684 research outputs found
The Contribution of Global Alliances to Airlines’ Environmental Performance
Global alliances have traditionally been related to improvements in the economic and operational performances of companies, particularly in the airline industry. However, we still do not know the effect of the participation in this kind of multilateral agreement on the environmental performance of airlines. The main aim of this work is to analyze whether the alliance membership of airlines has an effect upon their environmental performance, and if so, whether or not the characteristics of the global alliance, as well as the business model of the airline, may influence this relation to a greater or lesser extent. The results of regression and Analysis of Variance (ANOVA) in a sample of 252 airlines (58 included in one of the three global alliances: Star Alliance, Oneworld, and SkyTeam) show a strong and inverse relationship between environmental performance and belonging to an alliance. The paper also shows empirical evidence of the influence of the business model of the airline on environmental performance. These results suggest important implications for managers facing challenges regarding sustainability
The Use of Magnetic Susceptibility as a Technique to Measure the Impact of Wildfires on Archaeological Heritage
Wildfires are one of the main threats of natural areas and often fires can affect protected or heritage areas and properties, in which the preservation requirements demand the use of non-destructive techniques (NDTs). The magnetic susceptibility is an NDT that provides information on the mineralogical composition of the materials but has never been applied to the evaluation of fires. Here, we combine laboratory with field analysis to test the applicability of the magnetic susceptibility for the assessment of the impacts of wildfires. The laboratory results showed an increase in the magnetic susceptibility with the temperature, more evident in the samples heated to 600 °C and above. The in situ measures revealed a spatial variation in the magnetic susceptibility, which was related to the behaviour of the fire in the area. The samples were later analysed with other magnetic destructive techniques that were used to confirm the mineralogical processes that occurred in the materials. The increase in the susceptibility values were due to the formation of iron oxides. The destructive analysis also showed the presence of minerals such as hematite and magnetite in the samples. Overall, the study allowed a first approach to test the magnetic susceptibility as a simple and fast way to measure the impacts of wildfires
El desarrollo del pensamiento crítico en la infancia: análisis y posibilidades para una educación artística contemporánea
El presente trabajo tiene como principal objetivo demostrar la importancia de la educación artística para el desarrollo del pensamiento crítico en la infancia. Como es de esperar, esta premisa se entiende desde la realidad del siglo XXI, caracterizada por el auge de la cultura visual. Por su papel activo en la sociedad, la cultura visual es capaz de influir en el pensamiento del individuo a través de las imágenes y sus mensajes, que no pocas veces pasan desapercibidos; y resulta paradójico descubrir que, en un contexto donde predomina lo puramente icónico, la educación artística ha sido reducida de forma preocupante en las aulas de Primaria. Para establecer las bases del problema, se ha realizado un estudio bibliográfico de la situación actual de esta disciplina en España y del poder de la cultura visual, seguido de algunas propuestas pedagógicas que acercarán al lector a distintos modelos educativos que pueden perpetuar o transformar este escenario. Finalmente, se han extraído una serie de elementos favorecedores para el desarrollo del pensamiento crítico desde la enseñanza de las artes: con ellos, se ha planteado una propuesta para una educación artística contemporánea, en la que se anticipan las conclusiones recogidas al final de esta investigación.<br /
La aplicación del despido colectivo por causas económicas, técnicas, organizativas o de producción en el sector público local
Este trabajo analiza con brevedad el régimen del despido colectivo en el sector público
que regula el Real Decreto 1483/2012, de 29 de octubre, que aprueba el Reglamento de
los procedimientos de despido colectivo y de suspensión de contratos y reducción de jornada.
El Real Decreto citado trae causa de la modificación del Estatuto de los Trabajadores
operada al efecto por la Ley 3/2012, de 6 de julio, de medidas urgentes para la reforma del
mercado laboral. Se trata de una normativa que contempla expresamente la posibilidad
del despido colectivo del personal laboral que presta servicios en el sector público y que,
además, establece causas objetivas particulares y algunas otras especialidades del despido en
las Administraciones públicas. Esta circunstancia, añadida a las exigencias de estabilidad
presupuestaria y de sostenibilidad financiera impuestas a las Administraciones públicas,
configura un nuevo panorama para el despido en el ámbito públic
Proposal of the Dichotomous STATIS DUAL Method: Software and Application for the Analysis of Dichotomous Data, Applied to the Test of Learning Styles in University Students
The present work analyzed a review of methods for analyzing sequences of matrices or dichotomous data. A new method for a sequence of dichotomous matrices with a different number of rows is presented; the Dichotomous STATIS DUAL. Suppose we match the sequence of matrices by different years, with this method. In that case, we can graphically represent the relations among the different columns of all the matrices, and the relations between those columns and the different years, because everything can be represented in the same plots. As in all STATIS methods, three different plots can get (i) the interstructure, with the relations among the years; (ii) the compromise, with the stable part of the relations between the columns; and (iii) the intrastructure (also known as trajectories), with the relations between columns and years, in other words, the evolution of the columns through the time. This new mathematical method can be used with all kinds of dichotomous data, thanks to the software we propose. In the present work, the software was applied to the assessment of learning styles
Final results regarding the addition of dendritic cell vaccines to neoadjuvant chemotherapy in early HER2-negative breast cancer patients: clinical and translational analysis
Background: Primary breast cancer (BC) has shown a higher immune infiltration than the
metastatic disease, justifying the optimal scenario for immunotherapy. Recently, neoadjuvant
chemotherapy (NAC) combined with immune checkpoint inhibitors has demonstrated a gain
in pathological complete responses (tpCR) in patients with BC. The aim of our study is to
evaluate the safety, feasibility, and efficacy of the addition of dendritic cell vaccines (DCV) to
NAC in HER2-negative BC patients.
