Double or nothing: red flag symptoms of critical carotid stenosis, a case report

Abstract Background Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transient oculomotor nerve palsies have been described associated with stenosis or occlusion of the ICA. Case presentation We described a patient that develop a sequential combination of transient monocular loss of vision followed by binocular diplopia secondary to an unstable atherosclerotic preocclusive stenosis of an internal carotid artery previously treated with radiotherapy. Conclusions The peculiar sequence of transient monocular vision that give rise later into a transient binocular diplopia (double or nothing) should be kept in mind as a possible manifestation of critical stenosis of ICA

Pesticide Exposure Alters Follicle-Stimulating Hormone Levels in Mexican Agricultural Workers

Organophosphorous pesticides (OPs) are suspected of altering reproductive function by reducing brain acetylcholinesterase activity and monoamine levels, thus impairing hypothalamic and/or pituitary endocrine functions and gonadal processes. Our objective was to evaluate in a longitudinal study the association between OP exposure and serum levels of pituitary and sex hormones. Urinary OP metabolite levels were measured by gas–liquid chromatography, and serum pituitary and sex hormone levels by enzymatic immunoassay and radioimmunoassay in 64 men. A total of 147 urine and blood samples were analyzed for each parameter. More than 80% of the participants had at least one OP metabolite in their urine samples. The most frequent metabolite found was diethylthiophosphate (DETP; 55%), followed by diethylphosphate (DEP; 46%), dimethylthiophosphate (DMTP; 32%), and dimethyldithiophosphate (DMDTP; 31%). However, the metabolites detected at higher concentrations were DMTP, DEP, DMDTP, and dimethylphosphate. There was a high proportion of individuals with follicle-stimulating hormone (FSH) concentrations outside the range of normality (48%). The average FSH serum levels were higher during the heavy pesticide spraying season. However, a multivariate analysis of data collected in all periods showed that serum FSH levels were negatively associated with urinary concentrations of both DMTP and DMDTP, whereas luteinizing hormone (LH) was negatively associated with DMTP. We observed no significant associations between estradiol or testosterone serum levels with OP metabolites. The hormonal disruption in agricultural workers presented here, together with results from experimental animal studies, suggests that OP exposure disrupts the hypothalamic–pituitary endocrine function and also indicates that FSH and LH are the hormones most affected

Assessment of Rights-Related Personal Outcomes in Young People with Intellectual Disability and Autism Spectrum Disorder

Despite the great importance of the quality of life concept in the intellectual disability (ID) field, literature about its application to youth with autism spectrum disorder (ASD) is scarce, especially for the rights domain, an area that has become particularly important after the ratification of the Convention on the Rights of Persons with Disabilities. This study focuses on assessing the rights of youth with ASD and ID and comparing their results obtained by people with ID and other associated conditions: Down syndrome and cerebral palsy. The Rights subscale from the field-test version of the KidsLife Scale was administered in a sample composed of 153 participants with ID aged from 4 to 21 years old (ASD = 51; Down syndrome = 51; cerebral palsy = 51). The variables gender, type of schooling, level of ID and level of support needs were significant for the group with ASD. The three groups showed positive outcomes, though youth with Down syndrome obtained statistically significant higher scores than participants with ASD.Aun teniendo gran relevancia el concepto de calidad de vida en el ámbito de la discapacidad intelectual (DI), existe escasa investigación acerca de su aplicación en jóvenes con trastorno del espectro del autismo (TEA), especialmente acerca de la dimensión derechos, área que ha cobrado especial importancia en los últimos años con la ratificación de la Convención de los Derechos de las Personas con Discapacidad de Naciones Unidas. Este estudio se centra en la evaluación de derechos en jóvenes con TEA y DI, comparando sus resultados con dos grupos de jóvenes que presentan DI y otra condición comórbida: síndrome de Down y parálisis cerebral. Para ello, se utilizó la subescala derechos de la versión piloto de la Escala KidsLife en una muestra de 153 participantes con DI entre 4 y 21 años (TEA = 51; síndrome de Down = 51; parálisis cerebral = 51). En el grupo con TEA, el género, el tipo de escolarización, el nivel de DI y de necesidades de apoyo dieron lugar a diferencias significativas. Los tres grupos obtuvieron resultados positivos, aunque los jóvenes con síndrome de Down obtienen resultados significativamente superiores a los obtenidos por jóvenes con TEA

