Seismic Station Installations and Their Impact on the Recorded Signals and Derived Quantities

The role of local geology in controlling ground motion has long been acknowledged. Consequently, increasing attention is paid to the assessment of the geophysical properties of the soils at the seismic stations, which impact the station recordings and a series of related quantities, particularly those referring to seismic hazard estimates. Not the same level of attention is commonly dedicated to the seismic station installation, to the point that it is generally believed that housings and shelters containing seismic instruments are of no interest, because they can only affect frequencies well above the engineering range of interest. Using examples from seismometric and accelerometric stations, we describe the (1) housing, (2) foundation, and (3) pillar effects on the seismic records. We propose a simple working scheme to identify the existence of potential installation-related issues and to assess the frequency fidelity range of response of a seismic station to ground motion. Our scheme is developed mostly on ambient noise recordings and, thus, surface waves. The hope is that, besides the parameters that start to be routinely introduced in the seismic archives (VS30, soil classes, etc.), the assessment of the maximum reliable frequency, under which no soil–structure interaction is expected, also becomes a mandatory information. In our experience, for some installation sites, the maximum reliable frequency can even be less than a very few hert

The Different Response of Apparently Identical Structures: a Far-Field Lesson from the Mirandola 20th May 2012 Earthquake

Abstract Twin structures, that is structures very similar in terms of geometry, materials, mass distribution etc., founded on the same soil and set at very close distance, are rationally expected to have an identical response to earthquakes. When this does not occur, a role is usually played by factors like the interaction with the surrounding structures or by other anomalies hidden behind the apparent similarity. We present the case of two apparently twin towers that showed a very different response to the 2012 Mirandola (Italy) earthquake ground shaking: one remained perfectly intact while the other had a wide set of fractures on secondary walls. This resulted to be the effect of several contributing factors: the stiffness of the two structures, experimentally measured, provided unexpected differences. This reflected into different modal frequencies for the two towers, with the first and second modes of the damaged tower coincident or very close to the soil resonance. The final result was a coupled soil-structure resonance, implying a much higher displacement of one tower compared to the other, under the same input motion. In Italy, insurance against earthquake damage will probably become compulsory in the near future. This case suggests that the specific soil-structure and structure-structure interaction will have to be carefully evaluated since they can critically affect even apparently identical structures

An FDD-based modal parameter-less proportional flexibility-resembling matrix for response-only damage detection

Modal flexibility-based methods are effective tools for vibration-based structural damage detection, including in the output-only case. These methods are typically characterized by two stages: first, the modal parameters are identified, thus obtaining a certain number of modes; second, these modal parameters are used to assemble the modal flexibility matrix. This paper proposes a method for estimating a matrix that approximates a proportional flexibility matrix, termed proportional flexibility-resembling (PFR) matrix, and shows that this matrix can be used for damage detection and localization purposes. This matrix is obtained through signal processing operations to be executed after applying the first steps of the frequency-domain decomposition (FDD) technique-i.e., after the singular value decomposition of the spectral density matrix. The defining aspect of the PFR matrix is that, differently from the traditional formulation of modal flexibility and proportional flexibility matrices, it can be assembled without the need of an explicit identification of the modal parameters. In fact, the matrix is estimated by processing all first singular vectors and also all first singular values in a selected frequency range. In the proposed method, the typical two stage approach of traditional modal flexibility methods is avoided, and the intervention of an operator is limited to setting the values of a few parameters in the initial phase of the process. Numerical simulations and experimental data from a testbed structure were used to show the effectiveness of the proposed approach, and the analyses were performed by considering structures with different damage scenarios and damping properties

Potential instability of gas hydrates along the chilean margin due to ocean warming

In the last few years, interest in the offshore Chilean margin has increased rapidly due to the presence of gas hydrates. We have modelled the gas hydrate stability zone off Chilean shores (from 33\ub0 S to 46\ub0 S) using a steady state approach to evaluate the effects of climate change on gas hydrate stability. Present day conditions were modelled using published literature and compared with available measurements. Then, we simulated the effects of climate change on gas hydrate stability in 50 and 100 years on the basis of Intergovernmental Panel on Climate Change and National Aeronautics and Space Administration forecasts. An increase in temperature might cause the dissociation of gas hydrate that could strongly affect gas hydrate stability. Moreover, we found that the high seismicity of this area could have a strong effect on gas hydrate stability. Clearly, the Chilean margin should be considered as a natural laboratory for understanding the relationship between gas hydrate systems and complex natural phenomena, such as climate change, slope stability and earthquakes