Methods: Thirty-nine patients with early BC received DCV together with NAC conforming
the vaccinated group (VG) and compared with 44 patients as the control group (CG). All
patients received anthracyclines and taxanes-based NAC (ddECx4→Dx4) followed by
surgery ± radiotherapy ± hormonotherapy.
Results: The tpCR rate was 28.9% in the VG and 9.09% in the CG (p=0.03). Pathological CR
in the triple negative (TN) BC were 50.0% versus 30.7% (p=0.25), 16.6% versus 0% in luminal
B (p=0.15), and none among luminal A patients in VG versus CG, respectively. Impact of DCV
was significantly higher in the programmed cell death ligand 1 (PD-L1) negative population
(p<0.001). PD-L1 expression was increased in patients with residual disease in the VG as
compared with the CG (p<0.01). No grade ⩾3 vaccine-related adverse events occurred.
With a median follow-up of 8years, no changes were seen in event-free survival or overall
survival. Phenotypic changes post DCV in peripheral blood were observed in myeloid-derived
suppressor cells (MDSC), NK, and T cells. Increase in blood cell proliferation and interferon
(IFN)-γ production was detected in 69% and 74% in the VG, respectively. Humoral response
was also found. Clonality changes in TCR-β repertoire were detected in 67% of the patients
with a drop in diversity index after treatment.
Conclusion: The combination of DCV plus NAC is safe and increases tpCR, with a significant
benefit among PD-L1-negative tumors. DCV modify tumor milieu and perform cellular and
humoral responses in peripheral blood with no impact in outcome.
Trial registration: ClinicalTrials.gov number: NCT01431196. EudraCT 2009-017402-36
Detection of growth-related QTL in turbot (Scophthalmus maximus)
<p>Abstract</p> <p>Background</p> <p>The turbot (<it>Scophthalmus maximus</it>) is a highly appreciated European aquaculture species. Growth related traits constitute the main goal of the ongoing genetic breeding programs of this species. The recent construction of a consensus linkage map in this species has allowed the selection of a panel of 100 homogeneously distributed markers covering the 26 linkage groups (LG) suitable for QTL search. In this study we addressed the detection of QTL with effect on body weight, length and Fulton's condition factor.</p> <p>Results</p> <p>Eight families from two genetic breeding programs comprising 814 individuals were used to search for growth related QTL using the panel of microsatellites available for QTL screening. Two different approaches, maximum likelihood and regression interval mapping, were used in order to search for QTL. Up to eleven significant QTL were detected with both methods in at least one family: four for weight on LGs 5, 14, 15 and 16; five for length on LGs 5, 6, 12, 14 and 15; and two for Fulton's condition factor on LGs 3 and 16. In these LGs an association analysis was performed to ascertain the microsatellite marker with the highest apparent effect on the trait, in order to test the possibility of using them for marker assisted selection.</p> <p>Conclusions</p> <p>The use of regression interval mapping and maximum likelihood methods for QTL detection provided consistent results in many cases, although the high variation observed for traits mean among families made it difficult to evaluate QTL effects. Finer mapping of detected QTL, looking for tightly linked markers to the causative mutation, and comparative genomics are suggested to deepen in the analysis of QTL in turbot so they can be applied in marker assisted selection programs.</p
ENSO coupling to the equatorial Atlantic: analysis with an extended improved recharge oscillator model
© 2023 Crespo-Miguel, Polo, Mechoso, Rodríguez-Fonseca and Cao-García. Weacknowledge Javier Jarillo and Lander R. Crespo for their help during the early stages of manuscript writing. We acknowledge the World Climate Research Programme’s Working Group on Coupled Modeling, responsible for CMIP, and we thank the climate modeling groups for producing and making available their model output. This work was financially supported by 817578 TRIATLAS project of the Horizon 2020 Programme (EU) and RTI2018095802-B-I00 and PID2021-125806NB-I00 of Ministerio de Economía y Competitividad (Spain), Fondo Europeo de Desarrollo Regional (FEDER, EU), the European Union Seventh Framework Programme (EU-FP7/2007–2013) PREFACE (Grant Agreement No. 603521), the ERC STERCP project (grant 648982), the ARC Centre of Excellence in Climate Extremes (CE170100023) and the Spanish project (CGL201786415-R).Introduction: Observational and modeling studies have examined the interactions between El Niño-Southern Oscillation (ENSO) and the equatorial Atlantic variability as incorporated into the classical