Dynamical quark recombination in ultrarelativistic heavy-ion collisions and the proton to pion ratio

We study quark thermal recombination as a function of energy density during the evolution of a heavy-ion collision in a numerical model that reproduces aspects of QCD phenomenology. We show that starting with a set of free quarks (or quarks and antiquarks) the probability to form colorless clusters of three quarks differs from that to form colorless clusters of quark-antiquark and that the former has a sharp jump at a critical energy density whereas the latter transits smoothly from the low to the high energy density domains. We interpret this as a quantitative difference in the production of baryons and mesons with energy density. We use this approach to compute the proton and pion spectra in a Bjorken scenario that incorporates the evolution of these probabilities with energy density, and therefore with proper time. From the spectra, we compute the proton to pion ratio and compare to data at the highest RHIC energies. We show that for a standard choice of parameters, this ratio reaches one, though the maximum is very sensitive to the initial evolution proper time.Comment: 10 pages, 12 figures, version to appear in Phys. Rev.

Boundary and expansion effects on two-pion correlation functions in relativistic heavy-ion collisions

We examine the effects that a confining boundary together with hydrodynamical expansion play on two-pion distributions in relativistic heavy-ion collisions. We show that the effects arise from the introduction of further correlations due both to collective motion and the system's finite size. As is well known, the former leads to a reduction in the apparent source radius with increasing average pair momentum K. However, for small K, the presence of the boundary leads to a decrease of the apparent source radius with decreasing K. These two competing effects produce a maximum for the effective source radius as a function of K.Comment: 6 pages, 5 Eps figures, uses RevTeX and epsfi

Deviance detection in auditory subcortical structures: what can we learn from neurochemistry and neural connectivity?

[EN] A remarkable ability of animals that is critical for survival is to detect and respond to to unexpected stimuli in an ever-changing world. Auditory neurons that show stimulusspecific adaptation (SSA), i.e., a decrease in their response to frequently occurring stimuli while maintaining responsiveness when different stimuli are presented, might participate in the coding of deviance occurrence. Traditionally, deviance detection is measured by the mismatch negativity (MMN) potential in studies of evoked local field potentials.We present a review of the state-of-the-art of SSA in auditory subcortical nuclei, i.e., the inferior colliculus and medial geniculate body of the thalamus, and link the differential receptor distribution and neural connectivity of those regions in which extreme SSA has been found. Furthermore, we review both SSA and MMN-like responses in auditory and non-auditory areas that exhibit multimodal sensitivities that we suggest conform to a distributed network encoding for deviance detection. The understanding of the neurochemistry and response similarities across these different regions will contribute to a better understanding of the neural mechanism underlying deviance detection

Effective potential at finite temperature in a constant magnetic field I: Ring diagrams in a scalar theory

We study symmetry restoration at finite temperature in the theory of a charged scalar field interacting with a constant, external magnetic field. We compute the finite temperature effective potential including the contribution from ring diagrams. We show that in the weak field case, the presence of the field produces a stronger first order phase transition and that the temperature for the onset of the transition is lower, as compared to the case without magnetic field.Comment: Expanded comments, 4 figures added. Conclusions unchanged. Version to match published pape

Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus

[EN] In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA) may contribute to this process. Those neurons adapt to frequent sounds while retaining their excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source of projections with the physiological response. SSA neurons were confined to the non-lemniscal subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary, the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that are populated by SSA neurons enabling them to compare top-down signals with incoming sensory information from lower areas

Characterization of the annual regulation of reproductive and immune parameters on the testis of European sea bass

The European sea bass, Dicentrarchus labrax L., is a seasonal gonochoristic species, which males are generally mature during the second year of life. It has been demonstrated that cytokines and immune cells play a key role in the testicular development. This reproductive-immune interaction might be very important in the sea bass since several pathogens are able to colonize the gonad and persist in this tissue, altering further reproductive functions and spreading the disease. This study aims to investigate the reproductive cycle of one year European sea bass males by analyzing cell proliferation and apoptosis and expression profile of some reproductive and immune-related genes in the testis as well as the serum sex steroid levels. Our data demonstrate that in one year old European sea bass males, the testis undergoes the spermatogenesis process and that the reproductive and immune parameters analyzed varied during the reproductive cycle. In the testis, the highest proliferative rates were recorded at spermatogenesis stage, while the highest apoptotic rates were recorded at spawning stage. We have also analyzed, for the first time in European sea bass males, the serum levels of 17β-estradiol (E2) and dihydrotestosterone and the gene expression profile of the enzymes implied in their production, determining that at least E2 might be involved in the regulation of the reproductive cycle. Some immune relevant genes, including cytokines, lymphocyte receptors, anti-viral and antibacterial molecules were detected in the testis of naïve European sea bass specimens and their expression profile was related with the stages of the reproductive cycle, suggesting an important role for the defence of the reproductive tissues.Postprin