Spatio-temporal variability of droughts in Bolivia: 1955-2012

In this study, the spatio-temporal variability and trends of droughts across Bolivia between 1955 and 2012 were investigated using two climate drought indices: the Standardized Precipitation Index (SPI), which is based on precipitation data, and the Standardized Precipitation Evapotranspiration Index (SPEI), which is based on the difference between the precipitation and the reference evapotranspiration (ETo). We found that the average drought conditions across the country showed a temporal behaviour mainly characterized by decadal variations. The spatial pattern of drought evolution showed marked differences between the Amazonian region and the Bolivian Altiplano. Both regions showed different drought periods, a lower frequency of drought variability in the Amazon region and trends towards drier conditions in the Altiplano, mainly due to a higher atmospheric water demand as a consequence of increased ETo. We also showed that inclusion of ETo, obtained from maximum and minimum temperature records, increased the spatial heterogeneity of the drought evolution in relation to the evolution observed when only precipitation droughts were considered. The SPEI, the calculation of which includes precipitation and ETo, indicated intensification in drought severity in the last years analysed relative to the pattern found when precipitation droughts alone were considered, and also indicated an increase in the magnitude and duration of drought events. The potential for increasing drought conditions under various climate change scenarios is discussed. © 2015 Royal Meteorological Society.This work has been supported by research projects I-COOP H2O 2013CD0006: ‘Test multisectorial y actividades demostrativa sobre el potencial desarrollo de sistemas de monitorización de sequías en tiempo real en la región del oeste de Sudamérica’ financed by the Spanish National Research Council (CSIC), CGL2011-27574-CO2-02 financed by the Spanish Commission of Science and Technology and FEDER, ‘Demonstration and validation of innovative methodology for regional climate change adaptation in the Mediterranean area (LIFE MEDACC)’ financed by the LIFE programme of the European Commission, C.A.-M. received a postdoctoral fellowship # JCI-2011-10263. A.S.-L. is supported by the ‘Secretaria per a Universitats i Recerca del Departament d'Economia i Coneixement, de la Generalitat de Catalunya i del programa Cofund de les Accions Marie Curie del 7è Programa marc d'R + D de la Unió Europea’ (2011 BP-B 00078) and the postdoctoral fellowship # JCI-2012-12508.Peer Reviewe

Air and wet bulb temperature lapse rates and their impact on snowmaking in a Pyrenean ski resort

A set of 17 air temperature and relative humidity sensors were used to analyze the temporal variability of surface air temperature (Tair), wet bulb temperature (Twb), and daily snowmaking hours (SM, number of hours per day with Twb < − 2 °C), lapse rates, and the occurrence of thermal inversions at the Formigal ski resort (Spanish Pyrenees) from December to March during three consecutive ski seasons (2012–2013, 2013–2014, and 2014–2015). The Tair and Twb lapse rates showed strong hourly and daily variability, with both exhibiting almost identical temporal fluctuations. The Twb exhibited average lapse rates that were slightly steeper (− 5.2 °C/km) than those observed for Tair (− 4.9 °C/km). The less steep lapse rates and most thermal inversions were observed in December. Days having less (more) steep Tair and Twb lapse rates were observed under low (high) wind speeds and high (low) relative humidity and air pressure. The temporal dynamics of the SM lapse rates was more complex, as this involved consideration of the average Tair in the ski resort, in addition to the driving factors of the spatio-temporal variability of Twb. Thus, on a number of cold (warm) days, snowmaking was feasible at all elevations at the ski resort, independently of the slopes of the lapse rates. The SM exhibited an average daily lapse rate of 8.2 h/km, with a progressive trend of increase from December to March. Weather types over the Iberian Peninsula tightly control the driving factors of the Tair, Twb, and SM lapse rates (wind speed, relative humidity, and Tair), so the slopes of the lapse rates and the frequency of inversions in relation to elevation for the three variables are very dependent on the occurrence of specific weather types. The less steep lapse rates occurred associated with advections from the southeast, although low lapse rates also occurred during advections from the east and south, and under anticyclonic conditions. The steepest Tair and Twb lapse rates were observed during north and northwest advections, while the steepest rates for SM were observed during days of cyclonic circulation and advections from the northeast.This study was funded by the research project CGL2014-52599-P "Estudio del manto de nieve en la montaña española y su respuesta a la variabilidad y cambio climatico" (Ministry of Economy and Development, MINECO)