A wide field-of-view, modular, high-density diffuse optical tomography system for minimally constrained three-dimensional functional neuroimaging

The ability to produce high-quality images of human brain function in any environment and during unconstrained movement of the subject has long been a goal of neuroimaging research. Diffuse optical tomography, which uses the intensity of back-scattered near-infrared light from multiple source-detector pairs to image changes in haemoglobin concentrations in the brain, is uniquely placed to achieve this goal. Here, we describe a new generation of modular, fibre-less, high-density diffuse optical tomography technology that provides exceptional sensitivity, a large dynamic range, a field-of-view sufficient to cover approximately one-third of the adult scalp, and also incorporates dedicated motion sensing into each module. Using in-vivo measures, we demonstrate a noise-equivalent power of 318 fW, and an effective dynamic range of 142 dB. We describe the application of this system to a novel somatomotor neuroimaging paradigm that involves subjects walking and texting on a smartphone. Our results demonstrate that wearable high-density diffuse optical tomography permits three-dimensional imaging of the human brain function during overt movement of the subject; images of somatomotor cortical activation can be obtained while subjects move in a relatively unconstrained manner, and these images are in good agreement with those obtained while the subjects remain stationary. The scalable nature of the technology we described here paves the way for the routine acquisition of high-quality, three-dimensional, whole-cortex diffuse optical tomography images of cerebral haemodynamics, both inside and outside of the laboratory environment, which has profound implications for neuroscience

A method for concentrating lipid peptide DNA and siRNA nanocomplexes that retains their structure and transfection efficiency

Nonviral gene and small interfering RNA (siRNA) delivery formulations are extensively used for biological and therapeutic research in cell culture experiments, but less so in in vivo and clinical research. Difficulties with formulating the nanoparticles for uniformity and stability at concentrations required for in vivo and clinical use are limiting their progression in these areas. Here, we report a simple but effective method of formulating monodisperse nanocomplexes from a ternary formulation of lipids, targeting peptides, and nucleic acids at a low starting concentration of 0.2 mg/mL of DNA, and we then increase their concentration up to 4.5 mg/mL by reverse dialysis against a concentrated polymer solution at room temperature. The nanocomplexes did not aggregate and they had maintained their biophysical properties, but, importantly, they also mediated DNA transfection and siRNA silencing in cultured cells. Moreover, concentrated anionic nanocomplexes administered by convection-enhanced delivery in the striatum showed efficient silencing of the β-secretase gene BACE1. This method of preparing nanocomplexes could probably be used to concentrate other nonviral formulations and may enable more widespread use of nanoparticles in vivo

Tamaño del grupo, argumentación y lectura de tablas en estudiantes universitarios

La argumentación es una variable importante para entender el aprendizaje. Aunque hay varios artículos al respecto, su relación con el tamaño del grupo es una novedad. Se analiza la relación entre el tamaño del grupo (díada-tríada) y la distribución argumental (simétrica-asimétrica) en lectura de tablas de doble entrada, y su relación con el tipo de respuesta utilizada. Se utilizó un diseño cuasi-experimental de solo post-test en una muestra de 89 estudiantes universitarios. Los resultados muestran distribuciones argumentales simétricas en las díadas, mientras que las tríadas obtuvieron mayores valores de asimetría. No se encontraron relaciones significativas entre el tamaño del grupo y el tipo de respuesta final como así tampoco entre la distribución argumental y el tipo de respuesta. Esto indicaría que el tamaño del grupo afecta la posibilidad de las personas de aportar argumentos durante la interacción, así como el tipo de tarea condicionaría el tipo de argumentos empleados

Increase of CSF inflammatory profile in a case of highly active multiple sclerosis

