Assessment of prospective geological hazards in Torrevieja-La Mata coast (western Mediterranean) based on Pleistocene and Holocene events

The coastal zone in which the lagoons of La Mata and Torrevieja (Eastern Spain) developed can be described as a compilation of geo-hazards typical of the Mediterranean realm. This study has focused mainly on those linked to recent tectonics. Extensive use of the amino acid racemization dating method allowed us to establish the evolution of all the geomorphological units differentiated in the area, the most striking manifestation being at the La Mata Lagoon Bar, where MIS 5 deposits settled on MIS 7 sediments along a marked erosive unconformity, thereby attesting coastal uplift between these two stages. In addition, recent uplift processes were reflected on stepped abrasion platforms and, in some cases, enormous boulders were transported over these platforms by extreme surge waves. Furthermore, we obtained feasible evidence that, during the end of MIS 5, an earthquake with an offshore epicenter linked to Torrevieja Fault, Bajo Segura Fault or the set of faults linked to the former, was responsible for tsunami surge deposits represented in accumulations of randomly arranged and well-preserved Glycymeris and Acanthocardia shells. Recent catastrophic effects linked to the earthquakes were also detected. In this regard, comparison of the paleontological and taphonomic analyses allowed us to discern between wave and tsunami surge deposits. Therefore, evidence of these hazards undoubtedly points to important future (and present) erosive and/or catastrophic processes, which are enhanced by the presence of tourist resorts and salt-mining industry. Thus, these sites are also threatened by future increases in sea level in the context of warmer episodes, attested by raised marine fossil deposits. At the north of Cervera Cape, beaches will be eroded, without any possibility of sediment input from the starved Segura River delta. At the south of this cape, waves (and tsunamis) will erode the soft rocks that built up the cliff, creating deep basal notches

BRCA1 and BRCA2 mutations in males with familial breast and ovarian cancer syndrome. Results of a Spanish multicenter study

Producción CientíficaMale breast cancer (MBC) is a rare disease that represents <1 % of all breast cancers (BCs). We analyze the results of a multicenter study performed in Spanish familial MBC including family history of hereditary breast and ovarian cancer syndrome (HBOCS) and clinicopathological features. We also study the relationship between BRCA1/BRCA2 mutational status in male relatives affected with cancer (MAC) and, family history and tumor types. The study included 312 men index cases with family history of HBOCS and 61 MAC BRCA1/2 mutation-carriers. Family history, histological grade (HG), clinicopathological and immunohistochemistry data were collected. BRCA1/2 mutation analyses were performed by direct sequencing or screening methods and the large rearrangements by multiplex ligation dependent probe amplification. We found 49 mutation-carriers (15.7 %), 95.9 % with BRCA2 mutations. BRCA2 mutation-carriers were associated with families with at least one MBC and one BC in female (type II; p = 0.05). Strong association were found between the presence of pathogenic mutations in MBCs and the advanced HG (p = 0.003). c.658_659delTG, c.2808_2811delACAA, c.6275_6276delTT and c.9026_9030delATCAT were the most prevalent mutations. In 61 MAC we found 20 mutations in BRCA1 and 41 in BRCA2. For MAC we show that mutational status was differentially associated with family history (p = 0.018) and tumor type, being BRCA2 mutations linked with BC and prostatic cancer (p = 0.018). MBC caused by BRCA1/2 mutations define two types of MBCs. The most frequent caused by BRCA2 mutation linked to type II families and the rarest one attributed to BRCA1 mutation. Tumor associated with MAC suggest that only BRCA2 mutations have to do with a specific type of cancer (BC and prostatic cancer); but the linkage to tumors is questionable for BRCA1 mutations

Protein diagenesis in "Patella" shells: Implications for amino acid racemisation dating

Abstract: The inter- and intra-crystalline fractions of Patella vulgata limpets recovered from archaeological sites in Northern Spain (covering Neolithic, Mesolithic, Magdalenian, Solutrean, and Aurignacian periods) were examined for amino acid composition and racemisation over time. The calcitic apex and rim areas of the shells were found to probably be composed of similar proteins, as the D/L values and amino acids were comparable and varied in the same way with increasing age; however, the mineral structures present in these areas differed. The aragonitic intermediate part of the shell showed a distinctly different amino acid composition and mineral structure. The main protein leaching from the inter-crystalline fraction occurred within the first 6000 yr after the death of the organism. In contrast, the intra-crystalline fraction d comprised of a different protein composition than the inter-crystalline fraction d appeared to behave as a closed system for at least 34 ka, as reflected by the lack of a significant decrease in the amino acid content; however, changes in the amino acid percentages occurred during this period. The concentration of aspartic acid remained almost constant with age both in inter- and intra-crystalline proteins, and its contribution to the total amino acid content increased with age at the expense of other amino acids such as glutamic acid, serine, glycine and alanine. Temperature is thought to play a key role in the amino acid racemisation of P. vulgata and could explain why in the localities belonging to the Gravettian and Solutrean period, which formed during relatively cold conditions, D/L values were similar to those detected in shells from sites formed during the Magdalenian.This paper was made possible by funding from the Spanish Ministry of Science and Innovation projects: HAR2010-22115-C02-01 “La respuesta humana al cambio climático global en una zona litoral: el caso del tránsito al Holoceno en la costa cantábrica (10000-5000 cal BC)”, and HAR2010-22115-C02-02 “Aplicación del análisis de sustancias orgánicas e inorgánicas a la reconstrucción paleoambiental, cronológica y tafonómica de yacimientos arqueológicos del Norte de España”