Efecto de la bajada de peso y la competición sobre el perfil de estado de ánimo en deportes de combate

El propósito de este estudio ha sido describir los cambios que sufre el estado de ánimo que presentan los deportistas de combate durante las fases de bajada de peso y su posterior recuperación antes del comienzo de los eventos competitivos prioritarios de la temporada. Un total de 105 hombres y mujeres especialistas en las modalidades de combate de luchaolímpica, taekwondo y boxeo fueron pesados y contestaron la versión abreviada del Perfil de Estados de Ánimo (POMS) entre 30 y 60 minutos antes del pesaje oficial (PRE) y entre 30 y 60 minutos antes del comienzo del primer combate (POST) de sus respectivos campeonatos nacionales. Los resultados demostraron que las hubo mejoras significativas (p &lt; .05) en lasdimensiones de Cólera, Fatiga y Depresión, aunque estos cambios no parecen estar relacionados con la variación porcentual de la masa corporal que experimentan los deportistas durante este mismo periodo (r &lt; .261). Estos hallazgos nos indican que las 12-18 horas que separan el pesaje oficial y el comienzo del torneo en deportes de combate propician mejoras sustanciales en sus estados de ánimo, aunque estos cambios parecen ser independientesde sus fluctuación de la masa corporal

The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles

T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency of T cell activation and subsequent immune response. Here, we show that the cytosolic chaperonin CCT (chaperonin-containing TCP1) controls the changes in reciprocal orientation of the centrioles and polarization of the tubulin dynamics induced by T cell receptor in T lymphocytes forming an IS. CCT also controls the mitochondrial ultrastructure and the metabolic status of T cells, regulating the de novo synthesis of tubulin as well as posttranslational modifications (poly-glutamylation, acetylation, ?1 and ?2) of ??-tubulin heterodimers, fine-tuning tubulin dynamics. These changes ultimately determine the function and organization of the centrioles, as shown by three-dimensional reconstruction of resting and stimulated primary T cells using cryo-soft x-ray tomography. Through this mechanism, CCT governs T cell activation and polarity.Cryo-SXT work was supported by ALBA Synchrotron standard proposals 2015021148 and 2016021638 to F.J.C., N.B.M.-C., and J.M.V. This study was supported by grants SAF2017-82886-R (to F.S.-M.), PID2019-105872GB-I00/AEI/10.13039/501100011033 (AEI/FEDER, UE), BFU2016-75984 (to J.M.V.), and BIO2015-67580-P and PGC2018-097019-B-I00 (to J.V.) from the Spanish Ministry of Economy and Competitiveness (MINECO), grants INFLAMUNE-S2017/BMD-23671 (to F.S.-M.) and P2018/NMT-4389 (to J.M.V.) from the Comunidad de Madrid, ERC-2011-AdG 294340-GENTRIS (to F.S.-M.), a 2019 grant from the Ramón Areces Foundation “Ciencias de la Vida y la Salud” and a 2018 grant from Ayudas Fundación BBVA a Equipos de Investigación Científica (to F.S.-M.), and grants PRB3 (IPT17/0019-ISCIII-SGEFI/ERDF), the Fundació Marató TV3 (grant 122/C/2015), and “La Caixa” Banking Foundation (HR17-00016 to FSM and HR17-00247 to J.V.). D.T. is supported by a PhD fellowship from La Caixa Foundation. Work in the Vernos lab was supported by the grant CSD2006-00023 from the Spanish Ministry of Science and Innovation and grants BFU2012-37163 and BFU2015-68726-P from the Spanish Ministry of Economy and Competitiveness. The CRG acknowledges support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme/Generalitat de Catalunya. CIBER Cardiovascular (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015- 0505). The Centro Nacional de Biotecnología (CNB) is a Severo Ochoa Center of Excellence (MINECO award SEV 2017-0712). Funding agencies have not intervened in the design of the studies, with no copyright over the stud