BACKGROUND: Clinical and imaging follow-up coupled with cerebrospinal fluid (CSF) and possibly serum profiling could provide information on disease activity and disability evolution in multiple sclerosis patients. CASE PRESENTATION: We describe the case of a relapsing-remitting MS patient whose history was characterized by failure of several therapeutic approaches and sustained disease activity. By using a highly sensitive immunoassay methodology, we examined protein expression of 70 inflammatory/cytotoxic molecules in two consecutive paired CSF and serum samples, obtained respectively in 2006 and 2013. At disease diagnosis, elevated CSF protein levels of an inflammatory pattern, including CXCL13, CXCL12, IFNγ, TNF, sTNFR1, IL8, sCD163, APRIL, BAFF, pentraxin III and MMP2 were found compared with a group of controls. At the second lumbar puncture, sustained disease activity was accompanied by considerable (more than 2 fold changes) increase expression of most of these inflammatory molecules while no significant changes in serum inflammatory markers were detected in the two consecutive serum samples. CONCLUSIONS: Elevated CSF protein expression of pro-inflammatory mediators, possibly specifically associated to GM demyelination, could remain stable or increase over time in patients with active multiple sclerosis. We underline the role of fluid analysis in understanding the pathophysiology of the disease and providing information on possible markers of disease activity and evolution

Clasificación y descripción de sistemas categoriales sobre interacción sociocognitiva entre pares

Una psicología socioconstructivista sostiene el carácter interactivo del desarrollo y del conocimiento, por lo cual el estudio de la interacción sociocognitiva ha constituido un eje central en esta tradición. El análisis sistemático y confiable de la interacción plantea un gran desafío, por la complejidad, dinamicidad y multiplicidad que supone. La literatura registra gran variedad de propuestas metodológicas para el análisis de la interacción sociocognitiva, que van desde aproximaciones más holísticas hacia otras más sistemáticas basadas en la construcción de categorías. Las segundas constituyen el foco de interés del presente trabajo. El objetivo es proponer una clasificación y descripción de la variedad de sistemas categoriales utilizados recientemente para el análisis de la interacción sociocognitiva entre pares. A partir de una revisión sistemática de bases de datos internacionales, se analizaron 24 sistemas categoriales. La clasificación propuesta se basó en dos elementos fundamentales en la definición de un sistema de categorías: (a) la unidad de codificación o de análisis (molecular y molar); (b) el tipo de indicador empírico considerado (predominantemente lingüístico, predominantemente comportamental y mixto). Los resultados sugieren una clara predominancia de los sistemas moleculares predominantemente lingüísticos (50%), en comparación con los sistemas molares y/o predominantemente comportamentales o mixtos. Los resultados se discuten a la luz del concepto de intersubjetividad y del momento evolutivo-educativo de los participantes de los estudios analizados (nivel primario). Al mismo tiempo, se concluye en la necesidad de incorporar nuevos sistemas molares que reflejen más fielmente el carácter emergente e irreductible de la interacción sociocognitiva

Heterogeneity of Cortical Lesion Susceptibility Mapping in Multiple Sclerosis.

BACKGROUND AND PURPOSE: Quantitative susceptibility mapping has been used to characterize iron and myelin content in the deep gray matter of patients with multiple sclerosis. Our aim was to characterize the susceptibility mapping of cortical lesions in patients with MS and compare it with neuropathologic observations. MATERIALS AND METHODS: The pattern of microglial activation was studied in postmortem brain tissues from 16 patients with secondary-progressive MS and 5 age-matched controls. Thirty-six patients with MS underwent 3T MR imaging, including 3D double inversion recovery and 3D-echo-planar SWI. RESULTS: Neuropathologic analysis revealed the presence of an intense band of microglia activation close to the pial membrane in subpial cortical lesions or to the WM border of leukocortical cortical lesions. The quantitative susceptibility mapping analysis revealed 131 cortical lesions classified as hyperintense; 33, as isointense; and 84, as hypointense. Quantitative susceptibility mapping hyperintensity edge found in the proximity of the pial surface or at the white matter/gray matter interface in some of the quantitative susceptibility mapping–hyperintense cortical lesions accurately mirrors the microglia activation observed in the neuropathology analysis. CONCLUSIONS: Cortical lesion susceptibility maps are highly heterogeneous, even at individual levels. Quantitative susceptibility mapping hyperintensity edge found in proximity to the pial surface might be due to the subpial gradient of microglial activation