Mis casos clínicos de especialidades odontológicas

Libro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasLibro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasUniversidad Autónoma de Campeche Universidad Autónoma del Estado de Hidalgo Universidad Autónoma del Estado de Méxic

New geographic record of Meccus mazzotti in the State of Morelos, Mexico

Background: Chagas disease is caused by the hemoflagellate parasite Trypanosoma cruzi, transmitted by more than 133 species of hematophagous triatomines of the family Reduviidae. There are 8 million infected people in the world and 25 million live in at-risk areas. More than 34 species of triatomine carriers have been reported in Mexico, and Meccus mazzotti is considered an endemic species of epidemiological importance. Methods: Since 2017, a continuous search for triatomines has been carried out in the community of Tlayacapan, Morelos, Mexico, with the objective of determining the species present in that community, for their taxonomic identification the keys of Lent and Wygodzinsky (1979) are used. Results: 106 specimens were captured, of these 105 were identified as M. pallidipennis and 1 as M. mazzotti. Conclusion: For the first time, we report the finding of M. mazzotti in the state of Morelos, a region in which M. pallidipennis and T. barberi have predominated, so it is necessary to continue the search for this new species in that state and to reinforce the control measures for these vectors

Bulk and compound-specific δ13C and n-alkane indices in a palustrine intermontane record for assessing environmental changes over the past 320 ka: the Padul Basin (Southwestern Mediterranean realm)

Here we provide valuable information about the palaeoenvironmental evolution of Southwestern Mediterranean region during the last ca. 320 ka through a biomarker-based study of the longest continuous continental Quaternary record in the Iberian Peninsula. The n-alkane content and δ13C values of these lipids were measured in 300 samples taken from the uppermost 55 m of the Padul Basin (PB) record. The δ13C signal of long-chain n-alkanes was a reliable proxy for C4/C3 terrestrial vegetation composition in the basin, as emergent macrophytes made a minor contribution to these homologues. In contrast, the δ13C values of C23 and C25 alkanes reflected mainly phases of increasing water level of the lacustrine/palustrine water body since aquatic macrophytes contain a large proportion of these compounds. Low δ13C values were attributed to a marked contribution of plants using the C3 photosynthetic pathway. Intervals with the lowest δ13C values were attributed to an important input of angiosperms, although they could also be explained by changing environmental conditions or environmental stress, as large shifts in δ13C occurred in long-chain homologues typically abundant in terrestrial plants. Shifts in δ13C of medium-chain homologues reflected limited CO2 availability induced by water temperature, salinity, pH, enhanced productivity, low atmospheric pCO2, or stagnant barriers, rather than the abundance of aquatic macrophytes. Our results also suggest enhanced isotopic fractionation during lipid synthesis by aquatic macrophytes within MIS 7 and the Holocene, leading to increased δ13C values of bulk OM and of long-chain n-alkanes. Hence, the δ13C logs were ideal for studying the contribution of aquatic macrophytes to the lipid and isotopic composition of sediments and for the reconstruction of palaeoenvironmental conditions. These results confirmed that C4 plants had a low presence in the PB. Comparison with biomarker analysis and pollen data of the PB and other records of the Southwestern Mediterranean revealed that δ13C values of bulk OM and of long-chain n-alkanes reflected global climatic oscillations during MIS 7 and the episodes Heinrich Events 3, 2, 1 and Younger Dryas.Funding was obtained through the projects “Evidence from Quaternary Infills Palaeohydrogeology” (European Union, F14W/CT96/0031), “Evolución Paleoclimática de la Mitad Sur de la Península Ibérica” of ENRESA (National Company for Radioactive Waste Management, 703238) and “Paleoclima” of ENRESA and CSN (Spanish Nuclear Safety Council).Peer reviewe

Seroprevalence and Associated Risk Factors for Toxoplasma gondii Infection in Healthy Blood Donors: A Cross-Sectional Study in Sonora, Mexico

Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundred and eight blood donors who attended two public blood banks in Hermosillo city were examined for anti-T. gondii IgG and IgM antibodies by using enzyme-linked immunoassays. Of the 408 blood donors (mean age 31.77 ± 9.52; range 18-60 years old) studied, 55 (13.5%) were positive for anti-T. gondii IgG antibodies, and 12 (21.8%) of them were also positive for anti-T. gondii IgM antibodies. Multivariate analysis showed that seropositivity to T. gondii was associated with age (OR = 1.74; 95% CI: 1.03-2.94; = 0.03) and tobacco use (OR = 2.09; 95% CI: 1.02-4.29; = 0.04). Seropositivity to T. gondii was correlated with the number of pregnancies, deliveries, and cesarean sections. The seroprevalence of T. gondii infection in blood donors in Sonora is the highest reported in blood donors in northern Mexico so far. This is the first report of an association of T. gondii exposure and tobacco use. Further research to confirm this association is needed

