spectrometry, with a detection limit of 25 ng g-1. By using 0.5 g of sample, the concentrations of the target analytes varied for the different types of paper and ranged between 0.4–2.55 µg g-1 for Ba, 0.035–10.47 µg g-1 for As and 0.0046–2.37 µg g-1 for Hg

AN INITIAL DESIGN FRAMEWORK FOR VIRTUAL HISTORIC DUBLIN

As a single coherent model, the proposed Virtual Historic Dublin City will improve the current approaches for planning, conserving, presenting and interpreting cultural heritage buildings and their environments. The combination of digital recording, modelling and data management systems enable the interaction with complex, interlinked three-dimensional structures containing rich and diverse underlying data. End users can encompass architectural and engineering conservation, education and research, in addition to public engagement and cultural tourism. In this paper a digital design framework is presented, based on state of the art current approaches for recording, modelling and presenting Virtual Historic Dublin. The modelling sites and structures is based on remotely sensed survey data which is processed and modelled in Historic BIM or GIS allowing the addition of semantic attributes. Archiving and storage of both models and knowledge and information attributes requires open systems and server data base capable of handling vector and point cloud information in addition to other digital data. The dissemination and interaction with the models and attached knowledge attributions is based on combining game engine platforms, Historic BIM, Historic GIS and access to compatible storage and data base

Exploring Consumer and Patient Knowledge, Behavior, and Attitude Toward Medicinal and Lifestyle Products Purchased From the Internet: A Web-Based Survey.

BACKGROUND: In recent years, lifestyle products have emerged to help improve people's physical and mental performance. The Internet plays a major role in the spread of these products. However, the literature has reported issues regarding the authenticity of medicines purchased from the Internet and the impact of counterfeit medicines on public health. Little or no data are available on the authenticity of lifestyle products and actual toxicity associated with their use and misuse. OBJECTIVE: Our aim was to investigate consumer and patient attitudes toward the purchase of lifestyle products from the Internet, their knowledge of product authenticity and toxicity, and their experiences with counterfeit lifestyle products. METHODS: A Web-based study was performed between May 2014 and May 2015. Uniform collection of data was performed through an anonymous online questionnaire. Participants were invited worldwide via email, social media, or personal communication to complete the online questionnaire. A total of 320 participants completed the questionnaire. RESULTS: The results of the questionnaire showed that 208 (65.0%) participants purchased lifestyle products from the Internet mainly due to convenience and reduced cost. More than half (55.6%, 178/320) of participants purchased cosmetic products, whereas only a minority purchased medicinal products. Yet, 62.8% (201/320) of participants were aware of the presence of counterfeit lifestyle products from the Internet, and 11.9% (38/320) experienced counterfeit products. In only 0.9% (3/320) of those cases were counterfeit lifestyle products reported to authorities. Moreover, 7.2% (23/320) of the participants experienced adverse effects due to counterfeit lifestyle products. CONCLUSIONS: In summary, patients experienced counterfeit lifestyle products that resulted in adverse effects on their health. Although certain adverse effects were reported in this study, counterfeit products were underreported to authorities. Further public awareness campaigns and patient education are needed

A REVIEW OF 3D GIS FOR USE IN CREATING VIRTUAL HISTORIC DUBLIN

This paper illustrates how BIM integration with GIS is approached as part of the workflow in creating Virtual Historic Dublin. A design for a WEB based interactive 3D model of historic buildings and centres in Dublin City (Virtual Historic Dublin City) paralleling smart city initiates is now under construction and led by the National Monuments at the Office of Public Works in Ireland. The aim is to facilitate the conservation and maintenance of historic infrastructure and fabric and the dissemination of knowledge for education and cultural tourism using an extensive Historic Building Information Model. Remote sensing data is now processed with greater ease to create 3D intelligent models in Historic BIM. While the use of remote sensing, HBIM and game engine platforms are the main applications used at present, 3D GIS has potential to form part of the workflow for developing the Virtual Historic City. 2D GIS is now being replaced by 3D spatial data allowing more complex analysis to be carried out, 3D GIS can define and depict buildings, urban rural centres in relation to their geometry topological, semantic and visualisation properties. The addition of semantic attributes allows complex analysis and 3D spatial queries for modelling city and urban elements. This analysis includes fabric and structural elements of buildings, relief, vegetation, transportation, water bodies, city furniture and land use

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). If the MET current is abolished in adult IHCs, they revert into cells showing electrical and morphological features characteristic of pre-hearing IHCs, including the re-establishment of cholinergic efferent innervation. The MET current is thus critical for the maintenance of the functional properties of adult IHCs, implying a degree of plasticity in the mature auditory system in response to the absence of normal transduction of acoustic signals

Standing in a Garden of Forking Paths

According to the Path Principle, it is permissible to expand your set of beliefs iff (and because) the evidence you possess provides adequate support for such beliefs. If there is no path from here to there, you cannot add a belief to your belief set. If some thinker with the same type of evidential support has a path that they can take, so do you. The paths exist because of the evidence you possess and the support it provides. Evidential support grounds propositional justification. The principle is mistaken. There are permissible steps you may take that others may not even if you have the very same evidence. There are permissible steps that you cannot take that others can even if your beliefs receive the same type of evidential support. Because we have to assume almost nothing about the nature of evidential support to establish these results, we should reject evidentialism

Determination of Arsenic, Mercury and Barium in Herbarium Mount Paper using 5 Dynamic Ultrasound-Assisted Extraction prior to Atomic Fluorescence and Absorption 6 Spectrometries 7 8

Abstract 25 A dynamic ultrasound-assisted extraction method using Atomic Absorption and Atomic 26 Flourescence spectrometers as detectors was developed to analyse mercury, arsenic and 27 barium from herbarium mount paper originating from the herbarium collection of the 28 National Museum of Wales. The variables influencing extraction were optimised by a 29 multivariate approach. The optimal conditions were found to be 1% HNO 3 extractant solution 30 used at a flow rate of 1 mL min -1 . The duty cycle and amplitude of the ultrasonic probe was 31 found to be 50% in both cases with an ultrasound power of 400 W. The optimal distance 32 between the probe and the top face of the extraction chamber was found to be 0 cm. Under 33 these conditions the time required for complete extraction of the three analytes was 25 min. 34 2 Cold vapour and hydride generation coupled to atomic fluorescence spectrometry was 1 utilized to determine mercury and arsenic, respectively. The chemical and instrumental 2 conditions were optimized to provide detection limits of 0.01ng g -1 and 1.25 ng g -1 for 3 mercury and arsenic, respectively. Barium was determined by graphite-furnace atomic 4 absorption spectrometry, with a detection limit of 25 ng g -1 . By using 0.5 g of sample, the 5 concentrations of the target analytes varied for the different types of paper and ranged 6 between 0.4-2.55 µg g -1 for Ba, 0.035-10.47 µg g -1 for As and 0.0046-2.37 µg g -1 for Hg. 7 8