charge-recharge oscillator model of ENSO. These studies included the role of the Atlantic in the predictability of ENSO but assumed stationarity in the relationships, i.e., that models’ coefficients do not change overtime. Arecentworkbytheauthors has challenged the stationarity assumption in the ENSO framework but without considering the equatorial Atlantic influence on ENSO. Methods: The present paper addresses the changing relationship between ENSO and the Atlantic El Niño using an extended version of the recharge oscillator model. The classical two-variable model of ENSO is extended by adding a linear coupling on the SST anomalies in the equatorial Atlantic. The model’s coefficients are computed for different periods. This calculation is done using two methods tofitthemodel tothe data: (1) the traditional method (ReOsc), and (2) a novel method (ReOsc+) based on fitting the Fisher’s Z transform of the auto and cross-correlation functions. Results: Weshowthat, duringthe 20th century, the characteristic dampingrate of the SST and thermocline depth anomalies in the Pacific have decreased in time by a factor of 2 and 3, respectively. Moreover, the damping time of the ENSO fluctuations has doubled from 10 to 20 months, and the oscillation period of ENSO has decreased from 60-70 months before the 1960s to 50 months afterward. These two changes have contributed to enhancing ENSO amplitude. The results also show that correlations between ENSO and the Atlantic SST strengthened after the 70s and the way in which the impact of the equatorial Atlantic is added to the internal ENSO variability. Conclusions: The remote effects of the equatorial Atlantic on ENSO must be considered in studies of ENSO dynamics and predictability during specific time-periods. Our results provide further insight into the evolution of the ENSO dynamics anditscoupling to the equatorial Atlantic, as well as an improved tool to study the coupling of climatic and ecological variables.Depto. de Estructura de la Materia, Física Térmica y ElectrónicaDepto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasTRUEHorizon 2020 Programme (EU)Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo Regional (FEDER, EU)European Union Seventh Framework ProgrammeERC STERCP projectARC Centre of Excellence in Climate ExtremesSpanish projectpu
Supply Chain Management in a Degrowth Context: The Potential Contribution of Stakeholders
The planet is changing and consumption patterns appear to be one of the main causes. The Earth has physical limits and eternal growth is basically not possible. In this context the economic theory of degrowth arises to change present consumption and production habits in order to ensure the survival of our planet and its inhabitants. Sustainability is a very important concept in the operations management field nowadays. In this chapter, we will contribute to this field discussing areas where degrowth is present explaining the important contributions of the stakeholder theory to reach a more sustainable supply chain, contributing to the achievement of SDGs. With this, we aim to highlight the influence that stakeholder pressures have when making supply chain management decisions to achieve a higher sustainability level in the firm, and ultimately, in the whole system
Bioavailability, mobility and leaching of phosphorus in a Mediterranean agricultural soil (ne Spain) amended with different doses of biosolids
The precipitation of sparingly soluble
calcium phosphate in calcareous soils decreases the
bioavailability of macronutrients, which makes their
addition by way of fertilisers necessary. Sludge
resulting from treating urban wastewater does not
only provide significant amounts of phosphorus, but
also helps lower the pH, thus increasing its bioavailability.
The loss of part of soil nutrients due to
irrigation or rain can contaminate groundwater. In
order to assess the movement of phosphorus, a
experiment was conducted on percolation columns,
to which different doses of wastes were applied. The
pH decreased by as much as 0.89 units, as well as the
assimilable and soluble P, in intervals of 20 cm of
depth, obtaining maximum values of 254 mg P kg-1
and 1455 lg P kg-1 respectively, and the P present in
the leached water collected, which did not surpass
95 lg PL-1. The intent was to learn which was the
majoritarian inorganic formed crystalline phase that
immobilised the movement of phosphorus through the
percolation column. The results obtained by the
diffraction of X-rays are not conclusive, although
they point to the formation of octacalcium phosphate.
The diffractograms of the studied samples have
similar diffraction lines to those of apatites
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