On optimal temozolomide scheduling for slowly growing glioblastomas

Background: Temozolomide (TMZ) is an oral alkylating agent active against gliomas with a favorable toxicity profile. It is part of the standard of care in the management of glioblastoma (GBM), and is commonly used in low-grade gliomas (LGG). In-silico mathematical models can potentially be used to personalize treatments and to accelerate the discovery of optimal drug delivery schemes. Methods: Agent-based mathematical models fed with either mouse or patient data were developed for the in-silico studies. The experimental test beds used to confirm the results were: mouse glioma models obtained by retroviral expression of EGFR-wt/EGFR-vIII in primary progenitors from p16/p19 ko mice and grown in-vitro and in-vivo in orthotopic allografts, and human GBM U251 cells immobilized in alginate microfibers. The patient data used to parametrize the model were obtained from the TCGA/TCIA databases and the TOG clinical study. Results: Slow-growth "virtual" murine GBMs benefited from increasing TMZ dose separation in-silico. In line with the simulation results, improved survival, reduced toxicity, lower expression of resistance factors, and reduction of the tumor mesenchymal component were observed in experimental models subject to long-cycle treatment, particularly in slowly growing tumors. Tissue analysis after long-cycle TMZ treatments revealed epigenetically driven changes in tumor phenotype, which could explain the reduction in GBM growth speed. In-silico trials provided support for implementation methods in human patients. Conclusions: In-silico simulations, in-vitro and in-vivo studies show that TMZ administration schedules with increased time between doses may reduce toxicity, delay the appearance of resistances and lead to survival benefits mediated by changes in the tumor phenotype in slowly-growing GBMs.This research was funded by the James S. Mc. Donnell Foundation (USA) 21st Century Science Initiative in Mathematical and Complex Systems Approaches for Brain Cancer (Collaborative award 220020560, doi:10.37717/220020560); Ministry of Education, Science and Technological Development, Republic of Serbia (ref. number 451-03-9/2021-14/200007); Ministerio de Ciencia e Innovación and FEDER funds, Spain (grant number PID2019-110895RB-I00, doi: 10.13039/501100011033 to VMP-G, and RTI2018-093596 and PI21CIII/00002 to PS-G); and Universidad de Castilla-La Mancha (grant number 2020-PREDUCLM-15634 to JJ-S).S

Thermal ecology of the lizard Sceloporus gadoviae (Squamata: Phrynosomatidae) in a semiarid region of southern Puebla, Mexico.

Estudamos a ecologia térmica do lagarto Sceloporus gadoviaede Puebla, México. A temperatura corporal média (Tb) foi de 31.5 ± 0.3˚C. Uma regressão múltipla sugeriu que Tb foi afetada pela temperatura do substrato e insolação, e minimamente afetada pela temperatura do ar (Ta), sexo e tamanho do corpo. No entanto, a temperatura corporal foi mais elevada em fêmeas do que em machos e em fêmeas ovígeras do que em fêmeas não-ovígeras. Também encontramos diferenças significativas nas Tbs de lagartos que ocupam micro-habitats com diferentes graus de insolação (ensolarado, nublado e sombreado). Os resultados sugerem que a variação na Tb de S. gadoviae pode ser explicada pela condição reprodutiva, uso de micro-habitats e variação na temperatura do substrato dos micro-habitats ocupados por esses lagartos.We studied the thermal ecology of the lizard Sceloporus gadoviae from Puebla, Mexico. Mean body temperature (Tb) was 31.5 ± 0.3˚C. A multiple regression suggested that Tb was affected by substrate temperature and solar insolation, and minimally affected by ambient temperature (Ta), sex, and body size. However, body temperature was higher in females than males, and higher in gravid females than non-gravid females. We also found significant differences in Tbs of lizards occupying microhabitats with different insolation (sunny, overcast day, and shade). Results suggestthat variation in Tb of S. gadoviae can be explained by reproductive condition, microhabitat use, and variation in substrate temperature of microhabitats occupied by these lizards