The PAU survey: classifying low-z SEDs using Machine Learning clustering

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record Monthly Notices of the Royal Astronomical Society 524.3 (2023): 3569-3581 is available online at: https://academic.oup.com/mnras/article-abstract/524/3/3569/7225529?redirectedFrom=fulltextWe present an application of unsupervised Machine Learning clustering to the PAU survey of galaxy spectral energy distribution (SED) within the COSMOS field. The clustering algorithm is implemented and optimized to get the relevant groups in the data SEDs. We find 12 groups from a total number of 5234 targets in the survey at 0.01 < z < 0.28. Among the groups, 3545 galaxies (68 per cent) show emission lines in the SEDs. These groups also include 1689 old galaxies with no active star formation. We have fitted the SED to every single galaxy in each group with CIGALE. The mass, age, and specific star formation rates (sSFR) of the galaxies range from 0.15 < age/Gyr <11; 6 < log (M/M⊙) <11.26, and -14.67 < log (sSFR/yr-1) <-8. The groups are well-defined in their properties with galaxies having clear emission lines also having lower mass, are younger and have higher sSFR than those with elliptical like patterns. The characteristic values of galaxies showing clear emission lines are in agreement with the literature for starburst galaxies in COSMOS and GOODS-N fields at low redshift. The star-forming main sequence, sSFR versus stellar mass and UVJ diagram show clearly that different groups fall into different regions with some overlap among groups. Our main result is that the joint of low- resolution (R ∼50) photometric spectra provided by the PAU survey together with the unsupervised classification provides an excellent way to classify galaxies. Moreover, it helps to find and extend the analysis of extreme ELGs to lower masses and lower SFRs in the local UniverseThis work has been supported by the Ministry of Science and Innovation of Spain, project PID2019-107408GB-C43 (ESTALLIDOS), and the Government of the Canary Islands through EU FEDER funding, projects PID2020010050 and PID2021010077. This article is based on observations made in the Observatorios de Canarias of the Instituto de Astrofísica de Canarias (IAC) with the WHT operated on the island of La Palma by the Isaac Newton Group of Telescopes (ING) in the Observatorio del Roque de los Muchachos. The PAU Survey is partially supported by MINECO under grants CSD2007-00060, AYA2015-71825, ESP2017-89838, PGC2018-094773, PGC2018-102021, PID2019-111317GB, SEV-2016-0588, SEV-2016-0597, MDM-2015-0509 and Juan de la Cierva fellowship and LACEGAL and EWC Marie Sklodowska-Curie grant No 734374 and no.776247 with ERDF funds from the EU Horizon 2020 Programme, some of which include ERDF funds from the European Union. IEEC and IFAE are partially funded by the CERCA and Beatriu de Pinos program of the Generalitat de Catalunya. Funding for PAUS has also been provided by Durham Univer sity (via the ERC StG DEGAS-259586), ETH Zurich, Leiden University (via ERC StG ADULT-279396 and Netherlands Organisation for Scientific Research (NWO) Vici grant 639.043.512), University College London and from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 776247 EWC. The PAU data center is hosted by the Port d’Información Científica (PIC), maintained through a collaboration of CIEMAT and IFAE, with additional support from Universitat Autónoma de Barcelona and ERDF. We acknowledge the PIC services department team for their support and fruitful discussion

Cytomolecular identification of individual wheat-wheat chromosome arm associations in wheat-rye hybrids

Chromosome pairing in the meiotic metaphase I of wheatrye hybrids has been characterized by sequential genomic and fluorescent in situ hybridization allowing not only the discrimination of wheat and rye chromosomes, but also the identification of the individual wheat and rye chromosome arms involved in the chromosome associations. The majority of associations (93.8%) were observed between the wheat chromosomes. The largest number of wheat-wheat chromosome associations (53%) was detected between the A and D genomes, while the frequency of B-D and A-B associations was significantly lower (32 and 8%, respectively). Among the A-D chromosome associations, pairing between the 3AL and 3DL arms was observed with the highest frequency, while the most frequent of all the chromosome associations (0.113/ cell) was found to be the 3DS-3BS. Differences in the pairing frequency of the individual chromosome arms of wheat-rye hybrids have been discussed in relation to the homoeologous relationships between the constituent genomes of hexaploid wheat