Seroprevalence and Associated Risk Factors for Toxoplasma gondii Infection in Healthy Blood Donors: A Cross-Sectional Study in Sonora, Mexico

Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundred and eight blood donors who attended two public blood banks in Hermosillo city were examined for anti-T. gondii IgG and IgM antibodies by using enzyme-linked immunoassays. Of the 408 blood donors (mean age 31.77±9.52; range 18–60 years old) studied, 55 (13.5%) were positive for anti-T. gondii IgG antibodies, and 12 (21.8%) of them were also positive for anti-T. gondii IgM antibodies. Multivariate analysis showed that seropositivity to T. gondii was associated with age (OR = 1.74; 95% CI: 1.03–2.94; P=0.03) and tobacco use (OR = 2.09; 95% CI: 1.02–4.29; P=0.04). Seropositivity to T. gondii was correlated with the number of pregnancies, deliveries, and cesarean sections. The seroprevalence of T. gondii infection in blood donors in Sonora is the highest reported in blood donors in northern Mexico so far. This is the first report of an association of T. gondii exposure and tobacco use. Further research to confirm this association is needed

Educación y ocio en el tiempo libre

El presente Proyecto se desarrolló, principalmente, fuera del centro a excepción de fiestas y talleres que tuvieron lugar en el mismo centro. Los profesores implicados en el proyecto han sido cinco, todos ellos pertenecientes al Centro de Educación Especial Fernando Arce, siete personas más han colaborado como voluntarias. Los objetivos que se han perseguido durante el proyecto han sido, los siguienes: Ofrecer un programa alternativo y complementario al tiempo libre en casa. Favorecer en el alumno el desarrollo de la gestión autónoma de sus pertenencias, tanto económicas como materiales. Posibilitar el trabajo de los contenidos transversales del currículum (educación vial, educación sexual, educación medioambiental, educación para la salud, educación del consumidor, educación para la convivencia). Ofrecer al alumno la oportunidad de experimentar actividades y situaciones que no se pueden hacer de forma real dentro del currículum escolar. Facilitar la integración del alumno con necesidades educativas especiales en todos aquellos servicios de uso corriente de la comunidad donde vive. El desarrollo del proyecto consiste, fundamentalmente, en salidas de fin de semana (Puentenansa, Ramales), excursiones de día (Reinosa, Palacio de la Magdalena, Cabárceno y Cuevas de Pozalagua) y una salida de cuatro días a Beire. Los resulados han sido muy positivos, ya que todos los objetivos planteados han sido cumplidos de forma satisfactoria para todos los miembros de la comunidad Educativa. La evaluación ha sido continua, con revisiones y cambios en función de las circunstancias. Los recursos de los que se ha dispuesto para la puesta en marcha del plan han sido: humanos (personal del centro, voluntarios, objetores de conciencia), comunitarios (todos los ofrecidos por el entorno), materiales (los del centro y los de los albergues) y bibliográfico. Esta obra no está publicada.Gobierno de Cantabria. Consejería de Educación y JuventudCantabriaES

El Sidrón (Piloña, Asturias)

Los cazadores recolectores del Pleistoceno y del Holoceno en Iberia y el Estrecho de Gibraltar: estado actual del conocimiento del registro arqueológico, constituye una actualización del conocimiento de las sociedades con economía de predación que se asentaron en Iberia. El registro de esta región es esencial para la reconstrucción de la evolución humana biológica, comportamental y cultural en Europa ya que contiene los registros más primitivos y significativos de la humanización del continente y porque en ella se pueden trazar las grandes líneas explicativas del proceso. Ello es así por la gran riqueza de un registro muy amplio y completo, que abarca todas las etapas del desarrollo y las todas las formas adaptativas y culturales, cuyo descubrimiento ya se realizó en las primeras etapas de la disciplina en el siglo XIX. Este volumen pretende ser una presentación sistemática de datos empíricos realizada por los equipos de investigadores que están año tras año obteniendo y analizando ese registro. Se ha incluido en él los datos de los conjuntos arqueo-paleontológicos principales y con datos más significativos organizados en ocho grandes regiones fisiográficas y geológicas que buscan evidenciar la adaptación humana a entornos similares. Más allá de estas ocho regiones se ha creído conveniente presentar dos capítulos temáticos, dedicados a las regiones con registro de comportamiento simbólico rupestre más extenso: la región cantábrica y la levantina. Los registros rupestres externos a estas dos regiones se tratan cada uno dentro de las regiones correspondientes. Finalmente queremos señalar que, más allá de los datos empíricos, hemos querido poner de manifiesto las grandes líneas de investigación que la arqueología hispana moderna está desarrollando en este campo de investigación.Peer reviewe